ATE107665T1 - Proteaseresistenter pdgf und dessen verwendungen. - Google Patents

Proteaseresistenter pdgf und dessen verwendungen.

Info

Publication number: ATE107665T1
Authority: AT; Austria
Prior art keywords: pdgf; polypeptides; proteins; chain; protease resistant
Prior art date: 1990-07-23

Application number

AT91913764T

Other languages

English (en)

Inventor

Mark J Murray

Original Assignee

Zymogenetics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-23

Filing date

1991-07-22

Publication date

1994-07-15

1991-07-22 Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc

1994-07-15 Application granted granted Critical

1994-07-15 Publication of ATE107665T1 publication Critical patent/ATE107665T1/de

Links

108091005804 Peptidases Proteins 0.000 title 1
239000004365 Protease Substances 0.000 title 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title 1
229920001184 polypeptide Polymers 0.000 abstract 4
102000004196 processed proteins & peptides Human genes 0.000 abstract 4
108090000765 processed proteins & peptides Proteins 0.000 abstract 4
102000004169 proteins and genes Human genes 0.000 abstract 3
108090000623 proteins and genes Proteins 0.000 abstract 3
239000004472 Lysine Substances 0.000 abstract 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
206010052428 Wound Diseases 0.000 abstract 1
208000027418 Wounds and injury Diseases 0.000 abstract 1
125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 1
239000006143 cell culture medium Substances 0.000 abstract 1
210000004748 cultured cell Anatomy 0.000 abstract 1
230000037430 deletion Effects 0.000 abstract 1
238000012217 deletion Methods 0.000 abstract 1
230000035876 healing Effects 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/49—Platelet-derived growth factor [PDGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Dermatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Materials For Medical Uses (AREA)
Enzymes And Modification Thereof (AREA)

AT91913764T 1990-07-23 1991-07-22 Proteaseresistenter pdgf und dessen verwendungen. ATE107665T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US55721990A	1990-07-23	1990-07-23

Publications (1)

Publication Number	Publication Date
ATE107665T1 true ATE107665T1 (de)	1994-07-15

Family

ID=24224518

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91913764T ATE107665T1 (de)	1990-07-23	1991-07-22	Proteaseresistenter pdgf und dessen verwendungen.

Country Status (10)

Country	Link
US (2)	US5895755A (de)
EP (1)	EP0547064B1 (de)
JP (1)	JP2823690B2 (de)
AT (1)	ATE107665T1 (de)
AU (1)	AU8294991A (de)
CA (1)	CA2087969C (de)
DE (1)	DE69102651T2 (de)
DK (1)	DK0547064T3 (de)
ES (1)	ES2055611T3 (de)
WO (1)	WO1992001716A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030105007A1 (en) *	1995-06-07	2003-06-05	Andre Beaulieu	PDGF-betabeta and fibronectin combined in a solid wound dressing for the treatment of wounds
PT871730E (pt) *	1995-10-11	2004-11-30	Chiron Corp	Combinacao de pdgf, kgf, igf e igfbp para cicatrizacao de ferimentos
EP1935901A1 (de) *	1996-12-13	2008-06-25	Novartis Vaccines and Diagnostics, Inc.	Analyse und Trennung von PDGF-Proteinen
CZ298364B6 (cs)	1998-02-05	2007-09-05	Smithkline Beecham Biologicals S. A.	Deriváty antigenu asociovaných s nádory z MAGE rodiny a sekvence nukleových kyselin kodující tyto deriváty, jejich použití pro prípravu fúzních proteinu a prostredku pro vakcinaci
US6811777B2 (en) *	2002-04-13	2004-11-02	Allan Mishra	Compositions and minimally invasive methods for treating incomplete connective tissue repair
US7608258B2 (en) *	2002-04-13	2009-10-27	Allan Mishra	Method for treatment of tendinosis using platelet rich plasma
US20040248796A1 (en) *	2003-02-04	2004-12-09	Kari Alitalo	VEGF-B and PDGF modulation of stem cells
WO2005065242A2 (en) *	2003-12-29	2005-07-21	Am Biosolutions	Method of treating cancer using platelet releasate
WO2005065269A2 (en) *	2003-12-29	2005-07-21	Am Biosolutions	Compositions and method for decreasing the appearance of skin wrinkles
WO2005065419A2 (en) *	2003-12-29	2005-07-21	Am Biosolutions	Method of culturing cells
US7462268B2 (en)	2004-08-20	2008-12-09	Allan Mishra	Particle/cell separation device and compositions
FR2891149B1 (fr)	2005-09-26	2007-11-30	Biodex Sarl	Composition pharmaceutique a action cicatrisante comprenant un derive de dextrane soluble et un facteur de croissance derive des plaquettes.
WO2010042658A1 (en)	2008-10-07	2010-04-15	Bioparadox, Llc	Use of platelet rich plasma composition in the treatment of cardiac conduction abnormalities
US20140356893A1 (en)	2013-06-04	2014-12-04	Allan Mishra	Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation
CN105085652B (zh) *	2014-05-16	2021-06-22	中国人民解放军军事医学科学院生物工程研究所	血小板衍生生长因子b突变体、其制备方法及用途
MX2017004520A (es)	2014-10-14	2018-03-15	Lynch Samuel	Composiciones para tratar heridas.
US12344666B2 (en)	2021-06-09	2025-07-01	Washington University	PDGF mutants and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4766073A (en) *	1985-02-25	1988-08-23	Zymogenetics Inc.	Expression of biologically active PDGF analogs in eucaryotic cells
US4801542A (en) *	1984-10-12	1989-01-31	Zymogenetics, Inc.	Expression of biologically active PDGF analogs in eucaryotic cells
US5045633A (en) *	1985-02-25	1991-09-03	Zymogenetics, Inc.	Expression of biologically active PDGF analogs in eucaryotic cells
EP0259632B1 (de) *	1986-08-13	1995-12-13	Zymogenetics, Inc.	Expression von biologisch-aktiven PDGF-Analogen in eukaryotischen Zellen
AU624789B2 (en) *	1987-02-19	1992-06-25	Amgen, Inc.	Purified platelet-derived growth factor and methods for purification thereof
DE3834079A1 (de) *	1988-10-06	1990-04-12	Biotechnolog Forschung Gmbh	Wachstumstimulierendes pdgf-bb und dessen verwendung sowie ein verfahren zu seiner herstellung und der des monomeren
GB9101645D0 (en) *	1991-01-25	1991-03-06	British Bio Technology	Compounds

1991
- 1991-07-22 ES ES91913764T patent/ES2055611T3/es not_active Expired - Lifetime
- 1991-07-22 JP JP3512963A patent/JP2823690B2/ja not_active Expired - Fee Related
- 1991-07-22 DE DE69102651T patent/DE69102651T2/de not_active Expired - Fee Related
- 1991-07-22 CA CA002087969A patent/CA2087969C/en not_active Expired - Fee Related
- 1991-07-22 EP EP91913764A patent/EP0547064B1/de not_active Expired - Lifetime
- 1991-07-22 WO PCT/US1991/005183 patent/WO1992001716A1/en not_active Ceased
- 1991-07-22 AT AT91913764T patent/ATE107665T1/de not_active IP Right Cessation
- 1991-07-22 DK DK91913764.6T patent/DK0547064T3/da active
- 1991-07-22 AU AU82949/91A patent/AU8294991A/en not_active Abandoned
1994
- 1994-09-09 US US08/303,594 patent/US5895755A/en not_active Expired - Lifetime
1995
- 1995-05-08 US US08/436,140 patent/US5905142A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO1992001716A1 (en)	1992-02-06
US5895755A (en)	1999-04-20
DE69102651D1 (de)	1994-07-28
DK0547064T3 (da)	1995-03-20
CA2087969C (en)	2001-10-16
US5905142A (en)	1999-05-18
ES2055611T3 (es)	1994-08-16
JPH05508775A (ja)	1993-12-09
JP2823690B2 (ja)	1998-11-11
EP0547064A1 (de)	1993-06-23
DE69102651T2 (de)	1994-10-06
AU8294991A (en)	1992-02-18
EP0547064B1 (de)	1994-06-22
CA2087969A1 (en)	1992-01-24

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Legal Events

Date	Code	Title	Description
1995-02-15	UEP	Publication of translation of european patent specification
2011-10-15	EELA	Cancelled due to lapse of time