ATE103174T1 - Arzneimittel mit verzoegerter wirkstofffreigabe. - Google Patents
Arzneimittel mit verzoegerter wirkstofffreigabe.Info
- Publication number
- ATE103174T1 ATE103174T1 AT90917183T AT90917183T ATE103174T1 AT E103174 T1 ATE103174 T1 AT E103174T1 AT 90917183 T AT90917183 T AT 90917183T AT 90917183 T AT90917183 T AT 90917183T AT E103174 T1 ATE103174 T1 AT E103174T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- delayed
- sec
- date
- amylose
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Paints Or Removers (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Fats And Perfumes (AREA)
- Compounds Of Unknown Constitution (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Die Bonding (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898926639A GB8926639D0 (en) | 1989-11-24 | 1989-11-24 | Delayed release formulations |
| PCT/GB1990/001803 WO1991007949A1 (en) | 1989-11-24 | 1990-11-22 | Delayed release formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE103174T1 true ATE103174T1 (de) | 1994-04-15 |
Family
ID=10666886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90917183T ATE103174T1 (de) | 1989-11-24 | 1990-11-22 | Arzneimittel mit verzoegerter wirkstofffreigabe. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5294448A (de) |
| EP (1) | EP0502032B1 (de) |
| JP (1) | JP2975680B2 (de) |
| KR (1) | KR920703030A (de) |
| AT (1) | ATE103174T1 (de) |
| CA (1) | CA2069485C (de) |
| DE (1) | DE69007623T2 (de) |
| DK (1) | DK0502032T3 (de) |
| ES (1) | ES2053206T3 (de) |
| FI (1) | FI103091B (de) |
| GB (2) | GB8926639D0 (de) |
| HU (1) | HU209243B (de) |
| NO (1) | NO303424B1 (de) |
| NZ (1) | NZ236188A (de) |
| RU (1) | RU2093148C1 (de) |
| WO (1) | WO1991007949A1 (de) |
| ZA (1) | ZA909384B (de) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3034592B2 (ja) * | 1990-11-20 | 2000-04-17 | わかもと製薬株式会社 | 経口用固形製剤及びその製造法 |
| DE4120918A1 (de) * | 1991-06-25 | 1993-01-07 | Basf Ag | Pulverfoermige praeparate aus einer wasserunloeslichen kernsubstanz und einer schutzhuelle |
| US6764697B1 (en) | 1991-06-27 | 2004-07-20 | Alza Corporation | System for delaying drug delivery up to seven hours |
| DE69229710T2 (de) * | 1991-11-15 | 2000-03-02 | Kanegafuchi Kagaku Kogyo K.K., Osaka | Esterbindung enthaltende Polymere für pharmazeutische Zubereitungen |
| US7070806B2 (en) | 1992-01-27 | 2006-07-04 | Purdue Pharma Lp | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| PT621032E (pt) * | 1993-04-23 | 2001-01-31 | Novartis Ag | Dispositivo de distribuicao de libertacao controlada de farmaco |
| US5514663A (en) * | 1993-10-19 | 1996-05-07 | The Procter & Gamble Company | Senna dosage form |
| US5565407A (en) * | 1993-12-27 | 1996-10-15 | University Of Kansas Center For Research, Inc. | Biologically active agent encapsulated in biodegradable starch/polymer matrices |
| US6166024A (en) | 1995-03-30 | 2000-12-26 | Mayo Foundation For Medical Education And Research | Use of topical azathioprine and thioguanine to treat colorectal adenomas |
| US5656294A (en) * | 1995-06-07 | 1997-08-12 | Cibus Pharmaceutical, Inc. | Colonic delivery of drugs |
| US5811388A (en) * | 1995-06-07 | 1998-09-22 | Cibus Pharmaceutical, Inc. | Delivery of drugs to the lower GI tract |
| GB9516268D0 (en) | 1995-08-08 | 1995-10-11 | Danbiosyst Uk | Compositiion for enhanced uptake of polar drugs from the colon |
| US6004581A (en) * | 1995-12-21 | 1999-12-21 | Farmaceutisk Laboratorium Ferring A/S | Modified release oral pharmaceutical composition and method for the treatment of bowel diseases |
| UA67721C2 (en) * | 1995-12-21 | 2004-07-15 | Ferring Farma Lab | Modified release pharmaceutical composition and method for treatment of inflammatory bowel diseases |
| US6231888B1 (en) * | 1996-01-18 | 2001-05-15 | Perio Products Ltd. | Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps |
| US5840332A (en) * | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
| US5891474A (en) * | 1997-01-29 | 1999-04-06 | Poli Industria Chimica, S.P.A. | Time-specific controlled release dosage formulations and method of preparing same |
| US5788987A (en) * | 1997-01-29 | 1998-08-04 | Poli Industria Chimica Spa | Methods for treating early morning pathologies |
| DE19732903A1 (de) | 1997-07-30 | 1999-02-04 | Falk Pharma Gmbh | Pellet-Formulierung zur Behandlung des Intestinaltraktes |
| GB9722426D0 (en) * | 1997-10-23 | 1997-12-24 | Univ London Pharmacy | Controlled release formulations |
| GB9724186D0 (en) * | 1997-11-14 | 1998-01-14 | British Tech Group | Low temperature coatings |
| ITMI991316A1 (it) * | 1999-06-14 | 2000-12-14 | Cip Ninety Two 92 S A | Composizioni farmaceutiche orali a rilascio modificato di mesalazina |
| RU2153340C1 (ru) * | 1999-12-14 | 2000-07-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" | Фармацевтический состав, регулирующий метаболические процессы, и способ его получения |
| AU2001253479A1 (en) * | 2000-04-13 | 2001-10-30 | Sts Biopolymers, Inc. | Targeted therapeutic agent release devices and methods of making and using the same |
| RU2191782C2 (ru) * | 2000-09-21 | 2002-10-27 | Институт нефтехимии и катализа АН РБ и УНЦ РАН | Способ получения модифицированной гиалуроновой кислоты |
| RU2259817C2 (ru) * | 2000-10-13 | 2005-09-10 | Кембридж Байостэбилити Лтд. | Композиция для доставки стабильных инъецируемых жидкостей и способ доставки |
| CA2359812C (en) * | 2000-11-20 | 2004-02-10 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
| FI20002768L (fi) * | 2000-12-18 | 2002-06-19 | Licentia Oy | Enteropäällysteisiä lääkekoostumuksia ja niiden valmistus |
| KR20040047747A (ko) * | 2001-03-13 | 2004-06-05 | 펜웨스트 파머슈티칼즈 컴파니 | 변시치료 제형 |
| US7771468B2 (en) * | 2001-03-16 | 2010-08-10 | Angiotech Biocoatings Corp. | Medicated stent having multi-layer polymer coating |
| KR100979877B1 (ko) * | 2001-09-28 | 2010-09-02 | 뉴트라슈틱스 인코포레이티드 | 생물학적 성분의 전달 시스템 |
| US20070098784A1 (en) | 2001-09-28 | 2007-05-03 | Nutraceutix, Inc. | Delivery system for biological component |
| RU2311906C2 (ru) * | 2001-11-21 | 2007-12-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Композиция препарата замедленного высвобождения для высвобождения ингибитора секреции кислоты в желудке и способ ее получения |
| GB0203421D0 (en) * | 2002-02-13 | 2002-04-03 | Alizyme Therapeutics Ltd | Composition |
| CN1726012A (zh) * | 2002-12-11 | 2006-01-25 | 辉瑞产品公司 | 活性物质在高脂肪环境中的控制释放 |
| WO2005027843A2 (en) * | 2003-09-19 | 2005-03-31 | Penwest Pharmaceuticals Co. | Chronotherapeutic dosage forms |
| EA200600598A1 (ru) * | 2003-09-19 | 2006-08-25 | Пенвест Фармасьютикалз Ко. | Лекарственные формы замедленного высвобождения |
| CA2551528A1 (en) * | 2003-12-31 | 2005-07-21 | Genzyme Corporation | Enteric coated aliphatic amine polymer bile acid sequestrants |
| ES2323536T3 (es) * | 2004-09-01 | 2009-07-20 | The Procter And Gamble Company | Composiciones que comprenden acido-5-amino-2-hidroxibenzoico yh un azucar reductor. |
| US20060165745A1 (en) * | 2005-01-21 | 2006-07-27 | Yiwen Chew | Sustained release tablets for treatment of aqueous environment and methods for making the same |
| GB0600928D0 (en) | 2006-01-17 | 2006-02-22 | Novacta Biosystems Ltd | Improvements relating to lantibiotics |
| GB0607534D0 (en) | 2006-04-13 | 2006-05-24 | Univ London Pharmacy | Colonic drug delivery formulation |
| RU2322242C2 (ru) * | 2006-05-03 | 2008-04-20 | Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО БГМУ РОСЗДРАВА) | Способ эндоскопического лечения эрозивно-язвенных поражений слизистой желудка и двенадцатиперстной кишки у ангио-кардиохирургических больных |
| EP2061440A2 (de) | 2007-04-04 | 2009-05-27 | Sigmoid Pharma Limited | Pharmazeutische tacrolimus-zusammensetzung |
| TWI422398B (zh) * | 2007-06-04 | 2014-01-11 | Univ London | 結腸給藥配方 |
| GB0714030D0 (en) | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | The use of type-B lantibiotic-based compounds having antimicrobial activity |
| GB0714029D0 (en) | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | Lantibiotic-based compounds having antimicrobial activity |
| US20090036414A1 (en) * | 2007-08-02 | 2009-02-05 | Mutual Pharmaceutical Company, Inc. | Mesalamine Formulations |
| CA2739465C (en) | 2008-10-03 | 2017-01-31 | Dr. Falk Pharma Gmbh | Compositions and methods for the treatment of bowel diseases with granulated mesalamine |
| EP2179727B1 (de) † | 2008-10-27 | 2013-05-29 | Roquette Freres | Folienbeschichtungen aus wasserunlöslichem Polymer und modifiziertem Stärkederivat zur Dickdarmansteuerung |
| DK2387580T3 (da) | 2009-01-14 | 2014-10-13 | Novacta Biosystems Ltd | Deoxyactagardinderivater |
| EA020733B1 (ru) | 2009-02-04 | 2015-01-30 | Новакта Биосистемс Лимитед | Производные актагардина |
| GB201001688D0 (en) | 2010-02-02 | 2010-03-17 | Novacta Biosystems Ltd | Compounds |
| EP2386297A1 (de) * | 2010-04-28 | 2011-11-16 | Roquette Frères | Unverdauliches Polymer: Filmüberzüge auf Basis von acetylierter Stärke für Colon-Targeting |
| GB201013513D0 (en) | 2010-08-11 | 2010-09-22 | Novacta Biosystems Ltd | Formulations |
| MX366925B (es) | 2010-11-04 | 2019-07-31 | Albireo Ab | Inhibidores de ibat para el tratamiento de enfermedades hepaticas. |
| EP2830599B1 (de) | 2012-03-29 | 2018-08-15 | Therabiome, Llc | Ortsspezifische gastrointestinale orale impfrezepte zur wirkung am ileum und am blinddarm |
| SI2659881T1 (en) | 2012-04-30 | 2018-03-30 | Tillotts Pharma Ag | Formulation of the delayed release medicinal product |
| US9907755B2 (en) | 2013-03-14 | 2018-03-06 | Therabiome, Llc | Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents |
| EA032504B1 (ru) | 2013-10-29 | 2019-06-28 | Тиллоттс Фарма АГ | Лекарственный препарат с отсроченным высвобождением и его применение для доставки лекарственного средства |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| CA2952406A1 (en) | 2014-06-25 | 2015-12-30 | Ea Pharma Co., Ltd. | Solid formulation and method for preventing or reducing coloration thereof |
| WO2016071515A1 (en) | 2014-11-07 | 2016-05-12 | Sigmoid Pharma Limited | Compositions comprising cyclosporin |
| DE102015000795A1 (de) * | 2015-01-23 | 2016-07-28 | Se Tylose Gmbh & Co. Kg | Reversibel vernetzte Celluloseether und Verfahren zu deren Herstellung durch selektive Oxidation von vicinalen OH-Gruppen |
| JP6954927B2 (ja) * | 2016-02-09 | 2021-10-27 | アルビレオ・アクチボラグ | 経口コレスチラミン製剤及びその使用 |
| CN108601744B (zh) | 2016-02-09 | 2022-01-04 | 阿尔比里奥公司 | 口服考来烯胺制剂及其用途 |
| CA3011595C (en) | 2016-02-09 | 2024-01-02 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
| JP7391048B2 (ja) | 2018-06-05 | 2023-12-04 | アルビレオ・アクチボラグ | ベンゾチア(ジ)アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| KR20210024033A (ko) | 2018-06-20 | 2021-03-04 | 알비레오 에이비 | 오데빅시바트의 약학 제제 |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| ES3002632T3 (en) | 2018-12-07 | 2025-03-07 | Tillotts Pharma Ag | Delayed release drug formulation comprising an outerlayer with an enzymatically degradable polymer, its composition and its method of manufacturing |
| EP3662900A1 (de) | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Kolonwirkstoffverabreichungsformulierung |
| EP3662898A1 (de) | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Feste formulierung enthaltend mesalazin |
| EP3662902B1 (de) | 2018-12-07 | 2024-07-31 | Tillotts Pharma AG | Formulierung mit freisetzung eines wirkstoffs im kolon |
| US20240293429A1 (en) * | 2021-06-01 | 2024-09-05 | Nbi Biosciences Pvt Ltd | Microbial-triggered oral intestinal drug delivery formulation and method of preparation thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3360633D1 (en) * | 1982-02-12 | 1985-10-03 | Unitika Ltd | Anti-cancer device |
| US4755397A (en) * | 1986-12-24 | 1988-07-05 | National Starch And Chemical Corporation | Starch based particulate encapsulation process |
| US4911952A (en) * | 1987-07-10 | 1990-03-27 | The United States Of America As Represented By The Secretary Of Agriculture | Encapsulation by entrapment within matrix of unmodified starch |
| GB8812490D0 (en) * | 1988-05-26 | 1988-06-29 | Agricultural & Food Res | Delayed release formulations |
-
1989
- 1989-11-24 GB GB898926639A patent/GB8926639D0/en active Pending
-
1990
- 1990-11-22 AT AT90917183T patent/ATE103174T1/de not_active IP Right Cessation
- 1990-11-22 HU HU9201719A patent/HU209243B/hu unknown
- 1990-11-22 KR KR1019920701229A patent/KR920703030A/ko not_active Withdrawn
- 1990-11-22 ZA ZA909384A patent/ZA909384B/xx unknown
- 1990-11-22 RU SU5052091/14A patent/RU2093148C1/ru active
- 1990-11-22 DE DE69007623T patent/DE69007623T2/de not_active Expired - Lifetime
- 1990-11-22 NZ NZ236188A patent/NZ236188A/xx unknown
- 1990-11-22 JP JP3500199A patent/JP2975680B2/ja not_active Expired - Lifetime
- 1990-11-22 GB GB9025373A patent/GB2238243B/en not_active Expired - Lifetime
- 1990-11-22 US US07/867,696 patent/US5294448A/en not_active Expired - Lifetime
- 1990-11-22 DK DK90917183.7T patent/DK0502032T3/da active
- 1990-11-22 WO PCT/GB1990/001803 patent/WO1991007949A1/en not_active Ceased
- 1990-11-22 CA CA002069485A patent/CA2069485C/en not_active Expired - Lifetime
- 1990-11-22 ES ES90917183T patent/ES2053206T3/es not_active Expired - Lifetime
- 1990-11-22 EP EP90917183A patent/EP0502032B1/de not_active Expired - Lifetime
-
1992
- 1992-05-22 FI FI922369A patent/FI103091B/fi active
- 1992-05-22 NO NO922026A patent/NO303424B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO303424B1 (no) | 1998-07-13 |
| FI103091B1 (fi) | 1999-04-30 |
| HU209243B (en) | 1994-04-28 |
| NO922026L (no) | 1992-07-23 |
| FI922369L (fi) | 1992-05-22 |
| GB2238243B (en) | 1993-09-08 |
| ES2053206T3 (es) | 1994-07-16 |
| NZ236188A (en) | 1992-11-25 |
| FI103091B (fi) | 1999-04-30 |
| GB9025373D0 (en) | 1991-01-09 |
| DE69007623D1 (de) | 1994-04-28 |
| GB8926639D0 (en) | 1990-01-17 |
| EP0502032B1 (de) | 1994-03-23 |
| DE69007623T2 (de) | 1994-06-30 |
| EP0502032A1 (de) | 1992-09-09 |
| JP2975680B2 (ja) | 1999-11-10 |
| HUT62463A (en) | 1993-05-28 |
| WO1991007949A1 (en) | 1991-06-13 |
| GB2238243A (en) | 1991-05-29 |
| KR920703030A (ko) | 1992-12-17 |
| FI922369A0 (fi) | 1992-05-22 |
| NO922026D0 (no) | 1992-05-22 |
| JPH05504947A (ja) | 1993-07-29 |
| DK0502032T3 (da) | 1994-05-09 |
| RU2093148C1 (ru) | 1997-10-20 |
| HU9201719D0 (en) | 1992-08-28 |
| ZA909384B (en) | 1992-07-29 |
| CA2069485C (en) | 2000-04-18 |
| US5294448A (en) | 1994-03-15 |
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| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| EELA | Cancelled due to lapse of time |