ATA901593A - Verfahren zur isolierung und reinigung von mevinolin - Google Patents

Verfahren zur isolierung und reinigung von mevinolin

Info

Publication number: ATA901593A
Authority: AT; Austria
Prior art keywords: mevinolin; insulating; cleaning; cleaning mevinolin
Prior art date: 1992-11-04

Application number

AT0901593A

Other languages

English (en)

Other versions

AT401060B (de

Inventor

Vilmos Keri

Eva Ilkoey

Irma Hoegye

Antonia Jekkel

Ilona Bagdi

Gabor Ambrus

Attila Jakab

Attila Andor

Lajos Deak

Istvan Szabo

Janos Balint

Zsuzsanna Scheidl

Etelka Deli

Gyula Horvath

Csaba Szabo

Ildiko Lang

Imre Szekely

Imre Moravcsik

Vera Kovacs

Szabolcs Matyas

Zsuzsanna Sztaray

Laszlo Eszenyi

Original Assignee

Biogal Gyogyszergyar

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-11-04

Filing date

1993-09-08

Publication date

1995-10-15

1993-09-08 Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar

1995-10-15 Publication of ATA901593A publication Critical patent/ATA901593A/de

1996-06-25 Application granted granted Critical

1996-06-25 Publication of AT401060B publication Critical patent/AT401060B/de

Links

PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 title 1
238000004140 cleaning Methods 0.000 title 1
PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 title 1
QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT0901593A 1992-11-04 1993-09-08 Verfahren zur isolierung und reinigung von mevinolin AT401060B (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU9203458A HU210867B (en)	1992-11-04	1992-11-04	Method for extraction and purification of mevinolin from culture medium

Publications (2)

Publication Number	Publication Date
ATA901593A true ATA901593A (de)	1995-10-15
AT401060B AT401060B (de)	1996-06-25

Family

ID=10982513

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT0901593A AT401060B (de)	1992-11-04	1993-09-08	Verfahren zur isolierung und reinigung von mevinolin

Country Status (8)

Country	Link
AT (1)	AT401060B (de)
CA (1)	CA2127381C (de)
DE (2)	DE4395515T1 (de)
ES (1)	ES2081776B1 (de)
GR (1)	GR930100408A (de)
HU (1)	HU210867B (de)
IT (1)	IT1266672B1 (de)
WO (1)	WO1994010328A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI9300303A (en) *	1993-06-08	1994-12-31	Krka Tovarna Zdravil	Process for isolation of hypolipemic effective substance
EA000954B1 (ru) *	1995-12-06	2000-08-28	Балканфарма - Разград Ад	Способ получения ловастатина
SK282679B6 (sk) *	1999-04-16	2002-11-06	Biotika, A. S.	Spôsob izolácie lovastatínu z vyfermentovanej pôdy
AU2001236543B2 (en) *	2000-02-24	2005-02-03	Teva Gyogyszergyar Reszvenytarsasag	Method of purifying a fermentation broth
TR200403001T3 (tr) *	2000-03-03	2005-02-21	Plus Chemical, S.A.	Lovastatin ve simvastatinin, azaltılmış dimerik katışkı seviyelerine sahip olacak şekilde arıtılması için bir işlem
ES2204285B1 (es) *	2002-05-20	2005-03-01	Ercros Industrial, S.A.	Procedimiento para el aislamiento y purificacion de lovastatina.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5925599B2 (ja) *	1979-02-20	1984-06-19	三共株式会社	新生理活性物質モナコリンｋおよびその製造法
JPS55150898A (en) *	1979-05-11	1980-11-25	Sankyo Co Ltd	Preparation of a new physiologically active substance mb-530b
IL60219A (en) *	1979-06-15	1985-05-31	Merck & Co Inc	Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them
HU208997B (en) *	1992-06-17	1994-02-28	Gyogyszerkutato Intezet	Microbiological method for producing mevinoline

1992
- 1992-11-04 HU HU9203458A patent/HU210867B/hu not_active IP Right Cessation
1993
- 1993-09-08 AT AT0901593A patent/AT401060B/de not_active IP Right Cessation
- 1993-09-08 CA CA002127381A patent/CA2127381C/en not_active Expired - Fee Related
- 1993-09-08 DE DE4395515T patent/DE4395515T1/de active Pending
- 1993-09-08 WO PCT/HU1993/000051 patent/WO1994010328A1/en not_active Ceased
- 1993-09-08 ES ES09450018A patent/ES2081776B1/es not_active Expired - Fee Related
- 1993-09-08 DE DE4395515A patent/DE4395515C2/de not_active Expired - Fee Related
- 1993-10-18 GR GR930100408A patent/GR930100408A/el not_active IP Right Cessation
- 1993-11-04 IT IT93MI002343A patent/IT1266672B1/it active IP Right Grant

Also Published As

Publication number	Publication date
GR930100408A (el)	1994-07-29
ITMI932343A0 (it)	1993-11-04
DE4395515C2 (de)	1999-06-17
CA2127381C (en)	1997-12-23
AT401060B (de)	1996-06-25
ES2081776B1 (es)	1996-10-16
ITMI932343A1 (it)	1995-05-04
WO1994010328A1 (en)	1994-05-11
ES2081776A1 (es)	1996-03-01
DE4395515T1 (de)	1994-12-01
IT1266672B1 (it)	1997-01-09
HU210867B (en)	1995-10-30
CA2127381A1 (en)	1994-05-11

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Legal Events

Date	Code	Title	Description
2006-06-15	ELJ	Ceased due to non-payment of the annual fee