ATE105181T1 - Verfahren zur herstellung einer oel-in-wasseremulsion eines wirkstoffes. - Google Patents

Verfahren zur herstellung einer oel-in-wasseremulsion eines wirkstoffes.

Info

Publication number: ATE105181T1
Authority: AT; Austria
Prior art keywords: solution; drug; emulsion; pct; oil
Prior art date: 1989-08-23

Application number

AT9090913513T

Other languages

English (en)

Inventor

Stanley Stewart Davis

Clive Washington

Original Assignee

Univ Nottingham

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-23

Filing date

1990-08-21

Publication date

1994-05-15

1990-08-21 Application filed by Univ Nottingham filed Critical Univ Nottingham

1994-05-15 Application granted granted Critical

1994-05-15 Publication of ATE105181T1 publication Critical patent/ATE105181T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
239000007764 o/w emulsion Substances 0.000 title abstract 2
239000004480 active ingredient Substances 0.000 title 1
229940079593 drug Drugs 0.000 abstract 6
239000003814 drug Substances 0.000 abstract 6
239000000839 emulsion Substances 0.000 abstract 4
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 abstract 1
APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 abstract 1
229960003942 amphotericin b Drugs 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Dispersion Chemistry (AREA)
Organic Chemistry (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Colloid Chemistry (AREA)
Edible Oils And Fats (AREA)
Control Of Vending Devices And Auxiliary Devices For Vending Devices (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT9090913513T 1989-08-23 1990-08-21 Verfahren zur herstellung einer oel-in-wasseremulsion eines wirkstoffes. ATE105181T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB898919172A GB8919172D0 (en)	1989-08-23	1989-08-23	Useful composition
PCT/GB1990/001309 WO1991002517A1 (en)	1989-08-23	1990-08-21	Process for preparation of an oil in water emulsion of a drug

Publications (1)

Publication Number	Publication Date
ATE105181T1 true ATE105181T1 (de)	1994-05-15

Family

ID=10662011

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT9090913513T ATE105181T1 (de)	1989-08-23	1990-08-21	Verfahren zur herstellung einer oel-in-wasseremulsion eines wirkstoffes.

Country Status (11)

Country	Link
US (1)	US5389373A (de)
EP (1)	EP0487636B1 (de)
JP (1)	JP2963538B2 (de)
AT (1)	ATE105181T1 (de)
AU (1)	AU629983B2 (de)
CA (1)	CA2064190C (de)
DE (1)	DE69008729T2 (de)
DK (1)	DK0487636T3 (de)
ES (1)	ES2056482T3 (de)
GB (2)	GB8919172D0 (de)
WO (1)	WO1991002517A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4015108A1 (de) *	1990-05-11	1991-11-14	Leopold Pharma Gmbh	Stabile emulsion zur applikation pharmakologisch aktiver wirkstoffe
US5534502A (en) *	1990-11-06	1996-07-09	Nippon Shinyaku Co. Ltd.	Process for producing fat emulsion
EP0556392A4 (de) *	1990-11-06	1994-03-17	Nippon Shinyaku Co Ltd	Verfahren zur produktion einer fettemulsion.
GB9224502D0 (en) *	1992-11-23	1993-01-13	New Roger R C	Method of preparing a lipid-containing formulation
US5885486A (en)	1993-03-05	1999-03-23	Pharmaciaand Upjohn Ab	Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
US5785976A (en) *	1993-03-05	1998-07-28	Pharmacia & Upjohn Ab	Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
AU696956B2 (en) *	1993-03-22	1998-09-24	Betatene Pty Ltd	Water dispersible therapeutic compounds
JPH08510994A (ja) *	1993-03-22	1996-11-19	ベータティーン・リミテッド	黒色腫治療用薬剤
EP0670676B1 (de) *	1993-09-29	2005-12-07	DSM IP Assets B.V.	Modifizierte Formen des Natamycins, Verfahren zu ihrer Herstellung und sie enthaltende antifungale Zusammensetzungen
SE9303281D0 (sv) *	1993-10-07	1993-10-07	Astra Ab	New formulation
US5932196A (en) *	1994-11-04	1999-08-03	The Procter & Gamble Company	Buffered emulsion compositions containing actives subject to acid or base hydrolysis
IL120005A (en) *	1997-01-14	2000-08-31	Ramot University Authority Of	Pharmaceutical compositions for the treatment of the eye
GB9718568D0 (en) *	1997-09-03	1997-11-05	Chauvin Pharmaceuticals Limite	Compositions
WO1999043301A1 (en) *	1998-02-24	1999-09-02	The Board Of Trustees Of The University Of Illinois	Lipid emulsions in the treatment of systemic poisoning
US6383471B1 (en) *	1999-04-06	2002-05-07	Lipocine, Inc.	Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US8404217B2 (en) *	2000-05-10	2013-03-26	Novartis Ag	Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
IN188843B (de) *	2000-06-22	2002-11-09	Vinod Daftary Gautam Dr
CA2432319A1 (en)	2000-12-21	2002-07-18	Nektar Therapeutics	Pulmonary delivery of polyene antifungal agents
US20020146385A1 (en) *	2001-04-10	2002-10-10	Lin Tung Liang	Ionic antimicrobial coating
WO2006030450A2 (en) *	2004-09-13	2006-03-23	Bharat Serums & Vaccines Ltd.	Stable emulsion compositions for intravenous administration having antimicrobial preservative efficacy
WO2009102814A2 (en) *	2008-02-11	2009-08-20	Accentia Biopharmaceuticals, Inc.	Mucosally non-irritative liquid amphotericin b formulations and methods for treating non-invasive fungus-induced mucositis
EP3461338A1 (de) *	2012-07-30	2019-04-03	Matinas BioPharma Nanotechnologies, Inc.	Mit sojaphosphatidylserin hergestellte cochleate
WO2018129345A1 (en)	2017-01-08	2018-07-12	Resq Pharma, Inc.	Methods for decreasing injuries associated with intraoperative hypotension

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT70225A (en) *	1978-10-03	1979-10-01	Gist Brocades Nv	Process for the preparation of sodium amoxicillin preparations
JPH0818989B2 (ja) *	1984-01-12	1996-02-28	株式会社ミドリ十字	脂肪乳剤中のプロスタグランジンの安定化方法
US4831018A (en) *	1985-05-17	1989-05-16	Smithkline Beckman Corporation	Polyene antibiotic emulsion formulation
US4707470A (en) *	1985-05-17	1987-11-17	Smithkline Beckman Corporation	Polyene antibiotic emulsion formulation
US4816247A (en) *	1985-09-11	1989-03-28	American Cyanamid Company	Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs
US4784845A (en) *	1985-09-16	1988-11-15	American Cyanamid Company	Emulsion compostions for the parenteral administration of sparingly water soluble ionizable hydrophobic drugs
DE3702029A1 (de) *	1987-01-24	1988-08-04	Basf Ag	Waessriges oder pulverfoermiges, wasserdispergierbares praeparat eines in wasser schwerloeslichen pharmazeutischen wirkstoffs und verfahren zu seiner herstellung
GB8714652D0 (en) *	1987-06-23	1987-07-29	Davis S S	Drug emulsion
AU598958B2 (en) *	1987-11-12	1990-07-05	Vestar, Inc.	Improved amphotericin b liposome preparation

1989
- 1989-08-23 GB GB898919172A patent/GB8919172D0/en active Pending
1990
- 1990-08-21 AU AU63591/90A patent/AU629983B2/en not_active Ceased
- 1990-08-21 ES ES90913513T patent/ES2056482T3/es not_active Expired - Lifetime
- 1990-08-21 DE DE69008729T patent/DE69008729T2/de not_active Expired - Fee Related
- 1990-08-21 AT AT9090913513T patent/ATE105181T1/de not_active IP Right Cessation
- 1990-08-21 WO PCT/GB1990/001309 patent/WO1991002517A1/en not_active Ceased
- 1990-08-21 EP EP90913513A patent/EP0487636B1/de not_active Expired - Lifetime
- 1990-08-21 JP JP2512619A patent/JP2963538B2/ja not_active Expired - Lifetime
- 1990-08-21 CA CA002064190A patent/CA2064190C/en not_active Expired - Fee Related
- 1990-08-21 US US08/130,419 patent/US5389373A/en not_active Expired - Fee Related
- 1990-08-21 DK DK90913513.9T patent/DK0487636T3/da active
1992
- 1992-02-13 GB GB9203067A patent/GB2256136B/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2056482T3 (es)	1994-10-01
GB8919172D0 (en)	1989-10-04
US5389373A (en)	1995-02-14
AU629983B2 (en)	1992-10-15
GB9203067D0 (en)	1992-09-23
JPH05500062A (ja)	1993-01-14
WO1991002517A1 (en)	1991-03-07
DE69008729T2 (de)	1994-09-08
EP0487636B1 (de)	1994-05-04
GB2256136B (en)	1993-06-02
CA2064190A1 (en)	1991-02-24
EP0487636A1 (de)	1992-06-03
AU6359190A (en)	1991-04-03
GB2256136A (en)	1992-12-02
CA2064190C (en)	1999-04-06
JP2963538B2 (ja)	1999-10-18
DK0487636T3 (da)	1994-06-06
DE69008729D1 (de)	1994-06-09

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Legal Events

Date	Code	Title	Description
1994-10-15	UEP	Publication of translation of european patent specification
2000-05-15	REN	Ceased due to non-payment of the annual fee