ATE109624T1 - Bakteriocine enthaltende zusammensetzungen zur verwendung als verbesserte breitspektrum- bakterizide und verfahren zur verhütung und behandlung von mikrobiellen infektionen. - Google Patents
Bakteriocine enthaltende zusammensetzungen zur verwendung als verbesserte breitspektrum- bakterizide und verfahren zur verhütung und behandlung von mikrobiellen infektionen.Info
- Publication number
- ATE109624T1 ATE109624T1 AT90904988T AT90904988T ATE109624T1 AT E109624 T1 ATE109624 T1 AT E109624T1 AT 90904988 T AT90904988 T AT 90904988T AT 90904988 T AT90904988 T AT 90904988T AT E109624 T1 ATE109624 T1 AT E109624T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- lysostaphin
- broad range
- preventing
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dentistry (AREA)
- Biotechnology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/317,627 US4980163A (en) | 1989-03-01 | 1989-03-01 | Novel bacteriocin compositions for use as enhanced broad range bactericides and methods of preventing and treating microbial infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE109624T1 true ATE109624T1 (de) | 1994-08-15 |
Family
ID=23234535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90904988T ATE109624T1 (de) | 1989-03-01 | 1990-02-27 | Bakteriocine enthaltende zusammensetzungen zur verwendung als verbesserte breitspektrum- bakterizide und verfahren zur verhütung und behandlung von mikrobiellen infektionen. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4980163A (de) |
| EP (1) | EP0424484B1 (de) |
| JP (1) | JP2984744B2 (de) |
| KR (1) | KR0145738B1 (de) |
| AT (1) | ATE109624T1 (de) |
| AU (1) | AU618714B2 (de) |
| CA (1) | CA2028140C (de) |
| CZ (1) | CZ279273B6 (de) |
| DD (1) | DD301903A9 (de) |
| DE (1) | DE69011460T2 (de) |
| DK (1) | DK0424484T3 (de) |
| FI (1) | FI103861B1 (de) |
| HU (1) | HU217574B (de) |
| IE (1) | IE64710B1 (de) |
| IL (1) | IL93527A (de) |
| NO (1) | NO304721B1 (de) |
| NZ (1) | NZ232700A (de) |
| PL (1) | PL163940B1 (de) |
| RU (1) | RU2048151C1 (de) |
| WO (1) | WO1990009739A1 (de) |
| ZA (1) | ZA901499B (de) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5858962A (en) * | 1987-05-11 | 1999-01-12 | Ambi Inc. | Composition for treating mastitis and other staphylococcal infections |
| US5260271A (en) * | 1988-06-22 | 1993-11-09 | Applied Microbiology, Inc. | Nisin compositions for use as enhanced broad range bactericides |
| DE3938140A1 (de) * | 1989-11-16 | 1991-08-08 | Beiersdorf Ag | Desodorierende kosmetische mittel |
| NO911341L (no) * | 1990-04-20 | 1991-10-21 | Haarmann & Reimer Corp | Fremgangsmaate for aa drepe gram-negative bakterier. |
| CA2108455C (en) * | 1991-04-15 | 1999-01-19 | Peter J. Edwards | Pharmaceutical compositions against gastric disorders |
| GB9126686D0 (en) * | 1991-12-17 | 1992-02-12 | Smithkline Beecham Plc | Novel compositions |
| US5342612A (en) * | 1991-12-20 | 1994-08-30 | American Cyanamid Company | Compositions for the treatment of mammalian diseases |
| EP0629347B1 (de) * | 1992-01-23 | 1997-07-02 | Morinaga Milk Industry Co., Ltd. | Antibakterielles mittel und behandlung von gegenständen mit diesem |
| DE4229707A1 (de) * | 1992-09-05 | 1994-03-10 | Beiersdorf Ag | Germicide Wirkstoffkombinationen |
| EP0666759A1 (de) * | 1992-10-29 | 1995-08-16 | DENECKE, Rainer | Präparat zur therapie und insbesondere prophylaxe von erkrankungen des verdauungstraktes |
| DE4307352A1 (de) * | 1992-10-29 | 1994-05-05 | Denecke Rainer Dr Med Vet | Präparat zur Therapie und insbesondere Prophylaxe von Erkrankungen des Verdauungstraktes |
| GB9224598D0 (en) * | 1992-11-24 | 1993-01-13 | Smithkline Beecham Plc | Novel compositions |
| IL107887A (en) * | 1992-12-08 | 2003-07-06 | Ambi Inc | Stabilized lanthionine containing bacteriocin compositions |
| US5368845A (en) * | 1993-01-07 | 1994-11-29 | Colgate Palmolive Company | Oral composition |
| US5512269A (en) * | 1993-06-09 | 1996-04-30 | Burroughs Wellcome, Co. | Method of treating retained pulmonary secretions |
| CA2169847C (en) * | 1993-08-20 | 2006-02-14 | John Edmondson Peel | Method for the prevention and treatment of bovine mastitis |
| CA2121989A1 (en) * | 1993-11-18 | 1995-05-19 | Aloysius Knipper | Thermal abuse resistant egg |
| US5650320A (en) * | 1994-04-20 | 1997-07-22 | University Of Alabama At Birmingham Research Foundation | Lanthionine antibiotic compositions and methods |
| RU2143489C1 (ru) * | 1994-11-25 | 1999-12-27 | Нижегородский научно-исследовательский институт эпидемиологии и микробиологии | Способ получения лизостафина |
| US5762948A (en) * | 1995-06-07 | 1998-06-09 | Ambi Inc. | Moist bacteriocin disinfectant wipes and methods of using the same |
| DE69629691T2 (de) * | 1995-06-23 | 2004-02-26 | Ambi, Inc. | Verfahren zur kontrolle von antibiotikaresistenten grampositiven bakterien und behandlung von infektionen |
| US5703040A (en) * | 1995-11-22 | 1997-12-30 | Kansas State University Research Foundation | Broad spectrum antibiotic peptide |
| US5804549A (en) * | 1996-01-05 | 1998-09-08 | Ambi Inc. | Compositions with activity against helicobacter |
| US6086894A (en) * | 1996-06-27 | 2000-07-11 | Virginia Tech Intellectual Properties, Inc. | Recombinant vaccine for diseases caused by encapsulated organisms |
| US5932547A (en) * | 1996-07-03 | 1999-08-03 | Alza Corporation | Non-aqueous polar aprotic peptide formulations |
| RO119862B1 (ro) * | 1996-07-03 | 2005-05-30 | Alza Corporation | Formulare stabilă neapoasă şi procedeu pentru prepararea acesteia |
| US5916582A (en) * | 1996-07-03 | 1999-06-29 | Alza Corporation | Aqueous formulations of peptides |
| US5910479A (en) * | 1996-10-18 | 1999-06-08 | Ambi Inc. | Method for the treatment of Streptococcus pneumoniae infection |
| US6238377B1 (en) | 1997-01-27 | 2001-05-29 | Jin-Zhou Liu | Nasal-nasopharyngeal cleaning system |
| ZA984591B (en) * | 1997-06-09 | 1998-12-08 | Ambi Inc | A method for the treatment of diarrheal disease and for elmininating particular bacterial populations from the colon |
| US6028051A (en) * | 1997-07-23 | 2000-02-22 | Ambi Inc. | Method for the treatment of staphylococcal disease |
| US6315996B1 (en) | 1999-04-09 | 2001-11-13 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Topical lysostaphin therapy for staphylococcus ocular infections |
| US6187768B1 (en) | 1999-06-01 | 2001-02-13 | Becton, Dickinson And Company | Kit for flushing medical devices and method of preparation |
| US6342385B1 (en) | 2000-07-28 | 2002-01-29 | The Uab Research Foundation | Mutacin I biosynthesis genes and proteins |
| EP1362089B1 (de) * | 2001-02-17 | 2007-01-03 | Novozymes A/S | Verminderung von unangenehmen gerüchen von wäsche |
| US7572439B2 (en) * | 2002-03-26 | 2009-08-11 | Biosynexus Incorporated | Enzyme disruption of bacterial biofilms |
| RU2241339C2 (ru) * | 2002-09-19 | 2004-12-10 | Общество с ограниченной ответственностью "ЛЕНОК-М" | Способ производства консервов "зелёный горошек" из сушёного зерна |
| CA2502600A1 (en) * | 2002-10-18 | 2004-05-06 | Molichem Medicines, Inc. | Methods of treating dry eye disease with lantibiotics |
| AP2005003346A0 (en) * | 2002-12-10 | 2005-06-30 | Biosynexus Inc | Topical anti-infective formulations |
| US20100221237A1 (en) * | 2003-03-26 | 2010-09-02 | Biosynexus Incorporated | Enzyme disruption of bacterial biofilms |
| US6989370B2 (en) * | 2003-05-01 | 2006-01-24 | The United States Of America As Represented By The Secretary Of Agriculture | Bacteriocins and novel bacterial strains |
| MXPA06002060A (es) * | 2003-08-22 | 2006-05-19 | Danisco | Composicion que comprende una bacteriocina y un extracto a partir de una planta de la familia labiatae. |
| ES2481167T3 (es) * | 2003-08-22 | 2014-07-29 | Dupont Nutrition Biosciences Aps | Composición que comprende una bacteriocina y un extracto de una planta de la familia Labiatae |
| US20050058673A1 (en) | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
| EP3025704B1 (de) | 2005-03-10 | 2019-01-16 | 3M Innovative Properties Company | Verfahren zur verringerung von mikrobieller kontamination |
| CN101137359B (zh) | 2005-03-10 | 2011-01-12 | 3M创新有限公司 | 治疗耳感染的方法 |
| MX2007010908A (es) | 2005-03-10 | 2007-12-05 | 3M Innovative Properties Co | Composiciones antimicrobianas que comprenden esteres de acidos hidroxicarboxilicos. |
| EP1959740A2 (de) * | 2005-11-15 | 2008-08-27 | LG Electronics Inc. | Antimikrobielle beschichtung auf basis von kimchi-milchsäurebakterien |
| ES2346808T3 (es) * | 2006-03-31 | 2010-10-20 | The University Court Of The University Of St. Andrews | Composiciones antimicrobianas que comprenden un peptido cationico y una endopeptidasa de glicilglicina. |
| US8747872B2 (en) * | 2007-05-02 | 2014-06-10 | The Regents Of The University Of Michigan | Nanoemulsion therapeutic compositions and methods of using the same |
| US20110044968A1 (en) * | 2008-03-10 | 2011-02-24 | Pharmal N Corporation | Compositions for treatment with metallopeptidases, methods of making and using the same |
| WO2009150171A1 (en) * | 2008-06-10 | 2009-12-17 | Profos Ag | Method of treatment of inflammatory diseases |
| US8425968B2 (en) * | 2009-06-19 | 2013-04-23 | Pepsico., Inc. | Beverage preservative system containing pimaricin-cyclodextrin complex |
| US9200251B1 (en) | 2011-03-31 | 2015-12-01 | David Gordon Bermudes | Bacterial methionine analogue and methionine synthesis inhibitor anticancer, antiinfective and coronary heart disease protective microcins and methods of treatment therewith |
| US20140090833A1 (en) * | 2012-09-28 | 2014-04-03 | Halliburton Energy Services, Inc. | Methods for Treating Wellbore and Wellbore Operation Fluids |
| RU2629819C1 (ru) * | 2016-08-23 | 2017-09-04 | Федеральное бюджетное учреждение науки "Казанский научно-исследовательский институт эпидемиологии и микробиологии" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека | Антибактериальная композиция на основе хитозана и лизостафина |
| CN113396937A (zh) * | 2020-03-17 | 2021-09-17 | 孟州云大高科生物科技有限公司 | 一种多酶与生物类杀菌剂的组合物 |
| EP4146165A1 (de) | 2020-05-08 | 2023-03-15 | Fertin Pharma A/S | Orale pulvermischung mit kleinen teilchen |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2744827A (en) * | 1951-03-07 | 1956-05-08 | Nat Res Dev | Manufacture and preservation of cheese |
| GB738655A (en) * | 1952-05-09 | 1955-10-19 | Aplin & Barrett Ltd | A dry nisin preparation |
| US3278378A (en) | 1962-04-19 | 1966-10-11 | Schindler Charles Alvin | Staphylococcus-derived antibiotic |
| US3579354A (en) * | 1968-08-01 | 1971-05-18 | Beatrice Foods Co | Preparation of an elastic cheese product |
| US3899594A (en) * | 1971-09-13 | 1975-08-12 | Dirigo Corp | Food preservation |
| US3988307A (en) * | 1974-09-06 | 1976-10-26 | The United States Of America As Represented By The Secretary Of The Department Of Health, Education And Welfare | Solid phase synthesis of peptides with carboxyl-terminal amides |
| PL193146A1 (pl) * | 1976-10-19 | 1978-04-24 | Inst Przemyslu Mleczarskiego | Preparat enzymatyczny do dojrzewania bialkowych produktow mleczarskich |
| US4318928A (en) * | 1979-12-19 | 1982-03-09 | Sing Edmond L | Preparation of cottage cheese containing Streptococcus diacetilactis |
| US4477471A (en) * | 1982-04-15 | 1984-10-16 | Microlife Technics, Inc. | Preservation of foods with non-lactose fermenting Streptococcus Lactis subspecies diacetilactis |
| US4584199A (en) * | 1983-06-10 | 1986-04-22 | Aplin & Barrett, Ltd. | Antibotulinal agents for high moisture process cheese products |
| US4597972A (en) * | 1983-06-10 | 1986-07-01 | Aplin & Barrett, Ltd. | Nisin as an antibotulinal agent for food products |
| US4716115A (en) * | 1983-09-06 | 1987-12-29 | Microlife Technics, Inc. | Derived nisin producing microorganisms, method of production and use and products obtained thereby |
| US4485029A (en) * | 1984-03-19 | 1984-11-27 | Minnesota Mining And Manufacturing Company | Disinfecting method and compositions |
| US4929445A (en) * | 1988-01-25 | 1990-05-29 | Microlife Technics, Inc. | Method for inhibiting Listeria monocytogenes using a bacteriocin |
-
1989
- 1989-03-01 US US07/317,627 patent/US4980163A/en not_active Expired - Lifetime
-
1990
- 1990-02-26 IL IL9352790A patent/IL93527A/en not_active IP Right Cessation
- 1990-02-27 CA CA002028140A patent/CA2028140C/en not_active Expired - Fee Related
- 1990-02-27 JP JP2504798A patent/JP2984744B2/ja not_active Expired - Lifetime
- 1990-02-27 DK DK90904988.4T patent/DK0424484T3/da active
- 1990-02-27 EP EP90904988A patent/EP0424484B1/de not_active Expired - Lifetime
- 1990-02-27 NZ NZ232700A patent/NZ232700A/en unknown
- 1990-02-27 RU SU904831853A patent/RU2048151C1/ru not_active IP Right Cessation
- 1990-02-27 DE DE69011460T patent/DE69011460T2/de not_active Expired - Fee Related
- 1990-02-27 AU AU52850/90A patent/AU618714B2/en not_active Ceased
- 1990-02-27 ZA ZA901499A patent/ZA901499B/xx unknown
- 1990-02-27 WO PCT/US1990/001053 patent/WO1990009739A1/en not_active Ceased
- 1990-02-27 AT AT90904988T patent/ATE109624T1/de not_active IP Right Cessation
- 1990-02-27 HU HU849/90A patent/HU217574B/hu not_active IP Right Cessation
- 1990-02-27 KR KR1019900702363A patent/KR0145738B1/ko not_active Expired - Fee Related
- 1990-02-28 IE IE72190A patent/IE64710B1/en not_active IP Right Cessation
- 1990-03-01 CZ CS90984A patent/CZ279273B6/cs not_active IP Right Cessation
- 1990-03-01 PL PL90284095A patent/PL163940B1/pl not_active IP Right Cessation
- 1990-03-01 DD DD33828290A patent/DD301903A9/de unknown
- 1990-10-31 FI FI905378A patent/FI103861B1/fi not_active IP Right Cessation
- 1990-10-31 NO NO904729A patent/NO304721B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE64710B1 (en) | 1995-08-23 |
| FI103861B (fi) | 1999-10-15 |
| IE900721L (en) | 1990-09-01 |
| HU902849D0 (en) | 1991-05-28 |
| DE69011460D1 (de) | 1994-09-15 |
| DK0424484T3 (da) | 1994-10-03 |
| EP0424484A1 (de) | 1991-05-02 |
| RU2048151C1 (ru) | 1995-11-20 |
| HU217574B (hu) | 2000-02-28 |
| KR920700003A (ko) | 1992-02-19 |
| IL93527A (en) | 1995-03-15 |
| NO904729L (no) | 1990-11-15 |
| IL93527A0 (en) | 1990-11-29 |
| NO304721B1 (no) | 1999-02-08 |
| WO1990009739A1 (en) | 1990-09-07 |
| DD301903A9 (de) | 1994-06-30 |
| AU618714B2 (en) | 1992-01-02 |
| US4980163A (en) | 1990-12-25 |
| FI103861B1 (fi) | 1999-10-15 |
| JP2984744B2 (ja) | 1999-11-29 |
| DE69011460T2 (de) | 1994-12-22 |
| ZA901499B (en) | 1990-11-28 |
| KR0145738B1 (ko) | 1998-08-01 |
| CA2028140C (en) | 1996-12-03 |
| PL284095A1 (en) | 1992-09-21 |
| NZ232700A (en) | 1992-10-28 |
| JPH03504864A (ja) | 1991-10-24 |
| CA2028140A1 (en) | 1990-09-02 |
| HUT55607A (en) | 1991-06-28 |
| FI905378A0 (fi) | 1990-10-31 |
| EP0424484B1 (de) | 1994-08-10 |
| PL163940B1 (pl) | 1994-05-31 |
| CZ279273B6 (cs) | 1995-03-15 |
| NO904729D0 (no) | 1990-10-31 |
| AU5285090A (en) | 1990-09-26 |
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