IL90728A0 - 19-fluoro-or cyano-21-hydroxy-progesterone derivatives useful as 19-hydroxylase inhibitors - Google Patents

19-fluoro-or cyano-21-hydroxy-progesterone derivatives useful as 19-hydroxylase inhibitors

Info

Publication number: IL90728A0
Authority: IL; Israel
Prior art keywords: fluoro; cyano; hydroxy; hydroxylase inhibitors; derivatives useful
Prior art date: 1988-06-28

Application number

IL90728A

Other languages

English (en)

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-28

Filing date

1989-06-23

Publication date

1990-01-18

1989-06-23 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1990-01-18 Publication of IL90728A0 publication Critical patent/IL90728A0/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Manufacture Of Macromolecular Shaped Articles (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Organic Insulating Materials (AREA)

IL90728A 1988-06-28 1989-06-23 19-fluoro-or cyano-21-hydroxy-progesterone derivatives useful as 19-hydroxylase inhibitors IL90728A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/212,410 US4920114A (en)	1988-06-28	1988-06-28	19-fluoro- or cyano-21-hydroxyprogesterone derivatives useful as 19-hydroxylase inhibitors

Publications (1)

Publication Number	Publication Date
IL90728A0 true IL90728A0 (en)	1990-01-18

Family

ID=22790899

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL90728A IL90728A0 (en)	1988-06-28	1989-06-23	19-fluoro-or cyano-21-hydroxy-progesterone derivatives useful as 19-hydroxylase inhibitors

Country Status (19)

Country	Link
US (1)	US4920114A (de)
EP (1)	EP0348911B1 (de)
JP (1)	JP2727466B2 (de)
KR (1)	KR0140885B1 (de)
CN (1)	CN1039424A (de)
AT (1)	ATE100462T1 (de)
AU (1)	AU610413B2 (de)
CA (1)	CA1321579C (de)
DE (1)	DE68912422T2 (de)
DK (1)	DK318489A (de)
ES (1)	ES2061802T3 (de)
FI (1)	FI893162A7 (de)
HU (1)	HUT51289A (de)
IL (1)	IL90728A0 (de)
NO (1)	NO892679L (de)
NZ (1)	NZ229694A (de)
PH (1)	PH25771A (de)
PT (1)	PT90989B (de)
ZA (1)	ZA894753B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4433374A1 (de) *	1994-09-20	1996-03-21	Hoechst Ag	17-Desoxi-corticosteroid-21-/O/-Carbonsäure- ester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US6787530B1 (en)	1996-08-23	2004-09-07	Monash University	Use of pregnane-diones as analgesic agents

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3124574A (en) *		1964-03-10		Iz-halo pregnenes
US3154569A (en) *	1961-10-10	1964-10-27	Vismara Francesco Spa	19-nitrilosteroids and process for producing 19-norsteroids
IT1051705B (it) *	1962-05-12	1981-05-20	Vismara Spa F	Metodo per la preparazione di intermedi steroidali
GB984093A (en) *	1962-02-19	1965-02-24	Syntex Corp	Improvements in or relating to 19-halo-pregnane compounds
US3257389A (en) *	1962-09-21	1966-06-21	Syntex Corp	19-bisdifluoro-pregnanes
US3257435A (en) *	1962-09-21	1966-06-21	Syntex Corp	19-bisdifluoro pregnanes
US3205228A (en) *	1963-03-01	1965-09-07	Syntex Corp	19-substituted pregnenes
US3159620A (en) *	1963-05-22	1964-12-01	Vismara Francesco Spa	Process for the preparation of 17 alpha-ethynyl-19-norandrostene compounds
US3394128A (en) *	1964-09-26	1968-07-23	Syntex Corp	19-halo-androstane and pregnane derivatives and processes for the preparation thereof
FR2462445A1 (fr) *	1979-07-31	1981-02-13	Roussel Uclaf	Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
US4293548A (en) *	1980-09-02	1981-10-06	Merrell Dow Pharmaceuticals Inc.	18-Substituted pregn-4-ene-3,20-diones

1988
- 1988-06-28 US US07/212,410 patent/US4920114A/en not_active Expired - Lifetime
1989
- 1989-06-22 ZA ZA894753A patent/ZA894753B/xx unknown
- 1989-06-23 NZ NZ229694A patent/NZ229694A/en unknown
- 1989-06-23 IL IL90728A patent/IL90728A0/xx not_active IP Right Cessation
- 1989-06-26 KR KR1019890008781A patent/KR0140885B1/ko not_active Expired - Fee Related
- 1989-06-27 PT PT90989A patent/PT90989B/pt not_active IP Right Cessation
- 1989-06-27 AT AT89111699T patent/ATE100462T1/de not_active IP Right Cessation
- 1989-06-27 CA CA000604022A patent/CA1321579C/en not_active Expired - Lifetime
- 1989-06-27 PH PH38862A patent/PH25771A/en unknown
- 1989-06-27 ES ES89111699T patent/ES2061802T3/es not_active Expired - Lifetime
- 1989-06-27 CN CN89106339A patent/CN1039424A/zh active Pending
- 1989-06-27 HU HU893242A patent/HUT51289A/hu unknown
- 1989-06-27 DE DE68912422T patent/DE68912422T2/de not_active Expired - Lifetime
- 1989-06-27 NO NO89892679A patent/NO892679L/no unknown
- 1989-06-27 DK DK318489A patent/DK318489A/da not_active Application Discontinuation
- 1989-06-27 JP JP1162845A patent/JP2727466B2/ja not_active Expired - Lifetime
- 1989-06-27 EP EP89111699A patent/EP0348911B1/de not_active Expired - Lifetime
- 1989-06-28 AU AU37126/89A patent/AU610413B2/en not_active Ceased
- 1989-06-28 FI FI893162A patent/FI893162A7/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0348911A2 (de)	1990-01-03
FI893162L (fi)	1989-12-29
US4920114A (en)	1990-04-24
EP0348911B1 (de)	1994-01-19
CA1321579C (en)	1993-08-24
DK318489A (da)	1989-12-29
JP2727466B2 (ja)	1998-03-11
JPH0248597A (ja)	1990-02-19
DK318489D0 (da)	1989-06-27
ES2061802T3 (es)	1994-12-16
NO892679L (no)	1989-12-29
AU610413B2 (en)	1991-05-16
FI893162A7 (fi)	1989-12-29
CN1039424A (zh)	1990-02-07
PT90989B (pt)	1994-11-30
PH25771A (en)	1991-10-18
ATE100462T1 (de)	1994-02-15
PT90989A (pt)	1989-12-29
FI893162A0 (fi)	1989-06-28
HUT51289A (en)	1990-04-28
NO892679D0 (no)	1989-06-27
KR0140885B1 (ko)	1998-06-15
DE68912422D1 (de)	1994-03-03
ZA894753B (en)	1990-03-28
KR900000321A (ko)	1990-01-30
NZ229694A (en)	1992-03-26
EP0348911A3 (en)	1990-03-28
DE68912422T2 (de)	1994-08-18
AU3712689A (en)	1990-01-04

Legal Events

Date	Code	Title	Description
1996-03-31	RH	Patent void

Publication	Publication Date	Title
AU1071288A (en)	1988-07-28	Polyolefin stabilising composition
IE840302L (en)	1984-08-10	3-(5-aminopentyl)amino-1-benzazepin-2-one-1-alkanoic acids.
AU4840085A (en)	1986-04-24	Combinations of age inhibitors with dihydropyridines
BR8900004A (pt)	1989-08-15	Composicoes herbicidas de compostos de heterociclicos-alcoilenos de quinoxaliniloxifenoxipropanoato
EP0350012A3 (de)	1990-09-05	Antivirale Zusammensetzung
AU610473B2 (en)	1991-05-16	19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors
EP0124314A3 (de)	1985-09-18	Substituierte-3H-Indeno(1,2-c)pyridazin-3one
HUT41206A (en)	1987-04-28	Fungicide compositions containing alpha-oximino-alpha-carbamoyl-acetonitril derivatives as active agents and process for producing the active agents
HUT47795A (en)	1989-04-28	Herbicide composition containing substituted triazin derivatives as active components and process for producing the active components
NZ230711A (en)	1990-10-26	Substituted thienopyrans as antihypertensive agents
ZA894753B (en)	1990-03-28	19-fluoro-or cyano-21-hydroxyprogesterone derivatives useful as 19-hydroxylase inhibitors
AU3406189A (en)	1989-11-09	Agents for enhancing the growth of livestock
EP0297816A3 (en)	1990-09-05	Homocyclostatine and cyclostatine containing polypeptides as antihypertensive agents
ZA897253B (en)	1991-05-29	Novel substituted thienopyrans as antihypertensive agents
RO102205B1 (en)	1992-03-16	Process for stabilizing the structure of agricultural soils
ZA871901B (en)	1987-11-25	Composition for stabilizing soils
ZA878282B (en)	1988-07-27	Substance or composition for treatment of pregnancy-induced hypertension