DK58285D0 - Peptider samt fremstilling og anvendelse deraf - Google Patents

Peptider samt fremstilling og anvendelse deraf

Info

Publication number: DK58285D0
Authority: DK; Denmark
Prior art keywords: chain; human insulin; bridging; insulin; lys
Prior art date: 1984-05-30

Application number

DK58285A

Other languages

English (en)

Inventor

-Unknown

Original Assignee

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-30

Filing date

1985-02-08

Publication date

1985-02-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26064247&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK58285(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1984-05-30 Priority claimed from DK266584A external-priority patent/DK266584D0/da

1985-02-08 Application filed by Novo Industri As filed Critical Novo Industri As

1985-02-08 Priority to DK58285A priority Critical patent/DK58285D0/da

1985-02-08 Publication of DK58285D0 publication Critical patent/DK58285D0/da

1985-05-28 Priority to GR851304A priority patent/GR851304B/el

1985-05-29 Priority to EP85303775A priority patent/EP0163529B1/en

1985-05-29 Priority to NO852132A priority patent/NO174351C/no

1985-05-29 Priority to DE8585303775T priority patent/DE3583824D1/de

1985-05-29 Priority to CA000482722A priority patent/CA1304022C/en

1985-05-29 Priority to JP60116297A priority patent/JPH0630613B2/ja

1985-05-29 Priority to DK238585A priority patent/DK157938C/da

1985-05-29 Priority to ES543594A priority patent/ES8609483A1/es

1985-05-29 Priority to IE133185A priority patent/IE66387B1/en

1985-05-29 Priority to FI852135A priority patent/FI89183C/fi

1985-05-29 Priority to DE3588125T priority patent/DE3588125T2/de

1985-05-29 Priority to IE950351A priority patent/IE80630B1/en

1985-05-29 Priority to US06/739,123 priority patent/US4916212A/en

1985-05-29 Priority to AT90121887T priority patent/ATE143374T1/de

1985-05-29 Priority to AU43092/85A priority patent/AU590197B2/en

1985-05-29 Priority to NZ212243A priority patent/NZ212243A/en

1985-05-29 Priority to EP90121887A priority patent/EP0427296B1/en

1985-05-29 Priority to AT85303775T priority patent/ATE66490T1/de

1985-05-29 Priority to PT80551A priority patent/PT80551B/pt

1986-02-13 Priority to ES551941A priority patent/ES8702488A1/es

1987-06-25 Priority to DK323687A priority patent/DK157933C/da

1993-05-24 Priority to JP5121649A priority patent/JPH07121226B2/ja

1993-05-24 Priority to JP5121694A priority patent/JPH0746998B2/ja

1995-06-08 Priority to JP7142085A priority patent/JP2519023B2/ja

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 3
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 3
239000002243 precursor Substances 0.000 abstract 3
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
125000000539 amino acid group Chemical group 0.000 abstract 2
229940125396 insulin Drugs 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/69—Increasing the copy number of the vector
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/94—Saccharomyces
- Y10S435/942—Saccharomyces cerevisiae

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Mycology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DK58285A 1984-05-30 1985-02-08 Peptider samt fremstilling og anvendelse deraf DK58285D0 (da)

Priority Applications (25)

Application Number	Priority Date	Filing Date	Title
DK58285A DK58285D0 (da)	1984-05-30	1985-02-08	Peptider samt fremstilling og anvendelse deraf
GR851304A GR851304B (da)	1984-05-30	1985-05-28
EP90121887A EP0427296B1 (en)	1984-05-30	1985-05-29	Insulin precursors
AT85303775T ATE66490T1 (de)	1984-05-30	1985-05-29	Vorlaeufer des insulins, verfahren zu seiner herstellung und verfahren zur herstellung von humaninsulin aus solchen vorlaeufern des insulins.
PT80551A PT80551B (en)	1984-05-30	1985-05-29	Process for the preparation of insulin precursors useful for preparing human insulin
FI852135A FI89183C (fi)	1984-05-30	1985-05-29	Dna-sekvens som kodar foer insulinprekursorer, vektorer innehaollande denna sekvens, insulinprekursorer och foerfarande foer framstaellning av dessa samt foerfarande foer framstaellning av humaninsulin
US06/739,123 US4916212A (en)	1984-05-30	1985-05-29	DNA-sequence encoding biosynthetic insulin precursors and process for preparing the insulin precursors and human insulin
DE8585303775T DE3583824D1 (de)	1984-05-30	1985-05-29	Vorlaeufer des insulins, verfahren zu seiner herstellung und verfahren zur herstellung von humaninsulin aus solchen vorlaeufern des insulins.
CA000482722A CA1304022C (en)	1984-05-30	1985-05-29	Insulin precursors, process for their preparation and process for preparing human insulin from such insulin precursors
JP60116297A JPH0630613B2 (ja)	1984-05-30	1985-05-29	インシュリンの製造方法
DK238585A DK157938C (da)	1984-05-30	1985-05-29	Dna-sekvens for insulinprecursorer, vektorer indeholdende denne sekvens, gaerstammer transformeret med disse vektorer samt en fremgangsmaade til fremstilling af insulinprecursorerne og en fremgangsmaade til fremstilling af humaninsulin
ES543594A ES8609483A1 (es)	1984-05-30	1985-05-29	Un procedimiento para producir un precursor de insulina
IE133185A IE66387B1 (en)	1984-05-30	1985-05-29	Insulin precursors process for their preparation and process for preparing human insulin from such insulin precursors
EP85303775A EP0163529B1 (en)	1984-05-30	1985-05-29	Insulin precursors, process for their preparation and process for preparing human insulin from such insulin precursors
DE3588125T DE3588125T2 (de)	1984-05-30	1985-05-29	Insulin-Vorläufer
IE950351A IE80630B1 (en)	1984-05-30	1985-05-29	Insulin precursors
NO852132A NO174351C (no)	1984-05-30	1985-05-29	Fremgangsmåte for fremstilling av human insulinforlöper samt DNA-sekvens og vektor til anvendelse av fremgangsmåten
AT90121887T ATE143374T1 (de)	1984-05-30	1985-05-29	Insulin-vorläufer
AU43092/85A AU590197B2 (en)	1984-05-30	1985-05-29	Insulin precursors, process for their preparation and process for preparing human insulin from such insulin precursors
NZ212243A NZ212243A (en)	1984-05-30	1985-05-29	Yeast strains expressing modified recombinant insulin
ES551941A ES8702488A1 (es)	1984-05-30	1986-02-13	Un procedimiento para preparar un precursor de insulina
DK323687A DK157933C (da)	1984-05-30	1987-06-25	Insulinprecursorer
JP5121694A JPH0746998B2 (ja)	1984-05-30	1993-05-24	インシュリン前駆体の製造方法
JP5121649A JPH07121226B2 (ja)	1984-05-30	1993-05-24	インシュリン前駆体をコードするｄｎａ
JP7142085A JP2519023B2 (ja)	1984-05-30	1995-06-08	インシュリン前駆体

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK266584A DK266584D0 (da)	1984-05-30	1984-05-30	Dna-sekvens, der koder for en biosyntetisk insulinprecursor og fremgangsmaade til fremstilling af insulinprecursoren
DK58285A DK58285D0 (da)	1984-05-30	1985-02-08	Peptider samt fremstilling og anvendelse deraf

Publications (1)

Publication Number	Publication Date
DK58285D0 true DK58285D0 (da)	1985-02-08

Family

ID=26064247

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK58285A DK58285D0 (da)	1984-05-30	1985-02-08	Peptider samt fremstilling og anvendelse deraf
DK323687A DK157933C (da)	1984-05-30	1987-06-25	Insulinprecursorer

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK323687A DK157933C (da)	1984-05-30	1987-06-25	Insulinprecursorer

Country Status (15)

Country	Link
US (1)	US4916212A (da)
EP (2)	EP0163529B1 (da)
JP (4)	JPH0630613B2 (da)
AT (1)	ATE143374T1 (da)
AU (1)	AU590197B2 (da)
CA (1)	CA1304022C (da)
DE (2)	DE3588125T2 (da)
DK (2)	DK58285D0 (da)
ES (2)	ES8609483A1 (da)
FI (1)	FI89183C (da)
GR (1)	GR851304B (da)
IE (1)	IE66387B1 (da)
NO (1)	NO174351C (da)
NZ (1)	NZ212243A (da)
PT (1)	PT80551B (da)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5008241A (en) *	1985-03-12	1991-04-16	Novo Nordisk A/S	Novel insulin peptides
US4946828A (en) *	1985-03-12	1990-08-07	Novo Nordisk A/S	Novel insulin peptides
DK129385A (da) *	1985-03-22	1986-09-23	Novo Industri As	Peptider og fremstilling deraf
PH25772A (en) *	1985-08-30	1991-10-18	Novo Industri As	Insulin analogues, process for their preparation
US4963665A (en) *	1986-01-07	1990-10-16	Washington University	Human preproinsulin-like growth factor I
DK437786D0 (da) *	1986-09-12	1986-09-12	Nordisk Gentofte	Insulinprecursorer
DK450187D0 (da) *	1987-08-28	1987-08-28	Novo Industri As	Fremgangsmaade til fremstilling af proteiner
DK463887D0 (da) *	1987-09-07	1987-09-07	Novo Industri As	Gaerleader
US4904584A (en) *	1987-12-23	1990-02-27	Genetics Institute, Inc.	Site-specific homogeneous modification of polypeptides
DK336188D0 (da) *	1988-06-20	1988-06-20	Nordisk Gentofte	Propeptider
US6875589B1 (en)	1988-06-23	2005-04-05	Hoechst Aktiengesellschaft	Mini-proinsulin, its preparation and use
DE58906966D1 (de) *	1988-06-23	1994-03-24	Hoechst Ag	Mini-Proinsulin, seine Herstellung und Verwendung.
US5716927A (en) *	1988-12-23	1998-02-10	Novo Nordisk A/S	Insulin analogs having a modified B-chain
DE3844211A1 (de) *	1988-12-29	1990-07-05	Hoechst Ag	Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK105489D0 (da) *	1989-03-03	1989-03-03	Novo Nordisk As	Polypeptid
DK134189D0 (da) *	1989-03-20	1989-03-20	Nordisk Gentofte	Insulinforbindelser
WO1992010284A2 (en)	1990-12-07	1992-06-25	Cnc Development, Inc.	Catalytic chemical reactor
FR2686899B1 (fr) *	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
IL104727A (en)	1992-02-18	1997-01-10	Lilly Co Eli	Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1
US6001604A (en) *	1993-12-29	1999-12-14	Bio-Technology General Corp.	Refolding of proinsulins without addition of reducing agents
US6500645B1 (en)	1994-06-17	2002-12-31	Novo Nordisk A/S	N-terminally extended proteins expressed in yeast
US5891680A (en) *	1995-02-08	1999-04-06	Whitehead Institute For Biomedical Research	Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12
KR0150565B1 (ko) *	1995-02-15	1998-08-17	김정재	유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
CN1182451A (zh)	1995-03-17	1998-05-20	诺沃挪第克公司	新的内切葡聚糖酶
AU5724996A (en) *	1995-05-05	1996-11-21	Eli Lilly And Company	Single chain insulin with high bioactivity
GB9513967D0 (en) *	1995-07-08	1995-09-06	Univ Leicester	Insulin
US5840542A (en) *	1995-07-28	1998-11-24	Mogam Biotechnology Research Institute	Method for manufacture of proinsulin with high export yield
DK1975177T3 (da)	1996-03-01	2011-07-25	Novo Nordisk As	Appetitundertrykkende peptid, formuleringer dermed og anvendelse deraf
US6924120B1 (en) *	1998-03-31	2005-08-02	Tonghua Gantech Biotechnology, Ltd.	Chaperone protein containing an intramolecular chaperone-like sequence and its application to insulin production
CN1125081C (zh)	1999-09-08	2003-10-22	中国科学院上海生物化学研究所	重组天然和新型人胰岛素及其制备方法
JP2003530316A (ja)	1999-12-22	2003-10-14	ノボノルディスクアクティーゼルスカブ	スクランブルした一本鎖ポリペプチドの抽出的再生法
US7378390B2 (en)	1999-12-29	2008-05-27	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
US6521738B2 (en)	1999-12-29	2003-02-18	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogs
CA2392844A1 (en)	1999-12-29	2001-07-12	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
