ATE107644T1 - Tetrahydroisochinolin-2-yl-derivate als thromboxan a2-antagonisten. - Google Patents

Tetrahydroisochinolin-2-yl-derivate als thromboxan a2-antagonisten.

Info

Publication number: ATE107644T1
Authority: AT; Austria
Prior art keywords: group; carbon atoms; linear carbon; thromboxane; antagonists
Prior art date: 1987-07-22

Application number

AT88306582T

Other languages

English (en)

Inventor

Andrew Derrick Gribble

Frythe

Original Assignee

Smith Kline French Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-22

Filing date

1988-07-19

Publication date

1994-07-15

1988-07-19 Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab

1994-07-15 Application granted granted Critical

1994-07-15 Publication of ATE107644T1 publication Critical patent/ATE107644T1/de

Links

239000005557 antagonist Substances 0.000 title abstract 2
DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 title abstract 2
-1 TETRAHYDROISOCHINOLINE-2-YL Chemical class 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000002015 acyclic group Chemical group 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Other In-Based Heterocyclic Compounds (AREA)

AT88306582T 1987-07-22 1988-07-19 Tetrahydroisochinolin-2-yl-derivate als thromboxan a2-antagonisten. ATE107644T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878717374A GB8717374D0 (en)	1987-07-22	1987-07-22	Pharmaceutically active compounds

Publications (1)

Publication Number	Publication Date
ATE107644T1 true ATE107644T1 (de)	1994-07-15

Family

ID=10621127

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88306582T ATE107644T1 (de)	1987-07-22	1988-07-19	Tetrahydroisochinolin-2-yl-derivate als thromboxan a2-antagonisten.

Country Status (11)

Country	Link
US (1)	US4866076A (de)
EP (1)	EP0300725B1 (de)
JP (1)	JPS6440461A (de)
AT (1)	ATE107644T1 (de)
AU (1)	AU608339B2 (de)
DE (1)	DE3850308T2 (de)
DK (1)	DK168010B1 (de)
ES (1)	ES2054811T3 (de)
GB (1)	GB8717374D0 (de)
PT (1)	PT88062B (de)
ZA (1)	ZA885241B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2071897A1 (en) *	1989-12-28	1991-06-29	Richard A. Glennon	Sigma receptor ligands and the use thereof
AU7177694A (en) *	1993-06-23	1995-01-17	Cambridge Neuroscience, Inc.	Sigma receptor ligands and the use thereof
US6025355A (en) *	1997-05-19	2000-02-15	Cambridge Neuroscience, Inc.	Pharmaceutically active compounds and methods of use
US6242198B1 (en)	1996-07-25	2001-06-05	Cambridge Neuroscience, Inc.	Methods of treatment of eye trauma and disorders
US6756389B2 (en) *	1996-08-09	2004-06-29	Cambridge Neuroscience, Inc.	Pharmaceutically active compounds and methods of use
DE19934272A1 (de) *	1999-07-21	2001-01-25	Bayer Ag	Neue antivirale Mittel
EP1283199A4 (de) *	2000-05-16	2003-12-17	Takeda Chemical Industries Ltd	Antagonisten des melanin-konzentrierenden hormons
MY133587A (en)	2002-05-29	2007-11-30	Glaxo Group Ltd	Aromatic sulfones and their medical use
DE20307130U1 (de) *	2003-04-30	2003-07-10	Techno-Grafica GmbH, 75236 Kämpfelbach	Aschesammler für Raucher
AR080375A1 (es)	2010-03-05	2012-04-04	Sanofi Aventis	Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida
ES2654143T3 (es) *	2012-10-02	2018-02-12	Gilead Sciences, Inc.	Inhibidores de desmetilasas de histonas
JP2017512804A (ja) *	2014-03-31	2017-05-25	ギリアードサイエンシーズ，インコーポレイテッド	ヒストン脱メチル化酵素の阻害剤

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3988339A (en) *	1974-02-08	1976-10-26	Smithkline Corporation	Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase
US4242346A (en) *	1979-12-19	1980-12-30	Smithkline Corporation	Bis-2N-alkylene tetrahydroisoquinoline compounds
DE3000377A1 (de) *	1980-01-07	1981-07-09	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US4315935A (en) *	1980-04-14	1982-02-16	Smithkline Corporation	N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolinolyl]disulfonylimides and antiallergic compositions and method of use
US4321254A (en) *	1980-09-26	1982-03-23	Smithkline Corporation	Antiallergic imidodisulfamides
US4350698A (en) *	1981-09-25	1982-09-21	Smithkline Corporation	Antiallergic imidosulfamides
DE3139970A1 (de) *	1981-10-08	1983-04-28	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
US4536510A (en) *	1983-07-22	1985-08-20	Smith Kline Beckman Corporation	Method of antagonizing the effects of thromboxane
GB8419658D0 (en) *	1984-08-01	1984-09-05	Wellcome Found	Nitrogen containing heterocyclic compounds
EP0194548A3 (de) *	1985-03-12	1988-08-17	Dr. Karl Thomae GmbH	Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3514696A1 (de) *	1985-04-24	1986-11-06	Bayer Ag, 5090 Leverkusen	N-indolylethyl-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung
NZ218115A (en) *	1985-11-18	1990-02-26	Shionogi & Co	Bicyclic sulphonamides and pharmaceutical compositions
WO1988003137A1 (en) *	1986-10-28	1988-05-05	Smith Kline & French Laboratories Limited	Tetrahydroisoquinolin-2-yl derivatives of carboxylic acids as thromboxane a2 antagonists
EP0277384A3 (de) *	1986-12-24	1990-05-23	Janssen Pharmaceutica N.V.	1H-Imidazol-5-Kohlensäurederivate

1987
- 1987-07-22 GB GB878717374A patent/GB8717374D0/en active Pending
1988
- 1988-07-18 DK DK400688A patent/DK168010B1/da not_active IP Right Cessation
- 1988-07-19 EP EP88306582A patent/EP0300725B1/de not_active Expired - Lifetime
- 1988-07-19 AT AT88306582T patent/ATE107644T1/de not_active IP Right Cessation
- 1988-07-19 ES ES88306582T patent/ES2054811T3/es not_active Expired - Lifetime
- 1988-07-19 AU AU19137/88A patent/AU608339B2/en not_active Ceased
- 1988-07-19 DE DE3850308T patent/DE3850308T2/de not_active Expired - Fee Related
- 1988-07-19 JP JP63180160A patent/JPS6440461A/ja active Pending
- 1988-07-20 ZA ZA885241A patent/ZA885241B/xx unknown
- 1988-07-21 PT PT88062A patent/PT88062B/pt not_active IP Right Cessation
- 1988-07-21 US US07/222,484 patent/US4866076A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT88062A (pt)	1989-06-30
AU1913788A (en)	1989-01-27
DE3850308D1 (de)	1994-07-28
PT88062B (pt)	1995-03-01
EP0300725B1 (de)	1994-06-22
EP0300725A1 (de)	1989-01-25
JPS6440461A (en)	1989-02-10
DK400688D0 (da)	1988-07-18
ES2054811T3 (es)	1994-08-16
DK400688A (da)	1989-01-23
GB8717374D0 (en)	1987-08-26
ZA885241B (en)	1989-06-28
US4866076A (en)	1989-09-12
DE3850308T2 (de)	1994-10-06
AU608339B2 (en)	1991-03-28
DK168010B1 (da)	1994-01-17

Legal Events

Date	Code	Title	Description
1995-02-15	UEP	Publication of translation of european patent specification
1996-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ES2058257T5 (es)	1998-11-01	Compuestos herbicidas.
FI892787A0 (fi)	1989-06-07	Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-indolyylialkyyli-4-(substituoitu pyridinyyli)piperatsiinien valmistamiseksi
FI102965B1 (fi)	1999-03-31	Kondensoituneet heterosykliset yhdisteet, niiden valmistus ja käyttö
MX173358B (es)	1994-02-23	Compuestos antibacterianos y procedimiento para obtenerlos
DE68906183D1 (de)	1993-06-03	2'-desoxy-5-fluoruridinderivate.
DE3850308D1 (de)	1994-07-28	Tetrahydroisochinolin-2-yl-Derivate als Thromboxan A2-Antagonisten.
DK351788A (da)	1988-06-24	Tetrahydroisoquinolin-2-ylderivater af carboxylsyrer som thromboxan-a2-antagonister
ES536402A0 (es)	1985-12-16	Un procedimiento para la preparacion de nuevos derivados de quinazolina e isoquinolina.
MX9202975A (es)	1992-07-01	Nuevos compuestos biciclicos y sus sales farmaceuticamente aceptables y procedimiento para su preparacion.
ATE84028T1 (de)	1993-01-15	Biologisch aktive verbindungen.
ES8801639A1 (es)	1988-02-16	Procedimiento para la obtencion de derivados del acido barbiturico
ES8602663A1 (es)	1985-12-01	Un procedimiento para preparar derivados de piridona.
DK430586A (da)	1987-03-12	Diphenyletherderivater
BG60248B2 (en)	1994-03-24	Process for the preparation of phenoxyethylamine derivatives
ES8609248A1 (es)	1986-07-16	Un procedimiento para la preparacion de un compuesto de 2- oxindol-1-carboxamida
ES2001420A6 (es)	1988-05-16	Procedimiento para la preparacion de derivados de naftaleno.
ES402749A1 (es)	1976-01-01	Un procedimiento para la preparacion de derivados de tieno-diacepina.
ES445339A1 (es)	1977-06-01	Un procedimiento para la preparacion de derivados pirrolidi-nicos.
FI882956L (fi)	1988-06-21	4-piperidyl-substituerade karboxylsyraderivat och foerfarande foer deras framstaellning.
MY104164A (en)	1994-02-28	Heterocyclic compounds.
JPS52102271A (en)	1977-08-27	Synthesis of novel benzophenone derivatives
FR2244516A1 (en)	1975-04-18	Bis-1,2-(4-phenyl-1-piperazinyl)ethane derivs - hypolipaemic, analgesic and anti-inflammatory agents
ES415405A1 (es)	1976-02-16	Procedimiento para la preparacion de derivados de feniletilamina