ATE107289T1 - Verfahren zur herstellung von 1-phenylimidazolin- 2,5-dion-derivate. - Google Patents

Verfahren zur herstellung von 1-phenylimidazolin- 2,5-dion-derivate.

Info

Publication number: ATE107289T1
Authority: AT; Austria
Prior art keywords: preparation; formula; image; phenylimidazoline; denote
Prior art date: 1989-12-22

Application number

AT90403725T

Other languages

English (en)

Inventor

Patrick Seuron

Daniel Varraillon

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-22

Filing date

1990-12-21

Publication date

1994-07-15

1990-12-21 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1994-07-15 Application granted granted Critical

1994-07-15 Publication of ATE107289T1 publication Critical patent/ATE107289T1/de

Links

238000000034 method Methods 0.000 title abstract 2
RUEGAVIENIPHGK-UHFFFAOYSA-N 3-phenylimidazolidine-2,4-dione Chemical class O=C1CNC(=O)N1C1=CC=CC=C1 RUEGAVIENIPHGK-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003302 alkenyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000005133 alkynyloxy group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)
Reinforced Plastic Materials (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Photoreceptors In Electrophotography (AREA)
Compositions Of Macromolecular Compounds (AREA)

AT90403725T 1989-12-22 1990-12-21 Verfahren zur herstellung von 1-phenylimidazolin- 2,5-dion-derivate. ATE107289T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8917046A FR2656302B1 (fr)	1989-12-22	1989-12-22	Nouveau procede de preparation de l'anandron et derives de l'anandron.

Publications (1)

Publication Number	Publication Date
ATE107289T1 true ATE107289T1 (de)	1994-07-15

Family

ID=9388859

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90403725T ATE107289T1 (de)	1989-12-22	1990-12-21	Verfahren zur herstellung von 1-phenylimidazolin- 2,5-dion-derivate.

Country Status (24)

Country	Link
US (1)	US5166358A (de)
EP (1)	EP0436426B1 (de)
JP (1)	JP2836041B2 (de)
KR (1)	KR0173307B1 (de)
CN (1)	CN1048011C (de)
AT (1)	ATE107289T1 (de)
AU (1)	AU628699B2 (de)
CA (1)	CA2032988C (de)
CZ (1)	CZ281655B6 (de)
DE (1)	DE69009964T2 (de)
DK (1)	DK0436426T3 (de)
ES (1)	ES2055382T3 (de)
FI (1)	FI103203B (de)
FR (1)	FR2656302B1 (de)
HU (1)	HU207301B (de)
IE (1)	IE65510B1 (de)
IL (1)	IL96696A (de)
NZ (1)	NZ236621A (de)
PL (1)	PL164694B1 (de)
PT (1)	PT96313B (de)
RU (1)	RU1836356C (de)
SK (1)	SK278447B6 (de)
UA (1)	UA27220C2 (de)
ZA (1)	ZA909648B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5411981A (en) *	1991-01-09	1995-05-02	Roussel Uclaf	Phenylimidazolidines having antiandrogenic activity
FR2693461B1 (fr) *	1992-07-08	1994-09-02	Roussel Uclaf	Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2694290B1 (fr) *	1992-07-08	1994-09-02	Roussel Uclaf	Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
US5656651A (en) *	1995-06-16	1997-08-12	Biophysica Inc.	Androgenic directed compositions
DE19540027A1 (de) *	1995-10-27	1997-04-30	Gruenenthal Gmbh	Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe
FR2741346B1 (fr) *	1995-11-16	1997-12-19	Roussel Uclaf	Nouveau procede de preparation de derives phenylimidazolidine
FR2741342B1 (fr) *	1995-11-22	1998-02-06	Roussel Uclaf	Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques
JPH1072446A (ja) *	1996-06-24	1998-03-17	Sumitomo Chem Co Ltd	１−置換−ヒダントイン類の製造法
US20040077605A1 (en)	2001-06-20	2004-04-22	Salvati Mark E.	Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US7001911B2 (en)	2000-06-28	2006-02-21	Bristol-Myers Squibb Company	Fused cyclic modulators of nuclear hormone receptor function
MXPA02012605A (es) *	2000-06-28	2003-05-14	Squibb Bristol Myers Co	Moduladores selectivos del receptor androgeno y metodo para su identificacion, dise°o y uso.
EP1854798A3 (de)	2000-09-19	2007-11-28	Bristol-Myers Squibb Company	Kondensierte heterozyklische Succinimid-Verbindungen und Analoga daraus, Modulatoren der nuklearen Hormonrezeptorfunktion
US6953679B2 (en)	2000-09-19	2005-10-11	Bristol-Myers Squibb Company	Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
US20040087548A1 (en)	2001-02-27	2004-05-06	Salvati Mark E.	Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US7087636B2 (en)	2001-12-19	2006-08-08	Bristol-Myers Squibb Company	Fused heterocyclic compounds and analogs thereof, modulators of nuclear hormone receptor function
ATE502298T1 (de) *	2003-12-19	2011-04-15	Univ California	Verfahren und materialien zur beurteilung von prostatakrebstherapien
NZ550102A (en) *	2004-02-24	2010-10-29	Univ California	Methods and materials for assessing prostate cancer therapies and compounds (thiohydantoine derivatives)
US7709517B2 (en)	2005-05-13	2010-05-04	The Regents Of The University Of California	Diarylhydantoin compounds
SI2656842T1 (sl)	2006-03-27	2016-10-28	The Regents Of The University Of California	Modulator androgenih receptorjev za zdravljenje raka prostate in bolezni, povezanih z androgenimi receptorji
WO2007127010A2 (en)	2006-03-29	2007-11-08	The Regents Of The University Of California	Diarylthiohydantoin compounds
EP2620432A3 (de)	2007-10-26	2013-12-18	The Regents Of the University of California	Diarylhydantoinverbindungen
AU2011218173C1 (en)	2010-02-16	2015-04-16	Aragon Pharmaceuticals, Inc.	Androgen receptor modulators and uses thereof
NZ744456A (en)	2012-09-26	2019-09-27	Aragon Pharmaceuticals Inc	Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
PL2945628T3 (pl)	2013-01-15	2020-09-21	Aragon Pharmaceuticals, Inc.	Modulator receptorów androgenowych w skojarzeniu z octanem abirateronu i prednizonem do leczenia nowotworu stercza
TWI726969B (zh)	2016-01-11	2021-05-11	比利時商健生藥品公司	用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
US10702508B2 (en)	2017-10-16	2020-07-07	Aragon Pharmaceuticals, Inc.	Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH166004A (de) *	1934-06-06	1933-12-15	Chem Fab Vormals Sandoz	Verfahren zur Darstellung eines Derivates des 5,5-Phenyläthylhydantoins.
US2490813A (en) *	1944-11-29	1949-12-13	Standard Oil Co	Continuous process for making aryl amines
US2759002A (en) *	1954-03-24	1956-08-14	Abbott Lab	3-benzyl hydantoin and process
US3134663A (en) *	1957-07-23	1964-05-26	Geigy Chem Corp	Herbicidal composition and method employing hydantoins
US3914311A (en) *	1973-06-15	1975-10-21	Du Pont	Preparation of aromatic secondary and tertiary amines using a nickel complex catalyst
DE2414613A1 (de) *	1974-03-26	1975-10-16	Bayer Ag	1-aryl-5-alkyliden-2,4-dioxo-imidazolidine
FR2329276A1 (fr) *	1975-10-29	1977-05-27	Roussel Uclaf	Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
IL55774A (en) *	1977-10-28	1982-04-30	Sparamedica Ag	Pharmaceutical compositions containing urea derivatives,certain such novel derivatives and their manufacture
GB1598166A (en) *	1978-05-23	1981-09-16	Lilly Industries Ltd	3,5-disubstituted hydantoin derivatives
US4764625A (en) *	1980-12-12	1988-08-16	Xerox Corporation	Process for preparing arylamines
EP0091596B1 (de) *	1982-04-08	1991-09-11	Shell Internationale Researchmaatschappij B.V.	Neue Hydantoine, ihre Herstellung und Verwendung

1989
- 1989-12-22 FR FR8917046A patent/FR2656302B1/fr not_active Expired - Fee Related
1990
- 1990-11-16 IE IE414290A patent/IE65510B1/en not_active IP Right Cessation
- 1990-11-30 ZA ZA909648A patent/ZA909648B/xx unknown
- 1990-12-10 JP JP2407176A patent/JP2836041B2/ja not_active Expired - Lifetime
- 1990-12-17 IL IL9669690A patent/IL96696A/en not_active IP Right Cessation
- 1990-12-18 US US07/629,490 patent/US5166358A/en not_active Expired - Lifetime
- 1990-12-20 PL PL90288365A patent/PL164694B1/pl unknown
- 1990-12-20 AU AU68265/90A patent/AU628699B2/en not_active Expired
- 1990-12-21 DE DE69009964T patent/DE69009964T2/de not_active Expired - Lifetime
- 1990-12-21 AT AT90403725T patent/ATE107289T1/de not_active IP Right Cessation
- 1990-12-21 CA CA002032988A patent/CA2032988C/fr not_active Expired - Lifetime
- 1990-12-21 FI FI906366A patent/FI103203B/fi active IP Right Grant
- 1990-12-21 SK SK6567-90A patent/SK278447B6/sk not_active IP Right Cessation
- 1990-12-21 EP EP90403725A patent/EP0436426B1/de not_active Expired - Lifetime
- 1990-12-21 HU HU908416A patent/HU207301B/hu unknown
- 1990-12-21 KR KR1019900021357A patent/KR0173307B1/ko not_active Expired - Lifetime
- 1990-12-21 ES ES90403725T patent/ES2055382T3/es not_active Expired - Lifetime
- 1990-12-21 NZ NZ236621A patent/NZ236621A/en unknown
- 1990-12-21 CZ CS906567A patent/CZ281655B6/cs not_active IP Right Cessation
- 1990-12-21 UA UA4894040A patent/UA27220C2/uk unknown
- 1990-12-21 PT PT96313A patent/PT96313B/pt not_active IP Right Cessation
- 1990-12-21 DK DK90403725.6T patent/DK0436426T3/da active
- 1990-12-21 RU SU904894040A patent/RU1836356C/ru active
- 1990-12-22 CN CN90110071A patent/CN1048011C/zh not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IL96696A0 (en)	1991-09-16
JPH04103573A (ja)	1992-04-06
CZ656790A3 (en)	1996-08-14
AU628699B2 (en)	1992-09-17
CA2032988A1 (fr)	1991-06-23
PL288365A1 (en)	1991-09-09
KR0173307B1 (ko)	1999-02-01
PT96313A (pt)	1991-09-30
FR2656302B1 (fr)	1992-05-07
FI103203B1 (fi)	1999-05-14
RU1836356C (ru)	1993-08-23
HU207301B (en)	1993-03-29
HU908416D0 (en)	1991-07-29
CA2032988C (fr)	2003-04-29
EP0436426A1 (de)	1991-07-10
SK656790A3 (en)	1997-06-04
DE69009964D1 (de)	1994-07-21
FR2656302A1 (fr)	1991-06-28
DK0436426T3 (da)	1994-07-04
US5166358A (en)	1992-11-24
DE69009964T2 (de)	1994-10-13
PT96313B (pt)	1998-06-30
IE65510B1 (en)	1995-11-01
IL96696A (en)	1995-08-31
CZ281655B6 (cs)	1996-12-11
JP2836041B2 (ja)	1998-12-14
AU6826590A (en)	1991-06-27
IE904142A1 (en)	1991-07-03
UA27220C2 (uk)	2000-08-15
FI906366A0 (fi)	1990-12-21
CN1052666A (zh)	1991-07-03
CN1048011C (zh)	2000-01-05
EP0436426B1 (de)	1994-06-15
ES2055382T3 (es)	1994-08-16
FI906366L (fi)	1991-06-23
FI103203B (fi)	1999-05-14
KR910011799A (ko)	1991-08-07
SK278447B6 (en)	1997-06-04
ZA909648B (en)	1992-02-26
PL164694B1 (pl)	1994-09-30
NZ236621A (en)	1992-04-28

Legal Events

Date	Code	Title
1995-01-15	UEP	Publication of translation of european patent specification
2005-05-15	EEIH	Change in the person of patent owner
2011-03-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE107289T1 (de)	1994-07-15	Verfahren zur herstellung von 1-phenylimidazolin- 2,5-dion-derivate.
DE69114637D1 (de)	1995-12-21	Verbesserte Verfahren zur Herstellung von Zyklopentadienyleisen(II)arenen.
BR8405160A (pt)	1985-08-27	Compostos sensiveis a luz,mistura sensivel a luz a base dos mesmos e processo para obtencao de tais compostos
DE69029334D1 (de)	1997-01-16	Verfahren zur Herstellung von Alkoxyiminoacetamid-Derivaten und ein Zwischenproduckt dafür
DE69226590D1 (de)	1998-09-17	Verfahren zur Herstellung von substituierten N-Aryl-1,2,4-Triazolopyrimidin-2-Sulfonamiden
PT71773A (de)	1980-10-01	Verfahren zur herstellung von substituierten oxirancarbonsauren
DE58907421D1 (de)	1994-05-19	Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung und ihre Verwendung.
DE69513110D1 (de)	1999-12-09	Verfahren zur Herstellung von exotherm reagierenden Zusammensetzungen
ATE799T1 (de)	1982-04-15	Verfahren zur herstellung von isatosaeureanhydriden.
ATE88202T1 (de)	1993-04-15	Bismaleimid-siloxane und verfahren zu deren herstellung.
SE8001556L (sv)	1980-09-03	Tetrahydrobensotiazolylimidazolidinoner
ATE90682T1 (de)	1993-07-15	Verfahren zur herstellung von cefodizim.
ATE38665T1 (de)	1988-12-15	Verfahren zur herstellung von 5-perfluoralkyl-5,6-dihydrouracyl-derivaten und verwendbare zwischenprodukte.
ATE23993T1 (de)	1986-12-15	Verfahren zur herstellung von o,o'dithiobenzamiden.
DE69113323D1 (de)	1995-11-02	Verfahren zur Herstellung von alpha-Hydroxycarbonsäure amiden.
DE69011901D1 (de)	1994-10-06	1-Arylsulfonyl-2-piperidinon-Derivate, Verfahren und Zwischenprodukte zu ihrer Herstellung, ihre Verwendung als Arzneimittel und sie enthaltende Zusammensetzungen.
ATE42542T1 (de)	1989-05-15	3-amino-azetidin, seine salze, verfahren zu deren herstellung und zwischenprodukte.
KR850000390A (ko)	1985-02-27	치환된 알칸티오카복실산 유도체의 제조방법
DE59106854D1 (de)	1995-12-14	Verfahren zur Herstellung von N-(2-Chlor-pyridin-5-yl-methyl)-ethylendiamin.
DE69612337D1 (de)	2001-05-10	Verfahren zur Herstellung von Alkylanilin-Verbindungen
DE69700036D1 (de)	1998-11-12	Verfahren zur Substitution von Cyclopentadien
ATE11139T1 (de)	1985-01-15	2-(n-aryl-n-1,2,3-thiadiazolylcarbonyl)aminobutyrolactone, verfahren zu ihrer herstellung, diese enthaltende fungizide mittel und ihre anwendung als fungizide.
ATE71618T1 (de)	1992-02-15	2-anilino-chinoline, verfahren zu ihrer herstellung und diese enthaltende fungizide.
ATE17710T1 (de)	1986-02-15	Keten-0,0-acetale und verfahren zu ihrer herstellung.
ES483300A1 (es)	1980-09-01	Un procedimiento para la preparacion de derivados de benzo- diacepina