ATE107649T1 - Camptothecin-derivate und verfahren zu ihrer herstellung. - Google Patents

Camptothecin-derivate und verfahren zu ihrer herstellung.

Info

Publication number: ATE107649T1
Authority: AT; Austria
Prior art keywords: group; lower alkyl; phenyl; camptothecin derivatives; lower alkoxy
Prior art date: 1987-06-25

Application number

AT88110110T

Other languages

English (en)

Inventor

Seigo Sawada

Kenichiro Nokata

Satoru Okajima

Hisako Nagai

Takashi Yaegashi

Kenichi Tezuka

Tadashi Miyasaka

Original Assignee

Yakult Honsha Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-25

Filing date

1988-06-24

Publication date

1994-07-15

1988-06-24 Application filed by Yakult Honsha Kk filed Critical Yakult Honsha Kk

1994-07-15 Application granted granted Critical

1994-07-15 Publication of ATE107649T1 publication Critical patent/ATE107649T1/de

Links

VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000006702 (C1-C18) alkyl group Chemical group 0.000 abstract 1
MYQKIWCVEPUPIL-QFIPXVFZSA-N 7-ethylcamptothecin Chemical compound C1=CC=C2C(CC)=C(CN3C(C4=C([C@@](C(=O)OC4)(O)CC)C=C33)=O)C3=NC2=C1 MYQKIWCVEPUPIL-QFIPXVFZSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000004442 acylamino group Chemical group 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000000490 cinnamyl group Chemical group C(C=CC1=CC=CC=C1)* 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
-1 nitro, amino Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT88110110T 1987-06-25 1988-06-24 Camptothecin-derivate und verfahren zu ihrer herstellung. ATE107649T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP15649587		1987-06-25

Publications (1)

Publication Number	Publication Date
ATE107649T1 true ATE107649T1 (de)	1994-07-15

Family

ID=15629001

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88110110T ATE107649T1 (de)	1987-06-25	1988-06-24	Camptothecin-derivate und verfahren zu ihrer herstellung.

Country Status (7)

Country	Link
US (1)	US4914205A (de)
EP (1)	EP0296612B1 (de)
KR (1)	KR960004531B1 (de)
AT (1)	ATE107649T1 (de)
CA (1)	CA1332413C (de)
DE (1)	DE3850306T2 (de)
ES (1)	ES2058185T3 (de)

Families Citing this family (51)

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Publication number	Priority date	Publication date	Assignee	Title
US5364858A (en) *	1987-03-31	1994-11-15	Research Triangle Institute	Camptothecin analogs as potent inhibitors of topoisomerase I
US5244903A (en) *	1987-03-31	1993-09-14	Research Triangle Institute	Camptothecin analogs as potent inhibitors of topoisomerase I
US5227380A (en) *	1987-03-31	1993-07-13	Research Triangle Institute	Pharmaceutical compositions and methods employing camptothecins
US5122526A (en) *	1987-03-31	1992-06-16	Research Triangle Institute	Camptothecin and analogs thereof and pharmaceutical compositions and method using them
US5053512A (en) *	1987-04-14	1991-10-01	Research Triangle Institute	Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US5106742A (en) *	1987-03-31	1992-04-21	Wall Monroe E	Camptothecin analogs as potent inhibitors of topoisomerase I
US5122606A (en) *	1987-04-14	1992-06-16	Research Triangle Institute	10,11-methylenedioxy camptothecins
US5049668A (en) *	1989-09-15	1991-09-17	Research Triangle Institute	10,11-methylenedioxy-20(RS)-camptothecin analogs
US5340817A (en) *	1987-04-14	1994-08-23	Research Triangle Institute	Method of treating tumors with anti-tumor effective camptothecin compounds
US5180722A (en) *	1987-04-14	1993-01-19	Research Triangle Institute	10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
WO1991004260A2 (en) *	1989-09-15	1991-04-04	Research Triangle Institute	10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs
US5552154A (en) *	1989-11-06	1996-09-03	The Stehlin Foundation For Cancer Research	Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5225404A (en) *	1989-11-06	1993-07-06	New York University	Methods of treating colon tumors with tumor-inhibiting camptothecin compounds
US5883255A (en) *	1990-10-31	1999-03-16	Smithkline Beecham Corporation	Substituted indolizino 1,2-b!quinolinones
US6080751A (en) *	1992-01-14	2000-06-27	The Stehlin Foundation For Cancer Research	Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US5391745A (en) *	1992-07-23	1995-02-21	Sloan-Kettering Institute For Cancer Research	Methods of preparation of camptothecin analogs
US5446047A (en) *	1992-07-23	1995-08-29	Sloan-Kettering Institute For Cancer Research	Camptothecin analogues
ZA936580B (en) *	1992-09-08	1994-08-01	Smithkline Beecham Corp	Process for preparing certain pyrrolo (3 4-b)quinolines certain 1H-pyrano(3' 4':6,7)indolizino(1 2-b)quinolin-3 14(4H 12H)-diones and certain 8-methyl-7-(oxopropyl)-idolizino(1 2-b)quinolin-9(11H)-ones
US5352789A (en) *	1993-02-25	1994-10-04	The Stehlin Foundation For Cancer Research	Methods for purifying camptothecin compounds
US5527913A (en) *	1993-02-25	1996-06-18	The Stehlin Foundation For Cancer Research	Methods for purifying camptothecin compounds
WO1994025465A1 (en) *	1993-05-03	1994-11-10	Smithkline Beecham Corporation	SUBSTITUTED METHYLENEDIOXY[3',4':6,7]INDOLIZINO-[1,2-b]QUINOLINONES
US5447936A (en) *	1993-12-22	1995-09-05	Bionumerik Pharmaceuticals, Inc.	Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof
US5468754A (en) *	1994-04-19	1995-11-21	Bionumerik Pharmaceuticals, Inc.	11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof
US5604233A (en) *	1994-04-28	1997-02-18	Bionumerik Pharmaceuticals, Inc.	Lactone stable formulation of 7-ethyl camptothecin and methods for uses thereof
US5597829A (en) *	1994-05-09	1997-01-28	Bionumerik Pharmaceuticals, Inc.	Lactone stable formulation of camptothecin and methods for uses thereof
IT1269862B (it) *	1994-05-30	1997-04-15	Indena Spa	Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono
US5646159A (en) *	1994-07-20	1997-07-08	Research Triangle Institute	Water-soluble esters of camptothecin compounds
JPH0873461A (ja) *	1994-09-06	1996-03-19	Yakult Honsha Co Ltd	新規なカンプトテシン誘導体、その製造法および抗腫瘍剤
US5614529A (en) *	1994-09-22	1997-03-25	Research Triangle Institute	Inhibition of plasmodia parasites by camptothecin compounds
EP0835303A4 (de) *	1995-06-07	2000-09-13	Univ Jefferson	Anti-pilz agenzien und methoden zu deren identifizierung und verwendung
AU7732996A (en) *	1995-11-22	1997-06-11	Research Triangle Institute	Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties
US6096336A (en) *	1996-01-30	2000-08-01	The Stehlin Foundation For Cancer Research	Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US5731316A (en)	1996-01-30	1998-03-24	The Stehlin Foundation For Cancer Research	Derivatives of camptothecin and methods of treating cancer using these derivatives
US6407118B1 (en)	1996-01-30	2002-06-18	The Stehlin Foundation For Cancer Research	Derivatives of camptothecin and methods of treating cancer using these derivatives
JP4094710B2 (ja)	1997-11-06	2008-06-04	株式会社ヤクルト本社	新規なカンプトテシン誘導体
HUP0103314A3 (en) *	1998-08-05	2002-07-29	Aventis Pharma Sa	Use of camptothecin derivatives, with reduced gastrointestinal toxicity
FR2792937B1 (fr)	1999-04-27	2001-08-10	Cemaf	NOUVEAUX DERIVES DE PYRROLO-(3,4-b) QUINOLEINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENT
US6228855B1 (en)	1999-08-03	2001-05-08	The Stehlin Foundation For Cancer Research	Aromatic esters of camptothecins and methods to treat cancers
US6352996B1 (en)	1999-08-03	2002-03-05	The Stehlin Foundation For Cancer Research	Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
AU775373B2 (en)	1999-10-01	2004-07-29	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CA2401191C (en)	2000-02-28	2006-05-02	Aventis Pharma S.A.	A composition comprising camptothecin and a pyrimidine derivative for the treatment of cancer
US6545010B2 (en)	2000-03-17	2003-04-08	Aventis Pharma S.A.	Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer
US6548488B2 (en)	2000-03-17	2003-04-15	Aventis Pharma S.A.	Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer
US6486320B2 (en)	2000-09-15	2002-11-26	Aventis Pharma S.A.	Preparation of camptothecin and of its derivatives
AU1602902A (en)	2000-10-27	2002-05-06	Aventis Pharma Sa	A combination comprising camptothecin and a stilbene derivative for the treatment of cancer
US6608076B1 (en)	2002-05-16	2003-08-19	Enzon, Inc.	Camptothecin derivatives and polymeric conjugates thereof
CZ299329B6 (cs) *	2003-08-26	2008-06-18	Pliva-Lachema A.S.	Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs) *	2003-12-16	2008-09-10	Pliva-Lachema A. S.	Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
US20090104254A1 (en)	2004-12-22	2009-04-23	Rutgers, The State University Of New Jersey	Controlled Release Hydrogels
WO2012050591A1 (en)	2010-10-15	2012-04-19	Rutgers, The State University Of New Jersey	Hydrogel formulation for dermal and ocular delivery
AU2007232206B2 (en)	2006-03-30	2013-04-04	Drais Pharmaceuticals, Inc.	Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US32518A (en) *		1861-06-11		Improvement in city railroads
JPS5198300A (en) *	1975-02-20	1976-08-30		Kanputoteshin oyobi sonoruijitaino seizoho
DE2534601C2 (de) *	1975-08-02	1987-01-22	Basf Ag, 6700 Ludwigshafen	Verfahren zur Herstellung von Camptothecin und Camptothecin-Derivaten
US4399282A (en)	1979-07-10	1983-08-16	Kabushiki Kaisha Yakult Honsha	Camptothecin derivatives
JPS58154582A (ja) *	1982-03-10	1983-09-14	Yakult Honsha Co Ltd	新規なカンプトテシン誘導体およびその製造法

1988
- 1988-06-23 CA CA000570315A patent/CA1332413C/en not_active Expired - Fee Related
- 1988-06-24 US US07/210,918 patent/US4914205A/en not_active Expired - Lifetime
- 1988-06-24 DE DE3850306T patent/DE3850306T2/de not_active Expired - Fee Related
- 1988-06-24 ES ES88110110T patent/ES2058185T3/es not_active Expired - Lifetime
- 1988-06-24 AT AT88110110T patent/ATE107649T1/de not_active IP Right Cessation
- 1988-06-24 EP EP88110110A patent/EP0296612B1/de not_active Expired - Lifetime
- 1988-06-25 KR KR1019880007708A patent/KR960004531B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR960004531B1 (ko)	1996-04-06
ES2058185T3 (es)	1994-11-01
KR890000485A (ko)	1989-03-15
DE3850306D1 (de)	1994-07-28
EP0296612B1 (de)	1994-06-22
DE3850306T2 (de)	1994-10-06
CA1332413C (en)	1994-10-11
US4914205A (en)	1990-04-03
EP0296612A1 (de)	1988-12-28

Legal Events

Date	Code	Title	Description
1995-02-15	UEP	Publication of translation of european patent specification
2004-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE107649T1 (de)	1994-07-15	Camptothecin-derivate und verfahren zu ihrer herstellung.
ATE89559T1 (de)	1993-06-15	Camptothecin-derivate und verfahren zu ihrer herstellung.
ATE124695T1 (de)	1995-07-15	Kondensierte heterocyclische verbindungen, ihre herstellung und verwendung.
DE3767672D1 (de)	1991-02-28	Chinazolinonderivat und verfahren zu seiner herstellung.
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DE60124692D1 (de)	2007-01-04	Verfahren zur herstellung von optisch-aktiven sulfoxid-derivaten
DE3867403D1 (de)	1992-02-13	L-dopa-derivate oder ihre saeureadditionssalze, verfahren zu ihrer herstellung und ihre verwendung.
AT379800B (de)	1986-02-25	Verfahren zur herstellung von neuen 2-oxazetidin-derivaten
ATE194341T1 (de)	2000-07-15	Verfahren zur herstellng von cyano- methoxyiminomethylderivaten
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DE3864707D1 (de)	1991-10-17	Benzoxazin-derivate und verfahren zu ihrer herstellung.
ATE113594T1 (de)	1994-11-15	Verfahren zur herstellung von sulfonylharnstoff- derivaten.
HU903266D0 (en)	1990-10-28	Process for producing amine-derivatives and pharmaceutical preparatives containing these compounds as active substance
EP0726269A4 (de)	1997-01-22	Quinolincarbonsäurederivat une seine salze
ATE36318T1 (de)	1988-08-15	Verfahren zur herstellung von azetidinderivaten und zwischenprodukte.
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DE3777464D1 (de)	1992-04-23	Fluorine enthaltende vitamin-d3-derivate und verfahren zu ihrer herstellung.
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ES8801652A1 (es)	1988-02-16	Un procedimiento para la preparacion de un derivado de tiazolidina.
DE60310473D1 (de)	2007-02-01	Verfahren zur Herstellung von 1,2,4-Benzothiadiazin-1,1-Dioxid Derivate
HU913055D0 (en)	1992-01-28	An improved method for producing 4-methyl-sulfonyl-benzoic acid derivatives and their intermediate products
ATE128467T1 (de)	1995-10-15	Verfahren zur herstellung von carbamatderivaten des lankacidines.
ES8802300A1 (es)	1987-05-01	Un metodo para preparar derivados de 3-ariloxiazetidincarboxamida
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