DK400688A - Tetrahydroisoquinolinforbindelser og farmaceutisk middel indeholdende disse - Google Patents

Tetrahydroisoquinolinforbindelser og farmaceutisk middel indeholdende disse

Info

Publication number: DK400688A
Authority: DK; Denmark
Prior art keywords: group; compounds; carbon atoms; linear carbon; co2h
Prior art date: 1987-07-22

Application number

DK400688A

Other languages

English (en)

Other versions

DK400688D0 (da

DK168010B1 (da

Inventor

Andrew Derrick Gribble

Original Assignee

Smith Kline French Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-22

Filing date

1988-07-18

Publication date

1989-01-23

1988-07-18 Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab

1988-07-18 Publication of DK400688D0 publication Critical patent/DK400688D0/da

1989-01-23 Publication of DK400688A publication Critical patent/DK400688A/da

1994-01-17 Application granted granted Critical

1994-01-17 Publication of DK168010B1 publication Critical patent/DK168010B1/da

Links

150000001875 compounds Chemical class 0.000 title abstract 3
239000005426 pharmaceutical component Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000002015 acyclic group Chemical group 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK400688A 1987-07-22 1988-07-18 Tetrahydroisoquinolinforbindelser og farmaceutisk middel indeholdende en saadan forbindelse DK168010B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8717374		1987-07-22
GB878717374A GB8717374D0 (en)	1987-07-22	1987-07-22	Pharmaceutically active compounds

Publications (3)

Publication Number	Publication Date
DK400688D0 DK400688D0 (da)	1988-07-18
DK400688A true DK400688A (da)	1989-01-23
DK168010B1 DK168010B1 (da)	1994-01-17

Family

ID=10621127

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK400688A DK168010B1 (da)	1987-07-22	1988-07-18	Tetrahydroisoquinolinforbindelser og farmaceutisk middel indeholdende en saadan forbindelse

Country Status (11)

Country	Link
US (1)	US4866076A (da)
EP (1)	EP0300725B1 (da)
JP (1)	JPS6440461A (da)
AT (1)	ATE107644T1 (da)
AU (1)	AU608339B2 (da)
DE (1)	DE3850308T2 (da)
DK (1)	DK168010B1 (da)
ES (1)	ES2054811T3 (da)
GB (1)	GB8717374D0 (da)
PT (1)	PT88062B (da)
ZA (1)	ZA885241B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2071897A1 (en) *	1989-12-28	1991-06-29	Richard A. Glennon	Sigma receptor ligands and the use thereof
ZA944513B (en) *	1993-06-23	1996-01-16	Cambridge Neuroscience Inc	Sigma receptor ligands
US6025355A (en) *	1997-05-19	2000-02-15	Cambridge Neuroscience, Inc.	Pharmaceutically active compounds and methods of use
US6242198B1 (en)	1996-07-25	2001-06-05	Cambridge Neuroscience, Inc.	Methods of treatment of eye trauma and disorders
US6756389B2 (en)	1996-08-09	2004-06-29	Cambridge Neuroscience, Inc.	Pharmaceutically active compounds and methods of use
DE19934272A1 (de) *	1999-07-21	2001-01-25	Bayer Ag	Neue antivirale Mittel
US7229986B2 (en)	2000-05-16	2007-06-12	Takeda Pharmaceutical Company Ltd.	Melanin-concentrating hormone antagonist
AR040126A1 (es)	2002-05-29	2005-03-16	Glaxo Group Ltd	Compuesto de fenilsulfonilo, composicion farmaceutica que lo comprende y su uso para la elaboracion de un medicamento
DE20307130U1 (de) *	2003-04-30	2003-07-10	Techno-Grafica GmbH, 75236 Kämpfelbach	Aschesammler für Raucher
AR080375A1 (es)	2010-03-05	2012-04-04	Sanofi Aventis	Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida
DK2903968T3 (da) *	2012-10-02	2017-01-30	Gilead Sciences Inc	Inhibitorer af histon-demethylaser
CA2943824A1 (en) *	2014-03-31	2015-10-08	Gilead Sciences, Inc.	Inhibitors of histone demethylases

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3988339A (en) *	1974-02-08	1976-10-26	Smithkline Corporation	Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase
US4242346A (en) *	1979-12-19	1980-12-30	Smithkline Corporation	Bis-2N-alkylene tetrahydroisoquinoline compounds
DE3000377A1 (de) *	1980-01-07	1981-07-09	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US4315935A (en) *	1980-04-14	1982-02-16	Smithkline Corporation	N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolinolyl]disulfonylimides and antiallergic compositions and method of use
US4321254A (en) *	1980-09-26	1982-03-23	Smithkline Corporation	Antiallergic imidodisulfamides
US4350698A (en) *	1981-09-25	1982-09-21	Smithkline Corporation	Antiallergic imidosulfamides
DE3139970A1 (de) *	1981-10-08	1983-04-28	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
US4536510A (en) *	1983-07-22	1985-08-20	Smith Kline Beckman Corporation	Method of antagonizing the effects of thromboxane
GB8419658D0 (en) *	1984-08-01	1984-09-05	Wellcome Found	Nitrogen containing heterocyclic compounds
EP0194548A3 (de) *	1985-03-12	1988-08-17	Dr. Karl Thomae GmbH	Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3514696A1 (de) *	1985-04-24	1986-11-06	Bayer Ag, 5090 Leverkusen	N-indolylethyl-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung
CA1278577C (en) *	1985-11-18	1991-01-02	Tatsuo Tsuri	Bicyclic sulfonamide derivatives
AU600992B2 (en) *	1986-10-28	1990-08-30	Smith Kline & French Laboratories Limited	Tetrahydroisoquinolin-2-yl derivatives of carboxylic acids
EP0277384A3 (en) *	1986-12-24	1990-05-23	Janssen Pharmaceutica N.V.	1h-imidazole-5-carboxylic acid derivatives

1987
- 1987-07-22 GB GB878717374A patent/GB8717374D0/en active Pending
1988
- 1988-07-18 DK DK400688A patent/DK168010B1/da not_active IP Right Cessation
- 1988-07-19 DE DE3850308T patent/DE3850308T2/de not_active Expired - Fee Related
- 1988-07-19 AT AT88306582T patent/ATE107644T1/de not_active IP Right Cessation
- 1988-07-19 EP EP88306582A patent/EP0300725B1/en not_active Expired - Lifetime
- 1988-07-19 AU AU19137/88A patent/AU608339B2/en not_active Ceased
- 1988-07-19 ES ES88306582T patent/ES2054811T3/es not_active Expired - Lifetime
- 1988-07-19 JP JP63180160A patent/JPS6440461A/ja active Pending
- 1988-07-20 ZA ZA885241A patent/ZA885241B/xx unknown
- 1988-07-21 PT PT88062A patent/PT88062B/pt not_active IP Right Cessation
- 1988-07-21 US US07/222,484 patent/US4866076A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
GB8717374D0 (en)	1987-08-26
DK400688D0 (da)	1988-07-18
US4866076A (en)	1989-09-12
JPS6440461A (en)	1989-02-10
EP0300725B1 (en)	1994-06-22
DK168010B1 (da)	1994-01-17
PT88062B (pt)	1995-03-01
ZA885241B (en)	1989-06-28
PT88062A (pt)	1989-06-30
ES2054811T3 (es)	1994-08-16
EP0300725A1 (en)	1989-01-25
DE3850308T2 (de)	1994-10-06
ATE107644T1 (de)	1994-07-15
DE3850308D1 (de)	1994-07-28
AU1913788A (en)	1989-01-27
AU608339B2 (en)	1991-03-28

Legal Events

Date	Code	Title	Description
1994-01-17	B1	Patent granted (law 1993)
1996-03-25	PBP	Patent lapsed

Publication	Publication Date	Title
DK496089A (da)	1990-04-11	Biologisk aktive phenylalkansyreforbindelser og fremgangsmaade til fremstilling deraf
DK159308C (da)	1991-03-11	4-aminoquinolinderivater, farmaceutisk middel der indeholder disse samt anvendelse af disse til fremstilling af et laegemiddel
FI892787A0 (fi)	1989-06-07	Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-indolyylialkyyli-4-(substituoitu pyridinyyli)piperatsiinien valmistamiseksi
DK400688D0 (da)	1988-07-18	Tetrahydroisoquinolinforbindelser og farmaceutisk middel indeholdende disse
DK351788A (da)	1988-06-24	Tetrahydroisoquinolin-2-ylderivater af carboxylsyrer som thromboxan-a2-antagonister
AR217410A1 (es)	1980-03-31	Nuevos compuestos quimicos industriales de propiedades fungicidas constituidos por derivados de(1-fenil-2-triazolil-etil)-eteres,composiciones fungicidas a base de los mismos y procedimiento para la produccion de dichos compuestos
ES545728A0 (es)	1987-08-01	Procedimiento para preparar 5h,11h-pirrolo (2,1c)-(1,4)ben- zoxazepinas sustituidas en posicion 11
ES536402A0 (es)	1985-12-16	Un procedimiento para la preparacion de nuevos derivados de quinazolina e isoquinolina.
DK196688A (da)	1988-10-29	Bicykliske forbindelser og fremgangsmaade til fremstilling deraf
ATE84028T1 (de)	1993-01-15	Biologisch aktive verbindungen.
ES522418A0 (es)	1984-08-16	Un procedimiento para preparar -15-desoxiespergualina.
DK430586D0 (da)	1986-09-09	Diphenyletherderivater
ES8602663A1 (es)	1985-12-01	Un procedimiento para preparar derivados de piridona.
DE58902234D1 (de)	1992-10-15	Alpha-hydroxy-azolylethyloxirane und diese enthaltende fungizide.
ES8305350A1 (es)	1983-04-01	"un procedimiento para preparar derivados de dialcohilpirazol".
DK553482A (da)	1983-06-15	Fremgangsmaade til fremstilling af n,n-disubstituerede alkenamider og phenylalkenamider
ES535795A0 (es)	1985-08-01	Un procedimiento para preparar nuevas 5-aminometil-imidazol-1-il-1,3-dialquil-1h-pirazol-4-il-aroil-metanonas
TH2113A (th)	1985-01-02	สารประกอบแอโรมาติค
JPS52102271A (en)	1977-08-27	Synthesis of novel benzophenone derivatives