ATE109352T1 - Heilung von wunden. - Google Patents

Heilung von wunden.

Info

Publication number: ATE109352T1
Authority: AT; Austria
Prior art keywords: healing; wounds; mammal; growth factor; purified
Prior art date: 1988-05-20

Application number

AT89906917T

Other languages

English (en)

Inventor

Harry N Antoniaoes

Samuel E Lynch

Original Assignee

Inst Molecular Biology Inc

Harvard College

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-05-20

Filing date

1989-05-22

Publication date

1994-08-15

1989-05-22 Application filed by Inst Molecular Biology Inc, Harvard College filed Critical Inst Molecular Biology Inc

1994-08-15 Application granted granted Critical

1994-08-15 Publication of ATE109352T1 publication Critical patent/ATE109352T1/de

Links

241000124008 Mammalia Species 0.000 abstract 2
101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 abstract 1
102100037852 Insulin-like growth factor I Human genes 0.000 abstract 1
102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 1
108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 1
230000035876 healing Effects 0.000 abstract 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT89906917T 1988-05-20 1989-05-22 Heilung von wunden. ATE109352T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/196,975 US4983581A (en)	1988-05-20	1988-05-20	Wound healing composition of IGF-I and TGF-β

Publications (1)

Publication Number	Publication Date
ATE109352T1 true ATE109352T1 (de)	1994-08-15

Family

ID=22727512

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89906917T ATE109352T1 (de)	1988-05-20	1989-05-22	Heilung von wunden.

Country Status (6)

Country	Link
US (1)	US4983581A (de)
EP (1)	EP0419534B1 (de)
JP (1)	JPH0653674B2 (de)
AT (1)	ATE109352T1 (de)
DE (1)	DE68917300T2 (de)
WO (1)	WO1989011293A1 (de)

Families Citing this family (37)

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Publication number	Priority date	Publication date	Assignee	Title
US5256644A (en) *	1988-05-20	1993-10-26	Institute Of Molecular Biology, Inc.	Wound healing using IGF-II and TGF
US5145679A (en) *	1989-10-05	1992-09-08	Hinson Joan B	Topical emollient for prevention and treatment of circulatory induced lesions
ZA9010332B (en) *	1989-12-22	1991-08-28	Ciba Geigy	Method of reducing or preventing adverse effect of steroid therapy and compositions therefor
EP0531425B1 (de) *	1990-05-30	2002-08-14	The President And Fellows Of Harvard College	Kombination aus IGF-I und TGF-beta zur Knochenregenerierung
DE69132918T2 (de) *	1990-11-27	2002-10-31	American National Red Cross, Washington	Gewebeabdeckung und wachstumsfaktor enthaltende verbindungen zur förderung beschleunigter wundheilung
US6197325B1 (en)	1990-11-27	2001-03-06	The American National Red Cross	Supplemented and unsupplemented tissue sealants, methods of their production and use
US6117425A (en) *	1990-11-27	2000-09-12	The American National Red Cross	Supplemented and unsupplemented tissue sealants, method of their production and use
US7208179B1 (en)	1990-11-27	2007-04-24	The American National Red Cross	Methods for treating disease and forming a supplemented fibrin matrix
US6054122A (en) *	1990-11-27	2000-04-25	The American National Red Cross	Supplemented and unsupplemented tissue sealants, methods of their production and use
US6559119B1 (en)	1990-11-27	2003-05-06	Loyola University Of Chicago	Method of preparing a tissue sealant-treated biomedical material
CA2104678C (en)	1991-03-11	2002-05-14	Charles M. Cohen	Protein-induced morphogenesis
US5849686A (en) *	1991-03-11	1998-12-15	Creative Biomolecules, Inc.	Morphogen-induced liver regeneration
US6077823A (en) *	1991-03-11	2000-06-20	Creative Biomolecules, Inc.	Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US6211146B1 (en) *	1991-03-11	2001-04-03	Curis, Inc.	60A protein-induced morphogenesis
US6399569B1 (en)	1991-03-11	2002-06-04	Curis, Inc.	Morphogen treatments for limiting proliferation of epithelial cells
SE9101840L (sv) *	1991-06-14	1992-12-15	Kabi Pharmacia	Ny medicinsk anvaendning
AU678764B2 (en) *	1992-06-03	1997-06-12	Case Western Reserve University	Bandage for continuous application of biologicals
US5444047A (en) *	1994-06-16	1995-08-22	Dipasquale; Gene	Treatment of arthritic and post-surgical orthopedic conditions with Insulin-like Growth Factor-I
US5733884A (en) *	1995-11-07	1998-03-31	Nestec Ltd.	Enteral formulation designed for optimized wound healing
JP4847634B2 (ja)	1996-03-22	2011-12-28	ストライカー・コーポレーション	中枢神経系の虚血または外傷の機能的回復を増大させる方法
WO1998004681A2 (en) *	1996-07-25	1998-02-05	Genzyme Corporation	Chondrocyte media formulations and culture procedures
US20030220269A1 (en) *	1997-03-24	2003-11-27	Fujisawa Pharmaceutical Co., Ltd.	Bile secretagogues
US6221997B1 (en)	1997-04-28	2001-04-24	Kimberly Ann Woodhouse	Biodegradable polyurethanes
US6762336B1 (en)	1998-01-19	2004-07-13	The American National Red Cross	Hemostatic sandwich bandage
ES2239846T5 (es) *	1998-07-30	2011-03-04	The Government Of The United States Of America, As Repres. By The Secretary Of Health And Human Services, Nat. Inst. Of Health	Mejora de la curación de heridas mediante la timosina beta-4.
ES2187195T3 (es) *	1998-09-11	2003-05-16	Gerhard Dr Schmidmaier	Implantes biologicamente activos.
KR100385293B1 (ko) *	2000-05-13	2003-05-23	주식회사 리젠 바이오텍	βｉｇ-ｈ3의 일부 도메인을 이용한 세포 부착 및 창상치유 방법
US6648911B1 (en)	2000-11-20	2003-11-18	Avantec Vascular Corporation	Method and device for the treatment of vulnerable tissue site
GB2369572A (en) *	2000-11-29	2002-06-05	Raft Trustees Ltd	Wound treatment composition comprising insulin
AU2003270401B2 (en)	2002-09-10	2008-03-13	American National Red Cross	Hemostatic dressing
US20080033333A1 (en) *	2006-08-04	2008-02-07	Macphee Martin	Solid dressing for treating wounded tissue
US20090075891A1 (en) *	2007-08-06	2009-03-19	Macphee Martin	Methods and dressings for sealing internal injuries
WO2010064222A2 (en)	2008-12-01	2010-06-10	University College Cork, National University Of Ireland, Cork	Igf1 for myocardial repair
CN102781463A (zh)	2009-10-07	2012-11-14	戈诺珍公司	用于皮肤再生的方法和组合物
CA2962954A1 (en)	2014-10-14	2016-04-21	Samuel Lynch	Compositions for treating wounds
EP3856249B1 (de)	2018-09-26	2022-11-09	National University of Ireland Galway	Myokardinfarktbehandlung
CN114419192A (zh)	2022-01-20	2022-04-29	腾讯科技（深圳）有限公司	引导线的显示方法、装置、设备、介质及程序产品

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US468590A (en) *		1892-02-09		Upper-folding machine
DE2558537C2 (de) *	1975-12-24	1984-07-19	Hellmut Dr. 8000 München Mittenzwei	Verfahren zum Isolieren von Substanzen mit insulinähnlicher Wirksamkeit aus Blut oder Blutbestandteilen von Kälbern oder Schweinen
US4350687A (en) *	1980-02-10	1982-09-21	Research Corporation	Platelet derived cell growth factor
US4479896A (en) *	1981-12-11	1984-10-30	Antoniades Harry N	Method for extraction localization and direct recovery of platelet derived growth factor
DE3382562D1 (de) *	1982-09-24	1992-06-25	Us Health	Wiederherstellung von gewebe bei tieren.
JPS6028999A (ja) *	1983-06-30	1985-02-14	Maruho Kk	細胞増殖促進作用を有するたんぱく質、その組成物と製造方法
DE3587022T2 (de) *	1984-02-17	1993-06-17	Genentech Inc	Menschlicher transformationswachstumsfaktor und vorlaeufer oder fragment hiervon, zellen, dna, vektoren und verfahren zu ihrer herstellung, zusammensetzungen und produkte, die diese enthalten, sowie davon abgeleitete antikoerper und diagnostizierverfahren.
US4745179A (en) *	1984-04-02	1988-05-17	Fujisawa Pharmaceutical Co., Ltd.	59 Valine insulin-like growth factor I and process for production thereof
US4738921A (en) *	1984-09-27	1988-04-19	Eli Lilly And Company	Derivative of the tryptophan operon for expression of fused gene products
US4702908A (en) *	1985-11-01	1987-10-27	Thorbecke G Jeanette	Composition containing platelet factor 4 and method for restoring suppressed immune responses
NZ222413A (en) *	1986-11-05	1991-06-25	Ethicon Inc	Compositions containing a polypeptide growth factor and a water-soluble cellulose polymer stabiliser
NZ226171A (en) *	1987-09-18	1990-06-26	Ethicon Inc	Gel formulation containing polypeptide growth factor

1988
- 1988-05-20 US US07/196,975 patent/US4983581A/en not_active Expired - Lifetime
1989
- 1989-05-22 AT AT89906917T patent/ATE109352T1/de not_active IP Right Cessation
- 1989-05-22 DE DE68917300T patent/DE68917300T2/de not_active Expired - Lifetime
- 1989-05-22 JP JP1506485A patent/JPH0653674B2/ja not_active Expired - Lifetime
- 1989-05-22 EP EP89906917A patent/EP0419534B1/de not_active Expired - Lifetime
- 1989-05-22 WO PCT/US1989/002229 patent/WO1989011293A1/en not_active Ceased

Also Published As

Publication number	Publication date
DE68917300T2 (de)	1995-02-23
JPH03505870A (ja)	1991-12-19
DE68917300D1 (de)	1994-09-08
JPH0653674B2 (ja)	1994-07-20
EP0419534A1 (de)	1991-04-03
EP0419534B1 (de)	1994-08-03
WO1989011293A1 (en)	1989-11-30
EP0419534A4 (en)	1992-04-08
US4983581A (en)	1991-01-08

Legal Events

Date	Code	Title	Description
1995-02-15	UEP	Publication of translation of european patent specification
2009-08-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE109352T1 (de)	1994-08-15	Heilung von wunden.
DE3785758D1 (de)	1993-06-09	Wundheilung und knochenregeneration.
DK0479799T3 (da)	1997-08-25	Sårheling
FI924778A7 (fi)	1992-10-21	GM-CSF:n ja G-CSF:n käyttö haavojen paranemisen nopeuttamiseksi
CA2040410A1 (en)	1991-03-08	Wound healing compositions containing il-1 and a growth factor
FI940932A0 (fi)	1994-02-28	Koostumuksia ja menetelmiä haavojen hoitamiseksi
NO862964L (no)	1986-07-23	Saarhelingsmidler.
ES2107789T3 (es)	1997-12-01	Inhibicion de crecimiento de pelo.
NZ227429A (en)	1991-01-29	Wound healing composition comprising purified platelet-derived growth factor and purified transforming growth factor alpha and method of use
AU4738489A (en)	1990-05-03	Use of transforming growth factor to promote wound healing
ES2093774T3 (es)	1997-01-01	Estimulacion de la curacion de heridas con un compuesto 15-cetoprostaglandina.
ATE147265T1 (de)	1997-01-15	Verwendung von retinoiden zur umkehr glucocorticoid-induzierter hautatrophie
FI905236A7 (fi)	1990-10-24	Deoksiribonukleosideja sisältävät farmaseuttiset koostumukset haavojen parantamiseen
DE69321109D1 (de)	1998-10-22	Herstellung von trifluorvinylethern
DE69130497D1 (de)	1998-12-24	Neue Verwendung von 1-Alpha-hydroxylierten-19-nor-vitamin-D-Verbindungen zur Behandlung von Psoriasis
ES2132082T3 (es)	1999-08-16	Composiciones para cicatrizar heridas que contienen el factor de crecimiento fibroplasto y acido ascorbico.
ZA883744B (en)	1989-08-30	Promotion of healing of meniscal tissue
ATE222117T1 (de)	2002-08-15	Kombination aus igf-i und tgf-beta zur knochenregenerierung
SE9402331D0 (sv)	1994-07-01	New use
ITTO930024A0 (it)	1993-01-18	Composizione per accelerare la rimarginazione di ferite
DE69131058D1 (de)	1999-05-06	Verwendung einer therapeutischen Zusammensetzung zur Behandlung von Bronchitis
SE9201188L (sv)	1993-10-15	Ny användning
KR890000799U (ko)	1989-03-15	꼬임실 인출장치
BE877242A (fr)	1979-12-27	Esters d'acides steroidaux (16 alpha, 17-beta)naphtaleno- et cyclohexene-21-carboxyliques, a proprietes anti-inflammatoires
IE880470L (en)	1988-08-24	Topical use of igf ii for wound healing