ATE103633T1 - Verfahren zur reinigung von proteinen. - Google Patents

Verfahren zur reinigung von proteinen.

Info

Publication number
ATE103633T1
ATE103633T1 AT89310648T AT89310648T ATE103633T1 AT E103633 T1 ATE103633 T1 AT E103633T1 AT 89310648 T AT89310648 T AT 89310648T AT 89310648 T AT89310648 T AT 89310648T AT E103633 T1 ATE103633 T1 AT E103633T1
Authority
AT
Austria
Prior art keywords
mixture
contaminating proteins
streptokinase
group
reacting
Prior art date
Application number
AT89310648T
Other languages
English (en)
Inventor
Christopher Joseph Mannix
Richard Anthony Godwin Smith
Road
Ceris John Lewis
Julian Stanley Harber
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Application granted granted Critical
Publication of ATE103633T1 publication Critical patent/ATE103633T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/885—Streptococcus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Glass Compositions (AREA)
  • Removal Of Specific Substances (AREA)
AT89310648T 1988-10-19 1989-10-17 Verfahren zur reinigung von proteinen. ATE103633T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888824496A GB8824496D0 (en) 1988-10-19 1988-10-19 Process
EP89310648A EP0365278B1 (de) 1988-10-19 1989-10-17 Verfahren zur Reinigung von Proteinen

Publications (1)

Publication Number Publication Date
ATE103633T1 true ATE103633T1 (de) 1994-04-15

Family

ID=10645453

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89310648T ATE103633T1 (de) 1988-10-19 1989-10-17 Verfahren zur reinigung von proteinen.

Country Status (15)

Country Link
US (1) US5334384A (de)
EP (1) EP0365278B1 (de)
JP (1) JP2837467B2 (de)
KR (1) KR0136613B1 (de)
AT (1) ATE103633T1 (de)
AU (1) AU622492B2 (de)
CA (1) CA2000850A1 (de)
DE (1) DE68914242T2 (de)
DK (1) DK515889A (de)
ES (1) ES2062029T3 (de)
GB (1) GB8824496D0 (de)
IE (1) IE63478B1 (de)
NZ (1) NZ231039A (de)
PT (1) PT92024B (de)
ZA (1) ZA897849B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200002284T2 (tr) 1998-02-05 2000-11-21 Smithkline Beecham Biologicals S.A. Mage ailesinden tümör ile ilgili tümör türevleri
US6388073B1 (en) 2000-07-26 2002-05-14 Shire Us Inc. Method for the manufacture of anagrelide
US7094351B2 (en) 2000-10-12 2006-08-22 Corcoran Robert C Purification of substances by reaction affinity chromatography
KR20020007231A (ko) * 2001-08-01 2002-01-26 이병철 스트렙토키나제의 정제방법
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
US7910597B2 (en) * 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
NZ589557A (en) * 2008-06-04 2012-08-31 Talecris Biotherapeutics Inc Immobilised streptokinase, method and kit for preparing plasmin
ES2552337T3 (es) 2009-03-03 2015-11-27 Grifols Therapeutics Inc. Procedimientos para la preparación de plasminógeno

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2784145A (en) * 1955-11-22 1957-03-05 American Cyanamid Co Recovery of streptokinase
US3419472A (en) * 1960-10-24 1968-12-31 American Cyanamid Co Process for preparing streptokinaserich material
US3226304A (en) * 1960-10-24 1965-12-28 American Cyanamid Co High purity streptokinase and process for preparing same
US3255094A (en) * 1963-01-10 1966-06-07 Baxter Laboratories Inc Method for purification of streptokinase
US3444045A (en) * 1966-09-20 1969-05-13 American Cyanamid Co Process for purifying streptokinase
US4381346A (en) * 1979-11-13 1983-04-26 Huasin Syed S Isolation of plasminogen activators useful as therapeutic and diagnostic agents

Also Published As

Publication number Publication date
IE63478B1 (en) 1995-04-19
ZA897849B (en) 1990-10-31
AU4296489A (en) 1990-04-26
EP0365278B1 (de) 1994-03-30
PT92024B (pt) 1995-08-09
EP0365278A3 (de) 1991-08-28
PT92024A (pt) 1990-04-30
DK515889D0 (da) 1989-10-17
DE68914242T2 (de) 1994-07-07
KR0136613B1 (ko) 1998-04-25
NZ231039A (en) 1991-07-26
ES2062029T3 (es) 1994-12-16
JP2837467B2 (ja) 1998-12-16
US5334384A (en) 1994-08-02
DE68914242D1 (de) 1994-05-05
DK515889A (da) 1990-04-20
CA2000850A1 (en) 1990-04-19
GB8824496D0 (en) 1988-11-23
JPH02128688A (ja) 1990-05-17
EP0365278A2 (de) 1990-04-25
IE893338L (en) 1990-04-19
AU622492B2 (en) 1992-04-09
KR900006512A (ko) 1990-05-08

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee