ATE134379T1 - 38-decarboxy-38-hydroxymethylderivate von teicoplaninantibiotika, und verfahren zu deren herstellung - Google Patents

38-decarboxy-38-hydroxymethylderivate von teicoplaninantibiotika, und verfahren zu deren herstellung

Info

Publication number: ATE134379T1
Authority: AT; Austria
Prior art keywords: represents hydrogen; teicoplanin; decarboxy; hydroxymethyl; derivatives
Prior art date: 1990-12-05

Application number

AT91919523T

Other languages

English (en)

Inventor

Adriano Malabarba

Romeo Ciabatti

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-05

Filing date

1991-11-06

Publication date

1996-03-15

1991-11-06 Application filed by Lepetit Spa filed Critical Lepetit Spa

1996-03-15 Application granted granted Critical

1996-03-15 Publication of ATE134379T1 publication Critical patent/ATE134379T1/de

Links

108010053950 Teicoplanin Proteins 0.000 title abstract 3
229960001608 teicoplanin Drugs 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
239000003242 anti bacterial agent Substances 0.000 title 1
229940088710 antibiotic agent Drugs 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
DDTDNCYHLGRFBM-YZEKDTGTSA-N chembl2367892 Chemical compound CC(=O)N[C@H]1[C@@H](O)[C@H](O)[C@H](CO)O[C@H]1O[C@@H]([C@H]1C(N[C@@H](C2=CC(O)=CC(O[C@@H]3[C@H]([C@H](O)[C@H](O)[C@@H](CO)O3)O)=C2C=2C(O)=CC=C(C=2)[C@@H](NC(=O)[C@@H]2NC(=O)[C@@H]3C=4C=C(O)C=C(C=4)OC=4C(O)=CC=C(C=4)[C@@H](N)C(=O)N[C@H](CC=4C=C(Cl)C(O5)=CC=4)C(=O)N3)C(=O)N1)C(O)=O)=O)C(C=C1Cl)=CC=C1OC1=C(O[C@H]3[C@H]([C@@H](O)[C@H](O)[C@H](CO)O3)NC(C)=O)C5=CC2=C1 DDTDNCYHLGRFBM-YZEKDTGTSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
241000295644 Staphylococcaceae Species 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
125000005907 alkyl ester group Chemical group 0.000 abstract 1
-1 alpha-D-mannopyranosyl Chemical group 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
238000006722 reduction reaction Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/19—Antibiotic

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT91919523T 1990-12-05 1991-11-06 38-decarboxy-38-hydroxymethylderivate von teicoplaninantibiotika, und verfahren zu deren herstellung ATE134379T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP90123299		1990-12-05

Publications (1)

Publication Number	Publication Date
ATE134379T1 true ATE134379T1 (de)	1996-03-15

Family

ID=8204797

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91919523T ATE134379T1 (de)	1990-12-05	1991-11-06	38-decarboxy-38-hydroxymethylderivate von teicoplaninantibiotika, und verfahren zu deren herstellung

Country Status (13)

Country	Link
US (1)	US5869449A (de)
EP (1)	EP0560795B1 (de)
JP (1)	JPH06503306A (de)
KR (1)	KR930703357A (de)
AT (1)	ATE134379T1 (de)
AU (1)	AU8865191A (de)
CA (1)	CA2095725A1 (de)
DE (1)	DE69117304T2 (de)
HU (1)	HUT63860A (de)
IE (1)	IE914208A1 (de)
IL (1)	IL100101A0 (de)
WO (1)	WO1992010516A1 (de)
ZA (1)	ZA919554B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0596929T3 (da) *	1991-07-29	1995-09-11	Lepetit Spa	Amidderivater af antibiotikum A 40926
AU701463B2 (en) *	1995-07-05	1999-01-28	Sanofi Aventis S.P.A.	Purification of dalbaheptide antibiotics by isoelectric focusing
DK0912604T3 (da) *	1996-04-23	2002-03-25	Biosearch Italia Spa	Forbedret kemisk fremgangsmåde til fremstilling af amidderivater af A 40926 antibiotikum

