ATE106881T1 - Neue propanamine, ihre pharmakologischen eigenschaften und ihre therapeutischen verwendungen, besonders als antidiarrhöewirkstoffe. - Google Patents
Neue propanamine, ihre pharmakologischen eigenschaften und ihre therapeutischen verwendungen, besonders als antidiarrhöewirkstoffe.Info
- Publication number
- ATE106881T1 ATE106881T1 AT91400498T AT91400498T ATE106881T1 AT E106881 T1 ATE106881 T1 AT E106881T1 AT 91400498 T AT91400498 T AT 91400498T AT 91400498 T AT91400498 T AT 91400498T AT E106881 T1 ATE106881 T1 AT E106881T1
- Authority
- AT
- Austria
- Prior art keywords
- propanamines
- radical
- new
- pharmacological properties
- therapeutic uses
- Prior art date
Links
- 239000003793 antidiarrheal agent Substances 0.000 title 1
- 230000000144 pharmacologic effect Effects 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical class CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/01—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms
- C07C205/03—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C205/04—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/08—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms
- C07C205/09—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/32—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups bound to acyclic carbon atoms and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
- C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR909002495A FR2658821B1 (fr) | 1990-02-28 | 1990-02-28 | Nouvelles propanamines, leurs proprietes pharmacologiques et leur application a des fins therapeutiques, notamment antidiarrheuiques. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE106881T1 true ATE106881T1 (de) | 1994-06-15 |
Family
ID=9394222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91400498T ATE106881T1 (de) | 1990-02-28 | 1991-02-25 | Neue propanamine, ihre pharmakologischen eigenschaften und ihre therapeutischen verwendungen, besonders als antidiarrhöewirkstoffe. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5143938A (de) |
| EP (1) | EP0450995B1 (de) |
| JP (1) | JPH05320103A (de) |
| KR (1) | KR910021364A (de) |
| AT (1) | ATE106881T1 (de) |
| AU (1) | AU632398B2 (de) |
| CA (1) | CA2037084A1 (de) |
| DE (1) | DE69102335D1 (de) |
| FI (1) | FI910924L (de) |
| FR (1) | FR2658821B1 (de) |
| HU (1) | HUT62282A (de) |
| IE (1) | IE910621A1 (de) |
| IL (1) | IL97357A0 (de) |
| NZ (1) | NZ237228A (de) |
| PT (1) | PT96886A (de) |
| ZA (1) | ZA911396B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6190691B1 (en) | 1994-04-12 | 2001-02-20 | Adolor Corporation | Methods for treating inflammatory conditions |
| US5962477A (en) * | 1994-04-12 | 1999-10-05 | Adolor Corporation | Screening methods for cytokine inhibitors |
| US5739336A (en) * | 1995-06-23 | 1998-04-14 | Syntex (U.S.A.) Inc. | 1,3,8-triaza- and 3,8-diaza-1-oxaspiro 4,5! decane derivatives |
| AU6126596A (en) * | 1995-06-23 | 1997-01-22 | F. Hoffmann-La Roche Ag | 1,3,8-triaza- and 3,8-diaza-1-oxaspiro(4,5)decane derivatives |
| US6573282B1 (en) | 1995-09-12 | 2003-06-03 | Adolor Corporation | Peripherally active anti-hyperalgesic opiates |
| US5849761A (en) * | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
| US20070116643A1 (en) * | 2005-07-01 | 2007-05-24 | Concert Pharmaceuticals Inc. | Novel aryloxypropanamines |
| CA2629800A1 (en) * | 2005-11-23 | 2007-05-31 | Thomas G. Gant | Substituted aryloxypropylamines with serotoninergic and/or norepinephrinergic activity |
| CN102149280B (zh) | 2008-07-15 | 2017-05-24 | 泰拉科斯有限公司 | 氘化苄基苯衍生物及其使用方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB777794A (en) * | 1954-09-10 | 1957-06-26 | Thomae Gmbh Dr K | New 1:3-dioxolane derivatives and process for their preparation |
| US3182084A (en) * | 1961-09-06 | 1965-05-04 | Bristol Myers Co | Amino ketones and their method of preparation |
| CH539051A (de) * | 1970-11-06 | 1973-08-31 | Sandoz Ag | Verfahren zur Herstellung von 1-Alkyl-4,6-diphenylpyrimidin-2(1H)-onen |
| US3714159A (en) * | 1971-03-30 | 1973-01-30 | Janssen Pharmaceutica Nv | 2,2-diaryl-4-(4'-aryl-4'-hydroxy-piper-idino)-butyramides |
| CH620919A5 (en) * | 1973-12-21 | 1980-12-31 | Hoffmann La Roche | Process for the preparation of sulphur-containing heterocyclic compounds |
| JPS6393753A (ja) * | 1986-10-09 | 1988-04-25 | Nippon Kayaku Co Ltd | プロピオフエノン誘導体 |
| FR2641276B1 (fr) * | 1988-12-30 | 1991-07-12 | Sanofi Sa | Derives du benzene, leur preparation et les compositions pharmaceutiques en contenant |
| JP2861274B2 (ja) * | 1989-06-06 | 1999-02-24 | 武田薬品工業株式会社 | アミノケトン誘導体 |
-
1990
- 1990-02-28 FR FR909002495A patent/FR2658821B1/fr not_active Expired - Fee Related
-
1991
- 1991-02-25 EP EP91400498A patent/EP0450995B1/de not_active Expired - Lifetime
- 1991-02-25 DE DE69102335T patent/DE69102335D1/de not_active Expired - Lifetime
- 1991-02-25 IE IE062191A patent/IE910621A1/en unknown
- 1991-02-25 AU AU71341/91A patent/AU632398B2/en not_active Ceased
- 1991-02-25 AT AT91400498T patent/ATE106881T1/de not_active IP Right Cessation
- 1991-02-25 HU HU91626A patent/HUT62282A/hu unknown
- 1991-02-25 IL IL97357A patent/IL97357A0/xx unknown
- 1991-02-25 CA CA002037084A patent/CA2037084A1/en not_active Abandoned
- 1991-02-26 PT PT96886A patent/PT96886A/pt not_active Application Discontinuation
- 1991-02-26 US US07/660,873 patent/US5143938A/en not_active Expired - Fee Related
- 1991-02-26 NZ NZ237228A patent/NZ237228A/en unknown
- 1991-02-26 FI FI910924A patent/FI910924L/fi not_active Application Discontinuation
- 1991-02-26 KR KR1019910003129A patent/KR910021364A/ko not_active Withdrawn
- 1991-02-26 JP JP3216735A patent/JPH05320103A/ja active Pending
- 1991-02-26 ZA ZA911396A patent/ZA911396B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU7134191A (en) | 1991-08-29 |
| JPH05320103A (ja) | 1993-12-03 |
| PT96886A (pt) | 1991-10-31 |
| FR2658821A1 (fr) | 1991-08-30 |
| DE69102335D1 (de) | 1994-07-14 |
| IE910621A1 (en) | 1991-08-28 |
| EP0450995B1 (de) | 1994-06-08 |
| IL97357A0 (en) | 1992-05-25 |
| US5143938A (en) | 1992-09-01 |
| AU632398B2 (en) | 1992-12-24 |
| FI910924A7 (fi) | 1991-08-29 |
| FR2658821B1 (fr) | 1994-09-16 |
| HUT62282A (en) | 1993-04-28 |
| CA2037084A1 (en) | 1991-08-29 |
| KR910021364A (ko) | 1991-12-20 |
| ZA911396B (en) | 1992-05-27 |
| FI910924A0 (fi) | 1991-02-26 |
| HU910626D0 (en) | 1991-09-30 |
| EP0450995A1 (de) | 1991-10-09 |
| FI910924L (fi) | 1991-08-29 |
| NZ237228A (en) | 1992-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |