ATE109164T1 - Heparinderivate und verfahren zu deren herstellung. - Google Patents

Heparinderivate und verfahren zu deren herstellung.

Info

Publication number
ATE109164T1
ATE109164T1 AT89109030T AT89109030T ATE109164T1 AT E109164 T1 ATE109164 T1 AT E109164T1 AT 89109030 T AT89109030 T AT 89109030T AT 89109030 T AT89109030 T AT 89109030T AT E109164 T1 ATE109164 T1 AT E109164T1
Authority
AT
Austria
Prior art keywords
heparin derivatives
heparin
heparins
hemorrhagic
activity
Prior art date
Application number
AT89109030T
Other languages
English (en)
Inventor
Silvano Piani
Gianfranco Tamagnone
Raul Roberto Alpino
Maria Rita Milani
Marinella Fantuz
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Application granted granted Critical
Publication of ATE109164T1 publication Critical patent/ATE109164T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Materials For Medical Uses (AREA)
AT89109030T 1988-06-10 1989-05-19 Heparinderivate und verfahren zu deren herstellung. ATE109164T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8803504A IT1234508B (it) 1988-06-10 1988-06-10 Derivati eparinici e procedimento per la loro preparazione

Publications (1)

Publication Number Publication Date
ATE109164T1 true ATE109164T1 (de) 1994-08-15

Family

ID=11108618

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89109030T ATE109164T1 (de) 1988-06-10 1989-05-19 Heparinderivate und verfahren zu deren herstellung.

Country Status (18)

Country Link
US (1) US5010063A (de)
EP (1) EP0347588B1 (de)
JP (1) JPH0739442B2 (de)
KR (1) KR960015110B1 (de)
AT (1) ATE109164T1 (de)
CA (1) CA1309402C (de)
DE (2) DE347588T1 (de)
DK (1) DK173818B1 (de)
ES (1) ES2012748T3 (de)
FI (1) FI94534C (de)
GR (1) GR900300018T1 (de)
IE (1) IE64830B1 (de)
IL (1) IL90411A (de)
IT (1) IT1234508B (de)
NO (1) NO174259C (de)
NZ (1) NZ229212A (de)
PT (1) PT90817B (de)
ZA (1) ZA893882B (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5232040A (en) * 1990-07-12 1993-08-03 Lanxide Technology Company, Lp Method for reducing metal content of self-supporting composite bodies and articles formed thereby
IT1243987B (it) * 1990-10-29 1994-06-28 Derivati Organici Lab Procedimento per la preparazione di epossi-eparidi prodotti ottenuti ecomposizioni farmaceutiche che li contengono
IT1254216B (it) * 1992-02-25 1995-09-14 Opocrin Spa Derivati polisaccaridici di eparina, eparan solfato, loro frazioni e frammenti, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
US6750207B1 (en) * 1992-05-01 2004-06-15 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
US5861382A (en) * 1992-05-01 1999-01-19 Yeda Research And Development Co. Ltd. Methods for regulation of active TNF-α
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
US5296471A (en) * 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
IT1264101B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
IT1264102B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali
US20020055710A1 (en) 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
FR2723847A1 (fr) * 1994-08-29 1996-03-01 Debiopharm Sa Compositions antithrombotiques et non hemorragiques a base d'heparine, procede pour leur preparation et applications therapeutiques.
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
WO1997016556A1 (en) 1995-10-30 1997-05-09 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase i
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
IL129877A (en) * 1996-11-27 2004-08-31 Aventis Pharm Prod Inc A pharmaceutical preparation containing a component having an Xa antagonist activity and an antifouling agent
US6106454A (en) * 1997-06-17 2000-08-22 Medtronic, Inc. Medical device for delivering localized radiation
US6203536B1 (en) 1997-06-17 2001-03-20 Medtronic, Inc. Medical device for delivering a therapeutic substance and method therefor
US6013099A (en) * 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
EP1109919A2 (de) * 1998-08-27 2001-06-27 Massachusetts Institute Of Technology Von heparinase i und ii abgeleitete heparinasen
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
WO2000065521A2 (en) * 1999-04-23 2000-11-02 Massachusetts Institute Of Technology System and method for polymer notation
EP1192187A1 (de) * 1999-06-30 2002-04-03 Hamilton Civic Hospitals Research Development, Inc. Heparinzusammensetzungen, die gerinnselzugehörige gerinnungsfakoren verhindert
AU2001243512C1 (en) 2000-03-08 2008-04-17 Massachusetts Institute Of Technology Heparinase III and uses thereof
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
US20040038932A1 (en) * 2000-09-08 2004-02-26 Jack Hirsh Antithrombotic compositions
DK1319183T3 (da) 2000-09-12 2009-05-18 Massachusetts Inst Technology Fremgangsmåder og produkter relateret til heparin med lav molekylvægt
EP1328260A2 (de) * 2000-10-18 2003-07-23 Massachusetts Institute Of Technology Verfahren und produkte zur pulmonalen verabreichung von polysacchariden
US7285536B2 (en) * 2001-12-05 2007-10-23 Yeda Research And Development Co., Ltd. Anti-cancer therapeutic compounds
JP4828795B2 (ja) 2002-03-11 2011-11-30 モメンタ ファーマシューティカルズ インコーポレイテッド 硫酸化多糖類の分析
ITMI20031679A1 (it) * 2003-08-29 2005-02-28 Opocrin Spa Processo per la produzione di eparine a basso peso
EP1582531A1 (de) 2004-03-24 2005-10-05 Aventis Pharma S.A. Verfahren zur Oxydierung nicht-fraktionierten Heparins und die Detektion der Anwesenheit oder Abwesenheit von Glykoserin in Heparin und in von Heparin abgeleiteten Produkten
US7608246B2 (en) * 2005-09-02 2009-10-27 The Brigham And Women's Hospital, Inc. Apolipoprotein E as an adjuvant for lipid antigens
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US8435795B2 (en) * 2010-01-19 2013-05-07 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
CA3020369C (en) * 2010-09-14 2019-11-26 Fuso Pharmaceutical Industries, Ltd. High purity heparin and production method therefor
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
RU2639574C2 (ru) * 2016-05-23 2017-12-21 Алексей Георгиевич Александров Способ получения низкомолекулярного гепарина
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate
EP3997238A1 (de) 2019-07-09 2022-05-18 Optimvia, LLC Verfahren zur synthese von antikoagulierenden polysacchariden

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB863235A (en) * 1958-07-05 1961-03-22 Roussel Uclaf Improvements in or relating to organic compounds related to heparin
US3016331A (en) * 1960-01-28 1962-01-09 Ormonoterapia Richter Spa Purification of heparin
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
DE3422518A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
ES2003197A6 (es) * 1987-01-05 1988-10-16 Rovi Lab Farmaceut Sa Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione

Also Published As

Publication number Publication date
PT90817B (pt) 1994-11-30
NO892366D0 (no) 1989-06-09
KR910000771A (ko) 1991-01-30
IL90411A0 (en) 1990-01-18
KR960015110B1 (ko) 1996-10-28
US5010063A (en) 1991-04-23
DK285089A (da) 1989-12-11
IT8803504A0 (it) 1988-06-10
AU611028B2 (en) 1991-05-30
EP0347588A1 (de) 1989-12-27
ES2012748T3 (es) 1994-10-16
DK285089D0 (da) 1989-06-09
NO892366L (no) 1989-12-11
NZ229212A (en) 1991-02-26
FI94534C (fi) 1995-09-25
JPH0264102A (ja) 1990-03-05
CA1309402C (en) 1992-10-27
DE347588T1 (de) 1990-05-23
DK173818B1 (da) 2001-11-19
IE891762L (en) 1989-12-10
ES2012748A4 (es) 1990-04-16
AU3512889A (en) 1989-12-14
NO174259B (no) 1993-12-27
IT1234508B (it) 1992-05-19
FI892850A0 (fi) 1989-06-09
GR900300018T1 (en) 1991-06-07
IE64830B1 (en) 1995-09-06
JPH0739442B2 (ja) 1995-05-01
FI892850L (fi) 1989-12-11
DE68917040D1 (de) 1994-09-01
ZA893882B (en) 1990-02-28
DE68917040T2 (de) 1995-01-12
EP0347588B1 (de) 1994-07-27
NO174259C (no) 1994-04-06
PT90817A (pt) 1989-12-29
IL90411A (en) 1993-05-13
FI94534B (fi) 1995-06-15

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee