ES2055382T3 - Nuevo procedimiento de preparacion de derivados de la 1-fenilimidazolin-2,5-diona. - Google Patents

Nuevo procedimiento de preparacion de derivados de la 1-fenilimidazolin-2,5-diona.

Info

Publication number
ES2055382T3
ES2055382T3 ES90403725T ES90403725T ES2055382T3 ES 2055382 T3 ES2055382 T3 ES 2055382T3 ES 90403725 T ES90403725 T ES 90403725T ES 90403725 T ES90403725 T ES 90403725T ES 2055382 T3 ES2055382 T3 ES 2055382T3
Authority
ES
Spain
Prior art keywords
sub
preparation
phenylimidazolin
diona
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90403725T
Other languages
English (en)
Inventor
Patrick Seuron
Daniel Varraillon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of ES2055382T3 publication Critical patent/ES2055382T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Reinforced Plastic Materials (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Photoreceptors In Electrophotography (AREA)

Abstract

NUEVO PROCESO DE PREPARACION DE LOS PRODUCTOS CUYA FORMULA ES (I): EN LA QUE: R SUB 1, R SUB 2 Y R SUB 3 IDENTICOS O DIFERENTES, REPRESENTAN H, ALQUILO, ALQUENILO, ALQUINILO, ALQUILOXI, ALQUENILOXI, ALQUINILOXI, FENILO, FENOXI, NITRO, TRIFLUOROMETILO, ACILO O CARBOXI ESTERIFICADO, R SUB 4, R SUB 5 Y R SUB 6 IDENTICOS O DIFERENTES, REPRESENTAN H, ALQUILO, CARACTERIZADO PORQUE SE HACE REACCIONAR EL PRODUCTO, CUYA FORMULA ES (II) : EN LA QUE R SUB 1, R SUB 2 Y R SUB 3 TIENE LA SIGNIFICACION INDICADA AQUI ARRIBA Y HAL REPRESENTA UN ATOMO DE HALOGENO CON EL PRODUCTO CUYA FORMULA III ES: EN LA QUE R SUB 4, R SUB 5 Y R SUB 6 TIENE LA SIGNIFICACION INDICADA AQUI ARRIBA, EFECTUANDOSE LA REACCION EN PRESENCIA DE UN CATALIZADOR EVENTUALMENTE DE UN DISOLVENTE.
ES90403725T 1989-12-22 1990-12-21 Nuevo procedimiento de preparacion de derivados de la 1-fenilimidazolin-2,5-diona. Expired - Lifetime ES2055382T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8917046A FR2656302B1 (fr) 1989-12-22 1989-12-22 Nouveau procede de preparation de l'anandron et derives de l'anandron.

Publications (1)

Publication Number Publication Date
ES2055382T3 true ES2055382T3 (es) 1994-08-16

Family

ID=9388859

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90403725T Expired - Lifetime ES2055382T3 (es) 1989-12-22 1990-12-21 Nuevo procedimiento de preparacion de derivados de la 1-fenilimidazolin-2,5-diona.

Country Status (24)

Country Link
US (1) US5166358A (es)
EP (1) EP0436426B1 (es)
JP (1) JP2836041B2 (es)
KR (1) KR0173307B1 (es)
CN (1) CN1048011C (es)
AT (1) ATE107289T1 (es)
AU (1) AU628699B2 (es)
CA (1) CA2032988C (es)
CZ (1) CZ281655B6 (es)
DE (1) DE69009964T2 (es)
DK (1) DK0436426T3 (es)
ES (1) ES2055382T3 (es)
FI (1) FI103203B (es)
FR (1) FR2656302B1 (es)
HU (1) HU207301B (es)
IE (1) IE65510B1 (es)
IL (1) IL96696A (es)
NZ (1) NZ236621A (es)
PL (1) PL164694B1 (es)
PT (1) PT96313B (es)
RU (1) RU1836356C (es)
SK (1) SK656790A3 (es)
UA (1) UA27220C2 (es)
ZA (1) ZA909648B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411981A (en) * 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2693461B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
US5656651A (en) * 1995-06-16 1997-08-12 Biophysica Inc. Androgenic directed compositions
DE19540027A1 (de) * 1995-10-27 1997-04-30 Gruenenthal Gmbh Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe
FR2741346B1 (fr) * 1995-11-16 1997-12-19 Roussel Uclaf Nouveau procede de preparation de derives phenylimidazolidine
FR2741342B1 (fr) * 1995-11-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques
JPH1072446A (ja) * 1996-06-24 1998-03-17 Sumitomo Chem Co Ltd １−置換−ヒダントイン類の製造法
US20040077605A1 (en) 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
HUP0303172A3 (en) * 2000-06-28 2006-05-29 Bristol Myers Squibb Co Selective androgen receptor modulators and methods for their identification, desing and use
US7001911B2 (en) 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
EP1854798A3 (en) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US7087636B2 (en) 2001-12-19 2006-08-08 Bristol-Myers Squibb Company Fused heterocyclic compounds and analogs thereof, modulators of nuclear hormone receptor function
EP2299266A1 (en) * 2003-12-19 2011-03-23 The Regents of the University of California Methods and materials for assessing prostate cancer therapies
NZ550102A (en) * 2004-02-24 2010-10-29 Univ California Methods and materials for assessing prostate cancer therapies and compounds (thiohydantoine derivatives)
US7709517B2 (en) * 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
BRPI0709771B1 (pt) 2006-03-27 2022-01-25 The Regents Of The University Of California Composto e composição farmacêutica
NZ596260A (en) * 2006-03-29 2013-05-31 Univ California Diarylthiohydantoin compounds
TWI469971B (zh) 2007-10-26 2015-01-21 Univ California 二芳基乙內醯脲類化合物
EP3124481B1 (en) 2010-02-16 2018-03-28 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
WO2014052237A1 (en) 2012-09-26 2014-04-03 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
EP2945628B1 (en) 2013-01-15 2020-04-15 Aragon Pharmaceuticals, Inc. Androgen receptor modulator in combination with abiraterone acetate and prednisone for treating prostate cancer
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
KR20240096623A (ko) 2017-10-16 2024-06-26 아라곤 파마슈티컬스, 인코포레이티드 비-전이성 거세-저항성 전립선암의 치료를 위한 항-안드로겐

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH166004A (de) * 1934-06-06 1933-12-15 Chem Fab Vormals Sandoz Verfahren zur Darstellung eines Derivates des 5,5-Phenyläthylhydantoins.
US2490813A (en) * 1944-11-29 1949-12-13 Standard Oil Co Continuous process for making aryl amines
US2759002A (en) * 1954-03-24 1956-08-14 Abbott Lab 3-benzyl hydantoin and process
US3134663A (en) * 1957-07-23 1964-05-26 Geigy Chem Corp Herbicidal composition and method employing hydantoins
US3914311A (en) * 1973-06-15 1975-10-21 Du Pont Preparation of aromatic secondary and tertiary amines using a nickel complex catalyst
DE2414613A1 (de) * 1974-03-26 1975-10-16 Bayer Ag 1-aryl-5-alkyliden-2,4-dioxo-imidazolidine
FR2329276A1 (fr) * 1975-10-29 1977-05-27 Roussel Uclaf Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
IL55774A (en) * 1977-10-28 1982-04-30 Sparamedica Ag Pharmaceutical compositions containing urea derivatives,certain such novel derivatives and their manufacture
GB1598166A (en) * 1978-05-23 1981-09-16 Lilly Industries Ltd 3,5-disubstituted hydantoin derivatives
US4764625A (en) * 1980-12-12 1988-08-16 Xerox Corporation Process for preparing arylamines
EP0091596B1 (de) * 1982-04-08 1991-09-11 Shell Internationale Researchmaatschappij B.V. Neue Hydantoine, ihre Herstellung und Verwendung

Also Published As

Publication number Publication date
KR0173307B1 (ko) 1999-02-01
IE904142A1 (en) 1991-07-03
PT96313B (pt) 1998-06-30
ATE107289T1 (de) 1994-07-15
NZ236621A (en) 1992-04-28
UA27220C2 (uk) 2000-08-15
ZA909648B (en) 1992-02-26
RU1836356C (ru) 1993-08-23
DE69009964T2 (de) 1994-10-13
DE69009964D1 (de) 1994-07-21
SK278447B6 (en) 1997-06-04
FI103203B1 (fi) 1999-05-14
PL288365A1 (en) 1991-09-09
FI103203B (fi) 1999-05-14
JPH04103573A (ja) 1992-04-06
EP0436426B1 (fr) 1994-06-15
PT96313A (pt) 1991-09-30
IE65510B1 (en) 1995-11-01
FI906366A0 (fi) 1990-12-21
SK656790A3 (en) 1997-06-04
FI906366L (fi) 1991-06-23
IL96696A (en) 1995-08-31
PL164694B1 (pl) 1994-09-30
DK0436426T3 (da) 1994-07-04
CA2032988A1 (fr) 1991-06-23
CN1048011C (zh) 2000-01-05
CZ281655B6 (cs) 1996-12-11
IL96696A0 (en) 1991-09-16
AU628699B2 (en) 1992-09-17
AU6826590A (en) 1991-06-27
KR910011799A (ko) 1991-08-07
FR2656302A1 (fr) 1991-06-28
EP0436426A1 (fr) 1991-07-10
FR2656302B1 (fr) 1992-05-07
CA2032988C (fr) 2003-04-29
CZ656790A3 (en) 1996-08-14
HU207301B (en) 1993-03-29
CN1052666A (zh) 1991-07-03
US5166358A (en) 1992-11-24
JP2836041B2 (ja) 1998-12-14
HU908416D0 (en) 1991-07-29

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