ATE109477T1 - Diaryläther-heterozyklen. - Google Patents
Diaryläther-heterozyklen.Info
- Publication number
- ATE109477T1 ATE109477T1 AT90306765T AT90306765T ATE109477T1 AT E109477 T1 ATE109477 T1 AT E109477T1 AT 90306765 T AT90306765 T AT 90306765T AT 90306765 T AT90306765 T AT 90306765T AT E109477 T1 ATE109477 T1 AT E109477T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- optionally substituted
- diaryl ether
- heterocycle
- sulphinyl
- Prior art date
Links
- 150000001987 diarylethers Chemical class 0.000 title 1
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical group O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 oxy, thio, sulphinyl Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 abstract 1
- 108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Polyurethanes Or Polyureas (AREA)
- Eyeglasses (AREA)
- Lubricants (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP89402046 | 1989-07-18 | ||
| EP90401000 | 1990-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE109477T1 true ATE109477T1 (de) | 1994-08-15 |
Family
ID=26123157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90306765T ATE109477T1 (de) | 1989-07-18 | 1990-06-20 | Diaryläther-heterozyklen. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5208259A (de) |
| EP (1) | EP0409413B1 (de) |
| JP (1) | JPH0356474A (de) |
| KR (1) | KR910002827A (de) |
| AT (1) | ATE109477T1 (de) |
| AU (1) | AU636357B2 (de) |
| CA (1) | CA2019345A1 (de) |
| DD (1) | DD300432A5 (de) |
| DE (1) | DE69011234T2 (de) |
| DK (1) | DK0409413T3 (de) |
| ES (1) | ES2057410T3 (de) |
| FI (1) | FI903622A7 (de) |
| GB (1) | GB9015571D0 (de) |
| HU (1) | HU209889B (de) |
| IE (1) | IE64358B1 (de) |
| IL (1) | IL94732A0 (de) |
| NO (1) | NO903185L (de) |
| NZ (1) | NZ234061A (de) |
| PT (1) | PT94723A (de) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8926981D0 (en) * | 1988-12-23 | 1990-01-17 | Ici Plc | Heterocyclic derivatives |
| GB9018134D0 (en) * | 1989-09-29 | 1990-10-03 | Ici Plc | Heterocyclic derivatives |
| US5254581A (en) * | 1990-06-21 | 1993-10-19 | Imperial Chemical Industries Plc | Pyran derivatives and their use as inhibitors of 5-lipoxygenase |
| IE911853A1 (en) * | 1990-06-21 | 1992-01-01 | Ici Plc | Heterocyclene derivatives |
| IE913866A1 (en) * | 1990-11-28 | 1992-06-03 | Ici Plc | Aryl derivatives |
| IE914005A1 (en) * | 1990-12-14 | 1992-06-17 | Zeneca Ltd | Novel intermediates |
| AU645159B2 (en) * | 1991-01-17 | 1994-01-06 | Ici Pharma | Sulphonamide derivatives |
| US5227399A (en) * | 1991-02-28 | 1993-07-13 | Merck Frosst Canada, Inc. | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis |
| EP0501579A1 (de) * | 1991-02-28 | 1992-09-02 | Merck Frosst Canada Inc. | Naphthalinlactone als Inhibitoren der Leukotrien-Biosynthese |
| EP0501578A1 (de) * | 1991-02-28 | 1992-09-02 | Merck Frosst Canada Inc. | Pyranylphenyl-hydroyalkylnaphthalinsäuren als Inhibitoren der Leuktotrien-Biosynthese |
| US5281720A (en) * | 1991-02-28 | 1994-01-25 | Merck Frosst Canada, Inc. | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis |
| GB9214120D0 (en) * | 1991-07-25 | 1992-08-12 | Ici Plc | Therapeutic amides |
| EP0532239B1 (de) * | 1991-09-10 | 1995-12-13 | Zeneca Limited | Benzolsulfonamidderivate als 5-Lipoxygenasehemmer |
| GB9300894D0 (en) * | 1992-02-07 | 1993-03-10 | Zeneca Ltd | Oxime derivatives |
| EP0555067A1 (de) * | 1992-02-07 | 1993-08-11 | Zeneca Limited | Hydroxylaminderivate als 5-Lipoxygenasehemmer |
| CA2094465A1 (en) * | 1992-04-23 | 1993-10-24 | Pierre Andre Raymond Bruneau | Cycloalkane derivatives |
| CA2095005A1 (en) * | 1992-05-12 | 1993-11-13 | Philip Neil Edwards | Hydroxylamine derivatives |
| EP0570197B1 (de) * | 1992-05-12 | 1995-12-13 | Zeneca Limited | Hydroxylaminderivate |
| CA2095006A1 (en) * | 1992-05-12 | 1993-11-13 | Philip Neil Edwards | Oxime derivatives |
| IL105558A (en) * | 1992-05-18 | 1998-04-05 | Zeneca Ltd | Tertiary carbinols having potassium channel activity, process for their preparation and pharmaceutical compositions containing them |
| JPH063890A (ja) * | 1992-06-24 | 1994-01-14 | Toshiba Corp | 画像形成装置 |
| US5308852A (en) * | 1992-06-29 | 1994-05-03 | Merck Frosst Canada, Inc. | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis |
| EP0581464A1 (de) * | 1992-07-15 | 1994-02-02 | Zeneca Limited | Estern Derivate und diese enthaltende pharmazeutische Zusammenstellungen |
| US5426109A (en) * | 1992-08-27 | 1995-06-20 | Merck Frosst Canada, Inc. | Phenylnaphthalene hydroxy acids |
| US5350744A (en) * | 1992-08-27 | 1994-09-27 | Merck Frosst Canada, Inc. | Phenylnaphthalene lactones as inhibitors of leukotriene biosynthesis |
| US5428060A (en) * | 1992-08-27 | 1995-06-27 | Merck Frosst Canada, Inc. | Heteroarylnaphthalene lactones as inhibitors of leukotriene biosynthesis |
| US5252599A (en) * | 1992-08-27 | 1993-10-12 | Merck Frosst Canada, Inc. | Heteroarylnaphthalene hydroxy acids as inhibitors of leukotriene biosynthesis |
| EP0586229A1 (de) * | 1992-09-01 | 1994-03-09 | Zeneca Limited | 3-Hydroxy-3-(Subst.-Alkyl)-Pyrrolidine als 5-Lipoxygenase-Inhibitoren |
| AU4444393A (en) * | 1992-09-01 | 1994-03-10 | Zeneca Limited | Pyrrolidine derivatives |
| GR920100426A (el) * | 1992-10-08 | 1994-06-30 | Ici Pharma | Παράγωγα βενζολοσουλφοναμιδίου. |
| IL108187A0 (en) * | 1993-01-28 | 1994-04-12 | Zenecca Limited | Oxime derivatives |
| GB9305295D0 (en) * | 1993-03-15 | 1993-05-05 | Zeneca Ltd | Therapeutic compounds |
| IL109254A (en) * | 1993-04-29 | 1999-03-12 | Zeneca Ltd | Tetrahydropyran and tetrahydrofuran ether derivatives their preparation and pharmaceutical compositions comprising them |
| US5346914A (en) * | 1993-05-14 | 1994-09-13 | Abbott Laboratories | (4-alkoxypyran-4-yl) substituted arylalkylaryl-, arylalkenylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase |
| GB9310095D0 (en) * | 1993-05-17 | 1993-06-30 | Zeneca Ltd | Therapeutic compounds |
| WO1994029291A1 (en) * | 1993-06-07 | 1994-12-22 | Zeneca Limited | Aniline derivatives |
| ES2103130T3 (es) * | 1993-06-14 | 1997-08-16 | Pfizer | Inhibidores imidazoles como la lipoxigenasa. |
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| US6313127B1 (en) | 1996-02-02 | 2001-11-06 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
| GB9602166D0 (en) | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| CN1228087A (zh) * | 1996-08-14 | 1999-09-08 | 曾尼卡有限公司 | 取代的嘧啶衍生物和它们的药物用途 |
| UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
| DE69815509T2 (de) | 1997-02-13 | 2004-05-13 | Astrazeneca Ab | Heterozyklische verbindungen die als oxido-squalen-zyklase-inhibitoren anwendung finden |
| JP2001511798A (ja) | 1997-02-13 | 2001-08-14 | ゼネカ・リミテッド | オキシド−スクアレンシクラーゼ抑制剤として有用な複素環化合物 |
| GB9715895D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
| GB9902989D0 (en) | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
| WO2006045010A2 (en) | 2004-10-20 | 2006-04-27 | Resverlogix Corp. | Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases |
| US8410109B2 (en) | 2005-07-29 | 2013-04-02 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| PT2118074E (pt) | 2007-02-01 | 2014-03-20 | Resverlogix Corp | Compostos para a prevenção e tratamento de doenças cardiovasculares |
| SI2346837T1 (sl) | 2008-06-26 | 2015-05-29 | Resverlogix Corporation | Postopki pripravljanja kinazolinonskih derivatov |
| US8952021B2 (en) | 2009-01-08 | 2015-02-10 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
| KR101913109B1 (ko) | 2009-03-18 | 2018-10-31 | 리스버로직스 코퍼레이션 | 신규한 소염제 |
| US9757368B2 (en) | 2009-04-22 | 2017-09-12 | Resverlogix Corp. | Anti-inflammatory agents |
| CA2851996C (en) | 2011-11-01 | 2020-01-07 | Resverlogix Corp. | Pharmaceutical compositions for substituted quinazolinones |
| US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| JP2016507496A (ja) | 2012-12-21 | 2016-03-10 | ゼニス・エピジェネティクス・コーポレイションZenith Epigenetics Corp. | ブロモドメイン阻害剤としての新規複素環式化合物 |
| US10111885B2 (en) | 2015-03-13 | 2018-10-30 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4207241A (en) * | 1967-01-13 | 1980-06-10 | Syntex Corporation | 2-Naphthyl acetic acid derivatives and compositions and methods thereof |
| US3661917A (en) * | 1970-05-21 | 1972-05-09 | Smith Kline French Lab | 3-sulfonamido-4-hydroxyphenyl-2-piperidylcarbinols |
| US3743737A (en) * | 1970-05-21 | 1973-07-03 | Smith Kline French Lab | 3-sulfonamido-4-hydroxyphenyl-2-piperindinylcarbinol compositions |
| IE56702B1 (en) * | 1982-12-01 | 1991-11-06 | Usv Pharma Corp | Antiinflammatory antiallergic compounds |
| NZ213986A (en) * | 1984-10-30 | 1989-07-27 | Usv Pharma Corp | Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such |
| US4625034A (en) * | 1985-02-04 | 1986-11-25 | Usv Pharmaceutical Corp. | 1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives |
| US4839369A (en) * | 1985-04-16 | 1989-06-13 | Rorer Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
| DE3622599A1 (de) * | 1986-07-05 | 1988-01-14 | Basf Ag | Pyranderivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von schaedlingen |
| EP0271287A3 (de) * | 1986-12-11 | 1990-06-13 | Merck Frosst Canada Inc. | Chinolindicarbonsäuren und ihre Amide |
| US4920132A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
| US4920133A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
| US4920130A (en) * | 1987-11-02 | 1990-04-24 | Rorer Pharamceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
| US4920131A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
| US4918081A (en) * | 1988-06-20 | 1990-04-17 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene d4 |
| EP0349062A1 (de) * | 1988-06-27 | 1990-01-03 | Merck Frosst Canada Inc. | Chinolinetheralkansäuren |
| GB8926981D0 (en) * | 1988-12-23 | 1990-01-17 | Ici Plc | Heterocyclic derivatives |
-
1990
- 1990-06-12 IE IE211290A patent/IE64358B1/en not_active IP Right Cessation
- 1990-06-13 NZ NZ234061A patent/NZ234061A/xx unknown
- 1990-06-14 IL IL94732A patent/IL94732A0/xx unknown
- 1990-06-19 AU AU57575/90A patent/AU636357B2/en not_active Ceased
- 1990-06-20 EP EP90306765A patent/EP0409413B1/de not_active Expired - Lifetime
- 1990-06-20 AT AT90306765T patent/ATE109477T1/de active
- 1990-06-20 ES ES90306765T patent/ES2057410T3/es not_active Expired - Lifetime
- 1990-06-20 DE DE69011234T patent/DE69011234T2/de not_active Expired - Fee Related
- 1990-06-20 DK DK90306765.0T patent/DK0409413T3/da active
- 1990-06-20 CA CA002019345A patent/CA2019345A1/en not_active Abandoned
- 1990-06-30 KR KR1019900009970A patent/KR910002827A/ko not_active Withdrawn
- 1990-07-03 US US07/547,229 patent/US5208259A/en not_active Expired - Fee Related
- 1990-07-09 HU HU904131A patent/HU209889B/hu not_active IP Right Cessation
- 1990-07-16 GB GB909015571A patent/GB9015571D0/en active Pending
- 1990-07-17 PT PT94723A patent/PT94723A/pt not_active Application Discontinuation
- 1990-07-17 NO NO90903185A patent/NO903185L/no unknown
- 1990-07-18 FI FI903622A patent/FI903622A7/fi not_active Application Discontinuation
- 1990-07-18 JP JP2188155A patent/JPH0356474A/ja active Pending
- 1990-07-18 DD DD342895A patent/DD300432A5/de unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU904131D0 (en) | 1990-12-28 |
| FI903622A0 (fi) | 1990-07-18 |
| NZ234061A (en) | 1993-02-25 |
| DK0409413T3 (da) | 1994-08-29 |
| AU636357B2 (en) | 1993-04-29 |
| EP0409413A3 (en) | 1991-07-17 |
| DE69011234T2 (de) | 1994-12-08 |
| IE64358B1 (en) | 1995-07-26 |
| FI903622A7 (fi) | 1991-01-19 |
| ES2057410T3 (es) | 1994-10-16 |
| IE902112A1 (en) | 1991-06-19 |
| EP0409413B1 (de) | 1994-08-03 |
| US5208259A (en) | 1993-05-04 |
| DE69011234D1 (de) | 1994-09-08 |
| DD300432A5 (de) | 1992-06-11 |
| GB9015571D0 (en) | 1990-09-05 |
| CA2019345A1 (en) | 1991-01-18 |
| NO903185D0 (no) | 1990-07-17 |
| IL94732A0 (en) | 1991-04-15 |
| JPH0356474A (ja) | 1991-03-12 |
| EP0409413A2 (de) | 1991-01-23 |
| HU209889B (en) | 1994-11-28 |
| NO903185L (no) | 1991-01-21 |
| KR910002827A (ko) | 1991-02-26 |
| PT94723A (pt) | 1991-03-20 |
| AU5757590A (en) | 1991-01-24 |
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