ATE100443T1 - N-(substituierte aryl)-n'-(substituierte alkoxy)- harnstoffe als antihypercholesterolemische und antiatherosclerotische mittel. - Google Patents

N-(substituierte aryl)-n'-(substituierte alkoxy)- harnstoffe als antihypercholesterolemische und antiatherosclerotische mittel.

Info

Publication number
ATE100443T1
ATE100443T1 AT90102510T AT90102510T ATE100443T1 AT E100443 T1 ATE100443 T1 AT E100443T1 AT 90102510 T AT90102510 T AT 90102510T AT 90102510 T AT90102510 T AT 90102510T AT E100443 T1 ATE100443 T1 AT E100443T1
Authority
AT
Austria
Prior art keywords
substitute
antihypercholesterolemic
ureas
alkoxy
aryl
Prior art date
Application number
AT90102510T
Other languages
English (en)
Inventor
Bharat Kalidas Trivedi
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/308,911 external-priority patent/US4923896A/en
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE100443T1 publication Critical patent/ATE100443T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/22—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Detergent Compositions (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
AT90102510T 1989-02-09 1990-02-08 N-(substituierte aryl)-n'-(substituierte alkoxy)- harnstoffe als antihypercholesterolemische und antiatherosclerotische mittel. ATE100443T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/308,911 US4923896A (en) 1989-02-09 1989-02-09 N-(substituted aryl)-N'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents
US07/462,563 US5155127A (en) 1989-02-09 1990-01-18 N-(substituted aryl)-n'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents

Publications (1)

Publication Number Publication Date
ATE100443T1 true ATE100443T1 (de) 1994-02-15

Family

ID=26976513

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90102510T ATE100443T1 (de) 1989-02-09 1990-02-08 N-(substituierte aryl)-n'-(substituierte alkoxy)- harnstoffe als antihypercholesterolemische und antiatherosclerotische mittel.

Country Status (15)

Country Link
US (1) US5155127A (de)
EP (1) EP0386487B1 (de)
JP (1) JP3003941B2 (de)
KR (1) KR900012896A (de)
AT (1) ATE100443T1 (de)
AU (1) AU620966B2 (de)
CA (1) CA2009669C (de)
DE (1) DE69006048T2 (de)
DK (1) DK0386487T3 (de)
ES (1) ES2062120T3 (de)
FI (1) FI900607A7 (de)
IE (1) IE63412B1 (de)
NO (1) NO900585L (de)
NZ (1) NZ232410A (de)
PT (1) PT93088A (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310748A (en) * 1992-05-11 1994-05-10 The Du Pont Merck Pharmaceutical Company Imidazoles for the treatment of atherosclerosis
US5364875A (en) * 1992-05-11 1994-11-15 The Du Pont Merck Pharmaceutical Company Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis
US5326787A (en) * 1992-05-12 1994-07-05 Abbott Laboratories Cycloalkyl N-hydroxy derivatives having lipoxygenase inhibitory activity
RU94046149A (ru) * 1992-05-28 1996-11-27 Пфайзер Инк. (US) Новые n-арил и n-гетероарил производные мочевины как ингибиторы ацил кофермента а:холестерин ацил трансферазы (асат) фармацевтическая композиция, способ ингибирования (асат)
US5491152A (en) * 1994-03-23 1996-02-13 The Du Pont Merck Pharmaceutical Company Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis
US6133326A (en) 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
HUP0301010A3 (en) * 2000-02-02 2005-03-29 Warner Lambert Co Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders and pharmaceutical compositions containing them
WO2009073620A2 (en) 2007-11-30 2009-06-11 Newlink Genetics Ido inhibitors
WO2021044274A1 (en) * 2019-09-03 2021-03-11 3M Innovative Properties Company Optical films and methods of manufacturing such optical films

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3112342A (en) * 1960-10-03 1963-11-26 Du Pont 1-methoxy-1-methyl-3-(3-chloro-4-cumenyl) urea
GB1042191A (en) 1961-10-04 1966-09-14 Lepetit Spa Process for the preparation of hydroxylamine derivatives
US4387106A (en) * 1982-01-26 1983-06-07 American Cyanamid Company Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas
DE3737195A1 (de) * 1987-11-03 1989-05-18 Bayer Ag Chromanderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US4868210A (en) * 1988-03-30 1989-09-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents

Also Published As

Publication number Publication date
FI900607A7 (fi) 1990-08-10
ES2062120T3 (es) 1994-12-16
JP3003941B2 (ja) 2000-01-31
DK0386487T3 (da) 1994-02-28
PT93088A (pt) 1990-08-31
AU4919990A (en) 1990-08-16
NZ232410A (en) 1991-03-26
IE900457L (en) 1990-08-09
JPH02275848A (ja) 1990-11-09
US5155127A (en) 1992-10-13
EP0386487B1 (de) 1994-01-19
CA2009669C (en) 2001-05-15
FI900607A0 (fi) 1990-02-07
CA2009669A1 (en) 1990-08-09
IE63412B1 (en) 1995-04-19
EP0386487A1 (de) 1990-09-12
NO900585D0 (no) 1990-02-07
DE69006048D1 (de) 1994-03-03
AU620966B2 (en) 1992-02-27
DE69006048T2 (de) 1994-05-05
NO900585L (no) 1990-08-10
KR900012896A (ko) 1990-09-03

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee