ATE104310T1 - Verfahren zur herstellung von isepamicin. - Google Patents

Verfahren zur herstellung von isepamicin.

Info

Publication number: ATE104310T1
Authority: AT; Austria
Prior art keywords: isoserine; isepamicin; preparation; compounds; diformyl
Prior art date: 1989-06-21

Application number

AT90306657T

Other languages

English (en)

Inventor

Chou-Hong Tann

Tiruvettipuram K Thiruvengadam

John Sze-Hung Chiu

Cesar Colon

Michael D Green

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-21

Filing date

1990-06-19

Publication date

1994-04-15

1990-06-19 Application filed by Schering Corp filed Critical Schering Corp

1994-04-15 Application granted granted Critical

1994-04-15 Publication of ATE104310T1 publication Critical patent/ATE104310T1/de

Links

UDIIBEDMEYAVNG-ZKFPOVNWSA-N isepamicin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)O)[C@@H](N)C[C@H]1NC(=O)[C@@H](O)CN UDIIBEDMEYAVNG-ZKFPOVNWSA-N 0.000 title abstract 2
229960000798 isepamicin Drugs 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical class NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 2
MGZKLMXORRUSMO-VKHMYHEASA-N (2s)-3-formamido-2-hydroxypropanoic acid Chemical compound OC(=O)[C@@H](O)CNC=O MGZKLMXORRUSMO-VKHMYHEASA-N 0.000 abstract 1
ASOKPJOREAFHNY-UHFFFAOYSA-N 1-Hydroxybenzotriazole Chemical compound C1=CC=C2N(O)N=NC2=C1 ASOKPJOREAFHNY-UHFFFAOYSA-N 0.000 abstract 1
CFMZSMGAMPBRBE-UHFFFAOYSA-N 2-hydroxyisoindole-1,3-dione Chemical compound C1=CC=C2C(=O)N(O)C(=O)C2=C1 CFMZSMGAMPBRBE-UHFFFAOYSA-N 0.000 abstract 1
QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 abstract 1
RHRAMPXHWHSKQB-GGEUKFTFSA-N betamicin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)O)[C@@H](N)C[C@H]1N RHRAMPXHWHSKQB-GGEUKFTFSA-N 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000007822 coupling agent Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
RHRAMPXHWHSKQB-UHFFFAOYSA-N gentamicin B Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(C(O)C(O)C(CN)O2)O)C(N)CC1N RHRAMPXHWHSKQB-UHFFFAOYSA-N 0.000 abstract 1
NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 abstract 1
ZUSSTQCWRDLYJA-UHFFFAOYSA-N n-hydroxy-5-norbornene-2,3-dicarboximide Chemical compound C1=CC2CC1C1C2C(=O)N(O)C1=O ZUSSTQCWRDLYJA-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT90306657T 1989-06-21 1990-06-19 Verfahren zur herstellung von isepamicin. ATE104310T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US36957889A	1989-06-21	1989-06-21
EP90306657A EP0405820B1 (de)	1989-06-21	1990-06-19	Verfahren zur Herstellung von Isepamicin

Publications (1)

Publication Number	Publication Date
ATE104310T1 true ATE104310T1 (de)	1994-04-15

Family

ID=23456036

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT90306657T ATE104310T1 (de)	1989-06-21	1990-06-19	Verfahren zur herstellung von isepamicin.
AT93102033T ATE152094T1 (de)	1989-06-21	1990-06-19	N-geschützte (s)-isoserin-verbindungen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT93102033T ATE152094T1 (de)	1989-06-21	1990-06-19	N-geschützte (s)-isoserin-verbindungen

Country Status (16)

Country	Link
EP (3)	EP0547031B1 (de)
JP (2)	JPH0692433B2 (de)
KR (1)	KR940003496B1 (de)
AT (2)	ATE104310T1 (de)
AU (1)	AU629960B2 (de)
CA (2)	CA2062788C (de)
DE (2)	DE69008052T2 (de)
DK (2)	DK0405820T3 (de)
ES (2)	ES2063274T3 (de)
FI (1)	FI96955C (de)
GR (1)	GR3023942T3 (de)
HK (2)	HK185096A (de)
HU (1)	HU207338B (de)
NO (1)	NO177349C (de)
RU (1)	RU2120444C1 (de)
WO (1)	WO1990015810A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100927626B1 (ko) *	2002-09-18	2009-11-20	쯔지앙 하이썬 파머슈티컬 컴퍼니, 리미티드	이세파마이신의 제조 방법
CN101928310B (zh) *	2010-03-26	2012-09-05	常州方圆制药有限公司	3,2’,6’-三-N-乙酰基庆大霉素C1a的制备方法
CN102190690B (zh) *	2011-04-01	2015-01-21	福州博立医药科技有限公司	一种简便且高收率阿贝卡星合成方法
CN105524129B (zh) *	2015-12-25	2018-06-26	无锡济民可信山禾药业股份有限公司	一种硫酸依替米星的制备方法
RU2659032C1 (ru) *	2017-04-26	2018-06-27	Федеральное государственное бюджетное образовательное учреждение высшего образования "Удмуртский государственный университет"	Способ модификации гентамицина сополимером винилпирролидона с диацеталем акролеина
CN108586313B (zh) *	2018-03-31	2019-12-27	海正药业南通有限公司	一种新型合成n-取代苯酐-(s)-异丝氨酸的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4230847A (en) *	1976-06-17	1980-10-28	Schering Corporation	Aminoglycoside antibiotic compounds
US4136254A (en) *	1976-06-17	1979-01-23	Schering Corporation	Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby
IE48972B1 (en) *	1978-11-11	1985-06-26	Microbial Chem Res Found	The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
EP0156771A3 (de) *	1984-03-29	1986-03-19	Biochemie Gesellschaft M.B.H.	Cephalosporinverbindungen

1990
- 1990-06-19 EP EP93102033A patent/EP0547031B1/de not_active Expired - Lifetime
- 1990-06-19 EP EP90306657A patent/EP0405820B1/de not_active Expired - Lifetime
- 1990-06-19 DE DE69008052T patent/DE69008052T2/de not_active Expired - Fee Related
- 1990-06-19 EP EP90917766A patent/EP0478707A1/de active Pending
- 1990-06-19 ES ES90306657T patent/ES2063274T3/es not_active Expired - Lifetime
- 1990-06-19 CA CA002062788A patent/CA2062788C/en not_active Expired - Fee Related
- 1990-06-19 ES ES93102033T patent/ES2100380T3/es not_active Expired - Lifetime
- 1990-06-19 HU HU906641A patent/HU207338B/hu not_active IP Right Cessation
- 1990-06-19 CA CA002325082A patent/CA2325082A1/en not_active Abandoned
- 1990-06-19 DE DE69030590T patent/DE69030590T2/de not_active Expired - Fee Related
- 1990-06-19 AT AT90306657T patent/ATE104310T1/de not_active IP Right Cessation
- 1990-06-19 DK DK90306657.9T patent/DK0405820T3/da active
- 1990-06-19 JP JP2509550A patent/JPH0692433B2/ja not_active Expired - Lifetime
- 1990-06-19 AT AT93102033T patent/ATE152094T1/de not_active IP Right Cessation
- 1990-06-19 DK DK93102033.3T patent/DK0547031T3/da active
- 1990-06-19 RU SU5010871A patent/RU2120444C1/ru active
- 1990-06-19 KR KR1019910700196A patent/KR940003496B1/ko not_active Expired - Fee Related
- 1990-06-19 WO PCT/US1990/003328 patent/WO1990015810A2/en not_active Ceased
- 1990-06-19 AU AU59463/90A patent/AU629960B2/en not_active Ceased
1991
- 1991-12-18 FI FI915953A patent/FI96955C/fi active
- 1991-12-20 NO NO915071A patent/NO177349C/no not_active IP Right Cessation
1994
- 1994-05-09 JP JP6095303A patent/JP2500059B2/ja not_active Expired - Lifetime
1996
- 1996-10-03 HK HK185096A patent/HK185096A/en not_active IP Right Cessation
1997
- 1997-06-30 GR GR970401590T patent/GR3023942T3/el unknown
- 1997-08-20 HK HK97101672A patent/HK1000153A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69008052D1 (de)	1994-05-19
HK185096A (en)	1996-10-11
AU629960B2 (en)	1992-10-15
EP0547031B1 (de)	1997-04-23
HUT59934A (en)	1992-07-28
EP0547031A1 (de)	1993-06-16
ES2100380T3 (es)	1997-06-16
DK0547031T3 (da)	1997-05-20
NO177349C (no)	1995-08-30
AU5946390A (en)	1991-01-08
WO1990015810A3 (en)	1991-04-04
CA2062788A1 (en)	1990-12-22
CA2325082A1 (en)	1990-12-22
DK0405820T3 (da)	1994-05-16
NO915071L (no)	1991-12-20
EP0405820B1 (de)	1994-04-13
JPH04502474A (ja)	1992-05-07
KR920701226A (ko)	1992-08-11
FI96955B (fi)	1996-06-14
HU207338B (en)	1993-03-29
JP2500059B2 (ja)	1996-05-29
ATE152094T1 (de)	1997-05-15
JPH0692433B2 (ja)	1994-11-16
GR3023942T3 (en)	1997-09-30
CA2062788C (en)	2001-10-23
ES2063274T3 (es)	1995-01-01
EP0478707A1 (de)	1992-04-08
FI915953A0 (fi)	1991-12-18
DE69030590T2 (de)	1997-08-07
RU2120444C1 (ru)	1998-10-20
EP0405820A2 (de)	1991-01-02
FI96955C (fi)	1996-09-25
JPH07133267A (ja)	1995-05-23
HK1000153A1 (en)	1998-01-02
NO177349B (no)	1995-05-22
DE69008052T2 (de)	1994-07-28
WO1990015810A2 (en)	1990-12-27
KR940003496B1 (ko)	1994-04-23
EP0405820A3 (en)	1991-04-10
NO915071D0 (no)	1991-12-20
HU906641D0 (en)	1992-03-30
DE69030590D1 (de)	1997-05-28

Legal Events

Date	Code	Title	Description
1995-01-15	UEP	Publication of translation of european patent specification
2003-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE60026844D1 (de)	2006-05-11	Verfahren zur herstellung von 3,3-dimethylbutanal
FI945626A0 (fi)	1994-11-29	Menetelmä 2,2-difluoriketeenisilyyliasetaalien ja alfa, alfa-difluori-beta-silyylioksi-1,3-dioksolaani-4-propaanihappoestereiden valmistamiseksi
DE69008052D1 (de)	1994-05-19	Verfahren zur Herstellung von Isepamicin.
ATE67507T1 (de)	1991-10-15	Immunotoxine, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ATE56139T1 (de)	1990-09-15	Verfahren zur herstellung einer waessrigen pharmazeutischen loesung einer organischen saeure als wirkstoff.
DE69312566D1 (de)	1997-09-04	Verfahren zur Herstellung von Alkylpolyglukosiden
DE59104936D1 (de)	1995-04-20	Verfahren zur Herstellung von Allantoin.
ATE72243T1 (de)	1992-02-15	Verfahren zur herstellung epoxidierter fettalkohole.
ATE12221T1 (de)	1985-04-15	Verfahren zur hestellung von einem glutaraldehydvorlaeufer.
BG47196A3 (en)	1990-05-15	Method for preparing of carbonic acids
DE3855002D1 (de)	1996-03-21	Verfahren zur Herstellung von Dodecahydro-3a,6,6,9a-tetramethylnaphto(2,1-b)furan
DE69019843D1 (de)	1995-07-13	Verfahren zur Herstellung von NADH-Oxydase.
DE69503106D1 (de)	1998-07-30	Verfahren zur Herstellung von L-Ascorbinsäure
DE69024999D1 (de)	1996-03-07	Verfahren zur Herstellung von 2-Oxindol-1-carboxamiden
ATE1239T1 (de)	1982-07-15	Verfahren zur herstellung von 4-amino-5-chlor-1-phenyl-pyridazon-(6).
ATE86962T1 (de)	1993-04-15	Verfahren zur herstellung 1,4-disubstituierter 2- butene.
DE69427148D1 (de)	2001-05-31	Verfahren zur Herstellung von 2,4,5-Tribrompyrrol-3-carbonitril
JPS5422445A (en)	1979-02-20	Method of treating article
DE59501436D1 (de)	1998-03-19	Verfahren zur Herstellung von 2-Cyaniminothiazolidin
DE58907537D1 (de)	1994-06-01	Verfahren zur Herstellung eines Pyrrol-Derivats.
JPS53142594A (en)	1978-12-12	Immobilization of enzyme or microbial cells
AU2046888A (en)	1989-02-09	Process for the preparation of n6-benzyloxycarbonyl-2,6- diaminopimelamic acid in the l, l or d, d or racemic forms
DE3887070D1 (de)	1994-02-24	Verfahren zur Herstellung von Brenztraubensäure durch Fermentation.
KR890001568A (ko)	1989-03-27	돼지 이질의 예방 및 치료제
ES8507553A1 (es)	1985-09-01	Procedimiento de preparacion de 1,1-dioxido del acido 6,6-dibromopenicilanico.