DK351788A - Tetrahydroisoquinolin-2-ylderivater af carboxylsyrer som thromboxan-a2-antagonister - Google Patents

Tetrahydroisoquinolin-2-ylderivater af carboxylsyrer som thromboxan-a2-antagonister

Info

Publication number: DK351788A
Authority: DK; Denmark
Prior art keywords: antagonists; group; tetrahydroisoquinolin; derivatives; compounds
Prior art date: 1986-10-28

Application number

DK351788A

Other languages

English (en)

Other versions

DK160550C (da

DK160550B (da

DK351788D0 (da

Inventor

John Graham Durant

Andrew Derrick Gribble

Robert Anthony Slater

Original Assignee

Smith Kline French Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-10-28

Filing date

1988-06-24

Publication date

1988-06-24

1986-10-28 Priority claimed from GB868625739A external-priority patent/GB8625739D0/en

1987-06-30 Priority claimed from GB878715274A external-priority patent/GB8715274D0/en

1988-06-24 Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab

1988-06-24 Publication of DK351788A publication Critical patent/DK351788A/da

1988-06-24 Publication of DK351788D0 publication Critical patent/DK351788D0/da

1991-03-25 Publication of DK160550B publication Critical patent/DK160550B/da

1991-09-09 Application granted granted Critical

1991-09-09 Publication of DK160550C publication Critical patent/DK160550C/da

Links

239000005557 antagonist Substances 0.000 title abstract 3
150000001735 carboxylic acids Chemical class 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
-1 Tetrahydroisoquinolin-2-yl Chemical class 0.000 abstract 1
125000002015 acyclic group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000008177 pharmaceutical agent Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

DK351788A 1986-10-28 1988-06-24 Tetrahydroisoquinolin-2-ylderivater af carboxylsyrer som thromboxan-a2-antagonister, deres anvendelse i et medicinsk praeparat og farmaceutisk middel indeholdende dem DK160550C (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
GB868625739A GB8625739D0 (en)	1986-10-28	1986-10-28	Pharmaceutically active compounds
GB8625739		1986-10-28
GB878715274A GB8715274D0 (en)	1987-06-30	1987-06-30	Pharmaceutically active compounds
GB8715274		1987-06-30
PCT/GB1987/000757 WO1988003137A1 (en)	1986-10-28	1987-10-26	Tetrahydroisoquinolin-2-yl derivatives of carboxylic acids as thromboxane a2 antagonists
GB8700757		1987-10-26

Publications (4)

Publication Number	Publication Date
DK351788A true DK351788A (da)	1988-06-24
DK351788D0 DK351788D0 (da)	1988-06-24
DK160550B DK160550B (da)	1991-03-25
DK160550C DK160550C (da)	1991-09-09

Family

ID=26291459

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK351788A DK160550C (da)	1986-10-28	1988-06-24	Tetrahydroisoquinolin-2-ylderivater af carboxylsyrer som thromboxan-a2-antagonister, deres anvendelse i et medicinsk praeparat og farmaceutisk middel indeholdende dem

Country Status (11)

Country	Link
US (1)	US4812573A (da)
EP (1)	EP0266949B1 (da)
JP (1)	JPH01503233A (da)
AU (1)	AU600992B2 (da)
CA (1)	CA1296011C (da)
DE (1)	DE3766472D1 (da)
DK (1)	DK160550C (da)
ES (1)	ES2036213T3 (da)
GR (1)	GR3001267T3 (da)
PT (1)	PT86000B (da)
WO (1)	WO1988003137A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2613222B1 (fr) *	1987-04-03	1991-06-14	Guigon Nadine	Composition pour les soins locaux de l'epiderme, notamment du cuir chevelu
GB8717374D0 (en) *	1987-07-22	1987-08-26	Smith Kline French Lab	Pharmaceutically active compounds
HU198458B (en) *	1987-12-30	1989-10-30	Chinoin Gyogyszer Es Vegyeszet	Process for producing 2-aminoisoquinoline derivatives and pharmaceutical compositions comprising these compounds
US6137002A (en) *	1993-07-22	2000-10-24	Eli Lilly And Company	Glycoprotein IIb/IIIa antagonists
TW397812B (en) *	1995-02-11	2000-07-11	Astra Ab	Bicyclic isothiourea derivatives useful in therapy
DZ2446A1 (fr) *	1997-03-18	2003-01-11	Smithkline Beecham Plc	Nouveaux composés
WO1999016752A1 (en) *	1997-09-30	1999-04-08	Molecular Designs International, Inc.	β3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USING
DE19934272A1 (de) *	1999-07-21	2001-01-25	Bayer Ag	Neue antivirale Mittel
MXPA02006474A (es)	1999-12-28	2002-11-29	Eisai Co Ltd	Compuestos heterociclicos que contienen sulfonamida.
US6593341B2 (en)	2001-03-29	2003-07-15	Molecular Design International, Inc.	β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
AR038420A1 (es)	2002-02-15	2005-01-12	Glaxo Group Ltd	Compuesto de amida, procedimiento para la preparacion del mismo, su uso para la fabricacion de un medicamento y composicion farmaceutica que lo comprende
MY133587A (en)	2002-05-29	2007-11-30	Glaxo Group Ltd	Aromatic sulfones and their medical use
US6596734B1 (en)	2002-10-11	2003-07-22	Molecular Design International, Inc.	Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists
AU2007281746B2 (en) *	2006-08-07	2013-05-09	Janssen Pharmaceutica, N.V.	Process for the preparation of substituted-1,2,3,4-tetrahydroisoquinoline derivates
MX2011001887A (es) *	2008-08-22	2011-04-04	Baxter Int	Derivados de bencil carbonato polimericos.
EP3828172A1 (en)	2009-05-01	2021-06-02	Aerie Pharmaceuticals, Inc.	Dual mechanism inhibitors for the treatment of disease
CN109640966A (zh)	2016-08-31	2019-04-16	爱瑞制药公司	眼用组合物
US9840468B1 (en) *	2016-12-30	2017-12-12	Aerie Pharmaceuticals, Inc.	Methods for the preparation of 6-aminoisoquinoline
WO2018183911A1 (en)	2017-03-31	2018-10-04	Aerie Pharmaceuticals, Inc.	Aryl cyclopropyl-amino-isoquinolinyl amide compounds
US11427563B2 (en)	2018-09-14	2022-08-30	Aerie Pharmaceuticals, Inc.	Aryl cyclopropyl-amino-isoquinolinyl amide compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
USRE28034E (en) *	1972-12-14	1974-06-04		Alkylsulfinylalkyl- and sulfonyl- alkyl-i,z,j,x.tetrahydroisoqijinolines
DE3000377A1 (de) *	1980-01-07	1981-07-09	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US4321254A (en) *	1980-09-26	1982-03-23	Smithkline Corporation	Antiallergic imidodisulfamides
US4350698A (en) *	1981-09-25	1982-09-21	Smithkline Corporation	Antiallergic imidosulfamides
US4536510A (en) *	1983-07-22	1985-08-20	Smith Kline Beckman Corporation	Method of antagonizing the effects of thromboxane

1987
- 1987-10-26 ES ES198787309454T patent/ES2036213T3/es not_active Expired - Lifetime
- 1987-10-26 DE DE8787309454T patent/DE3766472D1/de not_active Expired - Lifetime
- 1987-10-26 EP EP87309454A patent/EP0266949B1/en not_active Expired - Lifetime
- 1987-10-26 AU AU81081/87A patent/AU600992B2/en not_active Ceased
- 1987-10-26 WO PCT/GB1987/000757 patent/WO1988003137A1/en not_active Ceased
- 1987-10-26 JP JP62501623A patent/JPH01503233A/ja active Pending
- 1987-10-27 CA CA000550294A patent/CA1296011C/en not_active Expired - Lifetime
- 1987-10-27 PT PT86000A patent/PT86000B/pt not_active IP Right Cessation
1988
- 1988-06-24 DK DK351788A patent/DK160550C/da not_active IP Right Cessation
- 1988-06-27 US US07/212,095 patent/US4812573A/en not_active Expired - Fee Related
1990
- 1990-12-31 GR GR90401225T patent/GR3001267T3/el unknown

Also Published As

Publication number	Publication date
AU8108187A (en)	1988-05-25
EP0266949A1 (en)	1988-05-11
CA1296011C (en)	1992-02-18
DE3766472D1 (de)	1991-01-10
EP0266949B1 (en)	1990-11-28
ES2036213T3 (es)	1993-05-16
JPH01503233A (ja)	1989-11-02
DK160550C (da)	1991-09-09
PT86000A (en)	1987-11-01
US4812573A (en)	1989-03-14
DK160550B (da)	1991-03-25
GR3001267T3 (en)	1992-08-25
DK351788D0 (da)	1988-06-24
WO1988003137A1 (en)	1988-05-05
PT86000B (pt)	1990-08-31
AU600992B2 (en)	1990-08-30

Legal Events

Date	Code	Title	Description
1995-06-26	PBP	Patent lapsed

Publication	Publication Date	Title
NO174296C (no)	1994-04-13	Analogifremgangsmåte til fremstilling av terapeutisk aktive 1-indolylalkyl-4-(substituert-pyridinyl)piperaziner
MX9206939A (es)	1993-06-01	Derivados de piperazina, procedimiento para su preparacion y composicion farmaceutica que los comprende
DK306586A (da)	1986-12-29	Pyridoncarboxylsyre-derivater og fremgangsmaade til fremstilling deraf
NO934536D0 (no)	1993-12-10	Fenoksy- og fenoksyalkyl-pepiridiner som antivirale midler
NZ503912A (en)	2002-09-27	Piperidinylaminomethyl trifluoromethyl cyclic ether compounds and their use as substance P antagonists
ES2036213T3 (es)	1993-05-16	Procedimiento para preparar derivados tetrahidroisoquinolin-1-ilicos de acidos carboxilicos.
ES2078267T3 (es)	1995-12-16	H-heteroaril-purin-6-aminas, un procedimiento para su preparacion y su uso como medicamentos.
DK217281A (da)	1981-11-20	Fremgangsmaade til fremstilling af 4-hydroxy-3-quinolincarboxylsyrederivater
ES2039221T3 (es)	1996-07-16	Procedimiento para producir derivados de piridazinona.
DE3850308D1 (de)	1994-07-28	Tetrahydroisochinolin-2-yl-Derivate als Thromboxan A2-Antagonisten.
DK138488A (da)	1988-03-14	Imidazolderivater
SE7605819L (sv)	1976-11-25	Nya propargyl-2-fenylaminoimidazolin-(2), dess syraadditionssalter, lekemedel innehallande dessa och forfarande for framstellning derav
ES479832A1 (es)	1979-11-16	Un procedimiento para preparar mercaptoacilaminoacidos sus- tituidos con halageno.
DK0573464T3 (da)	1997-09-01	Fremgangsmåde til fremstilling af trans-piperidin-2,5-dicarboxylater
DK447284A (da)	1984-11-20	Aminoderivater af 2-(n-(2,2,5,5-tetramethyl-3-pyrrolin-3-carbonyl)),deres fremstilling og anvendelse
DK149270C (da)	1986-08-25	Analogifremgangsmaade til fremstilling af beta-carbolin-3-carboxylsyrederivater
DK146688C (da)	1984-05-21	Analogifremgangsmaade til fremstilling af substituerede 2-phenylamino-imidazoliner-(2)
SE7812371L (sv)	1979-06-02	Forfarande for framstellning av fenoxialkanolaminderivat
PT92494A (pt)	1990-06-29	Processo para a preparacao de novos derivados do indol
ES421767A2 (es)	1977-07-01	Un procedimiento para la preparacion de acidos 5-sulfamil- benzoicos sustituidos en la posicion 2.
ES528460A0 (es)	1985-10-01	Procedimiento de preparacion de nuevos deridados de alfa-etibenzol con un grupo amino propanolico sustituido y sus sales de adicion acidas y amonicas cuaternarias.
SE8401064L (sv)	1984-08-29	Nya isoxazoler och forfarande for framstellning derav
DK316986A (da)	1987-01-06	Kemiske forbindelser, som er phosphodiesterase type iii inhibitorer
DK542183D0 (da)	1983-11-25	Fremgangsmade til fremstilling af acridanonderivater
FI854343A0 (fi)	1985-11-05	Foerfarande foer framstaellning av 3-amino-2,3-dihydro-1-benzoxepinfoereningar.