JP4773023B2 (ja) *	1999-12-29	2011-09-14	ノボノルディスクアクティーゼルスカブ	インスリン前駆体及びインスリン前駆体類似体の製造方法
US6777207B2 (en)	1999-12-29	2004-08-17	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
DK1265630T3 (da)	2000-03-24	2006-10-09	Genentech Inc	Anvendelse af insulin til behandling af brusksygdomme
US20050100991A1 (en) *	2001-04-12	2005-05-12	Human Genome Sciences, Inc.	Albumin fusion proteins
EP1274720A4 (en) *	2000-04-12	2004-08-18	Human Genome Sciences Inc	FUSION PROTEINS CONTAINING ALBUMIN
AR025646A1 (es) *	2000-09-13	2002-12-04	Beta Lab Sa	Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa.
KR100449454B1 (ko) *	2000-10-02	2004-09-21	이현철	단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
US20020164712A1 (en) *	2000-12-11	2002-11-07	Tonghua Gantech Biotechnology Ltd.	Chimeric protein containing an intramolecular chaperone-like sequence
IL157842A0 (en)	2001-03-22	2004-03-28	Novo Nordisk Healthcare Ag	Coagulation factor vii derivatives
US7105314B2 (en)	2001-04-02	2006-09-12	Novo Nordisk A/S	Method for making human insulin precursors
ATE443082T1 (de) *	2001-04-02	2009-10-15	Novo Nordisk As	Insulinvorstufen und verfahren zu deren herstellung
WO2002097038A2 (en) *	2001-05-25	2002-12-05	Human Genome Sciences, Inc.	Chemokine beta-1 fusion proteins
ATE532858T1 (de)	2001-09-27	2011-11-15	Novo Nordisk Healthcare Ag	Menschliche gerinnungsfaktor-vii-polypeptide
EP1463752A4 (en) *	2001-12-21	2005-07-13	Human Genome Sciences Inc	ALBUM INFUSION PROTEINS
PT1463751E (pt)	2001-12-21	2013-08-26	Human Genome Sciences Inc	Proteínas de fusão de albumina
DE60335497D1 (de)	2002-09-13	2011-02-03	Cornell Res Foundation Inc	Ergillus-phytasen
WO2004024862A2 (en) *	2002-09-13	2004-03-25	Wockhardt Limited	Yeast protein expression secretion system
CA2513213C (en)	2003-01-22	2013-07-30	Human Genome Sciences, Inc.	Albumin fusion proteins
WO2004085472A1 (en) *	2003-03-27	2004-10-07	Novo Nordisk A/S	Method for making human insulin precursors and human insulin
ATE405660T1 (de)	2003-06-17	2008-09-15	Sembiosys Genetics Inc	Verfahren zur insulinproduktion in pflanzen
EP2392655A3 (en)	2003-09-09	2012-02-29	Novo Nordisk Health Care AG	Coagulation factor VII polypeptides
EP1687428A1 (en)	2003-11-14	2006-08-09	Novo Nordisk A/S	Processes for making acylated insulin
JP5697831B2 (ja) *	2003-12-03	2015-04-08	ノヴォノルディスクアー／エス	単鎖インシュリン
JP5410020B2 (ja)	2005-02-02	2014-02-05	ノヴォノルディスクアー／エス	インスリン誘導体
ES2438145T3 (es)	2005-02-02	2014-01-16	Novo Nordisk A/S	Nuevos derivados de insulina
MX2007012887A (es)	2005-04-18	2007-12-10	Novo Nordisk As	Variantes il-21.
CN102660614A (zh)	2005-08-16	2012-09-12	诺沃-诺迪斯克有限公司	制备成熟胰岛素多肽的方法
WO2007031559A2 (en)	2005-09-14	2007-03-22	Novo Nordisk Health Care Ag	Human coagulation factor vii polypeptides
JP2009530243A (ja) *	2006-03-13	2009-08-27	ノボ・ノルデイスク・エー／エス	アシル化単鎖インスリン
HUE029512T2 (en)	2006-09-22	2017-03-28	Novo Nordisk As	Protease Resistant Insulin Analogs
US8518668B2 (en)	2006-09-27	2013-08-27	Novo Nordisk A/S	Method for making maturated insulin polypeptides in a fungal cell
US8153395B2 (en)	2006-11-22	2012-04-10	Novo Nordisk A/S	Method of making activated carboxypeptidases
US7790677B2 (en) *	2006-12-13	2010-09-07	Elona Biotechnologies	Insulin production methods and pro-insulin constructs
US10100098B2 (en)	2006-12-13	2018-10-16	Stelis Biopharma Private Limited	Insulin production methods and proinsulin constructs
CN101778862B (zh)	2007-08-13	2014-12-17	诺沃-诺迪斯克有限公司	快速作用的胰岛素类似物
ES2548304T3 (es)	2007-08-15	2015-10-15	Novo Nordisk A/S	Análogos de la insulina que contienen una fracción acilo y alquilenglicol
EP2178910B1 (en)	2007-08-15	2014-10-08	Novo Nordisk A/S	Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids
US20100152419A1 (en) *	2008-02-12	2010-06-17	Itoham Foods Inc.	Fusion protein containing highly-expressed and secreted insulin precursor, dna encoding same, and method of producing insulin
US9242011B2 (en)	2008-04-01	2016-01-26	Novo Nordisk A/S	Insulin albumin conjugates
WO2010103038A1 (en)	2009-03-11	2010-09-16	Novo Nordisk A/S	Interleukin-21 variants having antagonistic binding to the il-21 receptor
PT2612677E (pt)	2009-06-26	2015-09-10	Novo Nordisk As	Preparação compreendendo insulina, nicotinamida e arginina
WO2011006982A2 (en)	2009-07-17	2011-01-20	Rigshospitalet	Inhibitors of complement activation
US9096843B2 (en)	2009-12-01	2015-08-04	Novo Nordisk A/S	Peptidyl α-hydroxyglycine α-amidating lyases
US9815876B2 (en)	2010-03-05	2017-11-14	Omeros Corporation	Chimeric inhibitor molecules of complement activation
KR20130036290A (ko)	2010-06-23	2013-04-11	노보 노르디스크 에이/에스	추가 이황화 결합을 함유하는 인슐린 유도체
WO2011161083A1 (en)	2010-06-23	2011-12-29	Novo Nordisk A/S	Human insulin containing additional disulfide bonds
WO2011161124A1 (en)	2010-06-23	2011-12-29	Novo Nordisk A/S	Insulin analogues containing additional disulfide bonds
US20130331320A1 (en)	2010-12-14	2013-12-12	Novo Nordisk A/S	Fast-acting insulin in combination with long-acting insulin
CA2821613A1 (en)	2010-12-14	2012-06-21	Novo Nordisk A/S	Preparation comprising insulin, nicotinamide and an amino acid
CN103533952B (zh)	2011-03-15	2017-02-15	诺沃—诺迪斯克有限公司	包含半胱氨酸置换的人胰岛素类似物和衍生物
CN102675452B (zh)	2011-03-17	2015-09-16	重庆富进生物医药有限公司	具持续降血糖和受体高结合的人胰岛素及类似物的偶联物
US9260503B2 (en)	2011-06-15	2016-02-16	Novo Nordisk A/S	Multi-substituted insulins
JP6517018B2 (ja)	2012-02-09	2019-05-22	ヴァー２・ファーマシューティカルズ・アンパルトセルスカブＶＡＲ２ＰｈａｒｍａｃｅｕｔｉｃａｌｓＡｐＳ	コンドロイチン硫酸グリカンのターゲティング
WO2013186138A1 (en)	2012-06-14	2013-12-19	Novo Nordisk A/S	Preparation comprising insulin, nicotinamide and arginine
JP2015532307A (ja)	2012-10-15	2015-11-09	ノヴォ・ノルディスク・ヘルス・ケア・アーゲー	凝固因子ｖｉｉポリペプチド
US9707276B2 (en)	2012-12-03	2017-07-18	Merck Sharp & Dohme Corp.	O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
WO2014093696A2 (en)	2012-12-12	2014-06-19	Massachusetts Institute Of Technology	Insulin derivatives for diabetes treatment
US20160115216A1 (en)	2013-06-07	2016-04-28	Novo Nordisk A/S	Method for Making Mature Insulin Polypeptides
GB201321489D0 (en)	2013-12-05	2014-01-22	Chemical & Biopharmaceutical Lab Of Patras S A	Biologically active insulin derivatives
PL233560B1 (pl)	2014-12-05	2019-10-31	Mabion Spolka Akcyjna	Sposób otrzymywania insuliny lub analogu insuliny z prekursora rekombinowanego białka
EA037848B1 (ru)	2016-07-14	2021-05-27	Общество С Ограниченной Ответственностью "Биохимический Агент"	Гибридный белок, полинуклеотид, генетическая конструкция, продуцент, препарат для регенерации хряща (варианты)
BR112019004314A2 (pt)	2016-09-06	2019-05-28	Chemical & Biopharmaceutical Laboratories Of Patras S A	derivados pró-insulina
TW201917134A (zh)	2017-08-17	2019-05-01	丹麥商諾佛儂迪克股份有限公司	新穎的醯基化胰島素類似物及其用途
US20210278406A1 (en)	2018-07-13	2021-09-09	Varct Diagnostic Aps	Isolation of circulating cells of fetal origin using recombinant malaria protein var2csa
CN112584853B (zh)	2018-09-12	2021-12-10	美药星（南京）制药有限公司	一种新型门冬胰岛素原的结构和制备门冬胰岛素的方法
CN118420744A (zh)	2019-12-30	2024-08-02	甘李药业股份有限公司	胰岛素衍生物
AU2020418207A1 (en)	2019-12-30	2022-08-25	Gan & Lee Pharmaceuticals Co., Ltd.	Long-acting GLP-1 compound
WO2022049409A1 (en)	2020-09-02	2022-03-10	Sia Terragen	Express diagnosticum for sars-cov-2
WO2023144240A1 (en)	2022-01-26	2023-08-03	Novo Nordisk Research Centre Oxford Limited	Glucose sensitive insulin derivatives and uses thereof
US20250340610A1 (en)	2022-01-28	2025-11-06	Gan & Lee Pharmaceuticals Co., Ltd.	Acylated insulin

