ATE96175T1 - Verfahren zur enzymatischen herstellung von dipeptiden. - Google Patents

Verfahren zur enzymatischen herstellung von dipeptiden.

Info

Publication number: ATE96175T1
Authority: AT; Austria
Prior art keywords: amino acid; amino; formula; acid; optionally
Prior art date: 1987-02-13

Application number

AT88301230T

Other languages

English (en)

Inventor

Pia Thorbek

Fred Widmer

Stig Aasmul-Olsen

Original Assignee

Carlbiotech Ltd As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-02-13

Filing date

1988-02-15

Publication date

1993-11-15

1988-02-15 Application filed by Carlbiotech Ltd As filed Critical Carlbiotech Ltd As

1993-11-15 Application granted granted Critical

1993-11-15 Publication of ATE96175T1 publication Critical patent/ATE96175T1/de

Links

108010016626 Dipeptides Proteins 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
230000002255 enzymatic effect Effects 0.000 title 1
150000008575 L-amino acids Chemical class 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
125000003710 aryl alkyl group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 2
125000006239 protecting group Chemical group 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
102000005367 Carboxypeptidases Human genes 0.000 abstract 1
108010006303 Carboxypeptidases Proteins 0.000 abstract 1
150000007650 D alpha amino acids Chemical class 0.000 abstract 1
150000007649 L alpha amino acids Chemical class 0.000 abstract 1
-1 L-amino acid esters Chemical class 0.000 abstract 1
101000978265 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Carboxypeptidase Y Proteins 0.000 abstract 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
235000001014 amino acid Nutrition 0.000 abstract 1
150000003862 amino acid derivatives Chemical class 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
239000007900 aqueous suspension Substances 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000011065 in-situ storage Methods 0.000 abstract 1
230000000813 microbial effect Effects 0.000 abstract 1
239000012038 nucleophile Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
PTMHPRAIXMAOOB-UHFFFAOYSA-N phosphoramidic acid Chemical class NP(O)(O)=O PTMHPRAIXMAOOB-UHFFFAOYSA-N 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
230000006340 racemization Effects 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1
IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical class NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 abstract 1
150000003573 thiols Chemical class 0.000 abstract 1
235000013311 vegetables Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT88301230T 1987-02-13 1988-02-15 Verfahren zur enzymatischen herstellung von dipeptiden. ATE96175T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK072587A DK72587D0 (da)	1987-02-13	1987-02-13	Fremgangsmaade til enzymatisk fremstilling af dipeptider
EP88301230A EP0278787B1 (de)	1987-02-13	1988-02-15	Verfahren zur enzymatischen Herstellung von Dipeptiden

Publications (1)

Publication Number	Publication Date
ATE96175T1 true ATE96175T1 (de)	1993-11-15

Family

ID=8096821

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88301230T ATE96175T1 (de)	1987-02-13	1988-02-15	Verfahren zur enzymatischen herstellung von dipeptiden.

Country Status (9)

Country	Link
EP (1)	EP0278787B1 (de)
JP (1)	JPH01502158A (de)
AT (1)	ATE96175T1 (de)
AU (1)	AU613348B2 (de)
DE (1)	DE3884976T2 (de)
DK (1)	DK72587D0 (de)
FI (1)	FI884653A0 (de)
HU (1)	HU203790B (de)
WO (1)	WO1988006187A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3733198A1 (de) *	1987-10-01	1989-04-13	Kernforschungsanlage Juelich	Enzymatisches verfahren zur herstellung von dipeptiden
DK163435C (da) *	1988-08-12	1992-07-20	Carlsberg Biotechnology Ltd	Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf
DK53291D0 (da) *	1991-03-25	1991-03-25	Carlbiotech Ltd As	Smaa peptider og peptidrelaterede stoffer samt farmaceutiske praeparater indeholdende saadanne forbindelser
DK53191D0 (da) *	1991-03-25	1991-03-25	Carlbiotech Ltd As	Organosvovlforbindelse og farmaceutisk praeparat indeholdende en saadan forbindelse
EP0566824A1 (de) *	1992-01-28	1993-10-27	F. Hoffmann-La Roche Ag	Enzymatische Peptidsynthese
DE4423724A1 (de) *	1994-07-08	1996-01-11	Degussa	Kinetisch kontrolliertes Verfahren zur enzymatischen Herstellung von Peptiden
WO2003010189A1 (en) *	2001-07-26	2003-02-06	Ajinomoto Co., Inc.	Process for producing dipeptide, peptide synthase to be used therein and process for producing peptide synthase
DE10156274A1 (de) *	2001-11-16	2003-06-12	Noxxon Pharma Ag	Verfahren zur Synthese von all-D-Polypeptiden
AU2003248117A1 (en) *	2002-07-26	2004-03-29	Ajinomoto Co., Inc.	Novel enzyme forming peptide, microorganism producing the same and process for producing dipeptide using them
EP2295579B1 (de)	2002-07-26	2014-01-22	Ajinomoto Co., Inc.	Neuartiges peptidbildendes Enzymgen
WO2004011652A1 (ja) *	2002-07-26	2004-02-05	Ajinomoto Co., Inc.	トリペプチド以上のペプチドの製造方法
JP2005040037A (ja)	2003-07-25	2005-02-17	Ajinomoto Co Inc	ジペプチドの製造方法、それに用いるペプチド生成酵素、およびペプチド生成酵素の製造方法
JP2005168405A (ja)	2003-12-11	2005-06-30	Ajinomoto Co Inc	ジペプチドの製造方法
US8420605B2 (en)	2005-09-07	2013-04-16	The University Of Strathclyde	Hydrogel compositions
JP5754682B2 (ja) *	2010-01-27	2015-07-29	国立大学法人鳥取大学	Ｄ−，ｌ−ペプチドの立体選択的合成法
EP2566880A4 (de) *	2010-05-03	2014-10-08	Stealth Peptides Int Inc	Aromatisch-kationische peptide und verwendungen davon
AU2012315586B2 (en)	2011-09-29	2017-07-20	Mayo Foundation For Medical Education And Research	Aromatic-cationic peptides and methods for using same
WO2013051685A1 (ja)	2011-10-07	2013-04-11	味の素株式会社	変異型γ－グルタミルトランスフェラーゼ、及び、γ-グルタミルバリルグリシン又はその塩の製造法
CN107936089B (zh) *	2017-11-07	2021-01-29	重庆大学	一种合成苯丙氨酰-赖氨酸二肽的方法
EP3810569A1 (de)	2018-06-22	2021-04-28	Basf Se	Aminosäurebasierte tenside als beistoffe für biozide

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3972773A (en) *	1975-04-29	1976-08-03	Sagami Chemical Research Center	Process for producing peptide
US4086136A (en) *	1975-10-23	1978-04-25	(Zaidanhojin) Sagami Chemical Research Center	Process for producing a peptide using a serine or thiol proteinase
ZA801929B (en) *	1979-04-06	1981-11-25	Forenede Bryggerier As	A process for enzymatic production of peptides
US4506011A (en) *	1981-09-05	1985-03-19	Toyo Soda Manufacturing Co., Ltd.	Process for preparation of aspartylphenylalanine alkyl esters
DE3361649D1 (en) *	1982-01-26	1986-02-13	Imahori Kazutomo	Process for synthesizing peptides or peptide derivatives
JPS5917997A (ja) *	1982-07-23	1984-01-30	Toyo Soda Mfg Co Ltd	ジペプチドエステルとアミノ酸エステルとの付加化合物の製造方法
EP0303602A4 (de) *	1986-04-10	1990-06-26	Commw Scient Ind Res Org	Enzymatisches syntheseverfahren.

1987
- 1987-02-13 DK DK072587A patent/DK72587D0/da not_active Application Discontinuation
1988
- 1988-02-15 AT AT88301230T patent/ATE96175T1/de active
- 1988-02-15 JP JP63501981A patent/JPH01502158A/ja active Pending
- 1988-02-15 EP EP88301230A patent/EP0278787B1/de not_active Expired - Lifetime
- 1988-02-15 WO PCT/DK1988/000022 patent/WO1988006187A1/en not_active Ceased
- 1988-02-15 DE DE88301230T patent/DE3884976T2/de not_active Expired - Fee Related
- 1988-02-15 AU AU13484/88A patent/AU613348B2/en not_active Ceased
- 1988-02-15 HU HU881675A patent/HU203790B/hu not_active IP Right Cessation
- 1988-10-11 FI FI884653A patent/FI884653A0/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU203790B (en)	1991-09-30
HUT50879A (en)	1990-03-28
DK72587D0 (da)	1987-02-13
EP0278787A1 (de)	1988-08-17
FI884653A7 (fi)	1988-10-11
WO1988006187A1 (en)	1988-08-25
DE3884976D1 (de)	1993-11-25
AU613348B2 (en)	1991-08-01
FI884653A0 (fi)	1988-10-11
JPH01502158A (ja)	1989-08-03
EP0278787B1 (de)	1993-10-20
DE3884976T2 (de)	1994-02-17
AU1348488A (en)	1988-09-14

Publication	Publication Date	Title
DE3884976D1 (de)	1993-11-25	Verfahren zur enzymatischen Herstellung von Dipeptiden.
ATE103003T1 (de)	1994-04-15	Verfahren zur enzymatischen herstellung von dipeptiden.
ATE165868T1 (de)	1998-05-15	Verfahren zur enzymatischen herstellung geschützter und ungeschützter di- und oligopeptide in wässrigen lösungen
ES2174132T3 (es)	2002-11-01	N-acil-a,omp-alquil-hidrazino-carboximidamidas.
DE59106289D1 (de)	1995-09-28	Verfahren zur Herstellung von Salzen des L-Ornithins.
ATE9820T1 (de)	1984-10-15	Verfahren zur enzymatischen substitution der b-30-aminosaeure in den insulinen.
ATE206280T1 (de)	2001-10-15	Verwendung von 1,2,3- thiadiazolcarbonsäure(thio)estern zur bekämpfung von schädlingen sowie 1,2,3- thiadiazolcarbonsäure(thio)ester
ATE19884T1 (de)	1986-06-15	Verfahren zur herstellung von phosphonomethylierten aminosaeuren.
DE3875953D1 (de)	1992-12-17	Verfahren zur herstellung von organischen chemischen verbindungen.
ATE111959T1 (de)	1994-10-15	Verfahren zur enzymatischen trennung von 2-amino- 4-methylphosphinobuttersäurederivaten.
ATE19790T1 (de)	1986-05-15	Verfahren zum enzymatischen ersetzen von b-30 aminosaeuren in insulinen.
DE60133395D1 (de)	2008-05-08	Verfahren zur herstellung von alpha'-chlorketonen
ATE256700T1 (de)	2004-01-15	Verfahren zur herstellung von l-prolyl-l-m- sarcolysyl-l-p-fluorphenylalanin und von derivaten davon
ATE101616T1 (de)	1994-03-15	Verfahren zur herstellung von dipeptiden.
DE58909308D1 (de)	1995-07-27	Verfahren zur Herstellung von Tripeptiden.
ATE239746T1 (de)	2003-05-15	Verfahren zur herstellung von ascorbinsäure-2- phosphatsalzen
ATE251097T1 (de)	2003-10-15	Verfahren zur racemisierung von n-acetyl-d(l)- alpha-aminocarbonsäuren