ATE117681T1 - Chinolinderivate, ihre herstellung und verwendung. - Google Patents
Chinolinderivate, ihre herstellung und verwendung.Info
- Publication number
- ATE117681T1 ATE117681T1 AT89112683T AT89112683T ATE117681T1 AT E117681 T1 ATE117681 T1 AT E117681T1 AT 89112683 T AT89112683 T AT 89112683T AT 89112683 T AT89112683 T AT 89112683T AT E117681 T1 ATE117681 T1 AT E117681T1
- Authority
- AT
- Austria
- Prior art keywords
- quinoline derivatives
- preparation
- acyltransferase
- coa
- cholesterol
- Prior art date
Links
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 abstract 1
- 108010054082 Sterol O-acyltransferase Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C07D215/60—N-oxides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17413788 | 1988-07-12 | ||
| JP21426688 | 1988-08-29 | ||
| JP7592589 | 1989-03-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE117681T1 true ATE117681T1 (de) | 1995-02-15 |
Family
ID=27301993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89112683T ATE117681T1 (de) | 1988-07-12 | 1989-07-11 | Chinolinderivate, ihre herstellung und verwendung. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5254565A (de) |
| EP (1) | EP0354994B1 (de) |
| KR (1) | KR900001656A (de) |
| AT (1) | ATE117681T1 (de) |
| AU (1) | AU616542B2 (de) |
| CA (1) | CA1333068C (de) |
| DE (1) | DE68920796T2 (de) |
| DK (1) | DK345989A (de) |
| ES (1) | ES2066808T3 (de) |
| FI (1) | FI93353C (de) |
| GR (1) | GR3015554T3 (de) |
| HU (1) | HU210861B (de) |
| IE (1) | IE892088L (de) |
| IL (1) | IL90815A (de) |
| NO (1) | NO177300C (de) |
| NZ (1) | NZ229911A (de) |
| PT (1) | PT91121B (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW205037B (de) * | 1989-10-06 | 1993-05-01 | Takeda Pharm Industry Co Ltd | |
| JPH03181465A (ja) * | 1989-12-11 | 1991-08-07 | Takeda Chem Ind Ltd | キノリン誘導体 |
| DE4014171A1 (de) * | 1990-05-03 | 1991-11-07 | Basf Ag | Cyanochinolinverbindungen |
| US5143919A (en) * | 1990-08-17 | 1992-09-01 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives and their pharmaceutical use |
| US5256782A (en) * | 1990-08-17 | 1993-10-26 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives which are intermediates |
| US5668136A (en) * | 1990-09-25 | 1997-09-16 | Eisai Co., Ltd. | Trisubstituted benzene derivatives, composition and methods of treatment |
| JPH059179A (ja) * | 1990-09-27 | 1993-01-19 | Takeda Chem Ind Ltd | 複素環化合物、その製造法及びａｃａｔ阻害剤 |
| FI934710L (fi) * | 1991-04-26 | 1993-10-25 | Pfizer | 4-aryl-3-(heteroarylureido)kinolinderivat |
| IL101785A0 (en) * | 1991-05-10 | 1992-12-30 | Fujisawa Pharmaceutical Co | Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| JP2668163B2 (ja) * | 1992-01-23 | 1997-10-27 | ファイザー インク． | コレステロール血症および抗アテローム動脈硬化症薬としての４−アリール−３−（ヘテロアリールウレイド）−１，２−ジヒドロ−２−オキソ−キノリン誘導体 |
| TW232013B (de) * | 1992-04-24 | 1994-10-11 | Takeda Pharm Industry Co Ltd | |
| US5364875A (en) * | 1992-05-11 | 1994-11-15 | The Du Pont Merck Pharmaceutical Company | Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis |
| US5310748A (en) * | 1992-05-11 | 1994-05-10 | The Du Pont Merck Pharmaceutical Company | Imidazoles for the treatment of atherosclerosis |
| WO1994002452A1 (fr) * | 1992-07-20 | 1994-02-03 | Eisai Co., Ltd. | Derive du benzene |
| ATE161530T1 (de) * | 1992-09-04 | 1998-01-15 | Takeda Chemical Industries Ltd | Kondensierte heterozyklische verbindungen, deren herstellung und verwendung |
| US5565472A (en) * | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
| GB9302275D0 (en) * | 1993-02-05 | 1993-03-24 | Smithkline Beecham Plc | Novel compounds |
| NZ264063A (en) * | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| US5596001A (en) * | 1993-10-25 | 1997-01-21 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)quinoline derivatves |
| TW263498B (de) * | 1993-11-10 | 1995-11-21 | Takeda Pharm Industry Co Ltd | |
| US5491152A (en) * | 1994-03-23 | 1996-02-13 | The Du Pont Merck Pharmaceutical Company | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis |
| JP3720395B2 (ja) * | 1994-09-20 | 2005-11-24 | 京都薬品工業株式会社 | 新規ヘテロ環誘導体、その製造方法およびその医薬用途 |
| EP0842933B1 (de) * | 1995-05-31 | 2004-08-04 | Sumitomo Pharmaceuticals Company, Limited | Neue naphthyridinderivate. |
| CZ292632B6 (cs) | 1995-10-05 | 2003-11-12 | Kyoto Pharmaceutical Industries, Ltd. | Indolinový, indolový nebo tetrahydrochinolinový derivát a farmaceutický přípravek s jeho obsahem |
| CA2190708A1 (en) * | 1995-12-08 | 1997-06-09 | Johannes Aebi | Aminoalkyl substituted benzo-heterocyclic compounds |
| DE19627430A1 (de) * | 1996-07-08 | 1998-01-15 | Bayer Ag | Bicyclisch kondensierte Pyridine |
| US7429612B2 (en) * | 2002-07-17 | 2008-09-30 | Kyoto Pharmaceutical Industries, Ltd. | Indoline compound and medicinal use thereof |
| AU2006228683B2 (en) * | 2005-04-01 | 2012-02-02 | Vfp Therapies | New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-Alzheimer agents |
| US20160332971A1 (en) * | 2015-05-15 | 2016-11-17 | University Of Kentucky Research Foundation | Arylquinoline, arylquinolone and arylthioquinolone derivatives and use thereof to treat cancer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO133758C (de) * | 1970-04-04 | 1976-06-23 | Takeda Chemical Industries Ltd | |
| BE770249A (fr) * | 1970-07-23 | 1971-12-01 | Takeda Chemical Industries Ltd | Derives de quinoline |
| JPS555502B1 (de) * | 1971-07-31 | 1980-02-07 |
-
1989
- 1989-06-27 IE IE892088A patent/IE892088L/xx unknown
- 1989-06-30 IL IL90815A patent/IL90815A/xx not_active IP Right Cessation
- 1989-07-10 NO NO892851A patent/NO177300C/no unknown
- 1989-07-11 EP EP89112683A patent/EP0354994B1/de not_active Expired - Lifetime
- 1989-07-11 AT AT89112683T patent/ATE117681T1/de active
- 1989-07-11 FI FI893361A patent/FI93353C/fi not_active IP Right Cessation
- 1989-07-11 AU AU38025/89A patent/AU616542B2/en not_active Ceased
- 1989-07-11 ES ES89112683T patent/ES2066808T3/es not_active Expired - Lifetime
- 1989-07-11 PT PT91121A patent/PT91121B/pt not_active IP Right Cessation
- 1989-07-11 DE DE68920796T patent/DE68920796T2/de not_active Expired - Fee Related
- 1989-07-11 NZ NZ229911A patent/NZ229911A/en unknown
- 1989-07-11 HU HU893485A patent/HU210861B/hu not_active IP Right Cessation
- 1989-07-11 CA CA000605291A patent/CA1333068C/en not_active Expired - Fee Related
- 1989-07-12 DK DK345989A patent/DK345989A/da not_active Application Discontinuation
- 1989-07-12 KR KR1019890009937A patent/KR900001656A/ko not_active Abandoned
-
1991
- 1991-12-16 US US07/807,813 patent/US5254565A/en not_active Expired - Fee Related
-
1995
- 1995-03-28 GR GR950400730T patent/GR3015554T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT91121A (pt) | 1990-02-08 |
| IL90815A0 (en) | 1990-01-18 |
| EP0354994B1 (de) | 1995-01-25 |
| HU210861B (en) | 1995-08-28 |
| HUT52059A (en) | 1990-06-28 |
| FI93353B (fi) | 1994-12-15 |
| DK345989D0 (da) | 1989-07-12 |
| IE892088L (en) | 1990-01-12 |
| AU616542B2 (en) | 1991-10-31 |
| AU3802589A (en) | 1990-01-18 |
| KR900001656A (ko) | 1990-02-27 |
| EP0354994A3 (de) | 1991-05-15 |
| DE68920796D1 (de) | 1995-03-09 |
| FI893361A0 (fi) | 1989-07-11 |
| DK345989A (da) | 1990-01-13 |
| GR3015554T3 (en) | 1995-06-30 |
| IL90815A (en) | 1993-07-08 |
| NO177300C (no) | 1995-08-23 |
| EP0354994A2 (de) | 1990-02-21 |
| NO177300B (no) | 1995-05-15 |
| FI93353C (fi) | 1995-03-27 |
| NZ229911A (en) | 1991-08-27 |
| ES2066808T3 (es) | 1995-03-16 |
| DE68920796T2 (de) | 1995-07-06 |
| NO892851L (no) | 1990-01-15 |
| NO892851D0 (no) | 1989-07-10 |
| CA1333068C (en) | 1994-11-15 |
| US5254565A (en) | 1993-10-19 |
| PT91121B (pt) | 1995-01-31 |
| FI893361L (fi) | 1990-01-13 |
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