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4440859A (en) *	1977-05-27	1984-04-03	The Regents Of The University Of California	Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms
US4411994A (en) *	1978-06-08	1983-10-25	The President And Fellows Of Harvard College	Protein synthesis
US4431740A (en) *	1979-09-12	1984-02-14	The Regents Of The University Of California	DNA Transfer vector and transformed microorganism containing human proinsulin and pre-proinsulin genes
US4343898A (en) *	1980-02-11	1982-08-10	Novo Industri A/S	Process for preparing esters of human insulin
CA1202581A (en) *	1980-03-27	1986-04-01	Saran A. Narang	Adaptor molecules for dna and their application to synthesis of gene-derived products
NZ196609A (en) *	1980-03-27	1984-02-03	Lilly Co Eli	Preparation of proinsulin-like insulin precursors
ZA811895B (en) *	1980-04-07	1982-04-28	Univ California	Expression of hormone genomic clones
JPS5750948A (en) *	1980-09-12	1982-03-25	Shionogi & Co Ltd	Insulin analog and preparation
NZ199391A (en) *	1981-01-02	1985-12-13	Genentech Inc	Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
NZ199722A (en) *	1981-02-25	1985-12-13	Genentech Inc	Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
IE52768B1 (en) *	1981-04-06	1988-02-17	Boots Co Ltd	1-arylcyclobutylalkylamine compounds useful as therapeutic agents
CA1204682A (en) *	1981-06-19	1986-05-20	Saran A. Narang	Adaptors, and synthesis and cloning of proinsulin genes
ZA824218B (en) *	1981-06-29	1983-04-27	Cetus Corp	Plasmid for producing human insulin
AU560472B2 (en) *	1981-08-25	1987-04-09	Celltech Limited	Yeast expression vectors
WO1983003413A1 (en) *	1982-03-31	1983-10-13	Genetics Inst	Creation of dna sequences encoding modified proinsulin precursors
MC1586A1 (fr) *	1982-03-31	1985-02-22	Genetics Inst	Preparation de sequences d'adn codant pour des precurseurs de pro-insuline modifies
DK172738B1 (da) *	1983-04-07	1999-06-21	Chiron Corp	Fremgangsmåde til at udtrykke modent insulin og DNA-struktur til anvendelse ved fremgangsmåden
DK129385A (da) *	1985-03-22	1986-09-23	Novo Industri As	Peptider og fremstilling deraf
WO1987002670A1 (en) *	1985-10-25	1987-05-07	Mackay Vivian L	Method of using bar1 for secreting foreign proteins

1985
- 1985-02-08 DK DK58285A patent/DK58285D0/da unknown
- 1985-05-28 GR GR851304A patent/GR851304B/el unknown
- 1985-05-29 AT AT90121887T patent/ATE143374T1/de active
- 1985-05-29 PT PT80551A patent/PT80551B/pt not_active IP Right Cessation
- 1985-05-29 DE DE3588125T patent/DE3588125T2/de not_active Expired - Fee Related
- 1985-05-29 ES ES543594A patent/ES8609483A1/es not_active Expired
- 1985-05-29 NO NO852132A patent/NO174351C/no not_active IP Right Cessation
- 1985-05-29 FI FI852135A patent/FI89183C/fi not_active IP Right Cessation
- 1985-05-29 EP EP85303775A patent/EP0163529B1/en not_active Expired - Lifetime
- 1985-05-29 IE IE133185A patent/IE66387B1/en not_active IP Right Cessation
- 1985-05-29 DE DE8585303775T patent/DE3583824D1/de not_active Expired - Lifetime
- 1985-05-29 JP JP60116297A patent/JPH0630613B2/ja not_active Expired - Lifetime
- 1985-05-29 NZ NZ212243A patent/NZ212243A/en unknown
- 1985-05-29 CA CA000482722A patent/CA1304022C/en not_active Expired - Lifetime
- 1985-05-29 US US06/739,123 patent/US4916212A/en not_active Expired - Lifetime
- 1985-05-29 EP EP90121887A patent/EP0427296B1/en not_active Expired - Lifetime
- 1985-05-29 AU AU43092/85A patent/AU590197B2/en not_active Ceased
1986
- 1986-02-13 ES ES551941A patent/ES8702488A1/es not_active Expired
1987
- 1987-06-25 DK DK323687A patent/DK157933C/da not_active IP Right Cessation
1993
- 1993-05-24 JP JP5121694A patent/JPH0746998B2/ja not_active Expired - Fee Related
- 1993-05-24 JP JP5121649A patent/JPH07121226B2/ja not_active Expired - Fee Related
1995
- 1995-06-08 JP JP7142085A patent/JP2519023B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK157933C (da)	1990-08-27
ES8609483A1 (es)	1986-09-01
DE3588125D1 (de)	1996-10-31
IE851331L (en)	1985-11-30
PT80551B (en)	1987-04-09
JPH06141866A (ja)	1994-05-24
ES551941A0 (es)	1986-12-16
EP0427296A1 (en)	1991-05-15
ES543594A0 (es)	1986-09-01
JPH07121226B2 (ja)	1995-12-25
PT80551A (en)	1985-06-01
ES8702488A1 (es)	1986-12-16
NO174351C (no)	1994-04-20
JP2519023B2 (ja)	1996-07-31
NO174351B (no)	1994-01-10
FI852135A0 (fi)	1985-05-29
FI852135L (fi)	1985-12-01
DE3583824D1 (de)	1991-09-26
DE3588125T2 (de)	1997-02-13
ATE143374T1 (de)	1996-10-15
DK323687D0 (da)	1987-06-25
EP0163529A1 (en)	1985-12-04
JPH07309896A (ja)	1995-11-28
US4916212A (en)	1990-04-10
NO852132L (no)	1985-12-02
JPS611389A (ja)	1986-01-07
DK157933B (da)	1990-03-05
JPH0746998B2 (ja)	1995-05-24
GR851304B (da)	1985-11-25
CA1304022C (en)	1992-06-23
IE66387B1 (en)	1995-12-27
FI89183B (fi)	1993-05-14
NZ212243A (en)	1988-05-30
DK323687A (da)	1987-06-25
FI89183C (fi)	1993-08-25
JPH0630613B2 (ja)	1994-04-27
EP0163529B1 (en)	1991-08-21
AU4309285A (en)	1985-12-05
JPH06141865A (ja)	1994-05-24
AU590197B2 (en)	1989-11-02
EP0427296B1 (en)	1996-09-25

Publication	Publication Date	Title
ATE143374T1 (de)	1996-10-15	Insulin-vorläufer
EP0150126A3 (en)	1987-06-03	The synthesis of protein with an identification peptide
ES8801674A1 (es)	1988-02-16	Un procedimiento para la preparacion de una proteina que presenta actividad procoagulante.
NZ513422A (en)	2002-09-27	G-CSF analogues that do not possess any hematopoietic activity and are useful as antagonists against G-CSF effect, such as overproduction of G-CSF
DK336188D0 (da)	1988-06-20	Propeptider
KR850004273A (ko)	1985-07-11	안정성이 증대된 재조합 감마 인터페론 및 그의 제조방법
HU902697D0 (en)	1990-09-28	Process for the enzymatic removal of the n-terminal sequence of proteins
ES8802235A1 (es)	1988-04-16	Procedimiento para preparar un polipeptido
IL74426A (en)	1989-09-10	Atrial peptides and pharmaceutical compositions comprising them
EP0195680A3 (en)	1987-06-10	The synthesis of protein with an identification peptide
EP0095351A3 (en)	1985-01-16	A precursor of a c-terminal amidated peptide and production thereof
ES2044928T3 (es)	1994-01-16	Enzima alfa-amidante en terminal c y procedimiento para la produccion y el uso del mismo.
NZ216316A (en)	1991-11-26	Hepta and octapeptides with thymic humoral activity
ATE78872T1 (de)	1992-08-15	Herstellung von polypeptiden.
DK238585A (da)	1985-12-01	Peptider og fremstilling deraf
CA2047119A1 (en)	1992-01-19	Vitro processing of fusion proteins
WO1990000179A3 (fr)	1990-03-08	Nouvelles proteins, adn les codant et leur usage
EP0327360A3 (en)	1990-05-02	Novel polypeptides and dna encoding said polypeptides
Christiansen	1994	Synthetic yeast leader peptides
EP0266006A3 (en)	1990-04-11	Novel hypotensive diuretic peptides
DE3686036D1 (en)	1992-08-20	New fusion protein contg. small interleukin 2 ballast fragments
GB1210557A (en)	1970-10-28	Synthesis of polypeptides containing cysteine
CA1267086C (en)	1990-03-27	METHOD OF ADMINISTRATION OF EAR DIURETIC PEPTIDES
DK301090A (da)	1990-12-19	Insulinprecursorer
DK200200302A (da)	2002-02-27	Rekombinante polypeptider omfattende aminosyresekvensen af moden vævsfaktorinhibitor (TFI), polypeptidfragmenter deraf, ekspressionsvektorer der koder for disse, værtsceller transformeret dermed, og fremgangsmåde til fremstilling af et ........