ATE107314T1 - Verfahren zur herstellung von 63-carboxyamid- teicoplanin-antibiotika. - Google Patents

Verfahren zur herstellung von 63-carboxyamid- teicoplanin-antibiotika.

Info

Publication number: ATE107314T1
Authority: AT; Austria
Prior art keywords: teicoplanin; carboxyamide; preparation; amine; antibiotics
Prior art date: 1988-11-22

Application number

AT89120267T

Other languages

English (en)

Inventor

Adriano Malabarba

Aldo Trani

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-22

Filing date

1989-11-02

Publication date

1994-07-15

1989-11-02 Application filed by Lepetit Spa filed Critical Lepetit Spa

1994-07-15 Application granted granted Critical

1994-07-15 Publication of ATE107314T1 publication Critical patent/ATE107314T1/de

Links

229960001608 teicoplanin Drugs 0.000 title abstract 3
239000003242 anti bacterial agent Substances 0.000 title 1
229940088710 antibiotic agent Drugs 0.000 title 1
108010053950 Teicoplanin Proteins 0.000 abstract 2
150000001412 amines Chemical class 0.000 abstract 2
DDTDNCYHLGRFBM-YZEKDTGTSA-N chembl2367892 Chemical compound CC(=O)N[C@H]1[C@@H](O)[C@H](O)[C@H](CO)O[C@H]1O[C@@H]([C@H]1C(N[C@@H](C2=CC(O)=CC(O[C@@H]3[C@H]([C@H](O)[C@H](O)[C@@H](CO)O3)O)=C2C=2C(O)=CC=C(C=2)[C@@H](NC(=O)[C@@H]2NC(=O)[C@@H]3C=4C=C(O)C=C(C=4)OC=4C(O)=CC=C(C=4)[C@@H](N)C(=O)N[C@H](CC=4C=C(Cl)C(O5)=CC=4)C(=O)N3)C(=O)N1)C(O)=O)=O)C(C=C1Cl)=CC=C1OC1=C(O[C@H]3[C@H]([C@@H](O)[C@H](O)[C@H](CO)O3)NC(C)=O)C5=CC2=C1 DDTDNCYHLGRFBM-YZEKDTGTSA-N 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical class NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000002798 polar solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Cephalosporin Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Separation Of Suspended Particles By Flocculating Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT89120267T 1988-11-22 1989-11-02 Verfahren zur herstellung von 63-carboxyamid- teicoplanin-antibiotika. ATE107314T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888827202A GB8827202D0 (en)	1988-11-22	1988-11-22	Process for preparing 63-carboxyamides of teicoplanin antibiotics

Publications (1)

Publication Number	Publication Date
ATE107314T1 true ATE107314T1 (de)	1994-07-15

Family

ID=10647217

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89120267T ATE107314T1 (de)	1988-11-22	1989-11-02	Verfahren zur herstellung von 63-carboxyamid- teicoplanin-antibiotika.

Country Status (17)

Country	Link
EP (1)	EP0370283B1 (de)
JP (1)	JPH03115298A (de)
CN (1)	CN1043939A (de)
AT (1)	ATE107314T1 (de)
AU (1)	AU633528B2 (de)
CA (1)	CA2003325A1 (de)
DE (1)	DE68916189T2 (de)
DK (1)	DK573689A (de)
ES (1)	ES2054983T3 (de)
FI (1)	FI895396A7 (de)
GB (1)	GB8827202D0 (de)
HU (1)	HUT52528A (de)
IL (1)	IL92321A0 (de)
NO (1)	NO894626L (de)
NZ (1)	NZ231468A (de)
PT (1)	PT92349B (de)
ZA (1)	ZA898379B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2083374T3 (es) *	1988-12-27	1996-04-16	Lepetit Spa	Derivados amidicos en posicion c63 de 34-des(acetilglucosaminil)-34-desoxi-teicoplaninas.
IE64155B1 (en) *	1989-03-29	1995-07-12	Lepetit Spa	New substituted alkylamide derivatives of teicoplanin
DE69117304T2 (de) *	1990-12-05	1996-08-29	Lepetit Spa	38-decarboxy-38-hydroxymethylderivate von teicoplaninantibiotika, und verfahren zu deren herstellung
CA2095410C (en) *	1993-05-03	1999-04-13	Madeleine Ravaoarinoro	Production and characteristics of anti-teicoplanin polyclonal antibody
EP0715558A4 (de) *	1993-08-23	1996-10-02	Master Lock Co	Zylinderstiftschloss mit abreisstiften und herstellungsverfahren und -gerät
DK0836619T3 (da) *	1995-07-05	2004-12-06	Aventis Bulk S P A	Oprensning af dalbaheptid antibiotika ved hjælp af isoelektrisk fokusering
EP0912604B1 (de)	1996-04-23	2001-11-14	Biosearch Italia S.p.A.	Chemisches Verfahren zur Herstellung von Amidderivaten von A 40926 Antibiotikum
US5936074A (en) *	1997-04-17	1999-08-10	Eli Lilly And Company	Teicoplanin deacylation process and product

