ATE10091T1 - 8-substituierte 4-(3,4-dihydroxyphenyl)-1,2,3,4tetrahydroisochinoline. - Google Patents

8-substituierte 4-(3,4-dihydroxyphenyl)-1,2,3,4tetrahydroisochinoline.

Info

Publication number
ATE10091T1
ATE10091T1 AT81302248T AT81302248T ATE10091T1 AT E10091 T1 ATE10091 T1 AT E10091T1 AT 81302248 T AT81302248 T AT 81302248T AT 81302248 T AT81302248 T AT 81302248T AT E10091 T1 ATE10091 T1 AT E10091T1
Authority
AT
Austria
Prior art keywords
substituted
dimethoxyphenyl
cyclizing
dihydroxyphenyl
phenyl
Prior art date
Application number
AT81302248T
Other languages
English (en)
Inventor
L. Martin Brenner
Joe Russell Wardell, Jr.
Avenue Fourth
Original Assignee
Smithkline Beckman Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corporation filed Critical Smithkline Beckman Corporation
Application granted granted Critical
Publication of ATE10091T1 publication Critical patent/ATE10091T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT81302248T 1980-05-22 1981-05-21 8-substituierte 4-(3,4-dihydroxyphenyl)-1,2,3,4tetrahydroisochinoline. ATE10091T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/152,252 US4340600A (en) 1980-05-22 1980-05-22 Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines
EP81302248A EP0040956B1 (de) 1980-05-22 1981-05-21 8-Substituierte 4-(3,4-Dihydroxyphenyl)-1,2,3,4-tetrahydroisochinoline

Publications (1)

Publication Number Publication Date
ATE10091T1 true ATE10091T1 (de) 1984-11-15

Family

ID=22542141

Family Applications (1)

Application Number Title Priority Date Filing Date
AT81302248T ATE10091T1 (de) 1980-05-22 1981-05-21 8-substituierte 4-(3,4-dihydroxyphenyl)-1,2,3,4tetrahydroisochinoline.

Country Status (5)

Country Link
US (1) US4340600A (de)
EP (1) EP0040956B1 (de)
JP (1) JPS5716864A (de)
AT (1) ATE10091T1 (de)
DE (1) DE3166923D1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103830A3 (de) * 1982-09-22 1985-07-31 Bayer Ag Wachstumsfördernde Phenylethylamin-Derivate
US4518779A (en) * 1982-09-27 1985-05-21 Pennwalt Corporation 1,2,3,4-Tetrahydro-1-aminomethyl-4-phenyl isoquinolines
US5204468A (en) * 1987-03-27 1993-04-20 Yamanouchi Pharmaceutical Co., Ltd. Substituted 4,5,6,7-tetrahydrothiens[2,3-C]pyridine compounds
JPH01199948A (ja) * 1987-03-27 1989-08-11 Yamanouchi Pharmaceut Co Ltd アミノ置換テトラヒドロイソキノリン化合物及びその医薬
US4876261A (en) * 1987-03-27 1989-10-24 Akihiro Tanaka Substituted tetrahydroisoquinoline compounds and composition containing them
PT690863E (pt) * 1993-04-06 2003-07-31 Abbott Lab Compostos tetraciclicos como agonistas da dopamina
WO1998024753A1 (en) * 1996-12-02 1998-06-11 Chisso Corporation Optically active nitro alcohol derivatives, optically active amino alcohol derivates, and process for preparing the same
US5668141A (en) * 1996-04-02 1997-09-16 Abbott Laboratories Trans-2,6-,3,6-and 4,6-diaza-5,6,6a,7,8,12b-hexahydrobenzo[c]phenanthrene compounds as dopamine agonists
DK1246806T3 (da) * 1999-11-03 2008-06-16 Amr Technology Inc Aryl- og heteroarylsubstituerede tetrahydroisoquinoliner og anvendelse deraf til blokering af genoptagelse af norepinefrin, dopsmin og serotonin
CN100436420C (zh) * 1999-11-03 2008-11-26 Amr科技公司 4-苯基取代的四氢异喹啉及其用于制备药物的用途
US7163949B1 (en) * 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
MXPA03000275A (es) * 2000-07-11 2004-12-13 Albany Molecular Res Inc Nuevas tetrahidroisoquinolinas substituidas con 4-fenilo y su uso terapeutico.
AU2003217430B2 (en) * 2002-02-15 2008-10-23 Darpharma, Inc. Mono-ester and asymmetrically substituted Di-ester pro-drugs of the dopamine D1 receptor agonists
UA91341C2 (ru) * 2004-07-15 2010-07-26 Амр Текнолоджи, Інк. Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
US20060111385A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
US20060111393A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
KR20060059728A (ko) * 2004-11-29 2006-06-02 삼성에스디아이 주식회사 액정 표시 장치 및 그 제조 방법
US7956050B2 (en) 2005-07-15 2011-06-07 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es) * 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
JP5739415B2 (ja) 2009-05-12 2015-06-24 ブリストル−マイヤーズ スクウィブ カンパニー （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用
CN102595902B (zh) 2009-05-12 2015-04-29 阿尔巴尼分子研究公司 7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉及其用途
ES2446971T3 (es) 2009-05-12 2014-03-11 Albany Molecular Research, Inc. Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670694B2 (de) * 1966-05-05 1976-07-22 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von tetrahydroisochinolinen
US3872125A (en) * 1973-03-03 1975-03-18 Sandoz Ag 3-substituted-4-aryl isoquinolines
US3870722A (en) * 1973-11-02 1975-03-11 Sandoz Ag 2-Methyl-3-substituted-4-aryl isoquinolines
CA1069440A (en) * 1975-06-26 1980-01-08 Carl Kaiser Pharmaceutical compositions
GB1504424A (en) 1975-08-09 1978-03-22 Beecham Group Ltd Isoquinoline-derived aminoethers
DE2724610A1 (de) * 1977-06-01 1978-12-14 Hoechst Ag 4-phenyl-8-amino-tetrahydroisochinoline
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound

Also Published As

Publication number Publication date
JPS5716864A (en) 1982-01-28
EP0040956A1 (de) 1981-12-02
EP0040956B1 (de) 1984-10-31
US4340600A (en) 1982-07-20
DE3166923D1 (en) 1984-12-06

Similar Documents

Publication Publication Date Title
DE3166923D1 (en) 8-substituted 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines
IT7926603A0 (it) Difenilbutilpiperazincarbossammidi, loro sali di addizione con acidi e composizioni farmaceutiche; procedimenti di fabbricazione ed uso.
IT7819485A0 (it) Condensatore, come pure procedimento per l'esecuzione di una misurazione di forze.
ES512773A0 (es) "una disposicion de aguja de muestras multiples, para determinar la entrada en vena".
IT7825315A0 (it) Fenossi-benzil-ossicarbonilderivati sostituiti, procedimento per la loro preparazione e loro impiego come insetticidi e come acaricidi.
NL190519C (nl) 4-Gesubstitueerde fenylazijnzuurverbindingen, alsmede farmaceutische preparaten.
IT7831006A0 (it) Formulazioni insetticide.
IT7827624A0 (it) Cefemi composti e procedimenti per la loro preparazione.
ES522107A0 (es) Procedimiento para preparar composiciones farmaceuticas inyectadas que contienen derivados de 2-metil-3-carboxamida-4-hidroxitiazina 1,1-dioxido.
IT7828141A0 (it) Triazolil-o,n-acetali diastereomeri, procedimento per laloro preparazione ed il loro impiego come fungicidi.
FI874020A0 (fi) Tetrahydrokinolinderivat, foerfarande foer deras framstaellning, deras anvaendning och dessa innehaollande farmaceutiska preparat.
NL7812257A (nl) Verbindingen met anticholinergische en antisecretori- sche werking, alsmede farmaceutische preparaten en antitranspiratiepreparaten die zo'n verbinding bevat- ten.
NL7711446A (nl) Pharmaceutische desinfecterend preparaat.
IT7922743A0 (it) Componente di dosaggio farmaceutico a emissione controllata.
FI812804A7 (fi) Antidepressiivisinä lääkeaineina käyttökelpoisia 2-(1,4-bentsodioksan-2-yylialkyyli)-imidatsoleja.
FI861695L (fi) Farmaceutiskt preparat och foerfarande foer administrering daerav.
IT8121654A0 (it) Derivati tiazolidinici ad attivita' farmacologica, procedimento per la loro preparazione e composizioni farmaceutiche contenenti detti derivati.
IT8021370A0 (it) Derivati teofillinmetildiossolanici, procedimenti per la loro preparazione e relative composizioni farmaceutiche.
DE3873011D1 (de) Pharmazeutische zusammensetzung, enthaltend piperidinalkanolderivate.
FI870293A0 (fi) 8 -acylaminoergoliner, deras framstaellning och dessa innehaollande farmaceutiska kompositioner.
NL930014I2 (nl) 2,4-Dichloor-alpha(N-imidazolylmethyl)-dibenzyletherderivaat, alsmede een deze verbinding omvattend farmaceutisch preparaat.
IT8720618A0 (it) Derivati 3-(idrossimetil)isochinolinici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
ES482438A0 (es) Procedimiento para la preparacion de nuevos derivados de 2-(4-aminopiperidino)-3,4-dihidroquinoleina.
IT7829237A0 (it) Procedimento di preparazione distilbeni 4,4'-diossi-sostituiti.
IS1559B (is) Nýjar 16,17 asetalsúbstitúeraðar pregnan-21-karboxýlsýruafleiður

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee