ATE103174T1 - Arzneimittel mit verzoegerter wirkstofffreigabe. - Google Patents
Arzneimittel mit verzoegerter wirkstofffreigabe.Info
- Publication number
- ATE103174T1 ATE103174T1 AT90917183T AT90917183T ATE103174T1 AT E103174 T1 ATE103174 T1 AT E103174T1 AT 90917183 T AT90917183 T AT 90917183T AT 90917183 T AT90917183 T AT 90917183T AT E103174 T1 ATE103174 T1 AT E103174T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- delayed
- sec
- date
- amylose
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Die Bonding (AREA)
- Materials For Medical Uses (AREA)
- Compounds Of Unknown Constitution (AREA)
- Steroid Compounds (AREA)
- Fats And Perfumes (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Paints Or Removers (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898926639A GB8926639D0 (en) | 1989-11-24 | 1989-11-24 | Delayed release formulations |
| PCT/GB1990/001803 WO1991007949A1 (en) | 1989-11-24 | 1990-11-22 | Delayed release formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE103174T1 true ATE103174T1 (de) | 1994-04-15 |
Family
ID=10666886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90917183T ATE103174T1 (de) | 1989-11-24 | 1990-11-22 | Arzneimittel mit verzoegerter wirkstofffreigabe. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5294448A (de) |
| EP (1) | EP0502032B1 (de) |
| JP (1) | JP2975680B2 (de) |
| KR (1) | KR920703030A (de) |
| AT (1) | ATE103174T1 (de) |
| CA (1) | CA2069485C (de) |
| DE (1) | DE69007623T2 (de) |
| DK (1) | DK0502032T3 (de) |
| ES (1) | ES2053206T3 (de) |
| FI (1) | FI103091B (de) |
| GB (2) | GB8926639D0 (de) |
| HU (1) | HU209243B (de) |
| NO (1) | NO303424B1 (de) |
| NZ (1) | NZ236188A (de) |
| RU (1) | RU2093148C1 (de) |
| WO (1) | WO1991007949A1 (de) |
| ZA (1) | ZA909384B (de) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3034592B2 (ja) * | 1990-11-20 | 2000-04-17 | わかもと製薬株式会社 | 経口用固形製剤及びその製造法 |
| DE4120918A1 (de) * | 1991-06-25 | 1993-01-07 | Basf Ag | Pulverfoermige praeparate aus einer wasserunloeslichen kernsubstanz und einer schutzhuelle |
| US6764697B1 (en) * | 1991-06-27 | 2004-07-20 | Alza Corporation | System for delaying drug delivery up to seven hours |
| DE69229710T2 (de) * | 1991-11-15 | 2000-03-02 | Kanegafuchi Kagaku Kogyo K.K., Osaka | Esterbindung enthaltende Polymere für pharmazeutische Zubereitungen |
| US7070806B2 (en) | 1992-01-27 | 2006-07-04 | Purdue Pharma Lp | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| DE69425453T2 (de) * | 1993-04-23 | 2001-04-12 | Novartis Ag, Basel | Wirkstoffabgabevorrichtung mit gesteuerter Freigabe |
| US5514663A (en) * | 1993-10-19 | 1996-05-07 | The Procter & Gamble Company | Senna dosage form |
| US5565407A (en) * | 1993-12-27 | 1996-10-15 | University Of Kansas Center For Research, Inc. | Biologically active agent encapsulated in biodegradable starch/polymer matrices |
| US6166024A (en) | 1995-03-30 | 2000-12-26 | Mayo Foundation For Medical Education And Research | Use of topical azathioprine and thioguanine to treat colorectal adenomas |
| US5656294A (en) * | 1995-06-07 | 1997-08-12 | Cibus Pharmaceutical, Inc. | Colonic delivery of drugs |
| US5811388A (en) * | 1995-06-07 | 1998-09-22 | Cibus Pharmaceutical, Inc. | Delivery of drugs to the lower GI tract |
| GB9516268D0 (en) | 1995-08-08 | 1995-10-11 | Danbiosyst Uk | Compositiion for enhanced uptake of polar drugs from the colon |
| UA67721C2 (en) * | 1995-12-21 | 2004-07-15 | Ferring Farma Lab | Modified release pharmaceutical composition and method for treatment of inflammatory bowel diseases |
| US6004581A (en) * | 1995-12-21 | 1999-12-21 | Farmaceutisk Laboratorium Ferring A/S | Modified release oral pharmaceutical composition and method for the treatment of bowel diseases |
| US5840332A (en) * | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
| US6231888B1 (en) * | 1996-01-18 | 2001-05-15 | Perio Products Ltd. | Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps |
| US5891474A (en) * | 1997-01-29 | 1999-04-06 | Poli Industria Chimica, S.P.A. | Time-specific controlled release dosage formulations and method of preparing same |
| US5788987A (en) * | 1997-01-29 | 1998-08-04 | Poli Industria Chimica Spa | Methods for treating early morning pathologies |
| DE19732903A1 (de) | 1997-07-30 | 1999-02-04 | Falk Pharma Gmbh | Pellet-Formulierung zur Behandlung des Intestinaltraktes |
| GB9722426D0 (en) * | 1997-10-23 | 1997-12-24 | Univ London Pharmacy | Controlled release formulations |
| GB9724186D0 (en) * | 1997-11-14 | 1998-01-14 | British Tech Group | Low temperature coatings |
| ITMI991316A1 (it) * | 1999-06-14 | 2000-12-14 | Cip Ninety Two 92 S A | Composizioni farmaceutiche orali a rilascio modificato di mesalazina |
| RU2153340C1 (ru) * | 1999-12-14 | 2000-07-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" | Фармацевтический состав, регулирующий метаболические процессы, и способ его получения |
| WO2001078626A1 (en) * | 2000-04-13 | 2001-10-25 | Sts Biopolymers, Inc. | Targeted therapeutic agent release devices and methods of making and using the same |
| RU2191782C2 (ru) * | 2000-09-21 | 2002-10-27 | Институт нефтехимии и катализа АН РБ и УНЦ РАН | Способ получения модифицированной гиалуроновой кислоты |
| RU2259817C2 (ru) * | 2000-10-13 | 2005-09-10 | Кембридж Байостэбилити Лтд. | Композиция для доставки стабильных инъецируемых жидкостей и способ доставки |
| CA2359812C (en) * | 2000-11-20 | 2004-02-10 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
| FI20002768L (fi) * | 2000-12-18 | 2002-06-19 | Licentia Oy | Enteropäällysteisiä lääkekoostumuksia ja niiden valmistus |
| AP1748A (en) * | 2001-03-13 | 2007-06-11 | Penwest Pharmaceuticals Co | Chronotherapeutic dosage forms. |
| US7771468B2 (en) * | 2001-03-16 | 2010-08-10 | Angiotech Biocoatings Corp. | Medicated stent having multi-layer polymer coating |
| US20070098784A1 (en) | 2001-09-28 | 2007-05-03 | Nutraceutix, Inc. | Delivery system for biological component |
| EP1429802B1 (de) * | 2001-09-28 | 2012-11-07 | TNTGamble, Inc. | System zur abgabe eines biologischen bestandteiles |
| AU2002366029B2 (en) * | 2001-11-21 | 2008-01-31 | Eisai R And D Management Co., Ltd. | Preparation compositions containing acid-unstable physiologically active compounds and process for producing the same |
| GB0203421D0 (en) * | 2002-02-13 | 2002-04-03 | Alizyme Therapeutics Ltd | Composition |
| PL377479A1 (pl) * | 2002-12-11 | 2006-02-06 | Pfizer Products Inc. | Kontrolowane uwalnianie substancji czynnej do środowiska o wysokiej zawartości tłuszczu |
| US8389008B2 (en) * | 2003-09-19 | 2013-03-05 | Penwest Pharmaceuticals Co. | Delayed release dosage forms |
| MXPA06003101A (es) * | 2003-09-19 | 2006-06-20 | Penwest Pharmaceuticals Co | Formas de dosis cronoterapeuticas. |
| CA2551528A1 (en) * | 2003-12-31 | 2005-07-21 | Genzyme Corporation | Enteric coated aliphatic amine polymer bile acid sequestrants |
| ATE424189T1 (de) * | 2004-09-01 | 2009-03-15 | Procter & Gamble | Zusammensetzungen mit 5-amino-2- hydroxybenzoesäure und einem reduzierendem zucker |
| US20060165745A1 (en) * | 2005-01-21 | 2006-07-27 | Yiwen Chew | Sustained release tablets for treatment of aqueous environment and methods for making the same |
| GB0600928D0 (en) | 2006-01-17 | 2006-02-22 | Novacta Biosystems Ltd | Improvements relating to lantibiotics |
| GB0607534D0 (en) | 2006-04-13 | 2006-05-24 | Univ London Pharmacy | Colonic drug delivery formulation |
| RU2322242C2 (ru) * | 2006-05-03 | 2008-04-20 | Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО БГМУ РОСЗДРАВА) | Способ эндоскопического лечения эрозивно-язвенных поражений слизистой желудка и двенадцатиперстной кишки у ангио-кардиохирургических больных |
| ES2393814T3 (es) | 2007-04-04 | 2012-12-28 | Sigmoid Pharma Limited | Una composición farmacéutica oral |
| TWI422398B (zh) * | 2007-06-04 | 2014-01-11 | Univ London | 結腸給藥配方 |
| GB0714030D0 (en) | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | The use of type-B lantibiotic-based compounds having antimicrobial activity |
| GB0714029D0 (en) | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | Lantibiotic-based compounds having antimicrobial activity |
| US20090036414A1 (en) * | 2007-08-02 | 2009-02-05 | Mutual Pharmaceutical Company, Inc. | Mesalamine Formulations |
| JP5740306B2 (ja) | 2008-10-03 | 2015-06-24 | ドクトル ファルク ファルマ ゲーエムベーハー | メサラミン顆粒を用いて腸疾患を治療するための組成物および方法 |
| ES2425762T3 (es) * | 2008-10-27 | 2013-10-17 | Roquette Freres | Polímero insoluble en agua: revestimientos de película a base de derivados de almidón modificado para la liberación dirigida al colon |
| CA2749278A1 (en) | 2009-01-14 | 2010-07-22 | Novacta Biosystems Limited | Deoxyactagardine derivatives |
| CN102388060B (zh) | 2009-02-04 | 2014-09-10 | 诺瓦克塔生物系统有限公司 | 阿肽加定衍生物 |
| GB201001688D0 (en) | 2010-02-02 | 2010-03-17 | Novacta Biosystems Ltd | Compounds |
| EP2386297A1 (de) * | 2010-04-28 | 2011-11-16 | Roquette Frères | Unverdauliches Polymer: Filmüberzüge auf Basis von acetylierter Stärke für Colon-Targeting |
| GB201013513D0 (en) | 2010-08-11 | 2010-09-22 | Novacta Biosystems Ltd | Formulations |
| ES2687027T3 (es) | 2010-11-04 | 2018-10-23 | Albireo Ab | Inhibidores de ibat para el tratamiento de enfermedades hepáticas |
| CA3008794C (en) | 2012-03-29 | 2021-03-16 | Therabiome, Llc | Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix |
| EP3187171B1 (de) | 2012-04-30 | 2024-09-25 | Tillotts Pharma AG | Arzneimittelformulierung mit verzögerter freisetzung |
| AU2014239883B2 (en) | 2013-03-14 | 2019-01-17 | Therabiome, Llc | Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents |
| US10799515B2 (en) | 2013-10-29 | 2020-10-13 | Tillotts Pharma Ag | Delayed release drug formulation |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| CN106659726A (zh) | 2014-06-25 | 2017-05-10 | Ea制药株式会社 | 固体制剂及其着色防止或着色减少方法 |
| JP6716582B2 (ja) | 2014-11-07 | 2020-07-01 | サブリミティ・セラピューティクス・リミテッドSublimity Therapeutics Limited | シクロスポリンを含む組成物 |
| DE102015000795A1 (de) * | 2015-01-23 | 2016-07-28 | Se Tylose Gmbh & Co. Kg | Reversibel vernetzte Celluloseether und Verfahren zu deren Herstellung durch selektive Oxidation von vicinalen OH-Gruppen |
| WO2017138878A1 (en) * | 2016-02-09 | 2017-08-17 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| CN108601739B (zh) | 2016-02-09 | 2022-01-04 | 阿尔比里奥公司 | 考来烯胺丸剂及其制备方法 |
| ES2874669T3 (es) | 2016-02-09 | 2021-11-05 | Albireo Ab | Formulación oral de colestiramina y uso de la misma |
| CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
| CN112449637B (zh) | 2018-06-05 | 2024-03-19 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| PL3810581T3 (pl) | 2018-06-20 | 2025-04-28 | Albireo Ab | Modyfikacje kryształu odewiksibatu |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| EP3662900A1 (de) | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Kolonwirkstoffverabreichungsformulierung |
| EP3662901B1 (de) | 2018-12-07 | 2025-01-01 | Tillotts Pharma AG | Arzeimittelformulierumg mit verzögerter freisetzung mit einer aussenschicht enthaltend ein enzymatisch abbaubares polymer, ihre zusammensetzung und ihr herstellungsverfahren |
| EP3662898A1 (de) | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Feste formulierung enthaltend mesalazin |
| ES2994844T3 (en) | 2018-12-07 | 2025-02-03 | Tillotts Pharma Ag | Colonic drug delivery formulation |
| US20240293429A1 (en) * | 2021-06-01 | 2024-09-05 | Nbi Biosciences Pvt Ltd | Microbial-triggered oral intestinal drug delivery formulation and method of preparation thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3360633D1 (en) * | 1982-02-12 | 1985-10-03 | Unitika Ltd | Anti-cancer device |
| US4755397A (en) * | 1986-12-24 | 1988-07-05 | National Starch And Chemical Corporation | Starch based particulate encapsulation process |
| US4911952A (en) * | 1987-07-10 | 1990-03-27 | The United States Of America As Represented By The Secretary Of Agriculture | Encapsulation by entrapment within matrix of unmodified starch |
| GB8812490D0 (en) * | 1988-05-26 | 1988-06-29 | Agricultural & Food Res | Delayed release formulations |
-
1989
- 1989-11-24 GB GB898926639A patent/GB8926639D0/en active Pending
-
1990
- 1990-11-22 DE DE69007623T patent/DE69007623T2/de not_active Expired - Lifetime
- 1990-11-22 KR KR1019920701229A patent/KR920703030A/ko not_active Withdrawn
- 1990-11-22 CA CA002069485A patent/CA2069485C/en not_active Expired - Lifetime
- 1990-11-22 NZ NZ236188A patent/NZ236188A/xx unknown
- 1990-11-22 DK DK90917183.7T patent/DK0502032T3/da active
- 1990-11-22 ZA ZA909384A patent/ZA909384B/xx unknown
- 1990-11-22 RU SU5052091/14A patent/RU2093148C1/ru active
- 1990-11-22 GB GB9025373A patent/GB2238243B/en not_active Expired - Lifetime
- 1990-11-22 HU HU9201719A patent/HU209243B/hu unknown
- 1990-11-22 AT AT90917183T patent/ATE103174T1/de not_active IP Right Cessation
- 1990-11-22 WO PCT/GB1990/001803 patent/WO1991007949A1/en not_active Ceased
- 1990-11-22 US US07/867,696 patent/US5294448A/en not_active Expired - Lifetime
- 1990-11-22 ES ES90917183T patent/ES2053206T3/es not_active Expired - Lifetime
- 1990-11-22 JP JP3500199A patent/JP2975680B2/ja not_active Expired - Lifetime
- 1990-11-22 EP EP90917183A patent/EP0502032B1/de not_active Expired - Lifetime
-
1992
- 1992-05-22 FI FI922369A patent/FI103091B/fi active
- 1992-05-22 NO NO922026A patent/NO303424B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2069485C (en) | 2000-04-18 |
| EP0502032B1 (de) | 1994-03-23 |
| GB2238243B (en) | 1993-09-08 |
| RU2093148C1 (ru) | 1997-10-20 |
| US5294448A (en) | 1994-03-15 |
| NO922026L (no) | 1992-07-23 |
| DE69007623D1 (de) | 1994-04-28 |
| NZ236188A (en) | 1992-11-25 |
| JPH05504947A (ja) | 1993-07-29 |
| KR920703030A (ko) | 1992-12-17 |
| GB2238243A (en) | 1991-05-29 |
| FI103091B1 (fi) | 1999-04-30 |
| NO922026D0 (no) | 1992-05-22 |
| DE69007623T2 (de) | 1994-06-30 |
| DK0502032T3 (da) | 1994-05-09 |
| FI922369A0 (fi) | 1992-05-22 |
| HU9201719D0 (en) | 1992-08-28 |
| GB9025373D0 (en) | 1991-01-09 |
| HUT62463A (en) | 1993-05-28 |
| ZA909384B (en) | 1992-07-29 |
| FI922369L (fi) | 1992-05-22 |
| HU209243B (en) | 1994-04-28 |
| FI103091B (fi) | 1999-04-30 |
| GB8926639D0 (en) | 1990-01-17 |
| JP2975680B2 (ja) | 1999-11-10 |
| ES2053206T3 (es) | 1994-07-16 |
| WO1991007949A1 (en) | 1991-06-13 |
| NO303424B1 (no) | 1998-07-13 |
| EP0502032A1 (de) | 1992-09-09 |
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| EELA | Cancelled due to lapse of time |