ES2052937T3 - Derivados de imidazol sustituido y su procedimiento de preparacion y su utilizacion. - Google Patents
Derivados de imidazol sustituido y su procedimiento de preparacion y su utilizacion.Info
- Publication number
- ES2052937T3 ES2052937T3 ES89312755T ES89312755T ES2052937T3 ES 2052937 T3 ES2052937 T3 ES 2052937T3 ES 89312755 T ES89312755 T ES 89312755T ES 89312755 T ES89312755 T ES 89312755T ES 2052937 T3 ES2052937 T3 ES 2052937T3
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- hal
- alkyl
- preparation procedure
- substituted imidazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 2
- RAXXELZNTBOGNW-UHFFFAOYSA-O Imidazolium Chemical class C1=C[NH+]=CN1 RAXXELZNTBOGNW-UHFFFAOYSA-O 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 230000001242 postsynaptic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
COMPUESTOS DE LA FORMULA: O EN DONDE X ES -CH2 - O - C - R1 ES H, ALQUILO O BENCIL, QUE PUEDE SUSTITUIRSE O NO R2 ES H, ALQUILO, OH O ALCOHOXILO R3 ES H, CH3, CH2CH3, OCH3 O HAL R4 ES H, CH3, CH2CH3, OCH3 O HAL Y HAL ES HALOGENO SIEMPRE QUE CUANDO R2 SEA H O C1-3-ALQUILO, R1 NO PUEDA SER H, Y CUANDO R2 SEA OH O C1-3-ALCOHOXILO, X NO PUEDA SER CO, Y SALES ACIDAS DE ADICION NO TOXICAS Y SUS COMBINACIONES, QUE SON ANTAGONISTAS ALTAMENTE SELECTIVOS EN (ALFA)2-ADRENOCEPTORES POST-SINAPTICOS, Y ESPECIALMENTE UTILES EN EL TRATAMIENTO DE LA DIABETES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8828831A GB2225782A (en) | 1988-12-09 | 1988-12-09 | Imidazole derivatives useful for treatment of diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2052937T3 true ES2052937T3 (es) | 1994-07-16 |
Family
ID=10648267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES89312755T Expired - Lifetime ES2052937T3 (es) | 1988-12-09 | 1989-12-07 | Derivados de imidazol sustituido y su procedimiento de preparacion y su utilizacion. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5292887A (es) |
| EP (1) | EP0372954B1 (es) |
| JP (1) | JP2868813B2 (es) |
| KR (1) | KR900009605A (es) |
| CN (1) | CN1023219C (es) |
| AT (1) | ATE102608T1 (es) |
| AU (1) | AU619928B2 (es) |
| CA (1) | CA2004799A1 (es) |
| DD (1) | DD290880A5 (es) |
| DE (1) | DE68913673T2 (es) |
| DK (1) | DK603789A (es) |
| ES (1) | ES2052937T3 (es) |
| FI (1) | FI96026C (es) |
| GB (1) | GB2225782A (es) |
| HU (1) | HU205086B (es) |
| IE (1) | IE61870B1 (es) |
| IL (1) | IL92609A0 (es) |
| NO (1) | NO177138C (es) |
| NZ (1) | NZ231649A (es) |
| PT (1) | PT92515B (es) |
| RU (2) | RU1831479C (es) |
| ZA (1) | ZA899366B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI862039A0 (fi) * | 1986-05-15 | 1986-05-15 | Farmos Oy | Nytt foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat. |
| GB9127050D0 (en) * | 1991-12-20 | 1992-02-19 | Orion Yhtymae Oy | Substituted imidazole derivatives and their preparation and use |
| GB9312669D0 (en) | 1993-06-18 | 1993-08-04 | Orion Yhtymae Oy | New opticla isomers |
| FR2735776B1 (fr) * | 1995-06-22 | 1997-07-18 | Synthelabo | Derives de 2,3-dihydro-1h-indole, leur preparation et leur application en therapeutique |
| GB9520150D0 (en) * | 1995-10-03 | 1995-12-06 | Orion Yhtymae Oy | New imidazole derivatives |
| WO2000042023A1 (en) * | 1999-01-18 | 2000-07-20 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
| US6388090B2 (en) | 2000-01-14 | 2002-05-14 | Orion Corporation | Imidazole derivatives |
| FI20000073A0 (fi) * | 2000-01-14 | 2000-01-14 | Orion Yhtymae Oy | Uusia imidatsolijohdannaisia |
| AU2001258469B2 (en) | 2000-05-08 | 2005-04-14 | Orion Corporation | New polycyclic indanylimidazoles with alpha2 adrenergic activity |
| FR2839719B1 (fr) * | 2002-05-16 | 2004-08-06 | Pf Medicament | Nouveaux composes imidazoliques, leur procede de preparation et leur utilisation a titre de medicaments |
| US8188126B2 (en) | 2002-05-16 | 2012-05-29 | Pierre Fabre Medicament | Imidazolic compounds and use thereof as alpha-2 adrenergic receptors |
| GB0226076D0 (en) * | 2002-11-08 | 2002-12-18 | Rp Scherer Technologies Inc | Improved formulations containing substituted imidazole derivatives |
| CN117186010B (zh) * | 2023-08-15 | 2026-04-14 | 厦门欧瑞捷生物科技有限公司 | 一种盐酸阿替美唑的合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2167408B (en) * | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
| FI81092C (fi) * | 1986-05-15 | 1990-09-10 | Farmos Oy | Foerfarande foer framstaellning av terapeutiskt aktiva 4(5)-(2,3-dihydro-1h-inden-2-yl)-imidazolderivat. |
-
1988
- 1988-12-09 GB GB8828831A patent/GB2225782A/en not_active Withdrawn
-
1989
- 1989-11-09 FI FI895325A patent/FI96026C/fi not_active IP Right Cessation
- 1989-11-16 NO NO894563A patent/NO177138C/no not_active IP Right Cessation
- 1989-11-30 DK DK603789A patent/DK603789A/da not_active Application Discontinuation
- 1989-12-06 AU AU45992/89A patent/AU619928B2/en not_active Ceased
- 1989-12-06 NZ NZ231649A patent/NZ231649A/xx unknown
- 1989-12-06 US US07/446,839 patent/US5292887A/en not_active Expired - Fee Related
- 1989-12-06 CA CA002004799A patent/CA2004799A1/en not_active Abandoned
- 1989-12-07 EP EP89312755A patent/EP0372954B1/en not_active Expired - Lifetime
- 1989-12-07 IE IE392689A patent/IE61870B1/en not_active IP Right Cessation
- 1989-12-07 AT AT89312755T patent/ATE102608T1/de not_active IP Right Cessation
- 1989-12-07 ZA ZA899366A patent/ZA899366B/xx unknown
- 1989-12-07 ES ES89312755T patent/ES2052937T3/es not_active Expired - Lifetime
- 1989-12-07 DD DD89335371A patent/DD290880A5/de not_active IP Right Cessation
- 1989-12-07 DE DE68913673T patent/DE68913673T2/de not_active Expired - Fee Related
- 1989-12-07 KR KR1019890018116A patent/KR900009605A/ko not_active Ceased
- 1989-12-07 PT PT92515A patent/PT92515B/pt not_active IP Right Cessation
- 1989-12-08 RU SU4742612A patent/RU1831479C/ru active
- 1989-12-08 HU HU896481A patent/HU205086B/hu not_active IP Right Cessation
- 1989-12-08 IL IL92609A patent/IL92609A0/xx unknown
- 1989-12-08 JP JP1320387A patent/JP2868813B2/ja not_active Expired - Fee Related
- 1989-12-08 CN CN89109220A patent/CN1023219C/zh not_active Expired - Fee Related
-
1991
- 1991-01-08 RU SU91A patent/RU1833375C/ru active
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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