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1496386A (en) *	1975-03-05	1977-12-30	Lepetit Spa	Antibiotics
FI73697C (fi) *	1982-06-08	1987-11-09	Lepetit Spa	Foerfarande foer framstaellning av individuella faktorer 1, 2, 3, 4 och 5 av teikomysin a2.
GB8307847D0 (en) *	1983-03-22	1983-04-27	Lepetit Spa	Antibiotics l 17054 and l 17046
AU579120B2 (en) *	1983-12-16	1988-11-17	Gruppo Lepetit S.P.A.	Chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts
GB8333624D0 (en) *	1983-12-16	1984-01-25	Lepetit Spa	Antibiotics l 17054 and l 17392
GB8415093D0 (en) *	1984-06-13	1984-07-18	Lepetit Spa	Antibiotic l 17392
GB8415092D0 (en) *	1984-06-13	1984-07-18	Lepetit Spa	Ester derivatives
GB8425685D0 (en) *	1984-10-11	1984-11-14	Lepetit Spa	Antibiotic a 40926 complex
US4914187A (en) *	1984-11-13	1990-04-03	Gruppo Lepetit S.P.A	Ester derivatives of antibiotic L 17046
GB8522574D0 (en) *	1985-09-12	1985-10-16	Lepetit Spa	Amides of teicoplanin compounds
GB8529272D0 (en) *	1985-11-28	1986-01-02	Lepetit Spa	Teicoplanin derivatives
GB8531846D0 (en) *	1985-12-30	1986-02-05	Lepetit Spa	Antibiotic a 40926 mannosyl aglycon
GB8608809D0 (en) *	1986-04-11	1986-05-14	Lepetit Spa	Antibiotic
GR871488B (en) *	1986-10-10	1987-11-12	Lepetit Spa	New antibiotics
EP0273727A3 (de) *	1986-12-30	1990-01-17	Smithkline Beecham Corporation	Glykosilierte Glycopeptide
GB8701872D0 (en) *	1987-01-28	1987-03-04	Lepetit Spa	N15-alkyl & n15,n15-dialkyl derivatives
GB8704847D0 (en) *	1987-03-02	1987-04-08	Lepetit Spa	Substituted alkylamides of teicoplanin compounds
GB8711066D0 (en) *	1987-05-11	1987-06-17	Lepetit Spa	Teicoplanin derivatives
GB8715735D0 (en) *	1987-07-03	1987-08-12	Lepetit Spa	De-mannosyl teicoplanin derivatives
GB8720980D0 (en) *	1987-09-07	1987-10-14	Lepetit Spa	Derivatives
GB8726859D0 (en) *	1987-11-17	1987-12-23	Lepetit Spa	22-dechlorotei-coplanins
GB8802211D0 (en) *	1988-02-02	1988-03-02	Lepetit Spa	Teicoplanin hydrazides
GB8817053D0 (en) *	1988-07-18	1988-08-24	Lepetit Spa	Process for preparing n15 n15-dialkyl derivatives of teicoplanin compounds
GB8817052D0 (en) *	1988-07-18	1988-08-24	Lepetit Spa	Process for preparing n15-alkyl derivatives of teicoplanin compounds
GB8817397D0 (en) *	1988-07-21	1988-08-24	Lepetit Spa	N15-alkyl & n15 n15-di-alkyl derivatives of teicoplanin antibiotics carrying functional groups on alkyl side chain
GB8817736D0 (en) *	1988-07-26	1988-09-01	Lepetit Spa	New teicoplanin antibiotics
GB8827202D0 (en) *	1988-11-22	1988-12-29	Lepetit Spa	Process for preparing 63-carboxyamides of teicoplanin antibiotics
US5194424A (en) *	1988-12-27	1993-03-16	Gruppo Lepetit Spa	C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
US5500410A (en) *	1989-03-29	1996-03-19	Gruppo Lepetit S.P.A.	Substituted alkylamide derivatives of teicoplanin
US5185320A (en) *	1989-04-03	1993-02-09	Gruppo Lepetit S.P.A.	O56 -alkyl derivatives of aglycone and pseudo aglycones of teicoplanin
US4971753A (en) *	1989-06-23	1990-11-20	General Electric Company	Nuclear fuel element, and method of forming same
ES2110401T3 (es) *	1989-07-18	1998-02-16	Biosearch Italia Spa	Antibioticos pentapeptidicos derivados de dalbaheptidos.
EP0448940B1 (de) *	1990-03-28	1997-09-17	GRUPPO LEPETIT S.p.A.	Verfahren zur Herstellung von Mannosylteicoplaninderivaten und Mannosylteicoplaninaglykon
US5644025A (en) *	1990-12-10	1997-07-01	Gruppo Lepetit Spa	Tetrapeptides deriving from dalbaheptide antibiotics
US5438117A (en) *	1990-12-20	1995-08-01	Gruppo Lepetit S.P.A.	Hexapeptides deriving from aglucoteicoplanin and a process for preparing them
US5606036A (en) *	1991-03-27	1997-02-25	Gruppo Lepetit Spa	Antibiotic A 40926 ester derivatives
AU683881B2 (en) *	1993-05-19	1997-11-27	Vicuron Pharmaceuticals Inc.	Synthetic aglucodalbaheptide antibiotics

1991
- 1991-11-06 AT AT91919523T patent/ATE134379T1/de active
- 1991-11-06 EP EP91919523A patent/EP0560795B1/de not_active Expired - Lifetime
- 1991-11-06 HU HU931656A patent/HUT63860A/hu unknown
- 1991-11-06 WO PCT/EP1991/002097 patent/WO1992010516A1/en not_active Ceased
- 1991-11-06 JP JP3517354A patent/JPH06503306A/ja active Pending
- 1991-11-06 CA CA002095725A patent/CA2095725A1/en not_active Abandoned
- 1991-11-06 AU AU88651/91A patent/AU8865191A/en not_active Abandoned
- 1991-11-06 DE DE69117304T patent/DE69117304T2/de not_active Expired - Fee Related
- 1991-11-20 IL IL100101A patent/IL100101A0/xx unknown
- 1991-12-04 ZA ZA919554A patent/ZA919554B/xx unknown
- 1991-12-04 IE IE420891A patent/IE914208A1/en not_active Application Discontinuation
1992
- 1992-11-06 KR KR1019930701669A patent/KR930703357A/ko not_active Withdrawn
1997
- 1997-06-10 US US08/872,461 patent/US5869449A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5869449A (en)	1999-02-09
DE69117304D1 (de)	1996-03-28
EP0560795B1 (de)	1996-02-21
CA2095725A1 (en)	1992-06-06
IE914208A1 (en)	1992-06-17
HU9301656D0 (en)	1993-09-28
IL100101A0 (en)	1992-08-18
DE69117304T2 (de)	1996-08-29
AU8865191A (en)	1992-07-08
ZA919554B (en)	1992-10-28
JPH06503306A (ja)	1994-04-14
HUT63860A (en)	1993-10-28
EP0560795A1 (de)	1993-09-22
KR930703357A (ko)	1993-11-29
WO1992010516A1 (en)	1992-06-25

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