NO177349C - Fremgangsmåte for fremstilling av isepamicin - Google Patents

Fremgangsmåte for fremstilling av isepamicin

Info

Publication number: NO177349C
Authority: NO; Norway
Prior art keywords: isoserine; isepamicin; preparation; compounds; diformyl
Prior art date: 1989-06-21

Application number

NO915071A

Other languages

English (en)

Norwegian (no)

Other versions

NO915071L (no

NO915071D0 (no

NO177349B (no

Inventor

Chou-Hong Tann

Tiruvettipuram K Thiruvengadam

John Sze-Hung Chiu

Cesar Colon

Michael D Green

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-21

Filing date

1991-12-20

Publication date

1995-08-30

1991-12-20 Application filed by Schering Corp filed Critical Schering Corp

1991-12-20 Publication of NO915071L publication Critical patent/NO915071L/no

1991-12-20 Publication of NO915071D0 publication Critical patent/NO915071D0/no

1995-05-22 Publication of NO177349B publication Critical patent/NO177349B/no

1995-08-30 Publication of NO177349C publication Critical patent/NO177349C/no

Links

UDIIBEDMEYAVNG-ZKFPOVNWSA-N isepamicin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)O)[C@@H](N)C[C@H]1NC(=O)[C@@H](O)CN UDIIBEDMEYAVNG-ZKFPOVNWSA-N 0.000 title abstract 2
229960000798 isepamicin Drugs 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical class NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 2
MGZKLMXORRUSMO-VKHMYHEASA-N (2s)-3-formamido-2-hydroxypropanoic acid Chemical compound OC(=O)[C@@H](O)CNC=O MGZKLMXORRUSMO-VKHMYHEASA-N 0.000 abstract 1
ASOKPJOREAFHNY-UHFFFAOYSA-N 1-Hydroxybenzotriazole Chemical compound C1=CC=C2N(O)N=NC2=C1 ASOKPJOREAFHNY-UHFFFAOYSA-N 0.000 abstract 1
CFMZSMGAMPBRBE-UHFFFAOYSA-N 2-hydroxyisoindole-1,3-dione Chemical compound C1=CC=C2C(=O)N(O)C(=O)C2=C1 CFMZSMGAMPBRBE-UHFFFAOYSA-N 0.000 abstract 1
QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 abstract 1
RHRAMPXHWHSKQB-GGEUKFTFSA-N betamicin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)O)[C@@H](N)C[C@H]1N RHRAMPXHWHSKQB-GGEUKFTFSA-N 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000007822 coupling agent Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
RHRAMPXHWHSKQB-UHFFFAOYSA-N gentamicin B Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(C(O)C(O)C(CN)O2)O)C(N)CC1N RHRAMPXHWHSKQB-UHFFFAOYSA-N 0.000 abstract 1
NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 abstract 1
ZUSSTQCWRDLYJA-UHFFFAOYSA-N n-hydroxy-5-norbornene-2,3-dicarboximide Chemical compound C1=CC2CC1C1C2C(=O)N(O)C1=O ZUSSTQCWRDLYJA-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO915071A 1989-06-21 1991-12-20 Fremgangsmåte for fremstilling av isepamicin NO177349C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US36957889A	1989-06-21	1989-06-21
PCT/US1990/003328 WO1990015810A2 (en)	1989-06-21	1990-06-19	Improved process for preparing isepamicin

Publications (4)

Publication Number	Publication Date
NO915071L NO915071L (no)	1991-12-20
NO915071D0 NO915071D0 (no)	1991-12-20
NO177349B NO177349B (no)	1995-05-22
NO177349C true NO177349C (no)	1995-08-30

Family

ID=23456036

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO915071A NO177349C (no)	1989-06-21	1991-12-20	Fremgangsmåte for fremstilling av isepamicin

Country Status (16)

Country	Link
EP (3)	EP0547031B1 (de)
JP (2)	JPH0692433B2 (de)
KR (1)	KR940003496B1 (de)
AT (2)	ATE152094T1 (de)
AU (1)	AU629960B2 (de)
CA (2)	CA2325082A1 (de)
DE (2)	DE69008052T2 (de)
DK (2)	DK0405820T3 (de)
ES (2)	ES2063274T3 (de)
FI (1)	FI96955C (de)
GR (1)	GR3023942T3 (de)
HK (2)	HK185096A (de)
HU (1)	HU207338B (de)
NO (1)	NO177349C (de)
RU (1)	RU2120444C1 (de)
WO (1)	WO1990015810A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100927626B1 (ko) *	2002-09-18	2009-11-20	쯔지앙 하이썬 파머슈티컬 컴퍼니, 리미티드	이세파마이신의 제조 방법
CN101928310B (zh) *	2010-03-26	2012-09-05	常州方圆制药有限公司	3,2’,6’-三-N-乙酰基庆大霉素C1a的制备方法
CN102190690B (zh) *	2011-04-01	2015-01-21	福州博立医药科技有限公司	一种简便且高收率阿贝卡星合成方法
CN105524129B (zh) *	2015-12-25	2018-06-26	无锡济民可信山禾药业股份有限公司	一种硫酸依替米星的制备方法
RU2659032C1 (ru) *	2017-04-26	2018-06-27	Федеральное государственное бюджетное образовательное учреждение высшего образования "Удмуртский государственный университет"	Способ модификации гентамицина сополимером винилпирролидона с диацеталем акролеина
CN108586313B (zh) *	2018-03-31	2019-12-27	海正药业南通有限公司	一种新型合成n-取代苯酐-(s)-异丝氨酸的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4136254A (en) *	1976-06-17	1979-01-23	Schering Corporation	Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby
US4230847A (en) *	1976-06-17	1980-10-28	Schering Corporation	Aminoglycoside antibiotic compounds
IE48972B1 (en) *	1978-11-11	1985-06-26	Microbial Chem Res Found	The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
EP0156771A3 (de) *	1984-03-29	1986-03-19	Biochemie Gesellschaft M.B.H.	Cephalosporinverbindungen

1990
- 1990-06-19 ES ES90306657T patent/ES2063274T3/es not_active Expired - Lifetime
- 1990-06-19 DK DK90306657.9T patent/DK0405820T3/da active
- 1990-06-19 KR KR1019910700196A patent/KR940003496B1/ko not_active Expired - Fee Related
- 1990-06-19 DE DE69008052T patent/DE69008052T2/de not_active Expired - Fee Related
- 1990-06-19 CA CA002325082A patent/CA2325082A1/en not_active Abandoned
- 1990-06-19 RU SU5010871A patent/RU2120444C1/ru active
- 1990-06-19 CA CA002062788A patent/CA2062788C/en not_active Expired - Fee Related
- 1990-06-19 EP EP93102033A patent/EP0547031B1/de not_active Expired - Lifetime
- 1990-06-19 EP EP90306657A patent/EP0405820B1/de not_active Expired - Lifetime
- 1990-06-19 AT AT93102033T patent/ATE152094T1/de not_active IP Right Cessation
- 1990-06-19 AU AU59463/90A patent/AU629960B2/en not_active Ceased
- 1990-06-19 ES ES93102033T patent/ES2100380T3/es not_active Expired - Lifetime
- 1990-06-19 DK DK93102033.3T patent/DK0547031T3/da active
- 1990-06-19 HU HU906641A patent/HU207338B/hu not_active IP Right Cessation
- 1990-06-19 AT AT90306657T patent/ATE104310T1/de not_active IP Right Cessation
- 1990-06-19 EP EP90917766A patent/EP0478707A1/de active Pending
- 1990-06-19 JP JP2509550A patent/JPH0692433B2/ja not_active Expired - Lifetime
- 1990-06-19 DE DE69030590T patent/DE69030590T2/de not_active Expired - Fee Related
- 1990-06-19 WO PCT/US1990/003328 patent/WO1990015810A2/en not_active Ceased
1991
- 1991-12-18 FI FI915953A patent/FI96955C/fi active
- 1991-12-20 NO NO915071A patent/NO177349C/no not_active IP Right Cessation
1994
- 1994-05-09 JP JP6095303A patent/JP2500059B2/ja not_active Expired - Lifetime
1996
- 1996-10-03 HK HK185096A patent/HK185096A/en not_active IP Right Cessation
1997
- 1997-06-30 GR GR970401590T patent/GR3023942T3/el unknown
- 1997-08-20 HK HK97101672A patent/HK1000153A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0405820A2 (de)	1991-01-02
FI915953A0 (fi)	1991-12-18
JP2500059B2 (ja)	1996-05-29
AU5946390A (en)	1991-01-08
CA2062788C (en)	2001-10-23
NO915071L (no)	1991-12-20
DK0405820T3 (da)	1994-05-16
WO1990015810A2 (en)	1990-12-27
DE69008052D1 (de)	1994-05-19
JPH07133267A (ja)	1995-05-23
CA2325082A1 (en)	1990-12-22
GR3023942T3 (en)	1997-09-30
EP0405820B1 (de)	1994-04-13
EP0547031B1 (de)	1997-04-23
DE69030590D1 (de)	1997-05-28
RU2120444C1 (ru)	1998-10-20
ATE152094T1 (de)	1997-05-15
NO915071D0 (no)	1991-12-20
DK0547031T3 (da)	1997-05-20
JPH0692433B2 (ja)	1994-11-16
EP0478707A1 (de)	1992-04-08
KR940003496B1 (ko)	1994-04-23
EP0547031A1 (de)	1993-06-16
WO1990015810A3 (en)	1991-04-04
ES2100380T3 (es)	1997-06-16
HUT59934A (en)	1992-07-28
JPH04502474A (ja)	1992-05-07
NO177349B (no)	1995-05-22
CA2062788A1 (en)	1990-12-22
HK1000153A1 (en)	1998-01-02
DE69008052T2 (de)	1994-07-28
HU906641D0 (en)	1992-03-30
ES2063274T3 (es)	1995-01-01
KR920701226A (ko)	1992-08-11
DE69030590T2 (de)	1997-08-07
HK185096A (en)	1996-10-11
FI96955B (fi)	1996-06-14
HU207338B (en)	1993-03-29
ATE104310T1 (de)	1994-04-15
EP0405820A3 (en)	1991-04-10
AU629960B2 (en)	1992-10-15
FI96955C (fi)	1996-09-25

Legal Events

Date	Code	Title	Description
2003-02-10	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN DECEMBER 2003

Publication	Publication Date	Title
ES2083392T3 (es)	1996-04-16	Sustancia pf 1022, procedimiento para su preparacion y composicion antihelmintica que contiene esta sustancia.
CA2059305A1 (en)	1992-07-17	Hexa-cyclic compound
SE8103925L (sv)	1982-06-09	Acne-behandling
CA2098021A1 (en)	1992-06-20	Composition Used as a Therapeutic Agent Against Chronic Viral Hepatic Diseases
EP0293751A3 (en)	1990-07-25	Taurohyodeoxycholic acid for the therapy of calculosis of the biliary tract and of biliary dyspepsia
DK232483D0 (da)	1983-05-24	Fremgangsmade til fremstilling af ws 6049-forbindelser
NO915071D0 (no)	1991-12-20	Forbedret fremgangsmaate for fremstilling av isepamicin
AU4821079A (en)	1980-01-03	Agent for use in pulp production
FI102462B1 (fi)	1998-12-15	Menetelmä nimesulidin syklodekstriinikompleksin valmistamiseksi
ATE67507T1 (de)	1991-10-15	Immunotoxine, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
TW344662B (en)	1998-11-11	A process for preparing a freeze dried thiotepa composition
DE69312566D1 (de)	1997-09-04	Verfahren zur Herstellung von Alkylpolyglukosiden
NO159381C (no)	1988-12-21	Glutaraldehydforloeper og fremstilling derav.
HUT54299A (en)	1991-02-28	Process for producing pharmaceutical compositions containing purpuromycin as active component
DE69102428D1 (de)	1994-07-14	Copolymere aus dioxolanen und maleinsäureanhydrid.
JPS53124682A (en)	1978-10-31	Preparation of complex of enzyme and bioactive substance and its use
JPS5290694A (en)	1977-07-30	Preparation of protoporphyrine 1x
JPS5422445A (en)	1979-02-20	Method of treating article
AU6797590A (en)	1991-06-20	Improvements in or relating to organic compounds
JPS53142594A (en)	1978-12-12	Immobilization of enzyme or microbial cells
DE3262837D1 (en)	1985-05-02	New compound having mucoregulating and fluidifying activity, process for its production and relative pharmaceutical compositions
JPS5296694A (en)	1977-08-13	Addition of acid anhydride group to polymer
JPS5329993A (en)	1978-03-20	Immobilized enzyme and its preparation
ES8507553A1 (es)	1985-09-01	Procedimiento de preparacion de 1,1-dioxido del acido 6,6-dibromopenicilanico.
KR890001568A (ko)	1989-03-27	돼지 이질의 예방 및 치료제