ATA63681A - Verfahren zur herstellung von threoninb30-estern von menschlichem insulin - Google Patents

Verfahren zur herstellung von threoninb30-estern von menschlichem insulin

Info

Publication number: ATA63681A
Authority: AT; Austria
Prior art keywords: esters; producing; human insulin; insulin; human
Prior art date: 1980-02-11

Application number

AT0063681A

Other languages

English (en)

Other versions

AT399881B (de

Inventor

Jan Markussen

Original Assignee

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-02-11

Filing date

1981-02-11

Publication date

1994-12-15

1980-02-11 Priority claimed from DK57480A external-priority patent/DK147109C/da

1981-02-11 Application filed by Novo Industri As filed Critical Novo Industri As

1994-12-15 Publication of ATA63681A publication Critical patent/ATA63681A/de

1995-08-25 Application granted granted Critical

1995-08-25 Publication of AT399881B publication Critical patent/AT399881B/de

Links

101000976075 Homo sapiens Insulin Proteins 0.000 title 1
150000002148 esters Chemical class 0.000 title 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT0063681A 1980-02-11 1981-02-11 Verfahren zur herstellung von threoninb30-estern von menschlichem insulin AT399881B (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK57480A DK147109C (da)	1980-02-11	1980-02-11	Fremgangsmaade til fremstilling af humant insulin eller humane insulinestere eller et salt eller kompleks deraf
DK366280		1980-08-28

Publications (2)

Publication Number	Publication Date
ATA63681A true ATA63681A (de)	1994-12-15
AT399881B AT399881B (de)	1995-08-25

Family

ID=26064239

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT0063681A AT399881B (de)	1980-02-11	1981-02-11	Verfahren zur herstellung von threoninb30-estern von menschlichem insulin

Country Status (4)

Country	Link
US (1)	US4343898A (de)
AT (1)	AT399881B (de)
FR (1)	FR2475542B1 (de)
IE (1)	IE50892B1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK319780A (da) *	1980-07-24	1982-01-25	Forenede Bryggerier As	Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
EP0088117B1 (de) *	1981-09-15	1986-09-24	Nordisk Insulinlaboratorium	Verfahren zur herstellung von menschlichem insulin oder b-30-estern davon
DK353781A (da) *	1981-08-10	1983-02-11	Novo Industri As	Fremgangsmaade til fremstilling af insulinderivater
NL8201650A (nl) *	1982-04-21	1983-11-16	Akzo Nv	Semisynthetische bereiding van humane insuline.
US4528134A (en) *	1982-12-27	1985-07-09	University Of Tn Research Corporation	Method of separating A14 -125 I-insulin from heterogeneously labeled insulin molecules for biological studies
DK58285D0 (da) *	1984-05-30	1985-02-08	Novo Industri As	Peptider samt fremstilling og anvendelse deraf
PH25772A (en) *	1985-08-30	1991-10-18	Novo Industri As	Insulin analogues, process for their preparation
DK257988D0 (da) *	1988-05-11	1988-05-11	Novo Industri As	Nye peptider
DE3844211A1 (de) *	1988-12-29	1990-07-05	Hoechst Ag	Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK134189D0 (da) *	1989-03-20	1989-03-20	Nordisk Gentofte	Insulinforbindelser
US5512459A (en) *	1993-07-20	1996-04-30	Bionebraska, Inc.	Enzymatic method for modification or recombinant polypeptides
JP2001521004A (ja)	1997-10-24	2001-11-06	イーライ・リリー・アンド・カンパニー	脂肪酸−アシル化インスリン類似体
CO4970787A1 (es) *	1997-12-23	2000-11-07	Lilly Co Eli	Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
CA2392844A1 (en)	1999-12-29	2001-07-12	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
AR025646A1 (es) *	2000-09-13	2002-12-04	Beta Lab Sa	Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa.
US7396903B2 (en) *	2001-11-19	2008-07-08	Novo Nordisk A/S	Process for preparing insulin compounds
RU2376379C2 (ru)	2001-11-19	2009-12-20	Ново Нордиск А/С	Способ получения инсулиновых соединений
UA46667C2 (en) *	2001-12-29	2006-01-16	Omakooe Ltd Liability Company	Method for preparing semisynthetic human insulin
PL2319500T3 (pl) *	2004-03-12	2013-05-31	Biodel Inc	Szybko działające kompozycje do dostarczania leku
US20080248999A1 (en) *	2007-04-04	2008-10-09	Biodel Inc.	Amylin formulations
US20080090753A1 (en)	2004-03-12	2008-04-17	Biodel, Inc.	Rapid Acting Injectable Insulin Compositions
US20080096800A1 (en) *	2004-03-12	2008-04-24	Biodel, Inc.	Rapid mucosal gel or film insulin compositions
US20080085298A1 (en) *	2004-03-12	2008-04-10	Biodel, Inc.	Rapid Mucosal Gel or Film Insulin Compositions
CN101166545B (zh)	2005-05-13	2011-06-15	伊莱利利公司	Glp-1聚乙二醇化的化合物
US7977454B2 (en) *	2005-07-08	2011-07-12	Biocon Limited	Preparation of insulin conjugates
US7713929B2 (en) *	2006-04-12	2010-05-11	Biodel Inc.	Rapid acting and long acting insulin combination formulations
US8084420B2 (en) *	2005-09-29	2011-12-27	Biodel Inc.	Rapid acting and long acting insulin combination formulations
JP2009533471A (ja) *	2006-04-12	2009-09-17	バイオデル，インコーポレイテッド	即効型および長時間作用型組合せインスリン製剤
AU2007240313B2 (en)	2006-04-20	2012-02-02	Amgen Inc.	GLP-1 compounds
US20090175840A1 (en) *	2008-01-04	2009-07-09	Biodel, Inc.	Insulin formulations for insulin release as a function of tissue glucose levels
US20110212890A1 (en)	2008-07-30	2011-09-01	Takeda Pharmaceutical Company Limited	Metastin derivative and use thereof
US9060927B2 (en)	2009-03-03	2015-06-23	Biodel Inc.	Insulin formulations for rapid uptake
US8618049B2 (en)	2009-09-08	2013-12-31	Stephen B. H. Kent	Ester insulin
KR20130036290A (ko)	2010-06-23	2013-04-11	노보 노르디스크 에이/에스	추가 이황화 결합을 함유하는 인슐린 유도체
WO2011161083A1 (en)	2010-06-23	2011-12-29	Novo Nordisk A/S	Human insulin containing additional disulfide bonds
WO2011161124A1 (en)	2010-06-23	2011-12-29	Novo Nordisk A/S	Insulin analogues containing additional disulfide bonds
CN103533952B (zh)	2011-03-15	2017-02-15	诺沃—诺迪斯克有限公司	包含半胱氨酸置换的人胰岛素类似物和衍生物
US9260503B2 (en)	2011-06-15	2016-02-16	Novo Nordisk A/S	Multi-substituted insulins
US9707276B2 (en)	2012-12-03	2017-07-18	Merck Sharp & Dohme Corp.	O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
US20160115216A1 (en)	2013-06-07	2016-04-28	Novo Nordisk A/S	Method for Making Mature Insulin Polypeptides
CN105849273B (zh) *	2013-12-23	2020-01-14	拜康研究有限公司	人胰岛素甲酯的生产方法
TW201917134A (zh)	2017-08-17	2019-05-01	丹麥商諾佛儂迪克股份有限公司	新穎的醯基化胰島素類似物及其用途
WO2023144240A1 (en)	2022-01-26	2023-08-03	Novo Nordisk Research Centre Oxford Limited	Glucose sensitive insulin derivatives and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3276961A (en) *	1963-04-08	1966-10-04	Squibb & Sons Inc	Process for preparing human insulin

1981
- 1981-02-10 US US06/233,051 patent/US4343898A/en not_active Expired - Lifetime
- 1981-02-10 IE IE251/81A patent/IE50892B1/en not_active IP Right Cessation
- 1981-02-11 AT AT0063681A patent/AT399881B/de not_active IP Right Cessation
- 1981-02-11 FR FR8102716A patent/FR2475542B1/fr not_active Expired

Also Published As

Publication number	Publication date
US4343898A (en)	1982-08-10
IE50892B1 (en)	1986-08-06
IE810251L (en)	1981-08-11
FR2475542B1 (de)	1988-09-09
AT399881B (de)	1995-08-25
FR2475542A1 (de)	1981-08-14

Legal Events

Date	Code	Title	Description
1991-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties
1999-08-15	ELJ	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
AT399881B (de)	1995-08-25	Verfahren zur herstellung von threoninb30-estern von menschlichem insulin
AT373777B (de)	1984-02-27	Verfahren zur herstellung antiherpetisch wirksamer topischer arzneimittelformen
AT379615B (de)	1986-02-10	Verfahren zur herstellung von l-carnitin
AT377259B (de)	1985-02-25	Verfahren zur herstellung von dihydropyridylimidatestern
AT374827B (de)	1984-06-12	Verfahren zur herstellung von cholesterase
AT372856B (de)	1983-11-25	Verfahren zur herstellung von humanem relaxin
AT386602B (de)	1988-09-26	Verfahren zur herstellung von 17alpha-acyloxy-20 -keto-21-halogensteroiden
AT367436B (de)	1982-07-12	Verfahren zur herstellung von copolymerisaten
AT372675B (de)	1983-11-10	Verfahren zur herstellung von alpha-cyanophenoxybenzylestern
AT379399B (de)	1985-12-27	Verfahren zur herstellung von optisch aktiven penemen
AT380005B (de)	1986-03-25	Verfahren zur herstellung von gipsprodukten
AT372676B (de)	1983-11-10	Verfahren zur herstellung von alpha-cyanophenoxybenzylestern
AT380686B (de)	1986-06-25	Verfahren zur herstellung von buspiron
AT381311B (de)	1986-09-25	Verfahren zur herstellung von vincaminsaeureestern
AT375636B (de)	1984-08-27	Verfahren zur herstellung von 3-acylazopropionsaeureestern
AT389513B (de)	1989-12-27	Verfahren zur herstellung von alkoxyapovincaminsaeureestern
AT375328B (de)	1984-07-25	Verfahren zur herstellung von sintermagnesia
AT374828B (de)	1984-06-12	Verfahren zur herstellung von humaninterferon
AT370718B (de)	1983-04-25	Verfahren zur herstellung von di-n -propylessigsaeure
ATA110780A (de)	1981-04-15	Verfahren zur herstellung von o-trimethylsilyl- -cellulosen
ATA201283A (de)	1991-04-15	Verfahren zur herstellung von carboxyalkyldipeptiden
ATA254780A (de)	1982-06-15	Verfahren zur herstellung von isocyansaeureestern
AT370716B (de)	1983-04-25	Verfahren zur herstellung von naphthacendionderivaten
AT375913B (de)	1984-09-25	Verfahren zur herstellung von carbonsaeureestern
ATA170285A (de)	1991-08-15	Verfahren zur herstellung von human-leukozyten- interferonen