ATE100462T1 - 19-fluor- oder cyano-21-hydroxy-progesteronderivate als 19-hydroxylase-inhibitoren. - Google Patents

19-fluor- oder cyano-21-hydroxy-progesteronderivate als 19-hydroxylase-inhibitoren.

Info

Publication number: ATE100462T1
Authority: AT; Austria
Prior art keywords: cyano; fluoroor; hydroxy; hydroxylase inhibitors; progesterone derivatives
Prior art date: 1988-06-28

Application number

AT89111699T

Other languages

English (en)

Inventor

Gene W Holbert

J O'neal Johnston

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-28

Filing date

1989-06-27

Publication date

1994-02-15

1989-06-27 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1994-02-15 Application granted granted Critical

1994-02-15 Publication of ATE100462T1 publication Critical patent/ATE100462T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Toxicology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Manufacture Of Macromolecular Shaped Articles (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Organic Insulating Materials (AREA)

AT89111699T 1988-06-28 1989-06-27 19-fluor- oder cyano-21-hydroxy-progesteronderivate als 19-hydroxylase-inhibitoren. ATE100462T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/212,410 US4920114A (en)	1988-06-28	1988-06-28	19-fluoro- or cyano-21-hydroxyprogesterone derivatives useful as 19-hydroxylase inhibitors
EP89111699A EP0348911B1 (de)	1988-06-28	1989-06-27	19-Fluor- oder Cyano-21-hydroxy-progesteron-Derivate als 19-Hydroxylase-Inhibitoren

Publications (1)

Publication Number	Publication Date
ATE100462T1 true ATE100462T1 (de)	1994-02-15

Family

ID=22790899

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89111699T ATE100462T1 (de)	1988-06-28	1989-06-27	19-fluor- oder cyano-21-hydroxy-progesteronderivate als 19-hydroxylase-inhibitoren.

Country Status (19)

Country	Link
US (1)	US4920114A (de)
EP (1)	EP0348911B1 (de)
JP (1)	JP2727466B2 (de)
KR (1)	KR0140885B1 (de)
CN (1)	CN1039424A (de)
AT (1)	ATE100462T1 (de)
AU (1)	AU610413B2 (de)
CA (1)	CA1321579C (de)
DE (1)	DE68912422T2 (de)
DK (1)	DK318489A (de)
ES (1)	ES2061802T3 (de)
FI (1)	FI893162A7 (de)
HU (1)	HUT51289A (de)
IL (1)	IL90728A0 (de)
NO (1)	NO892679L (de)
NZ (1)	NZ229694A (de)
PH (1)	PH25771A (de)
PT (1)	PT90989B (de)
ZA (1)	ZA894753B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4433374A1 (de) *	1994-09-20	1996-03-21	Hoechst Ag	17-Desoxi-corticosteroid-21-/O/-Carbonsäure- ester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US6787530B1 (en)	1996-08-23	2004-09-07	Monash University	Use of pregnane-diones as analgesic agents

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3124574A (en) *		1964-03-10		Iz-halo pregnenes
IT1051705B (it) *	1962-05-12	1981-05-20	Vismara Spa F	Metodo per la preparazione di intermedi steroidali
US3154569A (en) *	1961-10-10	1964-10-27	Vismara Francesco Spa	19-nitrilosteroids and process for producing 19-norsteroids
GB984093A (en) *	1962-02-19	1965-02-24	Syntex Corp	Improvements in or relating to 19-halo-pregnane compounds
US3257435A (en) *	1962-09-21	1966-06-21	Syntex Corp	19-bisdifluoro pregnanes
US3257389A (en) *	1962-09-21	1966-06-21	Syntex Corp	19-bisdifluoro-pregnanes
US3205228A (en) *	1963-03-01	1965-09-07	Syntex Corp	19-substituted pregnenes
US3159620A (en) *	1963-05-22	1964-12-01	Vismara Francesco Spa	Process for the preparation of 17 alpha-ethynyl-19-norandrostene compounds
US3394128A (en) *	1964-09-26	1968-07-23	Syntex Corp	19-halo-androstane and pregnane derivatives and processes for the preparation thereof
FR2462445A1 (fr) *	1979-07-31	1981-02-13	Roussel Uclaf	Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
US4293548A (en) *	1980-09-02	1981-10-06	Merrell Dow Pharmaceuticals Inc.	18-Substituted pregn-4-ene-3,20-diones

1988
- 1988-06-28 US US07/212,410 patent/US4920114A/en not_active Expired - Lifetime
1989
- 1989-06-22 ZA ZA894753A patent/ZA894753B/xx unknown
- 1989-06-23 NZ NZ229694A patent/NZ229694A/en unknown
- 1989-06-23 IL IL90728A patent/IL90728A0/xx not_active IP Right Cessation
- 1989-06-26 KR KR1019890008781A patent/KR0140885B1/ko not_active Expired - Fee Related
- 1989-06-27 DE DE68912422T patent/DE68912422T2/de not_active Expired - Lifetime
- 1989-06-27 AT AT89111699T patent/ATE100462T1/de not_active IP Right Cessation
- 1989-06-27 CA CA000604022A patent/CA1321579C/en not_active Expired - Lifetime
- 1989-06-27 CN CN89106339A patent/CN1039424A/zh active Pending
- 1989-06-27 PH PH38862A patent/PH25771A/en unknown
- 1989-06-27 DK DK318489A patent/DK318489A/da not_active Application Discontinuation
- 1989-06-27 EP EP89111699A patent/EP0348911B1/de not_active Expired - Lifetime
- 1989-06-27 JP JP1162845A patent/JP2727466B2/ja not_active Expired - Lifetime
- 1989-06-27 ES ES89111699T patent/ES2061802T3/es not_active Expired - Lifetime
- 1989-06-27 NO NO89892679A patent/NO892679L/no unknown
- 1989-06-27 PT PT90989A patent/PT90989B/pt not_active IP Right Cessation
- 1989-06-27 HU HU893242A patent/HUT51289A/hu unknown
- 1989-06-28 FI FI893162A patent/FI893162A7/fi not_active Application Discontinuation
- 1989-06-28 AU AU37126/89A patent/AU610413B2/en not_active Ceased

Also Published As

Publication number	Publication date
NO892679D0 (no)	1989-06-27
EP0348911A2 (de)	1990-01-03
EP0348911B1 (de)	1994-01-19
FI893162L (fi)	1989-12-29
JP2727466B2 (ja)	1998-03-11
HUT51289A (en)	1990-04-28
US4920114A (en)	1990-04-24
DK318489D0 (da)	1989-06-27
ES2061802T3 (es)	1994-12-16
KR0140885B1 (ko)	1998-06-15
CA1321579C (en)	1993-08-24
NZ229694A (en)	1992-03-26
DE68912422D1 (de)	1994-03-03
ZA894753B (en)	1990-03-28
IL90728A0 (en)	1990-01-18
EP0348911A3 (en)	1990-03-28
DE68912422T2 (de)	1994-08-18
NO892679L (no)	1989-12-29
PH25771A (en)	1991-10-18
CN1039424A (zh)	1990-02-07
AU3712689A (en)	1990-01-04
JPH0248597A (ja)	1990-02-19
DK318489A (da)	1989-12-29
PT90989A (pt)	1989-12-29
FI893162A0 (fi)	1989-06-28
KR900000321A (ko)	1990-01-30
PT90989B (pt)	1994-11-30
AU610413B2 (en)	1991-05-16
FI893162A7 (fi)	1989-12-29

Legal Events

Date	Code	Title	Description
1994-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
NO881138D0 (no)	1988-03-15	Sammensetning til befrielse av fastsatte borestrenger.
MX9302932A (es)	1995-01-31	Nuevas 4-aza-5&-androstan-3-onas 7b-substituidas como inhibidores de la5&-reductasa.
DK249389D0 (da)	1989-05-23	2-acylamino-benzothiazol-forbindelser og deres anvendelse til fremstilling af laegemidler til behandling af tumorer
FI890238A7 (fi)	1989-07-19	Aktiivista ainetta ohjelmoidusti vapauttavia galeenisia koostumuksia
BR8900004A (pt)	1989-08-15	Composicoes herbicidas de compostos de heterociclicos-alcoilenos de quinoxaliniloxifenoxipropanoato
ES2191659T3 (es)	2003-09-16	Derivados heterociclicos substituidos utiles como inhibidores de la agregacion plaquetaria.
ES2060818T3 (es)	1994-12-01	Derivados de indol, benzofurano y benzotiofeno sustituidos como inhibidores de la 5-lipooxigenasa.
FI895447A7 (fi)	1989-11-15	Substituoidut terapeuttisina aineina käytettävät adeniinijohdannaiset
DE68922660D1 (de)	1995-06-22	19-Substituierte Progesterone als 19-Hydroxylase-Inhibitoren.
ATE88708T1 (de)	1993-05-15	Delta 22-derivate von ll-f28249-verbindungen.
FI894491A7 (fi)	1990-03-24	Antihypertensiivisinä aineina käytettäviä uusia substituoituja tienopyraaneja
DE68912422D1 (de)	1994-03-03	19-Fluor- oder Cyano-21-hydroxy-progesteron-Derivate als 19-Hydroxylase-Inhibitoren.
ATE176233T1 (de)	1999-02-15	Imidazo(1,2-c)chinazolinderivate als antihypertensive und antidysurie
DE68912159D1 (de)	1994-02-24	Dioxoquinazolinderivat enthaltendes Antihypertensivum.
EP0297816A3 (en)	1990-09-05	Homocyclostatine and cyclostatine containing polypeptides as antihypertensive agents
ATE44144T1 (de)	1989-07-15	6h-dibenzo(b,e)(1,4)oxathiepin-verbindungen.
KR900000009U (ko)	1990-01-07	경운기의 예취기 결합장치
LV5507A3 (lv)	1994-03-10	4,5.-Dihidrooksazolu atvasinajumu iegusanas panemiens
ATE31623T1 (de)	1988-01-15	Injizierbare zusammensetzungen von bbm-928a.