ATA510180A - Verfahren zur herstellung von benzodiazepinverbindungen - Google Patents

Verfahren zur herstellung von benzodiazepinverbindungen

Info

Publication number: ATA510180A
Authority: AT; Austria
Prior art keywords: benzodiazepine compounds; producing benzodiazepine; producing; compounds; benzodiazepine
Prior art date: 1979-10-16

Application number

AT0510180A

Other languages

English (en)

Other versions

AT373889B (de

Original Assignee

Lilly Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-10-16

Filing date

1980-10-14

Publication date

1983-07-15

1980-10-14 Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd

1983-07-15 Publication of ATA510180A publication Critical patent/ATA510180A/de

1984-02-27 Application granted granted Critical

1984-02-27 Publication of AT373889B publication Critical patent/AT373889B/de

Links

150000001557 benzodiazepines Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Anesthesiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

AT0510180A 1979-10-16 1980-10-14 Verfahren zur herstellung von neuen benzodiazepinverbindungen AT373889B (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB7935846		1979-10-16

Publications (2)

Publication Number	Publication Date
ATA510180A true ATA510180A (de)	1983-07-15
AT373889B AT373889B (de)	1984-02-27

Family

ID=10508540

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT0510180A AT373889B (de)	1979-10-16	1980-10-14	Verfahren zur herstellung von neuen benzodiazepinverbindungen

Country Status (33)

Country	Link
US (3)	US4404137A (de)
EP (1)	EP0027390B1 (de)
JP (1)	JPS5663987A (de)
KR (2)	KR850000471B1 (de)
AR (2)	AR228041A1 (de)
AT (1)	AT373889B (de)
AU (1)	AU538500B2 (de)
BE (1)	BE885729A (de)
BG (2)	BG35042A3 (de)
CA (1)	CA1159056A (de)
CH (1)	CH646700A5 (de)
CS (1)	CS244409B2 (de)
DD (1)	DD153692A5 (de)
DE (1)	DE3068706D1 (de)
DK (1)	DK437480A (de)
ES (1)	ES495948A0 (de)
FI (1)	FI67550C (de)
FR (1)	FR2467851A1 (de)
GB (1)	GB8327127D0 (de)
GR (1)	GR70720B (de)
HU (1)	HU182213B (de)
IE (1)	IE50358B1 (de)
IL (1)	IL61264A (de)
IT (1)	IT1143047B (de)
LU (1)	LU82853A1 (de)
MX (1)	MX6233E (de)
NZ (1)	NZ195248A (de)
PH (2)	PH16288A (de)
PL (2)	PL135044B1 (de)
PT (1)	PT71913B (de)
RO (2)	RO81351B (de)
YU (1)	YU261580A (de)
ZA (1)	ZA806342B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4404137A (en) *	1979-10-16	1983-09-13	Lilly Industries Limited	Pyrazolo [3,4-b][1,5]benzodiazepine compounds
US4431589A (en) *	1980-12-11	1984-02-14	Lilly House	Benzodiazepine compounds and their use as pharmaceuticals
US4596799A (en) *	1985-01-29	1986-06-24	Ciba-Geigy Corporation	9H-pyrrolo[2,1-c]-1,2,4-triazolo[4,3-a][1,4]benzodiazepines
TW219896B (de) *	1988-07-07	1994-02-01	Duphar Int Res
GB8819059D0 (en) *	1988-08-11	1988-09-14	Lilly Industries Ltd	Benzodiazepine compounds & their use as pharmaceuticals
US5631250A (en) *	1995-03-24	1997-05-20	Eli Lilly And Company	Process and solvate of 2-methyl-thieno-benzodiazepine
US5637584A (en) *	1995-03-24	1997-06-10	Eli Lilly And Company	Solvate of olanzapine
JP2006515628A (ja) *	2003-01-23	2006-06-01	アカディアファーマシューティカルズ，インコーポレーテッド	ヒト神経精神疾患を処置するためのｎ−デスメチルクロザピンの使用
US20050250767A1 (en) *	2003-01-23	2005-11-10	Weiner David M	Use of N-desmethylclozapine to treat human neuropsychiatric disease
US20050085463A1 (en) *	2003-01-23	2005-04-21	Weiner David M.	Use of N-desmethylclozapine to treat human neuropsychiatric disease
PT1696931E (pt) *	2003-12-22	2009-06-12	Acadia Pharm Inc	Análogos diaril[a,d]ciclo-hepteno substituídos com amino utilizados como agonistas muscarínicos e métodos de tratamento de perturbações neuropsiquiátricas
BRPI0509524A (pt) *	2004-04-01	2007-09-18	Acadia Pharm Inc	formas cristalinas de n-desmetilclozapina
WO2007053618A1 (en) *	2005-10-31	2007-05-10	Acadia Pharmaceuticals Inc.	Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders
JP5438482B2 (ja) *	2009-12-03	2014-03-12	Ｊｕｋｉ株式会社	ミシン、ミシンの縫製データ編集装置及びミシンの縫製データ編集プログラム

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3450694A (en) *	1966-02-23	1969-06-17	Abbott Lab	Substituted benzoxazepines and benzothiazepines
US3758479A (en) *	1967-03-22	1973-09-11	Sandoz Ag	Nitro and sulphamoyl substituted dibenzodiazepines
DE1795183B1 (de) *	1968-08-20	1972-07-20	Thomae Gmbh Dr K	5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on-derivate und Arzneimittel
CA918659A (en) *	1969-07-31	1973-01-09	Yoshitomi Pharmaceutical Industries	11-(4-substituted-1-piperazinyl)-dibenzo (b,f) (1,4) thiazepines
US4115568A (en) *	1974-11-26	1978-09-19	Lilly Industries Limited	Thieno[3,2-b]-[1,5]benzodiazepines
US4172831A (en) *	1974-11-26	1979-10-30	Lilly Industries Limited	Thieno-benzodiazepines
US3951981A (en) *	1975-02-24	1976-04-20	American Cyanamid Company	Substituted benzodiazepines and method of use
US3953430A (en) *	1975-02-24	1976-04-27	American Cyanamid Company	Substituted benzodiazepin-10-ones and method of use
DE2707270A1 (de) *	1977-02-19	1978-08-24	Hoechst Ag	Pyrazolo-diazepine und verfahren zu ihrer herstellung
DE2707269A1 (de) *	1977-02-19	1978-08-24	Hoechst Ag	Heterocyclische stickstoffverbindungen und verfahren zu ihrer herstellung
US4097597A (en) *	1977-02-23	1978-06-27	Abbott Laboratories	Dibenzo b,e! 1,4!diazepines
IT7851496A0 (it) *	1977-10-31	1978-10-13	Sandoz Ag	Menti pirazinobenzossazepine loro preparazione e loro impiego quali medica
CH643263A5 (de) *	1979-05-11	1984-05-30	Sandoz Ag	Benzodiazepine, ihre herstellung und verwendung.
EP0023707B1 (de) *	1979-08-03	1986-04-30	Byk Gulden Lomberg Chemische Fabrik GmbH	Substituierte Tetraazatricyclen, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende Arzneimittel
US4404137A (en) *	1979-10-16	1983-09-13	Lilly Industries Limited	Pyrazolo [3,4-b][1,5]benzodiazepine compounds

1980
- 1980-10-02 US US06/193,200 patent/US4404137A/en not_active Expired - Lifetime
- 1980-10-11 GR GR63138A patent/GR70720B/el unknown
- 1980-10-13 RO RO102349A patent/RO81351B/ro unknown
- 1980-10-13 IL IL61264A patent/IL61264A/xx unknown
- 1980-10-13 CS CS806938A patent/CS244409B2/cs unknown
- 1980-10-13 YU YU02615/80A patent/YU261580A/xx unknown
- 1980-10-13 MX MX809093U patent/MX6233E/es unknown
- 1980-10-13 PH PH24717A patent/PH16288A/en unknown
- 1980-10-13 RO RO108967A patent/RO85822B/ro unknown
- 1980-10-13 FR FR8021823A patent/FR2467851A1/fr active Granted
- 1980-10-13 NZ NZ195248A patent/NZ195248A/xx unknown
- 1980-10-14 AT AT0510180A patent/AT373889B/de not_active IP Right Cessation
- 1980-10-14 PT PT71913A patent/PT71913B/pt unknown
- 1980-10-14 CA CA000362328A patent/CA1159056A/en not_active Expired
- 1980-10-14 IT IT49899/80A patent/IT1143047B/it active
- 1980-10-14 AU AU63252/80A patent/AU538500B2/en not_active Ceased
- 1980-10-14 CH CH763980A patent/CH646700A5/fr not_active IP Right Cessation
- 1980-10-15 JP JP14423180A patent/JPS5663987A/ja active Pending
- 1980-10-15 ZA ZA00806342A patent/ZA806342B/xx unknown
- 1980-10-15 PL PL1980231270A patent/PL135044B1/pl unknown
- 1980-10-15 BE BE6/47291A patent/BE885729A/fr not_active IP Right Cessation
- 1980-10-15 IE IE2135/80A patent/IE50358B1/en unknown
- 1980-10-15 DE DE8080303649T patent/DE3068706D1/de not_active Expired
- 1980-10-15 DD DD80224618A patent/DD153692A5/de unknown
- 1980-10-15 HU HU802502A patent/HU182213B/hu not_active IP Right Cessation
- 1980-10-15 ES ES495948A patent/ES495948A0/es active Granted
- 1980-10-15 DK DK437480A patent/DK437480A/da not_active Application Discontinuation
- 1980-10-15 EP EP80303649A patent/EP0027390B1/de not_active Expired
- 1980-10-15 LU LU82853A patent/LU82853A1/fr unknown
- 1980-10-15 BG BG057344A patent/BG35042A3/xx unknown
- 1980-10-15 PL PL1980227306A patent/PL126824B1/pl unknown
- 1980-10-15 KR KR1019800003960A patent/KR850000471B1/ko not_active Expired
- 1980-10-15 FI FI803253A patent/FI67550C/fi not_active IP Right Cessation
- 1980-10-15 BG BG049366A patent/BG34907A3/xx unknown
- 1980-10-16 AR AR282893A patent/AR228041A1/es active
1982
- 1982-07-21 AR AR290034A patent/AR228101A1/es active
- 1982-07-28 PH PH27643A patent/PH17759A/en unknown
- 1982-09-29 US US06/426,580 patent/US4486591A/en not_active Expired - Fee Related
1983
- 1983-10-11 GB GB838327127A patent/GB8327127D0/en active Pending
1984
- 1984-07-24 KR KR1019840004388A patent/KR850000472B1/ko not_active Expired
- 1984-08-06 US US06/638,181 patent/US4542131A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK437480A (da)	1981-04-17
PL126824B1 (en)	1983-09-30
GR70720B (de)	1983-01-18
FI67550C (fi)	1985-04-10
US4542131A (en)	1985-09-17
MX6233E (es)	1985-01-14
IE802135L (en)	1981-04-16
PL231270A1 (de)	1981-12-23
HU182213B (en)	1983-12-28
ES8106905A1 (es)	1981-09-16
AR228101A1 (es)	1983-01-14
PH16288A (en)	1983-09-05
RO85822A (ro)	1984-11-25
EP0027390A1 (de)	1981-04-22
IL61264A0 (en)	1980-12-31
IE50358B1 (en)	1986-04-02
RO81351A (ro)	1983-02-15
EP0027390B1 (de)	1984-07-25
IL61264A (en)	1985-08-30
FI67550B (fi)	1984-12-31
LU82853A1 (fr)	1982-05-10
CS244409B2 (en)	1986-07-17
PH17759A (en)	1984-12-05
RO81351B (ro)	1983-02-28
FR2467851B1 (de)	1985-04-05
IT8049899A0 (it)	1980-10-14
BG34907A3 (en)	1983-12-15
KR850000472B1 (ko)	1985-04-08
DD153692A5 (de)	1982-01-27
AT373889B (de)	1984-02-27
ZA806342B (en)	1982-05-26
NZ195248A (en)	1983-11-18
AR228041A1 (es)	1983-01-14
PL227306A1 (de)	1981-09-18
FI803253L (fi)	1981-04-17
DE3068706D1 (en)	1984-08-30
RO85822B (ro)	1984-11-30
KR850000471B1 (ko)	1985-04-08
KR830004300A (ko)	1983-07-09
YU261580A (en)	1983-12-31
FR2467851A1 (fr)	1981-04-30
CH646700A5 (fr)	1984-12-14
IT1143047B (it)	1986-10-22
US4486591A (en)	1984-12-04
KR850001463A (ko)	1985-03-18
CA1159056A (en)	1983-12-20
PT71913B (en)	1981-08-31
US4404137A (en)	1983-09-13
PT71913A (en)	1980-11-01
ES495948A0 (es)	1981-09-16
AU538500B2 (en)	1984-08-16
JPS5663987A (en)	1981-05-30
AU6325280A (en)	1981-04-30
PL135044B1 (en)	1985-09-30
BG35042A3 (en)	1983-01-16
GB8327127D0 (en)	1983-11-09
BE885729A (fr)	1981-04-15

Legal Events

Date	Code	Title	Description
1988-04-15	ELJ	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
AT373146B (de)	1983-12-27	Verfahren zur herstellung von tabletten
AT359646B (de)	1980-11-25	Verfahren zur herstellung von nebenwirkungs- freien plasmafraktionen
AT379390B (de)	1985-12-27	Verfahren zur herstellung von neuen chinolonverbindungen
AT376674B (de)	1984-12-27	Verfahren zur herstellung von trans-8-fluor-5-
ATA510180A (de)	1983-07-15	Verfahren zur herstellung von benzodiazepinverbindungen
AT363958B (de)	1981-09-10	Verfahren zur selektiven herstellung von isosorbid-5-nitrat
ATA18380A (de)	1981-11-15	Verfahren zur herstellung von hexahydronaphthacen-derivaten
AT378003B (de)	1985-06-10	Verfahren zur herstellung von desactylcephalosporin c
AT369012B (de)	1982-11-25	Verfahren zur herstellung von diorganomagnesium- verbindungen
AT379161B (de)	1985-11-25	Verfahren zur herstellung von elastomer-duromer-verbundteilen
ATA286983A (de)	1985-09-15	Verfahren zur herstellung von 7-benzoylindolin-2-onen
AT367387B (de)	1982-06-25	Verfahren zur herstellung von hexahydronaphthacen-derivaten
AT367424B (de)	1982-07-12	Verfahren zur herstellung von 3-carbamoyloxymethylcephalosporinverbindungen
ATA328780A (de)	1982-07-15	Verfahren zur herstellung acylaminobenzoesaeurecerivaten
AT375073B (de)	1984-06-25	Verfahren zur herstellung von 2-isopropylaminopyrimidin
AT375072B (de)	1984-06-25	Verfahren zur herstellung von 2-isopropylaminopyrimidin
AT374181B (de)	1984-03-26	Verfahren zur herstellung von 4-benzyl-alpha-(p
AT375942B (de)	1984-09-25	Verfahren zur herstellung von imidazobenzodiazepinderivaten
AT376963B (de)	1985-01-25	Verfahren zur herstellung von 5-halogenpyrimidinen
AT371820B (de)	1983-08-10	Verfahren zur herstellung von substituierten 6-
AT374169B (de)	1984-03-26	Verfahren zur herstellung von alfa-6-desoxy-5 -hydroxytetracyclin
ATA486080A (de)	1983-09-15	Verfahren zur herstellung von nitrosobenzol
ATA332883A (de)	1989-07-15	Verfahren zur herstellung von humaninsulin
ATA621080A (de)	1982-06-15	Verfahren zur herstellung von cephalosporans[urederivaten
ATA585179A (de)	1983-04-15	Verfahren zur herstellung von (d)-(-)-p-hydroxyphenylglycylchlorid-hydrochlorid