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8522574D0 (en) *	1985-09-12	1985-10-16	Lepetit Spa	Amides of teicoplanin compounds
GB8704847D0 (en) *	1987-03-02	1987-04-08	Lepetit Spa	Substituted alkylamides of teicoplanin compounds

1988
- 1988-11-22 GB GB888827202A patent/GB8827202D0/en active Pending
1989
- 1989-11-02 AT AT89120267T patent/ATE107314T1/de not_active IP Right Cessation
- 1989-11-02 DE DE68916189T patent/DE68916189T2/de not_active Expired - Fee Related
- 1989-11-02 ES ES89120267T patent/ES2054983T3/es not_active Expired - Lifetime
- 1989-11-02 EP EP89120267A patent/EP0370283B1/de not_active Expired - Lifetime
- 1989-11-03 ZA ZA898379A patent/ZA898379B/xx unknown
- 1989-11-13 FI FI895396A patent/FI895396A7/fi not_active IP Right Cessation
- 1989-11-15 IL IL92321A patent/IL92321A0/xx unknown
- 1989-11-16 DK DK573689A patent/DK573689A/da not_active Application Discontinuation
- 1989-11-20 PT PT92349A patent/PT92349B/pt not_active IP Right Cessation
- 1989-11-20 CA CA002003325A patent/CA2003325A1/en active Pending
- 1989-11-21 NO NO89894626A patent/NO894626L/no unknown
- 1989-11-21 HU HU896033A patent/HUT52528A/hu unknown
- 1989-11-21 NZ NZ231468A patent/NZ231468A/en unknown
- 1989-11-21 CN CN89108726A patent/CN1043939A/zh active Pending
- 1989-11-22 AU AU45438/89A patent/AU633528B2/en not_active Ceased
- 1989-11-22 JP JP1304553A patent/JPH03115298A/ja active Pending

Also Published As

Publication number	Publication date
PT92349A (pt)	1990-05-31
DK573689A (da)	1990-05-23
FI895396A7 (fi)	1990-05-23
EP0370283A2 (de)	1990-05-30
AU633528B2 (en)	1993-02-04
HUT52528A (en)	1990-07-28
EP0370283B1 (de)	1994-06-15
IL92321A0 (en)	1990-07-26
NO894626L (no)	1990-05-23
PT92349B (pt)	1995-07-18
NZ231468A (en)	1992-07-28
ZA898379B (en)	1990-09-26
DE68916189T2 (de)	1994-10-20
GB8827202D0 (en)	1988-12-29
CA2003325A1 (en)	1990-05-22
AU4543889A (en)	1990-09-13
EP0370283A3 (de)	1991-08-07
DE68916189D1 (de)	1994-07-21
CN1043939A (zh)	1990-07-18
JPH03115298A (ja)	1991-05-16
DK573689D0 (da)	1989-11-16
NO894626D0 (no)	1989-11-21
ES2054983T3 (es)	1994-08-16
FI895396A0 (fi)	1989-11-13

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Legal Events

Date	Code	Title	Description
1994-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties