ES2060654T3 - Trigramina - un polipeptido inhibidor de la agregacion plaquetaria. - Google Patents

Trigramina - un polipeptido inhibidor de la agregacion plaquetaria.

Info

Publication number
ES2060654T3
ES2060654T3 ES88307818T ES88307818T ES2060654T3 ES 2060654 T3 ES2060654 T3 ES 2060654T3 ES 88307818 T ES88307818 T ES 88307818T ES 88307818 T ES88307818 T ES 88307818T ES 2060654 T3 ES2060654 T3 ES 2060654T3
Authority
ES
Spain
Prior art keywords
trigramine
platelet aggregation
polypeptide inhibitor
platelet
powerful inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88307818T
Other languages
English (en)
Inventor
Tur-Fu C O National Taiw Huang
Stefan Niewiarowski
John C Holt
Hanna Lukasiewicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Temple Univ School of Medicine
Original Assignee
Temple Univ School of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Temple Univ School of Medicine filed Critical Temple Univ School of Medicine
Application granted granted Critical
Publication of ES2060654T3 publication Critical patent/ES2060654T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA TRIGRAMINA, UN POLIPEPTIDO DE 72 AMINOACIDOS, TIENE LA SIGUIENTE SECUENCIA DE AMINOACIDOS: **FORMULA** LA MOLECULA ES UN POTENTE INHIBIDOR SOBRE EL COMPLEJO IIB/IIIA DE GLICOPROTEINA EN LA MEMBRANA DE PLAQUETAS. LA TRIGRAMINA ES ASI UN INHIBIDOR POTENTE DE AGREGACION DE PLAQUETAS HUMANAS INDUCIDA POR FIBRINOGENO. ES UTIL PARA LA INHIBICION DE LA FORMACION DE TAPONES DE PLAQUETAS HEMSTATICAS.
ES88307818T 1987-11-18 1988-08-24 Trigramina - un polipeptido inhibidor de la agregacion plaquetaria. Expired - Lifetime ES2060654T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12197287A 1987-11-18 1987-11-18
US16566188A 1988-03-08 1988-03-08

Publications (1)

Publication Number Publication Date
ES2060654T3 true ES2060654T3 (es) 1994-12-01

Family

ID=26820025

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88307818T Expired - Lifetime ES2060654T3 (es) 1987-11-18 1988-08-24 Trigramina - un polipeptido inhibidor de la agregacion plaquetaria.

Country Status (4)

Country Link
EP (1) EP0317053B1 (es)
JP (1) JPH0631317B2 (es)
DE (1) DE3886175T2 (es)
ES (1) ES2060654T3 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
WO1989005150A1 (en) * 1987-12-10 1989-06-15 La Jolla Cancer Research Foundation Conformationally stabilized cell adhesion peptides
NZ228710A (en) * 1988-04-22 1992-10-28 Merck & Co Inc Modified "echistatin" and anti-clotting pharmaceutical composition
US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
US5196403A (en) * 1989-01-27 1993-03-23 Biogen, Inc. Method of inhibiting platelet activation
EP0382451A3 (en) * 1989-02-07 1991-05-29 Merck & Co. Inc. Viper venom polypeptides and variants
JPH02275899A (ja) * 1989-02-09 1990-11-09 Merck & Co Inc ポリペプチド合成
US5686566A (en) * 1989-06-16 1997-11-11 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5807828A (en) * 1989-06-16 1998-09-15 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
DK0527798T3 (da) * 1990-04-06 1997-12-15 Jolla Cancer Res Found Fremgangsmåde og sammensætning til behandling af thrombose
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5612311A (en) * 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
AU666853B2 (en) * 1991-04-05 1996-02-29 Genentech Inc. Platelet aggregation inhibitors having high specificity for GP IIbIIIa
US7018627B1 (en) 1995-06-07 2006-03-28 Icos Corporation Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof

Also Published As

Publication number Publication date
DE3886175D1 (de) 1994-01-20
DE3886175T2 (de) 1994-04-07
EP0317053B1 (en) 1993-12-08
JPH0631317B2 (ja) 1994-04-27
EP0317053A3 (en) 1990-07-25
JPH01250399A (ja) 1989-10-05
EP0317053A2 (en) 1989-05-24

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