ATE10091T1 - 8-substituierte 4-(3,4-dihydroxyphenyl)-1,2,3,4tetrahydroisochinoline. - Google Patents

8-substituierte 4-(3,4-dihydroxyphenyl)-1,2,3,4tetrahydroisochinoline.

Info

Publication number
ATE10091T1
ATE10091T1 AT81302248T AT81302248T ATE10091T1 AT E10091 T1 ATE10091 T1 AT E10091T1 AT 81302248 T AT81302248 T AT 81302248T AT 81302248 T AT81302248 T AT 81302248T AT E10091 T1 ATE10091 T1 AT E10091T1
Authority
AT
Austria
Prior art keywords
substituted
dimethoxyphenyl
cyclizing
dihydroxyphenyl
phenyl
Prior art date
Application number
AT81302248T
Other languages
English (en)
Inventor
L. Martin Brenner
Joe Russell Wardell, Jr.
Avenue Fourth
Original Assignee
Smithkline Beckman Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corporation filed Critical Smithkline Beckman Corporation
Application granted granted Critical
Publication of ATE10091T1 publication Critical patent/ATE10091T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT81302248T 1980-05-22 1981-05-21 8-substituierte 4-(3,4-dihydroxyphenyl)-1,2,3,4tetrahydroisochinoline. ATE10091T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/152,252 US4340600A (en) 1980-05-22 1980-05-22 Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines
EP81302248A EP0040956B1 (de) 1980-05-22 1981-05-21 8-Substituierte 4-(3,4-Dihydroxyphenyl)-1,2,3,4-tetrahydroisochinoline

Publications (1)

Publication Number Publication Date
ATE10091T1 true ATE10091T1 (de) 1984-11-15

Family

ID=22542141

Family Applications (1)

Application Number Title Priority Date Filing Date
AT81302248T ATE10091T1 (de) 1980-05-22 1981-05-21 8-substituierte 4-(3,4-dihydroxyphenyl)-1,2,3,4tetrahydroisochinoline.

Country Status (5)

Country Link
US (1) US4340600A (de)
EP (1) EP0040956B1 (de)
JP (1) JPS5716864A (de)
AT (1) ATE10091T1 (de)
DE (1) DE3166923D1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103830A3 (de) * 1982-09-22 1985-07-31 Bayer Ag Wachstumsfördernde Phenylethylamin-Derivate
US4518779A (en) * 1982-09-27 1985-05-21 Pennwalt Corporation 1,2,3,4-Tetrahydro-1-aminomethyl-4-phenyl isoquinolines
US4876261A (en) * 1987-03-27 1989-10-24 Akihiro Tanaka Substituted tetrahydroisoquinoline compounds and composition containing them
JPH01199948A (ja) * 1987-03-27 1989-08-11 Yamanouchi Pharmaceut Co Ltd アミノ置換テトラヒドロイソキノリン化合物及びその医薬
US5204468A (en) * 1987-03-27 1993-04-20 Yamanouchi Pharmaceutical Co., Ltd. Substituted 4,5,6,7-tetrahydrothiens[2,3-C]pyridine compounds
DK0690863T3 (da) * 1993-04-06 2003-06-30 Abbott Lab Tetracykliske forbindelser som dopamin-agonister
US5668141A (en) * 1996-04-02 1997-09-16 Abbott Laboratories Trans-2,6-,3,6-and 4,6-diaza-5,6,6a,7,8,12b-hexahydrobenzo[c]phenanthrene compounds as dopamine agonists
AU4967997A (en) * 1996-12-02 1998-06-29 Chisso Corporation Optically active nitro alcohol derivatives, optically active amino alcohol derivates, and process for preparing the same
NZ519146A (en) * 1999-11-03 2004-02-27 Albany Molecular Res Inc 4-phenyl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US7163949B1 (en) * 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
WO2001032625A1 (en) * 1999-11-03 2001-05-10 Du Pont Pharmaceuticals Company Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
JP5132864B2 (ja) * 2000-07-11 2013-01-30 アルバニー モレキュラー リサーチ， インコーポレイテッド ４−フェニル置換テトラヒドロイソキノリンおよびその使用方法
JP2005526728A (ja) * 2002-02-15 2005-09-08 ダーファーマ，インコーポレイテッド ドーパミンｄ１受容体アゴニストのモノエステルプロドラッグおよび非対称置換ジエステルプロドラッグ
AU2005274927B2 (en) 2004-07-15 2011-11-03 Albany Molecular Research, Inc. Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US20060111385A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
US20060111393A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
KR20060059728A (ko) * 2004-11-29 2006-06-02 삼성에스디아이 주식회사 액정 표시 장치 및 그 제조 방법
KR101594898B1 (ko) 2005-07-15 2016-02-18 알바니 몰레큘라 리써치, 인크. 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es) * 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
CN102458123A (zh) * 2009-05-12 2012-05-16 阿尔巴尼分子研究公司 芳基、杂芳基和杂环取代的四氢异喹啉及其用途
WO2010132487A1 (en) 2009-05-12 2010-11-18 Bristol-Myers Squibb Company CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
US8802696B2 (en) 2009-05-12 2014-08-12 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoqu inoli and use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670694B2 (de) * 1966-05-05 1976-07-22 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von tetrahydroisochinolinen
US3872125A (en) * 1973-03-03 1975-03-18 Sandoz Ag 3-substituted-4-aryl isoquinolines
US3870722A (en) * 1973-11-02 1975-03-11 Sandoz Ag 2-Methyl-3-substituted-4-aryl isoquinolines
CA1069440A (en) * 1975-06-26 1980-01-08 Carl Kaiser Pharmaceutical compositions
GB1504424A (en) 1975-08-09 1978-03-22 Beecham Group Ltd Isoquinoline-derived aminoethers
DE2724610A1 (de) * 1977-06-01 1978-12-14 Hoechst Ag 4-phenyl-8-amino-tetrahydroisochinoline
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound

Also Published As

Publication number Publication date
EP0040956B1 (de) 1984-10-31
JPS5716864A (en) 1982-01-28
US4340600A (en) 1982-07-20
DE3166923D1 (en) 1984-12-06
EP0040956A1 (de) 1981-12-02

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee