ATE102219T1 - Fibrinogen-rezeptor-antagonisten. - Google Patents

Fibrinogen-rezeptor-antagonisten.

Info

Publication number
ATE102219T1
ATE102219T1 AT90311148T AT90311148T ATE102219T1 AT E102219 T1 ATE102219 T1 AT E102219T1 AT 90311148 T AT90311148 T AT 90311148T AT 90311148 T AT90311148 T AT 90311148T AT E102219 T1 ATE102219 T1 AT E102219T1
Authority
AT
Austria
Prior art keywords
fibrinogen receptor
receptor antagonists
fibrinogen
chem
phenyl
Prior art date
Application number
AT90311148T
Other languages
English (en)
Inventor
Ruth F Nutt
Mark E Duggan
Daniel F Veber
Stephen F Brady
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE102219T1 publication Critical patent/ATE102219T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT90311148T 1989-10-13 1990-10-11 Fibrinogen-rezeptor-antagonisten. ATE102219T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42104989A 1989-10-13 1989-10-13
EP90311148A EP0422937B1 (de) 1989-10-13 1990-10-11 Fibrinogen-Rezeptor-Antagonisten

Publications (1)

Publication Number Publication Date
ATE102219T1 true ATE102219T1 (de) 1994-03-15

Family

ID=23668978

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90311148T ATE102219T1 (de) 1989-10-13 1990-10-11 Fibrinogen-rezeptor-antagonisten.

Country Status (17)

Country Link
US (1) US5374622A (de)
EP (1) EP0422937B1 (de)
JP (1) JP2559289B2 (de)
KR (1) KR910007958A (de)
AT (1) ATE102219T1 (de)
AU (1) AU644380B2 (de)
CA (1) CA2027314A1 (de)
DE (1) DE69007004T2 (de)
DK (1) DK0422937T3 (de)
ES (1) ES2062400T3 (de)
FI (1) FI905023A7 (de)
IE (1) IE66253B1 (de)
IL (1) IL95918A0 (de)
NO (1) NO904430L (de)
NZ (1) NZ235564A (de)
PT (1) PT95581A (de)
ZA (1) ZA908159B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686570A (en) * 1989-06-16 1997-11-11 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5807828A (en) * 1989-06-16 1998-09-15 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5643872A (en) * 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US6107459A (en) * 1991-02-08 2000-08-22 Diatide, Inc. Technetium-99m labeled peptides for diagnostic imaging
JP2774378B2 (ja) * 1991-02-08 1998-07-09 ダイアテク，インコーポレイテッド 映像用テクネチウム−９９ｍ標識化ポリペプチド
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US5830856A (en) * 1991-02-08 1998-11-03 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US5635477A (en) * 1991-09-30 1997-06-03 The Dupont Merck Pharmaceutical Company Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA
IL103252A (en) 1991-09-30 1997-03-18 Du Pont Merck Pharma CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5674863A (en) * 1991-10-18 1997-10-07 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
DE69229004D1 (de) * 1991-11-07 1999-05-27 Univ Southern California Zusammensetzungen und verfahren zur verhinderung der adhäsionbildung
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5338725A (en) * 1992-06-30 1994-08-16 The Research Foundation Of The State University Of New York Anti-aggregatory agents for platelets
JPH08502261A (ja) * 1992-10-02 1996-03-12 ダイアテク，インコーポレイテッド 多重多価抗血栓症剤
EP0672059A1 (de) * 1992-11-18 1995-09-20 The Du Pont Merck Pharmaceutical Company Durch eine heteroringverbindung verbundene zyclische verbindungen mit plaettchen glycoprotein iib/iiia hemmung
ES2126748T3 (es) * 1993-03-29 1999-04-01 Du Pont Merck Pharma Proceso y compuestos intermedios para la preparacion de inhibidores de la glicoproteina plaquetaria ii b/iii a.
WO1994023758A1 (en) * 1993-04-08 1994-10-27 Diatech, Inc. Radiolabeled compounds for thrombus imaging
US5646000A (en) * 1994-09-29 1997-07-08 Merck & Co., Inc. Compounds and methods for identifying activated platelets
US5858972A (en) * 1996-01-11 1999-01-12 La Jolla Cancer Research Foundation Antithrombotic agents and methods of use
US6623981B2 (en) * 1998-01-27 2003-09-23 Bristol-Myers Squibb Company Detection of patients at risk for developing integrin antagonist/agonist mediated disease states
EP1063973B1 (de) 1998-03-19 2016-11-16 Bristol-Myers Squibb Company Zweiphasiges kontrolliertes verabreichungssystem für hochlösliche arzneimittel und verwandtes verfahren
DE69939165D1 (de) 1998-04-16 2008-09-04 Encysive Pharmaceuticals Inc N,n-disubstituierte amide welche die bindung von integrinen an ihre rezeptoren hemmen
US6808698B1 (en) 1999-03-26 2004-10-26 Bristol-Myers Squibb Pharma Company Method for localization of blood clots
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US7319149B2 (en) 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
CN103153288B (zh) 2010-07-09 2017-02-15 詹姆斯·特林卡·格林 用于包括瑞格列净的短半衰期药物的组合立即/延迟释放递送系统

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5921656A (ja) * 1982-07-28 1984-02-03 Takeda Chem Ind Ltd ポリペプチド誘導体
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
US4988621A (en) * 1985-05-24 1991-01-29 La Jolla Cancer Research Foundation Peptides in cell detachment and aggregation
ES2052595T3 (es) * 1986-12-15 1994-07-16 Inst Nat Sante Rech Med Nuevos derivados peptidicos y su aplicacion en especial en terapeutica.
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
AU639409B2 (en) * 1987-12-10 1993-07-29 La Jolla Cancer Research Foundation Conformationally stabilized cell adhesion peptides
ZW6189A1 (en) * 1988-05-09 1990-05-09 Smithkline Beckman Corp Anti-aggregatory peptides
JP2945680B2 (ja) * 1988-09-09 1999-09-06 旭硝子株式会社 ペプチド誘導体およびその用途
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
US4952562A (en) * 1989-09-29 1990-08-28 Rorer Pharmaceutical Corporation Anti-thrombotic peptides and pseudopeptides
NZ235563A (en) * 1989-10-13 1993-04-28 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical composition
CA2027936C (en) * 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides

Also Published As

Publication number Publication date
AU644380B2 (en) 1993-12-09
CA2027314A1 (en) 1991-04-14
FI905023A0 (fi) 1990-10-12
NO904430L (no) 1991-04-15
DE69007004T2 (de) 1994-10-06
KR910007958A (ko) 1991-05-30
EP0422937B1 (de) 1994-03-02
IE903629A1 (en) 1991-04-24
JP2559289B2 (ja) 1996-12-04
ZA908159B (en) 1991-07-31
PT95581A (pt) 1991-09-13
EP0422937A1 (de) 1991-04-17
IL95918A0 (en) 1991-07-18
JPH03206097A (ja) 1991-09-09
DE69007004D1 (de) 1994-04-07
AU6456890A (en) 1991-04-18
FI905023A7 (fi) 1991-04-14
IE66253B1 (en) 1995-12-27
NZ235564A (en) 1993-10-26
DK0422937T3 (da) 1994-03-28
NO904430D0 (no) 1990-10-12
ES2062400T3 (es) 1994-12-16
US5374622A (en) 1994-12-20

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee