DK0386487T3 - N-(Substitueret aryl)-N-(substitueret alkoxy)-urinstoffer og -thiourinstoffer som antihypercholesterolæmiske og antiatherosclerotiske midler - Google Patents
N-(Substitueret aryl)-N-(substitueret alkoxy)-urinstoffer og -thiourinstoffer som antihypercholesterolæmiske og antiatherosclerotiske midlerInfo
- Publication number
- DK0386487T3 DK0386487T3 DK90102510.6T DK90102510T DK0386487T3 DK 0386487 T3 DK0386487 T3 DK 0386487T3 DK 90102510 T DK90102510 T DK 90102510T DK 0386487 T3 DK0386487 T3 DK 0386487T3
- Authority
- DK
- Denmark
- Prior art keywords
- antihypercholesterolemic
- thioureas
- ureas
- substituted
- substituted aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/22—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Detergent Compositions (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/308,911 US4923896A (en) | 1989-02-09 | 1989-02-09 | N-(substituted aryl)-N'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents |
| US07/462,563 US5155127A (en) | 1989-02-09 | 1990-01-18 | N-(substituted aryl)-n'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0386487T3 true DK0386487T3 (da) | 1994-02-28 |
Family
ID=26976513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90102510.6T DK0386487T3 (da) | 1989-02-09 | 1990-02-08 | N-(Substitueret aryl)-N-(substitueret alkoxy)-urinstoffer og -thiourinstoffer som antihypercholesterolæmiske og antiatherosclerotiske midler |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5155127A (da) |
| EP (1) | EP0386487B1 (da) |
| JP (1) | JP3003941B2 (da) |
| KR (1) | KR900012896A (da) |
| AT (1) | ATE100443T1 (da) |
| AU (1) | AU620966B2 (da) |
| CA (1) | CA2009669C (da) |
| DE (1) | DE69006048T2 (da) |
| DK (1) | DK0386487T3 (da) |
| ES (1) | ES2062120T3 (da) |
| FI (1) | FI900607A7 (da) |
| IE (1) | IE63412B1 (da) |
| NO (1) | NO900585L (da) |
| NZ (1) | NZ232410A (da) |
| PT (1) | PT93088A (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5310748A (en) * | 1992-05-11 | 1994-05-10 | The Du Pont Merck Pharmaceutical Company | Imidazoles for the treatment of atherosclerosis |
| US5364875A (en) * | 1992-05-11 | 1994-11-15 | The Du Pont Merck Pharmaceutical Company | Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis |
| US5326787A (en) * | 1992-05-12 | 1994-07-05 | Abbott Laboratories | Cycloalkyl N-hydroxy derivatives having lipoxygenase inhibitory activity |
| RU94046149A (ru) * | 1992-05-28 | 1996-11-27 | Пфайзер Инк. (US) | Новые n-арил и n-гетероарил производные мочевины как ингибиторы ацил кофермента а:холестерин ацил трансферазы (асат) фармацевтическая композиция, способ ингибирования (асат) |
| US5491152A (en) * | 1994-03-23 | 1996-02-13 | The Du Pont Merck Pharmaceutical Company | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis |
| US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| HUP0301010A3 (en) * | 2000-02-02 | 2005-03-29 | Warner Lambert Co | Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders and pharmaceutical compositions containing them |
| WO2009073620A2 (en) | 2007-11-30 | 2009-06-11 | Newlink Genetics | Ido inhibitors |
| WO2021044274A1 (en) * | 2019-09-03 | 2021-03-11 | 3M Innovative Properties Company | Optical films and methods of manufacturing such optical films |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3112342A (en) * | 1960-10-03 | 1963-11-26 | Du Pont | 1-methoxy-1-methyl-3-(3-chloro-4-cumenyl) urea |
| GB1042191A (en) | 1961-10-04 | 1966-09-14 | Lepetit Spa | Process for the preparation of hydroxylamine derivatives |
| US4387106A (en) * | 1982-01-26 | 1983-06-07 | American Cyanamid Company | Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas |
| DE3737195A1 (de) * | 1987-11-03 | 1989-05-18 | Bayer Ag | Chromanderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| US4868210A (en) * | 1988-03-30 | 1989-09-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| US5116848A (en) * | 1988-03-30 | 1992-05-26 | Warner-Lambert Company | N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents |
-
1990
- 1990-01-18 US US07/462,563 patent/US5155127A/en not_active Expired - Lifetime
- 1990-02-07 AU AU49199/90A patent/AU620966B2/en not_active Expired - Fee Related
- 1990-02-07 NO NO90900585A patent/NO900585L/no unknown
- 1990-02-07 FI FI900607A patent/FI900607A7/fi not_active IP Right Cessation
- 1990-02-07 NZ NZ232410A patent/NZ232410A/en unknown
- 1990-02-08 DE DE90102510T patent/DE69006048T2/de not_active Expired - Fee Related
- 1990-02-08 JP JP2027341A patent/JP3003941B2/ja not_active Expired - Fee Related
- 1990-02-08 KR KR1019900001508A patent/KR900012896A/ko not_active Withdrawn
- 1990-02-08 DK DK90102510.6T patent/DK0386487T3/da active
- 1990-02-08 PT PT93088A patent/PT93088A/pt not_active Application Discontinuation
- 1990-02-08 EP EP90102510A patent/EP0386487B1/en not_active Expired - Lifetime
- 1990-02-08 IE IE45790A patent/IE63412B1/en not_active IP Right Cessation
- 1990-02-08 AT AT90102510T patent/ATE100443T1/de not_active IP Right Cessation
- 1990-02-08 ES ES90102510T patent/ES2062120T3/es not_active Expired - Lifetime
- 1990-02-09 CA CA002009669A patent/CA2009669C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI900607A7 (fi) | 1990-08-10 |
| ES2062120T3 (es) | 1994-12-16 |
| JP3003941B2 (ja) | 2000-01-31 |
| PT93088A (pt) | 1990-08-31 |
| AU4919990A (en) | 1990-08-16 |
| NZ232410A (en) | 1991-03-26 |
| IE900457L (en) | 1990-08-09 |
| JPH02275848A (ja) | 1990-11-09 |
| US5155127A (en) | 1992-10-13 |
| EP0386487B1 (en) | 1994-01-19 |
| CA2009669C (en) | 2001-05-15 |
| FI900607A0 (fi) | 1990-02-07 |
| CA2009669A1 (en) | 1990-08-09 |
| IE63412B1 (en) | 1995-04-19 |
| EP0386487A1 (en) | 1990-09-12 |
| NO900585D0 (no) | 1990-02-07 |
| DE69006048D1 (de) | 1994-03-03 |
| AU620966B2 (en) | 1992-02-27 |
| ATE100443T1 (de) | 1994-02-15 |
| DE69006048T2 (de) | 1994-05-05 |
| NO900585L (no) | 1990-08-10 |
| KR900012896A (ko) | 1990-09-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0474733T3 (da) | Antihyperlipidæmiske og antiatherosklerotiske urinstofforbindelser | |
| ES2060682T3 (es) | N-((fenil(2,6-disubstituido))-n'-aril)ureas como agentes antihipercolesterolemicos y antiateroscleroticos. | |
| ES2056992T3 (es) | N-((fenil(2,6-disubstituido))-n'-diarilalquil)ureas como agentes antihiperlipidemicos y antiateroscleroticos. | |
| NO903593D0 (no) | Anvendelse av omsetningsprodukter av alkenylspirobislaktoner og aminer som parafindispergatorer. | |
| ES2037768T3 (es) | Procedimiento para preparar n-(fenil(2,6-disustituido))-ureas y carbamatos inhibidores de acil-coa: colesterol acil-transferasa. | |
| PT89502A (pt) | Processo para a preparacao de derivados de 2-(2-hidroxi-3-fenoxi-metilo e de composicoes farmaceuticas que os contem | |
| DE68906940D1 (de) | Antihyperlipidemische und antiatherosclerotische verbindungen und zusammensetzungen. | |
| NO871640D0 (no) | Fremgangsmaate for fremstilling av n-(2[-aminofenyl)-benzamidderivater. | |
| NO174708C (no) | Substituerte arylureaforbindelser som sötningsmidler med höy styrke. | |
| DE69006048D1 (de) | N-(substituierte aryl)-N'-(substituierte alkoxy)-Harnstoffe als antihypercholesterolemische und antiatherosclerotische Mittel. | |
| PT87680A (pt) | A process for the preparation of n-(aryl-,arylthio-arylsulfinyl-and arylsulfonyl-n,n'-(or n'n')alkylamino-alkyl ureas and cyanoguanidines and of pharmaceutical compositions containing the same | |
| PT99435A (pt) | Processo para a preparacao de derivados de amino-sulfonil-ureia e de composicoes farmaceuticas que os contem | |
| AR224251A1 (es) | Procedimiento para la obtencion de derivados de n-(3-fenoxi-2-hidroxi-propil)-n'-(2,4-diozo-pirimidil(6))-alquilendiamina de formula general i | |
| NO903386L (no) | Fremgangsmaate for fremstilling av 4-(n-substituert amino)-2-butynyl-1-karbamater og -tiokarbamater og derivater derav. | |
| PT86611A (pt) | Process for the manufacture of n,n-(dibenzohexatrienylene)ureas | |
| DE3768368D1 (de) | Insektizide mittel. | |
| ATE44875T1 (de) | 4-amino-2-(imidazolidin-2-on-l-yl)-pyrimidin-5carbons|ure-(n-(3-trifluormethyl-phenyl)-amide) zur antithrombotischen prophylaxe und behandlung sowie ihre verwendung zur herstellung von antithrombotisch wirksamen arzneimitteln. | |
| FI902764A7 (fi) | N-(3-(((aryyli)amino)sulfonyyli)-1H-1,2,4,-triatsol-5-yyli)amiinien valmistus | |
| BR9403572A (pt) | Composto, processo para sua preparação e formulação farmacêutica | |
| PT87738A (pt) | Process for the preparation of novel thiophen compounds | |
| DK227878A (da) | N-substituerede n-((aryformimidoyl) methylamino) thio)-sulfonamider og fremgangsmaader til deres anvendelse som pestcider | |
| GB815885A (en) | Sulphonyl-ureas and a process for their manufacture | |
| NO883987L (no) | Fremgangsmaate for fremstilling av n-(substituert aklyliden) kondensert bicykloalkyliden og anvendelse derav som medikamenter. | |
| AU1183676A (en) | N-(6-acyloxybenzothiazo-2-yl)-n'-phenyl (or substituted phenyl) ureas | |
| GB896303A (en) | Improvements in and relating to sulphonylureas and the manufacture thereof |