ATE104985T1 - Trimethylsilylacetylenverbindungen, ihre herstellung und ihre verwendung zur herstellung von daunomycinon-derivaten. - Google Patents

Trimethylsilylacetylenverbindungen, ihre herstellung und ihre verwendung zur herstellung von daunomycinon-derivaten.

Info

Publication number: ATE104985T1
Authority: AT; Austria
Prior art keywords: preparation; compounds; daunomycinone; trimethylsilylacetylene; derivatives
Prior art date: 1989-02-10

Application number

AT9090200210T

Other languages

English (en)

Inventor

Johan Wilhelm Scheeren

Bie Joannes Franciscus Mart De

Vos Dirk De

Original Assignee

Pharmachemie Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-10

Filing date

1990-01-29

Publication date

1994-05-15

1990-01-29 Application filed by Pharmachemie Bv filed Critical Pharmachemie Bv

1994-05-15 Application granted granted Critical

1994-05-15 Publication of ATE104985T1 publication Critical patent/ATE104985T1/de

Links

238000002360 preparation method Methods 0.000 title abstract 4
YOFDHOWPGULAQF-MQJDWESPSA-N (7s,9s)-9-acetyl-6,7,9,11-tetrahydroxy-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical class C1[C@@](O)(C(C)=O)C[C@H](O)C2=C1C(O)=C1C(=O)C(C=CC=C3OC)=C3C(=O)C1=C2O YOFDHOWPGULAQF-MQJDWESPSA-N 0.000 title abstract 3
CWMFRHBXRUITQE-UHFFFAOYSA-N trimethylsilylacetylene Chemical class C[Si](C)(C)C#C CWMFRHBXRUITQE-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
YOFDHOWPGULAQF-UHFFFAOYSA-N Daunomycin-Aglycone Natural products C1C(O)(C(C)=O)CC(O)C2=C1C(O)=C1C(=O)C(C=CC=C3OC)=C3C(=O)C1=C2O YOFDHOWPGULAQF-UHFFFAOYSA-N 0.000 abstract 2
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 1
WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 abstract 1
229940009456 adriamycin Drugs 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 1
230000000707 stereoselective effect Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT9090200210T 1989-02-10 1990-01-29 Trimethylsilylacetylenverbindungen, ihre herstellung und ihre verwendung zur herstellung von daunomycinon-derivaten. ATE104985T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL8900328A NL8900328A (nl)	1989-02-10	1989-02-10	Trimethylsilylethynylverbindingen, hun bereiding en hun toepassing bij het bereiden van daunomycinonderivaten.
EP90200210A EP0387929B1 (de)	1989-02-10	1990-01-29	Trimethylsilylacetylenverbindungen, ihre Herstellung und ihre Verwendung zur Herstellung von Daunomycinon-Derivaten

Publications (1)

Publication Number	Publication Date
ATE104985T1 true ATE104985T1 (de)	1994-05-15

Family

ID=19854109

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT9090200210T ATE104985T1 (de)	1989-02-10	1990-01-29	Trimethylsilylacetylenverbindungen, ihre herstellung und ihre verwendung zur herstellung von daunomycinon-derivaten.

Country Status (7)

Country	Link
US (1)	US5079349A (de)
EP (1)	EP0387929B1 (de)
JP (1)	JPH02235889A (de)
AT (1)	ATE104985T1 (de)
CA (1)	CA2009095A1 (de)
DE (1)	DE69008396D1 (de)
NL (1)	NL8900328A (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL9001834A (nl) *	1990-08-16	1992-03-16	Pharmachemie Bv	Nieuwe antracyclineverbindingen met anti-tumorwerkzaamheid, nieuwe tussenverbindingen voor de bereiding van deze antracyclineverbindingen, alsmede preparaten die de aktieve antracyclineverbindingen bevatten.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4415498A (en) *	1979-11-07	1983-11-15	Research Corporation	Synthesis of daunomycinone and the derivatives thereof

1989
- 1989-02-10 NL NL8900328A patent/NL8900328A/nl not_active Application Discontinuation
1990
- 1990-01-29 EP EP90200210A patent/EP0387929B1/de not_active Expired - Lifetime
- 1990-01-29 AT AT9090200210T patent/ATE104985T1/de not_active IP Right Cessation
- 1990-01-29 DE DE69008396T patent/DE69008396D1/de not_active Expired - Lifetime
- 1990-02-01 US US07/473,537 patent/US5079349A/en not_active Expired - Fee Related
- 1990-02-01 CA CA002009095A patent/CA2009095A1/en not_active Abandoned
- 1990-02-03 JP JP2024986A patent/JPH02235889A/ja active Pending

Also Published As

Publication number	Publication date
JPH02235889A (ja)	1990-09-18
EP0387929B1 (de)	1994-04-27
CA2009095A1 (en)	1990-08-10
DE69008396D1 (de)	1994-06-01
EP0387929A1 (de)	1990-09-19
US5079349A (en)	1992-01-07
NL8900328A (nl)	1990-09-03

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Legal Events

Date	Code	Title	Description
1994-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties