ATE102608T1 - Substituierte imidazol-derivate und verfahren zu deren herstellung und anwendung. - Google Patents

Substituierte imidazol-derivate und verfahren zu deren herstellung und anwendung.

Info

Publication number: ATE102608T1
Authority: AT; Austria
Prior art keywords: processes; preparation; hal; alkyl; imidazole derivatives
Prior art date: 1988-12-09

Application number

AT89312755T

Other languages

English (en)

Inventor

Arto Johannes Karjalainen

Raimo Einari Virtanen

Arja Leena Karjalainen

Original Assignee

Orion Yhtymae Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-09

Filing date

1989-12-07

Publication date

1994-03-15

1989-12-07 Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy

1994-03-15 Application granted granted Critical

1994-03-15 Publication of ATE102608T1 publication Critical patent/ATE102608T1/de

Links

RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
230000001242 postsynaptic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT89312755T 1988-12-09 1989-12-07 Substituierte imidazol-derivate und verfahren zu deren herstellung und anwendung. ATE102608T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8828831A GB2225782A (en)	1988-12-09	1988-12-09	Imidazole derivatives useful for treatment of diabetes
EP89312755A EP0372954B1 (de)	1988-12-09	1989-12-07	Substituierte Imidazol-Derivate und Verfahren zu deren Herstellung und Anwendung

Publications (1)

Publication Number	Publication Date
ATE102608T1 true ATE102608T1 (de)	1994-03-15

Family

ID=10648267

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89312755T ATE102608T1 (de)	1988-12-09	1989-12-07	Substituierte imidazol-derivate und verfahren zu deren herstellung und anwendung.

Country Status (22)

Country	Link
US (1)	US5292887A (de)
EP (1)	EP0372954B1 (de)
JP (1)	JP2868813B2 (de)
KR (1)	KR900009605A (de)
CN (1)	CN1023219C (de)
AT (1)	ATE102608T1 (de)
AU (1)	AU619928B2 (de)
CA (1)	CA2004799A1 (de)
DD (1)	DD290880A5 (de)
DE (1)	DE68913673T2 (de)
DK (1)	DK603789A (de)
ES (1)	ES2052937T3 (de)
FI (1)	FI96026C (de)
GB (1)	GB2225782A (de)
HU (1)	HU205086B (de)
IE (1)	IE61870B1 (de)
IL (1)	IL92609A0 (de)
NO (1)	NO177138C (de)
NZ (1)	NZ231649A (de)
PT (1)	PT92515B (de)
RU (2)	RU1831479C (de)
ZA (1)	ZA899366B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI862039A0 (fi) *	1986-05-15	1986-05-15	Farmos Oy	Nytt foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat.
GB9127050D0 (en) *	1991-12-20	1992-02-19	Orion Yhtymae Oy	Substituted imidazole derivatives and their preparation and use
GB9312669D0 (en)	1993-06-18	1993-08-04	Orion Yhtymae Oy	New opticla isomers
FR2735776B1 (fr) *	1995-06-22	1997-07-18	Synthelabo	Derives de 2,3-dihydro-1h-indole, leur preparation et leur application en therapeutique
GB9520150D0 (en) *	1995-10-03	1995-12-06	Orion Yhtymae Oy	New imidazole derivatives
WO2000042023A1 (en) *	1999-01-18	2000-07-20	Novo Nordisk A/S	Substituted imidazoles, their preparation and use
US6388090B2 (en)	2000-01-14	2002-05-14	Orion Corporation	Imidazole derivatives
FI20000073A0 (fi) *	2000-01-14	2000-01-14	Orion Yhtymae Oy	Uusia imidatsolijohdannaisia
AU2001258469B2 (en)	2000-05-08	2005-04-14	Orion Corporation	New polycyclic indanylimidazoles with alpha2 adrenergic activity
FR2839719B1 (fr) *	2002-05-16	2004-08-06	Pf Medicament	Nouveaux composes imidazoliques, leur procede de preparation et leur utilisation a titre de medicaments
US8188126B2 (en)	2002-05-16	2012-05-29	Pierre Fabre Medicament	Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
GB0226076D0 (en) *	2002-11-08	2002-12-18	Rp Scherer Technologies Inc	Improved formulations containing substituted imidazole derivatives
CN117186010B (zh) *	2023-08-15	2026-04-14	厦门欧瑞捷生物科技有限公司	一种盐酸阿替美唑的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2167408B (en) *	1984-11-23	1988-05-25	Farmos Oy	Substituted imidazole derivatives and their preparation and use
FI81092C (fi) *	1986-05-15	1990-09-10	Farmos Oy	Foerfarande foer framstaellning av terapeutiskt aktiva 4(5)-(2,3-dihydro-1h-inden-2-yl)-imidazolderivat.

1988
- 1988-12-09 GB GB8828831A patent/GB2225782A/en not_active Withdrawn
1989
- 1989-11-09 FI FI895325A patent/FI96026C/fi not_active IP Right Cessation
- 1989-11-16 NO NO894563A patent/NO177138C/no not_active IP Right Cessation
- 1989-11-30 DK DK603789A patent/DK603789A/da not_active Application Discontinuation
- 1989-12-06 AU AU45992/89A patent/AU619928B2/en not_active Ceased
- 1989-12-06 NZ NZ231649A patent/NZ231649A/xx unknown
- 1989-12-06 US US07/446,839 patent/US5292887A/en not_active Expired - Fee Related
- 1989-12-06 CA CA002004799A patent/CA2004799A1/en not_active Abandoned
- 1989-12-07 EP EP89312755A patent/EP0372954B1/de not_active Expired - Lifetime
- 1989-12-07 IE IE392689A patent/IE61870B1/en not_active IP Right Cessation
- 1989-12-07 AT AT89312755T patent/ATE102608T1/de not_active IP Right Cessation
- 1989-12-07 ZA ZA899366A patent/ZA899366B/xx unknown
- 1989-12-07 ES ES89312755T patent/ES2052937T3/es not_active Expired - Lifetime
- 1989-12-07 DD DD89335371A patent/DD290880A5/de not_active IP Right Cessation
- 1989-12-07 DE DE68913673T patent/DE68913673T2/de not_active Expired - Fee Related
- 1989-12-07 KR KR1019890018116A patent/KR900009605A/ko not_active Ceased
- 1989-12-07 PT PT92515A patent/PT92515B/pt not_active IP Right Cessation
- 1989-12-08 RU SU4742612A patent/RU1831479C/ru active
- 1989-12-08 HU HU896481A patent/HU205086B/hu not_active IP Right Cessation
- 1989-12-08 IL IL92609A patent/IL92609A0/xx unknown
- 1989-12-08 JP JP1320387A patent/JP2868813B2/ja not_active Expired - Fee Related
- 1989-12-08 CN CN89109220A patent/CN1023219C/zh not_active Expired - Fee Related
1991
- 1991-01-08 RU SU91A patent/RU1833375C/ru active

Also Published As

Publication number	Publication date
NO894563D0 (no)	1989-11-16
DK603789D0 (da)	1989-11-30
GB2225782A (en)	1990-06-13
NO894563L (no)	1990-06-11
HU205086B (en)	1992-03-30
ZA899366B (en)	1991-03-27
DK603789A (da)	1990-06-10
PT92515B (pt)	1995-08-09
JPH02202874A (ja)	1990-08-10
CN1043128A (zh)	1990-06-20
AU619928B2 (en)	1992-02-06
CA2004799A1 (en)	1990-06-09
FI96026B (fi)	1996-01-15
CN1023219C (zh)	1993-12-22
DE68913673T2 (de)	1994-07-14
DE68913673D1 (de)	1994-04-14
NO177138B (no)	1995-04-18
EP0372954B1 (de)	1994-03-09
JP2868813B2 (ja)	1999-03-10
FI96026C (fi)	1996-04-25
NO177138C (no)	1995-07-26
US5292887A (en)	1994-03-08
KR900009605A (ko)	1990-07-05
EP0372954A1 (de)	1990-06-13
NZ231649A (en)	1991-09-25
RU1833375C (en)	1993-08-07
RU1831479C (ru)	1993-07-30
IE893926L (en)	1990-06-09
IE61870B1 (en)	1994-11-30
GB8828831D0 (en)	1989-01-18
AU4599289A (en)	1990-08-16
ES2052937T3 (es)	1994-07-16
HUT52065A (en)	1990-06-28
FI895325A0 (fi)	1989-11-09
PT92515A (pt)	1990-06-29
DD290880A5 (de)	1991-06-13
IL92609A0 (en)	1990-08-31

Legal Events

Date	Code	Title	Description
1994-12-15	UEP	Publication of translation of european patent specification
2004-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE85050T1 (de)	1993-02-15	Substituierte imidazol-derivate und verfahren zu deren herstellung und deren anwendung.
DE3677452D1 (de)	1991-03-14	Chinazolinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE68913673D1 (de)	1994-04-14	Substituierte Imidazol-Derivate und Verfahren zu deren Herstellung und Anwendung.
DE69013607D1 (de)	1994-12-01	Pyrazol-Derivate, Verfahren zu deren Herstellung und Anwendung.
ATE224T1 (de)	1981-10-15	1,2-dihydro-chinolin-2-on-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel.
AT389108B (de)	1989-10-25	Neue pyridazinonderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen
ATE89561T1 (de)	1993-06-15	3,4-disubstituierte-2-azetidinon-derivate und verfahren zu ihrer herstellung.
DE3879258D1 (de)	1993-04-22	Praeparat gegen ulcus.
ATE24316T1 (de)	1987-01-15	1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln.
ATE41659T1 (de)	1989-04-15	Benzothiazepinderivate, verfahren zur herstellung und pharmazeutische zusammensetzungen.
ATE36853T1 (de)	1988-09-15	Beta-carbolin-3-carbonsaeurederivate und methode zu ihrer herstellung.
PT78717B (de)	1986-10-21	Neue 1-acetonyl-2-(phenylimino)-imidazolidine deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
ATE31929T1 (de)	1988-01-15	Derivate von 9-oxalysergsaeure, ihre salze, verfahren und zwischenprodukte zu ihrer herstellung, verwendung als arzneimittel und diese enthaltende zusammensetzungen.
ATE96803T1 (de)	1993-11-15	Indolo(3,2,1-de>(1,4>-oxazino(2,3,4ij>(1,5>naphthyridinderivate, verfahren zu ihrer herstellung und zwischenprodukte, ihre verwendung als arzneimittel und diese enthaltende zubereitungen.
PT77466A (de)	1983-11-01	Neue 4-hydroxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxide verfahren zu ihrer herstellung ihre verwendung und diese verbindungen enthaltende arzneimittel
ATE33493T1 (de)	1988-04-15	Phenylethylaminopropiophenon-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ATE67194T1 (de)	1991-09-15	Thiadiazolylacetamid-derivate, verfahren zu ihrer herstellung und ihre verwendung.
DK382588A (da)	1989-01-11	Anti-psykotiske sammensaetninger indeholdende dioxopiperidin derivater