ATE103003T1 - Verfahren zur enzymatischen herstellung von dipeptiden. - Google Patents

Verfahren zur enzymatischen herstellung von dipeptiden.

Info

Publication number: ATE103003T1
Authority: AT; Austria
Prior art keywords: amino; aralkyl; aryl; alkyl; acid residue
Prior art date: 1988-08-12

Application number

AT89308232T

Other languages

English (en)

Inventor

Stig Aasmul-Olsen

Pia Thorbek

Fred Widmer

Soren Hansen

Original Assignee

Carlbiotech Ltd As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-12

Filing date

1989-08-14

Publication date

1994-04-15

1989-08-14 Application filed by Carlbiotech Ltd As filed Critical Carlbiotech Ltd As

1994-04-15 Application granted granted Critical

1994-04-15 Publication of ATE103003T1 publication Critical patent/ATE103003T1/de

Links

108010016626 Dipeptides Proteins 0.000 title abstract 3
230000002255 enzymatic effect Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
125000003710 aryl alkyl group Chemical group 0.000 abstract 6
125000003118 aryl group Chemical group 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 2
108090000371 Esterases Proteins 0.000 abstract 2
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 2
235000001014 amino acid Nutrition 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 2
150000001414 amino alcohols Chemical group 0.000 abstract 2
125000006239 protecting group Chemical group 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
108700023418 Amidases Proteins 0.000 abstract 1
102000005367 Carboxypeptidases Human genes 0.000 abstract 1
108010006303 Carboxypeptidases Proteins 0.000 abstract 1
150000007650 D alpha amino acids Chemical group 0.000 abstract 1
108010031186 Glycoside Hydrolases Proteins 0.000 abstract 1
102000005744 Glycoside Hydrolases Human genes 0.000 abstract 1
150000007649 L alpha amino acids Chemical class 0.000 abstract 1
108090001060 Lipase Proteins 0.000 abstract 1
102000004882 Lipase Human genes 0.000 abstract 1
239000004367 Lipase Substances 0.000 abstract 1
150000001299 aldehydes Chemical class 0.000 abstract 1
102000005922 amidase Human genes 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000006185 dispersion Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
150000002576 ketones Chemical class 0.000 abstract 1
235000019421 lipase Nutrition 0.000 abstract 1
239000012038 nucleophile Substances 0.000 abstract 1
PTMHPRAIXMAOOB-UHFFFAOYSA-N phosphoramidic acid Chemical class NP(O)(O)=O PTMHPRAIXMAOOB-UHFFFAOYSA-N 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
230000006340 racemization Effects 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1
IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical class NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 abstract 1
150000003573 thiols Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

AT89308232T 1988-08-12 1989-08-14 Verfahren zur enzymatischen herstellung von dipeptiden. ATE103003T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK452188A DK163435C (da)	1988-08-12	1988-08-12	Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf
EP89308232A EP0359399B1 (de)	1988-08-12	1989-08-14	Verfahren zur enzymatischen Herstellung von Dipeptiden

Publications (1)

Publication Number	Publication Date
ATE103003T1 true ATE103003T1 (de)	1994-04-15

Family

ID=8134301

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89308232T ATE103003T1 (de)	1988-08-12	1989-08-14	Verfahren zur enzymatischen herstellung von dipeptiden.

Country Status (7)

Country	Link
EP (1)	EP0359399B1 (de)
JP (1)	JPH04501056A (de)
AT (1)	ATE103003T1 (de)
AU (1)	AU4079289A (de)
DE (1)	DE68913880T2 (de)
DK (1)	DK163435C (de)
WO (1)	WO1990001555A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR930002966B1 (ko) *	1990-11-24	1993-04-16	주식회사 미 원	디펩티드의 제조방법
US5508182A (en) *	1991-02-13	1996-04-16	Schneider; Manfred P.	Esterification of hydrophilic polyols by adsorption onto a solid support and employing a substrate-immiscible solvent
DK53191D0 (da) *	1991-03-25	1991-03-25	Carlbiotech Ltd As	Organosvovlforbindelse og farmaceutisk praeparat indeholdende en saadan forbindelse
AU7338294A (en) *	1993-07-20	1995-02-20	Bionebraska, Inc.	Method for endomodification of proteins
FR2708938B1 (fr) *	1993-08-09	1995-11-03	Bioeurope	Procédé enzymatique perfectionné de préparation d'oligomères de L-lysine.
DE19834308C2 (de) *	1998-07-30	2002-11-07	Univ Leipzig	Verfahren zur Herstellung von Säureamiden
EP1411116B1 (de)	2001-07-26	2008-04-23	Ajinomoto Co., Inc.	Peptidsynthasegen, peptidsynthase und verfahren zur herstellung eines dipeptids
KR20030080439A (ko) *	2002-04-08	2003-10-17	새롬시엠에스 주식회사	인쇄매체를 이용한 홀로그램 부분 정착, 박리방법 및 그에의해 형성된 플라스틱 필름
JP4483579B2 (ja)	2002-07-26	2010-06-16	味の素株式会社	トリペプチド以上のペプチドの製造方法
EP2298909B1 (de)	2002-07-26	2014-10-01	Ajinomoto Co., Inc.	Neuartiges peptidbildendes Enzymgen
CN1316016C (zh) *	2002-07-26	2007-05-16	味之素株式会社	新的生成肽的酶、生成该酶的微生物和利用它们合成二肽的方法
JP2005040037A (ja)	2003-07-25	2005-02-17	Ajinomoto Co Inc	ジペプチドの製造方法、それに用いるペプチド生成酵素、およびペプチド生成酵素の製造方法
JP2005168405A (ja)	2003-12-11	2005-06-30	Ajinomoto Co Inc	ジペプチドの製造方法
JP5754682B2 (ja) *	2010-01-27	2015-07-29	国立大学法人鳥取大学	Ｄ−，ｌ−ペプチドの立体選択的合成法
WO2013051685A1 (ja)	2011-10-07	2013-04-11	味の素株式会社	変異型γ－グルタミルトランスフェラーゼ、及び、γ-グルタミルバリルグリシン又はその塩の製造法
CN107936089B (zh) *	2017-11-07	2021-01-29	重庆大学	一种合成苯丙氨酰-赖氨酸二肽的方法
WO2019208700A1 (ja) *	2018-04-26	2019-10-31	ゼリア新薬工業株式会社	ジペプチド及びこれを含有する医薬組成物
EP4695412A1 (de) *	2023-04-13	2026-02-18	Ohio State Innovation Foundation	Phosphonoalanin-oligopeptide und verfahren zur herstellung und verwendung davon

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI70597C (fi) *	1979-04-06	1986-09-24	Carlsberg Biotechnology Ltd	Foerfarande foer enzymatisk framstaellning av peptider
US4506011A (en) *	1981-09-05	1985-03-19	Toyo Soda Manufacturing Co., Ltd.	Process for preparation of aspartylphenylalanine alkyl esters
EP0154472B1 (de) *	1984-03-07	1989-10-11	Ajinomoto Co., Inc.	Verfahren zur Herstellung des L-Aspartyl-L-Phenyl-Alaninesters
NZ217813A (en) *	1985-10-21	1991-01-29	Grace W R & Co	Dipeptides and process for their preparation using an enzyme coupling agent
EP0269390B1 (de) *	1986-11-21	1993-08-25	Genencor International, Inc.	Enzymatische Herstellung von L-Aspartyl-L-Phenylalanin-Alkylester
DK72587D0 (da) *	1987-02-13	1987-02-13	Carlsberg Biotechnology Ltd	Fremgangsmaade til enzymatisk fremstilling af dipeptider

1988
- 1988-08-12 DK DK452188A patent/DK163435C/da not_active IP Right Cessation
1989
- 1989-08-14 DE DE68913880T patent/DE68913880T2/de not_active Expired - Fee Related
- 1989-08-14 EP EP89308232A patent/EP0359399B1/de not_active Expired - Lifetime
- 1989-08-14 AU AU40792/89A patent/AU4079289A/en not_active Abandoned
- 1989-08-14 JP JP1508952A patent/JPH04501056A/ja active Pending
- 1989-08-14 AT AT89308232T patent/ATE103003T1/de not_active IP Right Cessation
- 1989-08-14 WO PCT/DK1989/000193 patent/WO1990001555A1/en not_active Ceased

Also Published As

Publication number	Publication date
WO1990001555A1 (en)	1990-02-22
EP0359399A1 (de)	1990-03-21
DK163435C (da)	1992-07-20
DE68913880D1 (de)	1994-04-21
AU4079289A (en)	1990-03-05
DK452188D0 (da)	1988-08-12
JPH04501056A (ja)	1992-02-27
DE68913880T2 (de)	1994-09-22
DK452188A (da)	1990-02-13
DK163435B (da)	1992-03-02
EP0359399B1 (de)	1994-03-16

Legal Events

Date	Code	Title	Description
1994-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE103003T1 (de)	1994-04-15	Verfahren zur enzymatischen herstellung von dipeptiden.
ATE96175T1 (de)	1993-11-15	Verfahren zur enzymatischen herstellung von dipeptiden.
DE59608521D1 (de)	2002-01-31	Verfahren zur herstellung von o-acetylserin, l-cystein und l-cystein-verwandten produkten
ATE165868T1 (de)	1998-05-15	Verfahren zur enzymatischen herstellung geschützter und ungeschützter di- und oligopeptide in wässrigen lösungen
ATE126829T1 (de)	1995-09-15	Verfahren zur herstellung von salzen des l- ornithins.
ATE185577T1 (de)	1999-10-15	Verfahren zur herstellung von polysuccinimid in einem organischen medium
ATE40570T1 (de)	1989-02-15	Verfahren zur herstellung eines optisch aktiven 3-(3,4-dihydroxyphenyl)-serins und ein geschuetztes derivat davon.
DE69120318D1 (de)	1996-07-25	Esterase von Serratia und Verfahren zur Herstellung
ATE56472T1 (de)	1990-09-15	Verfahren zur herstellung aromatisch substituierter l-aminosaeuren.
DE602004008201D1 (de)	2007-09-27	Verfahren zur Herstellung von Dipeptiden
IE820220L (en)	1982-08-02	Amino protected asp-phe alkyl ester
ATE360087T1 (de)	2007-05-15	Verfahren zur racematspaltung von arylalkylcarbonsäureestern
EP0892044A3 (de)	2001-05-02	Esterase und seine verwendung zur Herstellung von optisch aktiver Chroman-Verbindungen
ATE147395T1 (de)	1997-01-15	Verfahren zur herstellung von acylaminomethanphosphonsäuren
ATA88691A (de)	1994-01-15	Verfahren zur enzymatischen hydrolyse eines carbonsäurederivates
Kim et al.	1993	Synthesis and inhibitory activity of optically active 2-benzyl-3-mercaptopropanoic acid against carboxypeptidase A
DE59309261D1 (de)	1999-02-11	Verfahren zur stereoselektiven synthese von 3-substituierten 2-thiomethylpropionsäuren
HUP0104386A2 (hu)	2002-04-29	Eljárás L-prolil-L-m-szarkolizil-L-p-fluorfenilalanin és származékai előállítására
DE3887854D1 (de)	1994-03-24	Verfahren zur Herstellung von Dipeptiden.
ATE113662T1 (de)	1994-11-15	Verfahren zur herstellung von r-(+)-3- oxocycloalkancarbonsäureniederalkylestern.
DE59601603D1 (de)	1999-05-12	Verfahren zur herstellung von optisch aktiven 2-halogenpropionsäuren
Boesten et al.	1986	Efficient enzymic production of enantiomerically pure amino acids
DE58909308D1 (de)	1995-07-27	Verfahren zur Herstellung von Tripeptiden.
ATE251097T1 (de)	2003-10-15	Verfahren zur racemisierung von n-acetyl-d(l)- alpha-aminocarbonsäuren
NL8800224A (nl)	1989-08-16	Werkwijze ter bereiding van zwavelhoudende l-alpha-aminozuren.