ATE107312T1 - Neurokinin-a-antagonisten. - Google Patents

Neurokinin-a-antagonisten.

Info

Publication number: ATE107312T1
Authority: AT; Austria
Prior art keywords: neurokinin; antagonists
Prior art date: 1988-06-20

Application number

AT89111108T

Other languages

English (en)

Inventor

Stephen H Buck

John L Krstenansky

James R Mccarthy

Scott L Harbeson

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-20

Filing date

1989-06-19

Publication date

1994-07-15

1989-06-19 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1994-07-15 Application granted granted Critical

1994-07-15 Publication of ATE107312T1 publication Critical patent/ATE107312T1/de

Links

HEAUFJZALFKPBA-JPQUDPSNSA-N (3s)-3-[[(2s,3r)-2-[[(2s)-6-amino-2-[[(2s)-2-amino-3-(1h-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]-3-hydroxybutanoyl]amino]-4-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[2-[[(2s)-1-[[(2s)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amin Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 HEAUFJZALFKPBA-JPQUDPSNSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Pulmonology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Cardiology (AREA)
Transplantation (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Psychiatry (AREA)
Crystallography & Structural Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)

AT89111108T 1988-06-20 1989-06-19 Neurokinin-a-antagonisten. ATE107312T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US20892688A	1988-06-20	1988-06-20

Publications (1)

Publication Number	Publication Date
ATE107312T1 true ATE107312T1 (de)	1994-07-15

Family

ID=22776618

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89111108T ATE107312T1 (de)	1988-06-20	1989-06-19	Neurokinin-a-antagonisten.

Country Status (19)

Country	Link
EP (1)	EP0347802B1 (de)
JP (1)	JP2711720B2 (de)
KR (1)	KR0136605B1 (de)
CN (1)	CN1030703C (de)
AR (1)	AR246085A1 (de)
AT (1)	ATE107312T1 (de)
AU (1)	AU619857B2 (de)
CA (1)	CA1340824C (de)
DE (1)	DE68916113T2 (de)
DK (1)	DK174964B1 (de)
ES (1)	ES2057024T3 (de)
FI (1)	FI94351C (de)
HU (1)	HU204850B (de)
IE (1)	IE61362B1 (de)
IL (1)	IL90637A (de)
NO (1)	NO176105C (de)
NZ (1)	NZ229552A (de)
PT (1)	PT90902B (de)
ZA (1)	ZA894533B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5877277A (en)	1987-09-24	1999-03-02	Biomeasure, Inc.	Octapeptide bombesin analogs
ZA906188B (en) *	1989-08-10	1991-06-26	Merrell Dow Pharma	Cyclic neurokinin a antagonists
IE77033B1 (en) *	1989-08-16	1997-11-19	Univ Tulane	Substance P antagonists
FR2666335B1 (fr)	1990-09-05	1992-12-11	Sanofi Sa	Arylalkylamines, procede pour leur preparation et compositions pharmaceutiques les contenant.
EP0584256B1 (de) *	1991-04-22	1999-11-10	Mallinckrodt Medical, Inc.	Verbindungen und pharmazeutische zusammensetzungen zum nachweis und zur lokalisierung von geweben mit neurokinin-1-rezeptoren
FR2676055B1 (fr) *	1991-05-03	1993-09-03	Sanofi Elf	Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5625060A (en) *	1991-05-03	1997-04-29	Elf Sanofi	Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present
DK0585397T3 (da) *	1991-05-23	1997-08-25	Merrell Pharma Inc	Bombesinanaloger
GB9727123D0 (en) *	1997-12-22	1998-02-25	Int Centre Genetic Eng & Bio	Synthesis of diamines
JP2000021345A (ja)	1998-07-06	2000-01-21	Hitachi Ltd	走査型電子顕微鏡

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1302926C (en) *	1986-03-04	1992-06-09	Hideo Sugawara	Antibiotic f-0769, process for its production, and its use as a growthaccelerating and feed efficiency increasing agent and as an antitumour agent
IT1233696B (it) *	1989-05-29	1992-04-14	Menarini Farma Ind	Peptidi di sintesi antagonisti della neurochinina a. loro sali e relativi procedimenti di fabbricazione
ZA906188B (en) *	1989-08-10	1991-06-26	Merrell Dow Pharma	Cyclic neurokinin a antagonists

1989
- 1989-06-14 ZA ZA894533A patent/ZA894533B/xx unknown
- 1989-06-14 NZ NZ229552A patent/NZ229552A/en unknown
- 1989-06-16 IL IL90637A patent/IL90637A/xx not_active IP Right Cessation
- 1989-06-16 AU AU36523/89A patent/AU619857B2/en not_active Expired
- 1989-06-16 AR AR89314190A patent/AR246085A1/es active
- 1989-06-19 ES ES89111108T patent/ES2057024T3/es not_active Expired - Lifetime
- 1989-06-19 CA CA000603179A patent/CA1340824C/en not_active Expired - Fee Related
- 1989-06-19 FI FI893002A patent/FI94351C/fi active IP Right Grant
- 1989-06-19 DK DK198903018A patent/DK174964B1/da not_active IP Right Cessation
- 1989-06-19 HU HU893138A patent/HU204850B/hu not_active IP Right Cessation
- 1989-06-19 IE IE198789A patent/IE61362B1/en not_active IP Right Cessation
- 1989-06-19 KR KR1019890008510A patent/KR0136605B1/ko not_active Expired - Lifetime
- 1989-06-19 PT PT90902A patent/PT90902B/pt not_active IP Right Cessation
- 1989-06-19 AT AT89111108T patent/ATE107312T1/de not_active IP Right Cessation
- 1989-06-19 NO NO892542A patent/NO176105C/no not_active IP Right Cessation
- 1989-06-19 DE DE68916113T patent/DE68916113T2/de not_active Expired - Lifetime
- 1989-06-19 EP EP89111108A patent/EP0347802B1/de not_active Expired - Lifetime
- 1989-06-20 CN CN89104205A patent/CN1030703C/zh not_active Expired - Fee Related
- 1989-06-20 JP JP1155993A patent/JP2711720B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
KR910000791A (ko)	1991-01-30
AU3652389A (en)	1989-12-21
JP2711720B2 (ja)	1998-02-10
JPH0245497A (ja)	1990-02-15
AU619857B2 (en)	1992-02-06
NO176105B (no)	1994-10-24
EP0347802A3 (de)	1991-07-17
FI94351B (fi)	1995-05-15
NO892542D0 (no)	1989-06-19
DK174964B1 (da)	2004-04-05
EP0347802B1 (de)	1994-06-15
NZ229552A (en)	1992-06-25
HU204850B (en)	1992-02-28
PT90902B (pt)	1994-12-30
IE61362B1 (en)	1994-11-02
KR0136605B1 (ko)	1998-04-25
NO176105C (no)	1995-02-01
IL90637A (en)	1993-07-08
ES2057024T3 (es)	1994-10-16
HUT50196A (en)	1989-12-28
DE68916113T2 (de)	1994-09-22
AR246085A1 (es)	1994-03-30
IL90637A0 (en)	1990-01-18
PT90902A (pt)	1989-12-29
DE68916113D1 (de)	1994-07-21
CN1030703C (zh)	1996-01-17
DK301889D0 (da)	1989-06-19
EP0347802A2 (de)	1989-12-27
CN1039597A (zh)	1990-02-14
DK301889A (da)	1989-12-21
ZA894533B (en)	1990-03-28
FI893002L (fi)	1989-12-21
FI893002A0 (fi)	1989-06-19
FI94351C (fi)	1995-08-25
NO892542L (no)	1989-12-21
CA1340824C (en)	1999-11-16
IE891987L (en)	1989-12-20

Legal Events

Date	Code	Title	Description
1995-02-15	UEP	Publication of translation of european patent specification
2009-09-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE82273T1 (de)	1992-11-15	Leucotrien-antagonisten.
FI890234L (fi)	1989-07-19	Individuellt justerbart kuddsystem.
NO894919D0 (no)	1989-12-07	Nye aminobenzoater.
FI901875A0 (fi)	1990-04-12	Fuktande vehikel foer lokal anvaendning av a-vitaminsyra.
NO892416L (no)	1989-12-18	Polyamider.
DE68901510D1 (de)	1992-06-17	Heftverbandsbahn.
FI895677A0 (fi)	1989-11-28	Dispenser.
DE68916113D1 (de)	1994-07-21	Neurokinin-A-Antagonisten.
FI893422A0 (fi)	1989-07-14	Madrasskonstruktion foer vattenbaedd.
NO893775D0 (no)	1989-09-22	Substituerte tienepyraner.
NO894907L (no)	1990-06-11	Nye alfa-cyano-beta-oksopropionamider.
NO894589D0 (no)	1989-11-17	Substituerte oksadiaminobutaner.
FI892337L (fi)	1989-11-19	Dispenser foer gashaltiga drycker.
DE3875030D1 (de)	1992-11-05	Leukotrien-antagonisten.
FI890892A0 (fi)	1989-02-24	B-amylasgen.
FI894455A0 (fi)	1989-09-20	1,4-dihydropyridinderivat.
DE58907370D1 (de)	1994-05-11	Substituierte Azolylmethyloxirane.
ATE116653T1 (de)	1995-01-15	Nmda-antagonisten.
DE58905035D1 (de)	1993-09-02	Kaemmaschine.
FI893714A7 (fi)	1990-02-17	2-amino-4-morfolino-6-propyl -1,3,5-triaziner.
FI890277L (fi)	1989-07-22	Tetrahydropyridinderivat.
TR24177A (tr)	1991-05-01	Fenoksifenil ikame edilmis tetrazolinonlar.
NO912122L (no)	1990-01-23	Nye allylaminoetylazoler.
DE68908538D1 (de)	1993-09-23	Thromboxan a2-antagonisten.
FI880732A0 (fi)	1988-02-17	Harv.