ATE116653T1 - Nmda-antagonisten. - Google Patents

Nmda-antagonisten.

Info

Publication number: ATE116653T1
Authority: AT; Austria
Prior art keywords: nmda antagonists; nmda; antagonists
Prior art date: 1989-09-19

Application number

AT90118033T

Other languages

English (en)

Inventor

Jeffrey P Whitten

Bruce M Baron

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-19

Filing date

1990-09-19

Publication date

1995-01-15

1990-07-20 Priority claimed from US07/553,431 external-priority patent/US5095009A/en

1990-09-19 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1995-01-15 Application granted granted Critical

1995-01-15 Publication of ATE116653T1 publication Critical patent/ATE116653T1/de

Links

HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT90118033T 1989-09-19 1990-09-19 Nmda-antagonisten. ATE116653T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US40947889A	1989-09-19	1989-09-19
US50833390A	1990-04-11	1990-04-11
US07/553,431 US5095009A (en)	1990-04-11	1990-07-20	NMDA antagonists

Publications (1)

Publication Number	Publication Date
ATE116653T1 true ATE116653T1 (de)	1995-01-15

Family

ID=27410806

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90118033T ATE116653T1 (de)	1989-09-19	1990-09-19	Nmda-antagonisten.

Country Status (20)

Country	Link
EP (1)	EP0418863B1 (de)
JP (1)	JP2934295B2 (de)
KR (2)	KR100191116B1 (de)
CN (1)	CN1027694C (de)
AR (2)	AR247889A1 (de)
AT (1)	ATE116653T1 (de)
AU (1)	AU632362B2 (de)
CA (1)	CA2025326C (de)
DE (1)	DE69015745T2 (de)
DK (1)	DK0418863T3 (de)
ES (1)	ES2069644T3 (de)
FI (1)	FI102613B1 (de)
GR (1)	GR3015656T3 (de)
HU (1)	HU207523B (de)
IE (1)	IE65118B1 (de)
IL (1)	IL95718A (de)
MX (1)	MX9203696A (de)
NO (1)	NO178375C (de)
NZ (1)	NZ235322A (de)
PT (1)	PT95344B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5554773A (en) *	1991-11-15	1996-09-10	Merrell Pharmaceuticals Inc.	N-trityl protected aspartic acid derivatives for the preparation of phosphonate NMDA antagonists
DE69208888T2 (de) *	1991-11-15	1996-08-01	Merrell Pharma Inc	N-trityl asparaginsäurederivate zur herstellung von phosphonat nmda antagonisten
GB9325368D0 (en) *	1993-12-10	1994-02-16	Univ Bristol	Organic compounds
EP0684238A3 (de) *	1994-04-27	1997-01-15	Hoffmann La Roche	Verfahren zur Herstellung von Dicarboxamiden.
EP3427729A1 (de)	2017-07-13	2019-01-16	Paris Sciences et Lettres - Quartier Latin	Probenecid zur behandlung von epileptischen erkrankungen, störungen oder zuständen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3970684A (en) *	1973-07-06	1976-07-20	Syntex (U.S.A.) Inc.	Polyunsaturated prostaglandin derivatives
CA1248531A (en) *	1984-04-17	1989-01-10	Jeffrey C. Watkins	4-substituted piperazine-2-carboxylic acids

1990
- 1990-09-13 CA CA002025326A patent/CA2025326C/en not_active Expired - Fee Related
- 1990-09-13 AU AU62474/90A patent/AU632362B2/en not_active Ceased
- 1990-09-14 NZ NZ235322A patent/NZ235322A/en unknown
- 1990-09-17 IL IL95718A patent/IL95718A/en not_active IP Right Cessation
- 1990-09-18 PT PT95344A patent/PT95344B/pt not_active IP Right Cessation
- 1990-09-18 KR KR1019900014729A patent/KR100191116B1/ko not_active Expired - Fee Related
- 1990-09-18 IE IE338090A patent/IE65118B1/en not_active IP Right Cessation
- 1990-09-18 NO NO904061A patent/NO178375C/no not_active IP Right Cessation
- 1990-09-18 HU HU905945A patent/HU207523B/hu not_active IP Right Cessation
- 1990-09-18 FI FI904588A patent/FI102613B1/fi not_active IP Right Cessation
- 1990-09-19 JP JP2247635A patent/JP2934295B2/ja not_active Expired - Lifetime
- 1990-09-19 ES ES90118033T patent/ES2069644T3/es not_active Expired - Lifetime
- 1990-09-19 DE DE69015745T patent/DE69015745T2/de not_active Expired - Fee Related
- 1990-09-19 AT AT90118033T patent/ATE116653T1/de not_active IP Right Cessation
- 1990-09-19 AR AR90317901A patent/AR247889A1/es active
- 1990-09-19 EP EP90118033A patent/EP0418863B1/de not_active Expired - Lifetime
- 1990-09-19 DK DK90118033.1T patent/DK0418863T3/da active
- 1990-09-19 CN CN90104580A patent/CN1027694C/zh not_active Expired - Fee Related
1991
- 1991-01-25 AR AR91318918A patent/AR248028A1/es active
1992
- 1992-06-29 MX MX9203696A patent/MX9203696A/es unknown
1995
- 1995-04-03 GR GR950400800T patent/GR3015656T3/el unknown
1998
- 1998-09-29 KR KR1019980040434A patent/KR100196265B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NO178375B (no)	1995-12-04
HU207523B (en)	1993-04-28
AU6247490A (en)	1991-03-28
EP0418863B1 (de)	1995-01-04
AU632362B2 (en)	1992-12-24
AR247889A1 (es)	1995-04-28
IE65118B1 (en)	1995-10-04
KR100196265B1 (ko)	1999-06-15
AR248028A1 (es)	1995-05-31
PT95344B (pt)	1998-02-27
DE69015745T2 (de)	1995-05-11
ES2069644T3 (es)	1995-05-16
MX9203696A (es)	1992-09-01
PT95344A (pt)	1991-06-25
EP0418863A3 (en)	1991-06-12
FI904588A0 (fi)	1990-09-18
HUT54699A (en)	1991-03-28
NO904061D0 (no)	1990-09-18
KR910006311A (ko)	1991-04-29
IL95718A (en)	1998-03-10
JP2934295B2 (ja)	1999-08-16
CA2025326A1 (en)	1991-03-20
JPH03130295A (ja)	1991-06-04
IE903380A1 (en)	1991-04-10
DE69015745D1 (de)	1995-02-16
CA2025326C (en)	2001-04-24
EP0418863A2 (de)	1991-03-27
GR3015656T3 (en)	1995-07-31
FI102613B (fi)	1999-01-15
NZ235322A (en)	1993-02-25
NO904061L (no)	1991-03-20
NO178375C (no)	1996-03-13
CN1027694C (zh)	1995-02-22
CN1050387A (zh)	1991-04-03
FI102613B1 (fi)	1999-01-15
DK0418863T3 (da)	1995-03-20
KR100191116B1 (ko)	1999-06-15

Legal Events

Date	Code	Title	Description
1995-08-15	UEP	Publication of translation of european patent specification
2003-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69020494D1 (de)	1995-08-03	Metrologie.
DE69002926D1 (de)	1993-09-30	Abgabevorrichtung.
FI913370A0 (fi)	1991-07-11	Aeggformad kryddhaollare.
FI900074A7 (fi)	1990-07-08	Dispenser.
DE69020982D1 (de)	1995-08-24	Vulkanisierungsform.
DE69017059D1 (de)	1995-03-30	Mehrplattenspieler.
DE59003933D1 (de)	1994-02-03	Bauelement.
FI920880A7 (fi)	1992-08-29	NMDA-antagonisteja
DE59005135D1 (de)	1994-04-28	Formstein.
FI902949A0 (fi)	1990-06-12	Kyldisk.
DE69022756D1 (de)	1995-11-09	Ausgabevorrichtung.
FI890462A0 (fi)	1989-01-31	Roddanordning.
DE69015745D1 (de)	1995-02-16	NMDA-Antagonisten.
FI922788L (fi)	1992-06-16	Skopa foer graevmaskin.
FI890299A0 (fi)	1989-01-20	Form.
FI895448A0 (fi)	1989-11-15	Antennsystem foer fordon.
DE69005107D1 (de)	1994-01-20	Fusskreuz.
FI890300A0 (fi)	1989-01-20	Form.
FI893732A0 (fi)	1989-08-08	Centraldammsugarens centralenhet.
FI890563A0 (fi)	1989-02-07	Under badandet anvaendbart redskap.
NO893672D0 (no)	1989-09-14	Engangsforskaling.
FI895900A7 (fi)	1991-06-12	Stoedben foer vaexelflak.
DE59004250D1 (de)	1994-02-24	Digitalisiergerät.
FI890863A7 (fi)	1990-08-24	Foerskrapa foer transportband.
FI890166A7 (fi)	1990-07-14	Kontinuerligt fungerande fuktighetsmaetare.