DK0912604T3 - Forbedret kemisk fremgangsmåde til fremstilling af amidderivater af A 40926 antibiotikum - Google Patents

Forbedret kemisk fremgangsmåde til fremstilling af amidderivater af A 40926 antibiotikum

Info

Publication number: DK0912604T3
Authority: DK; Denmark
Prior art keywords: formula; compound; alk3; alk2; alk1
Prior art date: 1996-04-23

Application number

DK97919359T

Other languages

English (en)

Inventor

Gianbattista Panzone

Alessandra Maria Marazzi

Ermenegildo Restelli

Anacleto Gianantonio

Original Assignee

Biosearch Italia Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-23

Filing date

1997-04-15

Publication date

2002-03-25

1997-04-15 Application filed by Biosearch Italia Spa filed Critical Biosearch Italia Spa

2002-03-25 Application granted granted Critical

2002-03-25 Publication of DK0912604T3 publication Critical patent/DK0912604T3/da

Links

238000001311 chemical methods and process Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
150000001408 amides Chemical class 0.000 title 1
230000003115 biocidal effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 8
-1 alpha-D-mannopyranosyl Chemical group 0.000 abstract 3
238000000034 method Methods 0.000 abstract 3
239000011541 reaction mixture Substances 0.000 abstract 2
101100490437 Mus musculus Acvrl1 gene Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
238000007112 amidation reaction Methods 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
239000007810 chemical reaction solvent Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
238000007865 diluting Methods 0.000 abstract 1
239000003480 eluent Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000011707 mineral Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
229920006122 polyamide resin Polymers 0.000 abstract 1
GPTFURBXHJWNHR-UHFFFAOYSA-N protopine Chemical compound C1=C2C(=O)CC3=CC=C4OCOC4=C3CN(C)CCC2=CC2=C1OCO2 GPTFURBXHJWNHR-UHFFFAOYSA-N 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
230000002829 reductive effect Effects 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)

DK97919359T 1996-04-23 1997-04-15 Forbedret kemisk fremgangsmåde til fremstilling af amidderivater af A 40926 antibiotikum DK0912604T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP96106341		1996-04-23
PCT/EP1997/001874 WO1997040067A1 (en)	1996-04-23	1997-04-15	Improved chemical process for preparing amide derivatives of antibiotic a 40926

Publications (1)

Publication Number	Publication Date
DK0912604T3 true DK0912604T3 (da)	2002-03-25

Family

ID=8222699

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97919359T DK0912604T3 (da)	1996-04-23	1997-04-15	Forbedret kemisk fremgangsmåde til fremstilling af amidderivater af A 40926 antibiotikum

Country Status (13)

Country	Link
US (1)	US6218505B1 (da)
EP (1)	EP0912604B1 (da)
JP (1)	JP2000508671A (da)
KR (1)	KR20000010589A (da)
AT (1)	ATE208791T1 (da)
AU (1)	AU719947B2 (da)
CA (1)	CA2250578C (da)
DE (1)	DE69708293T2 (da)
DK (1)	DK0912604T3 (da)
ES (1)	ES2165047T3 (da)
IL (1)	IL126430A0 (da)
PT (1)	PT912604E (da)
WO (1)	WO1997040067A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6392012B1 (en)	1998-12-23	2002-05-21	Advanced Medicine, Inc.	Glycopeptide derivatives and pharmaceutical compositions containing the same
US20060074014A1 (en) *	2002-11-18	2006-04-06	Vicuron Pharmaceuticals Inc.	Dalbavancin compositions for treatment of bacterial infections
EP1565201B1 (en) *	2002-11-18	2018-10-31	Vicuron Pharmaceuticals, Inc.	Methods of administering dalbavancin for treatment of bacterial infections
US7119061B2 (en) *	2002-11-18	2006-10-10	Vicuron Pharmaceuticals, Inc.	Dalbavancin compositions for treatment of bacterial infections

Family Cites Families (52)

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GB1496386A (en)	1975-03-05	1977-12-30	Lepetit Spa	Antibiotics
FI73697C (fi)	1982-06-08	1987-11-09	Lepetit Spa	Foerfarande foer framstaellning av individuella faktorer 1, 2, 3, 4 och 5 av teikomysin a2.
GB8307847D0 (en)	1983-03-22	1983-04-27	Lepetit Spa	Antibiotics l 17054 and l 17046
GB8311136D0 (en)	1983-04-25	1983-06-02	Lepetit Spa	Immobilised oligopeptides
GB8333624D0 (en)	1983-12-16	1984-01-25	Lepetit Spa	Antibiotics l 17054 and l 17392
AU579120B2 (en)	1983-12-16	1988-11-17	Gruppo Lepetit S.P.A.	Chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts
GB8415093D0 (en)	1984-06-13	1984-07-18	Lepetit Spa	Antibiotic l 17392
GB8415092D0 (en)	1984-06-13	1984-07-18	Lepetit Spa	Ester derivatives
GB8420405D0 (en)	1984-08-10	1984-09-12	Lepetit Spa	Preparing antibiotic l 17046
GB8425685D0 (en)	1984-10-11	1984-11-14	Lepetit Spa	Antibiotic a 40926 complex
US4914187A (en)	1984-11-13	1990-04-03	Gruppo Lepetit S.P.A	Ester derivatives of antibiotic L 17046
EP0184625B2 (en)	1984-12-03	1993-09-08	Maschinenfabrik Rieter Ag	Thread treating nozzle
GB8512795D0 (en)	1985-05-21	1985-06-26	Lepetit Spa	Increasing ratio of components of teicoplanin a2 complex
GB8522574D0 (en)	1985-09-12	1985-10-16	Lepetit Spa	Amides of teicoplanin compounds
GB8529272D0 (en)	1985-11-28	1986-01-02	Lepetit Spa	Teicoplanin derivatives
GB8531846D0 (en)	1985-12-30	1986-02-05	Lepetit Spa	Antibiotic a 40926 mannosyl aglycon
GB8608798D0 (en)	1986-04-11	1986-05-14	Lepetit Spa	Recovery of glycopeptide antibiotics from aqueous solutions
GB8608809D0 (en)	1986-04-11	1986-05-14	Lepetit Spa	Antibiotic
CA1282725C (en)	1986-04-18	1991-04-09	Brian A. Naughton	Process for replicating bone marrow in vitro and using the same
GR871488B (en)	1986-10-10	1987-11-12	Lepetit Spa	New antibiotics
GB8701872D0 (en)	1987-01-28	1987-03-04	Lepetit Spa	N15-alkyl & n15,n15-dialkyl derivatives
GB8704847D0 (en)	1987-03-02	1987-04-08	Lepetit Spa	Substituted alkylamides of teicoplanin compounds
GB8711066D0 (en)	1987-05-11	1987-06-17	Lepetit Spa	Teicoplanin derivatives
GB8715735D0 (en)	1987-07-03	1987-08-12	Lepetit Spa	De-mannosyl teicoplanin derivatives
GB8720980D0 (en)	1987-09-07	1987-10-14	Lepetit Spa	Derivatives
US4816706A (en)	1987-09-10	1989-03-28	International Business Machines Corporation	Sense amplifier with improved bitline precharging for dynamic random access memory
GB8729989D0 (en)	1987-12-23	1988-02-03	Lepetit Spa	Novel hydrogenated derivatives of antibiotic a/16686
GB8802211D0 (en)	1988-02-02	1988-03-02	Lepetit Spa	Teicoplanin hydrazides
GB8808658D0 (en)	1988-04-13	1988-05-18	Lepetit Spa	Aglycons of a/16686 antibiotics
GB8817052D0 (en)	1988-07-18	1988-08-24	Lepetit Spa	Process for preparing n15-alkyl derivatives of teicoplanin compounds
GB8817053D0 (en)	1988-07-18	1988-08-24	Lepetit Spa	Process for preparing n15 n15-dialkyl derivatives of teicoplanin compounds
GB8817397D0 (en)	1988-07-21	1988-08-24	Lepetit Spa	N15-alkyl & n15 n15-di-alkyl derivatives of teicoplanin antibiotics carrying functional groups on alkyl side chain
GB8817736D0 (en)	1988-07-26	1988-09-01	Lepetit Spa	New teicoplanin antibiotics
GB8827202D0 (en)	1988-11-22	1988-12-29	Lepetit Spa	Process for preparing 63-carboxyamides of teicoplanin antibiotics
ES2084595T3 (es)	1988-12-27	1996-05-16	Lepetit Spa	Procedimiento quimico mejorado para preparar el antibiotico l/17392 (desglucoteicoplanina) y sus sales.
US5194424A (en)	1988-12-27	1993-03-16	Gruppo Lepetit Spa	C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
US5500410A (en)	1989-03-29	1996-03-19	Gruppo Lepetit S.P.A.	Substituted alkylamide derivatives of teicoplanin
US5185320A (en)	1989-04-03	1993-02-09	Gruppo Lepetit S.P.A.	O56 -alkyl derivatives of aglycone and pseudo aglycones of teicoplanin
ES2110401T3 (es)	1989-07-18	1998-02-16	Biosearch Italia Spa	Antibioticos pentapeptidicos derivados de dalbaheptidos.
EP0427142B1 (en)	1989-11-07	1995-05-17	GRUPPO LEPETIT S.p.A.	Antibiotic A/16686 recovery process
EP0448940B1 (en)	1990-03-28	1997-09-17	GRUPPO LEPETIT S.p.A.	Process for the preparation of mannosyl teicoplanin derivatives and mannosyl teicoplanin aglycone
DK0479086T3 (da)	1990-10-01	1995-10-23	Lepetit Spa	Fremgangsmåde til indvinding af teicoplanin
ATE134379T1 (de) *	1990-12-05	1996-03-15	Lepetit Spa	38-decarboxy-38-hydroxymethylderivate von teicoplaninantibiotika, und verfahren zu deren herstellung
US5644025A (en)	1990-12-10	1997-07-01	Gruppo Lepetit Spa	Tetrapeptides deriving from dalbaheptide antibiotics
US5438117A (en)	1990-12-20	1995-08-01	Gruppo Lepetit S.P.A.	Hexapeptides deriving from aglucoteicoplanin and a process for preparing them
JP3314930B2 (ja) *	1991-03-27	2002-08-19	バイオサーチ・イタリア・ソチエタ・ペル・アチオニ	抗生物質ａ４０９２６エステル誘導体
US5606036A (en)	1991-03-27	1997-02-25	Gruppo Lepetit Spa	Antibiotic A 40926 ester derivatives
US5750509A (en)	1991-07-29	1998-05-12	Gruppo Lepetit S.P.A.	Amide derivatives of antibiotic A 40926
DK0596929T3 (da) *	1991-07-29	1995-09-11	Lepetit Spa	Amidderivater af antibiotikum A 40926
AU683881B2 (en)	1993-05-19	1997-11-27	Vicuron Pharmaceuticals Inc.	Synthetic aglucodalbaheptide antibiotics
JP2888741B2 (ja) *	1993-09-27	1999-05-10	日本ペイント株式会社	薄膜パターン形成法
AU701463B2 (en) *	1995-07-05	1999-01-28	Sanofi Aventis S.P.A.	Purification of dalbaheptide antibiotics by isoelectric focusing

1997
- 1997-04-15 DK DK97919359T patent/DK0912604T3/da active
- 1997-04-15 WO PCT/EP1997/001874 patent/WO1997040067A1/en not_active Ceased
- 1997-04-15 AU AU23861/97A patent/AU719947B2/en not_active Ceased
- 1997-04-15 IL IL12643097A patent/IL126430A0/xx unknown
- 1997-04-15 DE DE69708293T patent/DE69708293T2/de not_active Expired - Fee Related
- 1997-04-15 US US09/155,869 patent/US6218505B1/en not_active Expired - Fee Related
- 1997-04-15 AT AT97919359T patent/ATE208791T1/de not_active IP Right Cessation
- 1997-04-15 KR KR1019980708465A patent/KR20000010589A/ko not_active Abandoned
- 1997-04-15 CA CA002250578A patent/CA2250578C/en not_active Expired - Fee Related
- 1997-04-15 PT PT97919359T patent/PT912604E/pt unknown
- 1997-04-15 ES ES97919359T patent/ES2165047T3/es not_active Expired - Lifetime
- 1997-04-15 JP JP9537688A patent/JP2000508671A/ja not_active Ceased
- 1997-04-15 EP EP97919359A patent/EP0912604B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
KR20000010589A (ko)	2000-02-15
ES2165047T3 (es)	2002-03-01
EP0912604A1 (en)	1999-05-06
DE69708293D1 (de)	2001-12-20
AU2386197A (en)	1997-11-12
ATE208791T1 (de)	2001-11-15
PT912604E (pt)	2002-05-31
DE69708293T2 (de)	2002-05-02
EP0912604B1 (en)	2001-11-14
US6218505B1 (en)	2001-04-17
IL126430A0 (en)	1999-08-17
CA2250578A1 (en)	1997-10-30
WO1997040067A1 (en)	1997-10-30
AU719947B2 (en)	2000-05-18
JP2000508671A (ja)	2000-07-11
CA2250578C (en)	2003-06-24

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