ATE110578T1 - Von hydrogel angetriebene verabreichungsvorrichtung. - Google Patents

Von hydrogel angetriebene verabreichungsvorrichtung.

Info

Publication number
ATE110578T1
ATE110578T1 AT90300301T AT90300301T ATE110578T1 AT E110578 T1 ATE110578 T1 AT E110578T1 AT 90300301 T AT90300301 T AT 90300301T AT 90300301 T AT90300301 T AT 90300301T AT E110578 T1 ATE110578 T1 AT E110578T1
Authority
AT
Austria
Prior art keywords
hydrogel
powered
beneficial agents
devices
administration device
Prior art date
Application number
AT90300301T
Other languages
German (de)
English (en)
Inventor
William John Curatolo
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE110578T1 publication Critical patent/ATE110578T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Materials For Medical Uses (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Prostheses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT90300301T 1989-01-12 1990-01-10 Von hydrogel angetriebene verabreichungsvorrichtung. ATE110578T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29646489A 1989-01-12 1989-01-12

Publications (1)

Publication Number Publication Date
ATE110578T1 true ATE110578T1 (de) 1994-09-15

Family

ID=23142114

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90300301T ATE110578T1 (de) 1989-01-12 1990-01-10 Von hydrogel angetriebene verabreichungsvorrichtung.

Country Status (19)

Country Link
US (2) US5516527A (fr)
EP (1) EP0378404B1 (fr)
JP (1) JPH07119171B2 (fr)
KR (1) KR920008702B1 (fr)
AT (1) ATE110578T1 (fr)
AU (1) AU615129B2 (fr)
CA (1) CA2007463C (fr)
DE (1) DE69011878T2 (fr)
DK (1) DK0378404T3 (fr)
ES (1) ES2058775T3 (fr)
FI (1) FI900153A7 (fr)
HU (1) HUT54038A (fr)
IE (1) IE64201B1 (fr)
IL (1) IL92966A (fr)
MY (1) MY105761A (fr)
NO (1) NO900151L (fr)
NZ (1) NZ232078A (fr)
PT (1) PT92838B (fr)
ZA (1) ZA90197B (fr)

Families Citing this family (180)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366738A (en) * 1982-07-29 1994-11-22 Merck & Co., Inc. Controlled release drug dispersion delivery device
IL92966A (en) * 1989-01-12 1995-07-31 Pfizer Dispensing devices powered by hydrogel
US5024843A (en) * 1989-09-05 1991-06-18 Alza Corporation Oral hypoglycemic glipizide granulation
US5160744A (en) * 1991-06-27 1992-11-03 Alza Corporation Verapmil therapy
US6764697B1 (en) 1991-06-27 2004-07-20 Alza Corporation System for delaying drug delivery up to seven hours
EP0607321A1 (fr) * 1991-10-10 1994-07-27 Alza Corporation Dispositifs de perfusion osmotique de medicaments utilisant des materiaux de paroi hydrophobes
SK279964B6 (sk) * 1991-12-27 1999-06-11 Merck & Co. Dávkovacia forma na riadené uvoľňovanie liečiva a
US5543154A (en) * 1991-12-27 1996-08-06 Merck & Co., Inc. Controlled release nifedipine delivery device
US5330762A (en) * 1992-02-27 1994-07-19 Alza Corporation Tandospiaine antidepressive therapy
ZA935569B (en) * 1992-07-31 1994-04-12 Daratech Pty Ltd Controlled release implants
SK281042B6 (sk) 1992-09-18 2000-11-07 Yamanouchi Pharmaceutical Co., Ltd Prípravok hydrogélového typu s ustáleným uvoľňovaním
JPH06256166A (ja) * 1993-01-06 1994-09-13 ▲寛▼治 ▲高▼田 薬物放出制御製剤
US6440457B1 (en) 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
HUT77530A (hu) * 1994-05-06 1998-05-28 Pfizer Inc. Azitromicint tartalmazó, szabályozott hatóanyag-felszabadítású dózisformák
US5582838A (en) * 1994-12-22 1996-12-10 Merck & Co., Inc. Controlled release drug suspension delivery device
US5654005A (en) * 1995-06-07 1997-08-05 Andrx Pharmaceuticals, Inc. Controlled release formulation having a preformed passageway
GB9523752D0 (en) * 1995-11-21 1996-01-24 Pfizer Ltd Pharmaceutical formulations
US6096339A (en) * 1997-04-04 2000-08-01 Alza Corporation Dosage form, process of making and using same
GB9611328D0 (en) * 1996-05-31 1996-08-07 Zeneca Ltd Pharmaceutical compositions
DE69735002T2 (de) * 1996-10-25 2006-10-26 Shire Laboratories, Inc. Osmotisches Verabreichungssystem für lösliche Dosen
US6706283B1 (en) 1999-02-10 2004-03-16 Pfizer Inc Controlled release by extrusion of solid amorphous dispersions of drugs
ATE433318T1 (de) * 1999-02-10 2009-06-15 Pfizer Prod Inc Osmotisches system zur verabreichung von wirkstoffen, die feste amorphe dispersionen enthalten
US6228392B1 (en) * 1999-04-29 2001-05-08 Gene Tools, Llc Osmotic delivery composition, solution, and method
US6251432B1 (en) * 1999-07-01 2001-06-26 Abbott Laboratories Sustained release dosage form unit having latex coating and method of making the same
EP1967185A1 (fr) * 1999-12-23 2008-09-10 Pfizer Products Inc. Forme de dosage de médicament entraîné par un hydrogél
JP2003518487A (ja) 1999-12-23 2003-06-10 ファイザー・プロダクツ・インク ヒドロゲル駆動型積層薬物製剤
CN1402629A (zh) 1999-12-23 2003-03-12 辉瑞产品公司 提供提高的药物浓度的药物组合物
US6753011B2 (en) 2000-01-14 2004-06-22 Osmotica Corp Combined diffusion/osmotic pumping drug delivery system
US6352721B1 (en) 2000-01-14 2002-03-05 Osmotica Corp. Combined diffusion/osmotic pumping drug delivery system
US6669954B2 (en) 2000-01-25 2003-12-30 John R. Crison Controlled release of drugs
US6309810B1 (en) 2000-06-13 2001-10-30 Eastman Kodak Company Photochemical delivery article and method of use
US6361225B1 (en) 2000-06-13 2002-03-26 Eastman Kodak Company Apparatus for providing a photochemical reaction
US6296993B1 (en) 2000-06-13 2001-10-02 Eastman Kodak Company Method of providing digitized photographic image
US20030086972A1 (en) * 2000-08-09 2003-05-08 Appel Leah E. Hydrogel-driven drug dosage form
US6770721B1 (en) * 2000-11-02 2004-08-03 Surface Logix, Inc. Polymer gel contact masks and methods and molds for making same
CN1204922C (zh) * 2001-02-15 2005-06-08 株式会社三和化学研究所 新的眼科用组合物
NZ527930A (en) * 2001-03-16 2005-11-25 Andrx Pharmaceuticals Llc Controlled release sulfonylurea formulation
US20030008007A1 (en) * 2001-04-23 2003-01-09 Jose Gutierrez-Rocca Release pharmaceutical construct for gastric retention
NZ532096A (en) * 2001-09-28 2006-10-27 Mcneil Ppc Inc Dosage forms having an inner core and outer shell with different shapes
WO2003045437A1 (fr) * 2001-11-30 2003-06-05 Pfizer Products Inc. Compositions pharmaceutiques de 5,7,14-triazatetracyclo[10.3.1.0(2,11).0(4,9)]-hexadeca-2(11)3,5,7,9-pentaene
CN1625397A (zh) 2002-02-01 2005-06-08 辉瑞产品公司 胆固醇酯转移蛋白抑制剂的控制释放药物剂型
AR038375A1 (es) 2002-02-01 2005-01-12 Pfizer Prod Inc Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo
US7125563B2 (en) 2002-04-12 2006-10-24 Dava Pharmaceuticals, Inc. Sustained release pharmaceutical preparations and methods for producing the same
EA200401462A1 (ru) * 2002-05-06 2005-06-30 Рэнбакси Лабораториз Лимитед Однокамерная система осмотически регулируемой доставки лекарственного средства
NZ570198A (en) * 2002-07-29 2010-01-29 Alza Corp Methods and dosage forms for controlled delivery of paliperidone or risperidone
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
US9107804B2 (en) 2002-12-10 2015-08-18 Nortec Development Associates, Inc. Method of preparing biologically active formulations
UY28326A1 (es) * 2003-05-22 2004-06-30 Osmotica Argentina S A Dispositivo de ruptura de liberacion controlada con un pasaje preformado
US8029822B2 (en) 2003-05-22 2011-10-04 Osmotica Kereskedelmi és Seolgáltató KFT Rupturing controlled release device having a preformed passageway
JP5628467B2 (ja) 2003-06-26 2014-11-19 シヴィダ・ユーエス・インコーポレイテッドＰｓｉｖｉｄａ Ｕｓ， Ｉｎｃ． 生体分解性徐放性ドラッグデリバリーシステム
DK1635875T3 (da) 2003-06-26 2009-01-12 Psivida Inc In-situ-geldannende lægemiddeladministrationssystem
US20050142203A1 (en) * 2003-12-30 2005-06-30 Grant Heinicke Oral dosage formulations of active pharmaceutical ingredients and methods of preparing the same
CA2574976C (fr) * 2004-08-02 2012-01-10 Samyang Corporation Composition polymerique biodegradable multiblocs capable de transition sol-gel
WO2006054152A1 (fr) * 2004-11-22 2006-05-26 Ranbaxy Laboratories Limited Systeme de liberation monocompartimental de doxazosine a regulation osmotique
JP2007070344A (ja) * 2005-08-11 2007-03-22 Tsukioka:Kk 内服薬
US8187639B2 (en) * 2005-09-27 2012-05-29 Tissue Tech, Inc. Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
CA2999420A1 (fr) 2005-09-27 2007-04-05 Tissuetech, Inc. Preparations de membrane amniotique et compositions purifiees, et procedes d'utilisation
NZ543314A (en) * 2005-10-28 2007-08-31 Interag A delivery system where the driving substance contains the active component
US7858609B2 (en) 2005-11-28 2010-12-28 Marinus Pharmaceuticals Solid ganaxolone formulations and methods for the making and use thereof
WO2008021212A2 (fr) 2006-08-11 2008-02-21 Payload Systems, Inc. dispositif exerçant une pression hémostatique et présentant une haute vitesse de gonflement
EP2056818B1 (fr) 2006-08-11 2011-05-25 The Johns Hopkins University Compositions et méthodes de neuroprotection
DK2526933T3 (en) 2006-09-22 2015-05-18 Pharmacyclics Inc Inhibitors of Bruton's tyrosine kinase
US8812637B2 (en) * 2006-11-28 2014-08-19 International Business Machines Corporation Aggregation of multiple media streams to a user
US20080127272A1 (en) * 2006-11-28 2008-05-29 Brian John Cragun Aggregation of Multiple Media Streams to a User
US8637080B2 (en) 2007-06-28 2014-01-28 Osmotica Kereskedelmi és Szolgáltató, KFT Rupturing controlled release device comprising a subcoat
US8263641B2 (en) 2007-09-10 2012-09-11 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN102026628A (zh) * 2008-02-15 2011-04-20 太阳医药高级研发有限公司 具有降低崩裂效果的口服控释片剂
TWI392673B (zh) 2008-08-27 2013-04-11 Calcimedica Inc 調控細胞內鈣離子濃度之化合物
WO2010124296A2 (fr) 2009-04-24 2010-10-28 Tissuetech, Inc. Composition contenant le complexe hc•ha et procédés d'utilisation de celle-ci
SMT202000093T1 (it) 2009-06-16 2020-03-13 Pfizer Forme di dosaggio di apixaban
WO2011006066A1 (fr) 2009-07-10 2011-01-13 Ironwood Pharmaceuticals, Inc. Agonistes des récepteurs cb
US7718662B1 (en) 2009-10-12 2010-05-18 Pharmacyclics, Inc. Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase
CN102695501A (zh) 2009-11-09 2012-09-26 聚光灯技术合伙有限责任公司 碎裂水凝胶
CN106913902A (zh) 2009-11-09 2017-07-04 聚光灯技术合伙有限责任公司 多糖基水凝胶
JP5731538B2 (ja) 2009-12-23 2015-06-10 アイアンウッド ファーマシューティカルズ インコーポレイテッド Ｃｒｔｈ２モジュレーター
US20130196960A1 (en) 2010-02-09 2013-08-01 Ironwood Pharmaceuticals, Inc. Cannabinoid Receptor Agonists
US20130178453A1 (en) 2010-02-09 2013-07-11 Ironwood Pharmaceuticals, Inc. Cannabinoid Agonists
WO2011115804A1 (fr) 2010-03-17 2011-09-22 Ironwood Pharmaceuticals, Inc. Stimulateurs de sgc
JPWO2011118454A1 (ja) * 2010-03-23 2013-07-04 リンテック株式会社 固形製剤
WO2011130689A1 (fr) 2010-04-15 2011-10-20 Tracon Pharmaceuticals, Inc. Potentialisation de l'activité anticancéreuse par polythérapie avec des inhibiteurs de la voie ber
EP2563759B1 (fr) 2010-04-27 2022-04-06 Calcimedica, Inc. Composés qui modulent le calcium intracellulaire
JP6112486B2 (ja) 2010-04-27 2017-04-12 カルシメディカ，インク． 細胞内カルシウムを調節する化合物
CA3007787C (fr) 2010-06-03 2020-03-10 Pharmacyclics Llc Utilisation d'inhibiteurs de la tyrosine kinase de bruton (btk)
EP2588465B1 (fr) 2010-06-30 2017-01-25 Ironwood Pharmaceuticals, Inc. Stimulateurs de sgc
US20130259830A1 (en) 2010-07-12 2013-10-03 Ironwood Pharmaceuticals, Inc. Crth2 modulators
WO2012009137A1 (fr) 2010-07-12 2012-01-19 Ironwood Pharmaceuticals, Inc. Modulateurs de crth2
EP2609095A4 (fr) 2010-08-27 2014-06-18 Calcimedica Inc Composés modulant le calcium intracellulaire
CN107266433A (zh) 2010-11-09 2017-10-20 铁木医药有限公司 sGC刺激剂
WO2012149486A1 (fr) 2011-04-28 2012-11-01 Tissuetech, Inc. Procédés de modulation de remodélisation osseuse
EP2717888B1 (fr) 2011-06-10 2020-09-09 Tissuetech, Inc. Procédés de traitement de tissus foetaux de support
JP6330118B2 (ja) 2011-09-13 2018-05-30 ファーマサイクリックス エルエルシー ベンダムスチンと組み合わせたヒストンデアセチラーゼ阻害剤の製剤とその使用
CN106117194A (zh) 2011-12-27 2016-11-16 铁木医药有限公司 可用作sgc刺激剂的2‑苄基、3‑(嘧啶‑2‑基)取代的吡唑类
US8377946B1 (en) 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
US9487495B2 (en) 2012-01-06 2016-11-08 The Scripts Research Institute Carbamate compounds and of making and using same
US9046085B2 (en) * 2012-03-14 2015-06-02 Eden Medical, Inc. Miniature pumps
US20150080381A1 (en) 2012-04-12 2015-03-19 Ironwood Pharmaceuticals, Inc. Methods of treating alopecia and acne
KR20210033067A (ko) 2012-06-04 2021-03-25 파마싸이클릭스 엘엘씨 브루톤 타이로신 키나아제 저해제의 결정 형태
EP3838293A1 (fr) 2012-07-11 2021-06-23 Tissuetech, Inc. Compositions contenant des complexes hc-ah/ptx3 et procédés d'utilisation associés
WO2014047111A1 (fr) 2012-09-18 2014-03-27 Ironwood Pharmaceuticals, Inc. Stimulateurs de la sgc
EP2897953B8 (fr) 2012-09-19 2019-06-26 Cyclerion Therapeutics, Inc. Stimulateurs de sgc
WO2014052914A1 (fr) 2012-09-28 2014-04-03 University Of Washington Through Its Center For Commercialization Composés et procédés de prévention, de traitement et/ou de protection contre la mort de cellules ciliées sensorielles
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
US10172791B2 (en) * 2013-03-14 2019-01-08 Massachusetts Institute Of Technology Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
US9555007B2 (en) * 2013-03-14 2017-01-31 Massachusetts Institute Of Technology Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
EA033168B1 (ru) 2013-03-15 2019-09-30 Сайклерион Терапьютикс, Инк. СТИМУЛЯТОРЫ sGC
US9611263B2 (en) 2013-10-08 2017-04-04 Calcimedica, Inc. Compounds that modulate intracellular calcium
GB201319791D0 (en) * 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
US9382246B2 (en) 2013-12-05 2016-07-05 Pharmacyclics Llc Inhibitors of Bruton's tyrosine kinase
CA2933250A1 (fr) 2013-12-11 2015-06-18 Ironwood Pharmaceuticals, Inc. Stimulateurs de la sgc
CN104971414A (zh) * 2014-04-01 2015-10-14 黄震山 药物缓释器
EP3134418A4 (fr) 2014-04-23 2018-01-03 The Research Foundation for The State University of New York Réaction de ligature bio-orthogonale rapide et efficace et hétérocycles contenant du bore utiles en association avec celle-ci
TW201603818A (zh) 2014-06-03 2016-02-01 組織科技股份有限公司 組成物及方法
US9839644B2 (en) 2014-09-09 2017-12-12 ARKAY Therapeutics, LLC Formulations and methods for treatment of metabolic syndrome
EP3194386A2 (fr) 2014-09-17 2017-07-26 Ironwood Pharmaceuticals, Inc. Stimulateurs de sgc
EP3194382B1 (fr) 2014-09-17 2021-09-08 Cyclerion Therapeutics, Inc. Dérivés de pyrazole utilisés comme stimulateurs de sgc
US20170298055A1 (en) 2014-09-17 2017-10-19 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
US9359316B1 (en) 2014-11-25 2016-06-07 Concentric Analgesics, Inc. Prodrugs of phenolic TRPV1 agonists
WO2016127123A2 (fr) 2015-02-06 2016-08-11 University Of Washington Composés et procédés pour prévenir ou traiter la mort de cellules capillaires sensorielles
US10227333B2 (en) 2015-02-11 2019-03-12 Curtana Pharmaceuticals, Inc. Inhibition of OLIG2 activity
WO2016138025A2 (fr) 2015-02-23 2016-09-01 Tissuetech, Inc. Appareils et méthodes de traitement de maladies et de troubles ophtalmiques
MX394452B (es) 2015-02-27 2025-03-21 Curtana Pharmaceuticals Inc Inhibicion de la actividad de olig2.
IL315294A (en) 2015-03-03 2024-10-01 Pharmacyclics Llc Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
MA41828A (fr) 2015-03-27 2018-01-30 Pharmacyclics Llc Co-cristaux d'un inhibiteur de la tyrosine kinase de bruton
MA41827A (fr) 2015-03-27 2018-01-30 Pharmacyclics Llc Formes solvatées d'un inhibiteur de la tyrosine kinase de bruton
SG10202012002TA (en) 2015-05-11 2021-01-28 Lundbeck La Jolla Research Center Inc Methods of treating inflammation or neuropathic pain
TWI720984B (zh) 2015-05-20 2021-03-11 美商帝聖工業公司 用於防止上皮細胞增生及上皮-間質轉移之組合物及方法
MA45973A (fr) 2015-08-31 2019-06-26 Pharmacyclics Llc Combinaisons d'inhibiteurs de btk pour le traitement du myélome multiple
EP3827838B1 (fr) 2015-12-16 2023-06-07 The Walter and Eliza Hall Institute of Medical Research Inhibition de protéines sh2 induites par des cytokines dans des cellules nk
US20190290650A1 (en) 2016-01-19 2019-09-26 Janssen Pharmaceutic Nv Formulations/compositions comprising a btk inhibitor
MX2018008771A (es) 2016-01-19 2018-11-09 Janssen Pharmaceutica Nv Formulaciones/composiciones que comprenden un inhibidor de btk.
TW201733600A (zh) 2016-01-29 2017-10-01 帝聖工業公司 胎兒扶持組織物及使用方法
US10851123B2 (en) 2016-02-23 2020-12-01 Concentric Analgesics, Inc. Prodrugs of phenolic TRPV1 agonists
JP7049683B2 (ja) 2016-04-04 2022-04-07 シノピア バイオサイエンシーズ，インク． トラピジルを使用する錐体外路症候群の処置
EP3463576A4 (fr) 2016-05-25 2020-01-15 Concentric Analgesics, Inc. Promédicaments à base d'agonistes de trpv1 phénoliques en association avec des anesthésiques locaux et des vasoconstricteurs pour améliorer une anesthésie locale
WO2017205769A1 (fr) 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibiteurs de la kinase associée au récepteur de l'interleukine 1
WO2017205766A1 (fr) 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibiteurs de la kinase associée au récepteur de l'interleukine-1
WO2017205762A1 (fr) 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibiteurs de la kinase associée au récepteur de l'interleukine 1
CN113214198B (zh) 2016-07-18 2022-12-23 广州瑞安博医药科技有限公司 用于治疗或预防与痛风或高尿酸血症相关的症状的化合物、组合物和方法
AU2017314842B9 (en) 2016-08-26 2022-02-10 Curtana Pharmaceuticals, Inc. Inhibition of Olig2 activity
SI3507291T1 (sl) 2016-09-02 2021-11-30 Cyclerion Therapeutics, Inc. Kondenzirani biciklični SGS stimulatorji
ES2972711T3 (es) 2016-11-08 2024-06-14 Tisento Therapeutics Inc Tratamiento de enfermedades del CNS con estimuladores de la GCs
CN110267949A (zh) 2016-11-08 2019-09-20 塞科里昂医疗股份有限公司 sGC刺激剂
KR20190085046A (ko) 2016-11-16 2019-07-17 어바이드 테라퓨틱스, 인크. 약학 제제
DK3541807T3 (da) 2016-11-16 2021-12-06 H Lundbeck As Krystallinsk form af en magl-inhibitor
EP3675865B1 (fr) 2017-09-01 2025-04-02 University of Washington Formes cristallines de composés pour prévenir ou traiter la mort de cellules ciliées sensorielles
US11685722B2 (en) 2018-02-28 2023-06-27 Curtana Pharmaceuticals, Inc. Inhibition of Olig2 activity
WO2020023794A1 (fr) 2018-07-27 2020-01-30 Concentric Analgesics, Inc. Promédicaments pegylés d'agonistes du trpv1 phénolique
CA3121624A1 (fr) 2018-12-06 2020-06-11 Arthrosi Therapeutics, Inc. Methodes de traitement ou de prevention de la goutte ou de l'hyperuricemie
US12145917B2 (en) 2018-12-06 2024-11-19 Arthrosi Therapeutics, Inc. Crystalline forms of a compound for treating or preventing gout or hyperuricemia
SG11202106304RA (en) 2018-12-31 2021-07-29 Biomea Fusion Llc Irreversible inhibitors of menin-mll interaction
MX2021011081A (es) 2019-03-15 2022-01-18 Unicycive Therapeutics Inc Derivados de nicorandil.
MX2022011879A (es) 2020-03-26 2023-01-11 Sinopia Biosciences Inc Derivados de trapidilo marcados isotopicamente.
IL297470A (en) 2020-04-21 2022-12-01 H Lundbeck As Synthesis of a monoacylglycerol lipase inhibitor
US12435085B2 (en) 2020-05-11 2025-10-07 Casi Pharmaceuticals, Inc. Crystalline forms and formulations of a VCP/p97 inhibitor
WO2022133064A1 (fr) 2020-12-16 2022-06-23 Biomea Fusion, Inc. Composés de pyrimidine fusionnée utilisés comme inhibiteurs de l'interaction ménine-mll
WO2022150525A1 (fr) 2021-01-06 2022-07-14 Awakn Life Sciences Mdma dans le traitement d'un trouble de consommation d'alcool
US20240190809A1 (en) 2021-05-11 2024-06-13 Awakn Ls Europe Holdings Limited Therapeutic aminoindane compounds and compositions
AU2022283967A1 (en) 2021-06-03 2024-01-18 Arcadia Medicine, Inc. Enantiomeric entactogen compositions and methods of their use
TW202320796A (zh) 2021-08-11 2023-06-01 美商拜歐米富士恩股份有限公司 用於糖尿病的menin-mll相互作用之共價抑制劑
US12018032B2 (en) 2021-08-20 2024-06-25 Biomea Fusion, Inc. Crystalline forms of N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide as an irreversible inhibitor of menin-MLL interaction
EP4392027A4 (fr) 2021-08-23 2025-07-23 Alexander Shulgin Res Institute Inc Empathogènes fluorés
EP4392028A4 (fr) 2021-08-23 2025-09-24 Alexander Shulgin Res Institute Inc Empathogènes deutérés
WO2023027966A1 (fr) 2021-08-24 2023-03-02 Biomea Fusion, Inc. Composés de pyrazine en tant qu'inhibiteurs irréversibles de flt3
AU2022338032A1 (en) 2021-08-31 2024-03-07 Cerespir Incorporated Co-crystals
EP4396162A4 (fr) 2021-09-03 2025-11-12 Alexander Shulgin Res Institute Inc Allyl tryptamines asymétriques
US20240409558A1 (en) 2021-09-13 2024-12-12 Biomea Fusion, Inc. Irreversible inhibitors of kras
WO2023049480A1 (fr) 2021-09-25 2023-03-30 Alexander Shulgin Research Institute Phénylalkylamines substituées
US20250066386A1 (en) 2021-11-09 2025-02-27 Biomea Fusion, Inc. Inhibitors of kras
MX2024008057A (es) 2021-12-30 2024-08-28 Biomea Fusion Inc Compuestos de pirazina como inhibidores de flt3.
CA3249142A1 (fr) 2022-01-19 2023-07-27 Awakn Ls Europe Holdings Limited Esters de 1,3-benzodioxole et leur utilisation thérapeutique
CA3244485A1 (fr) 2022-02-16 2023-08-24 Awakn Ls Europe Holdings Limited Composes cycliques pontés et leur utilisation thérapeutique comme agents du snc
WO2023235618A1 (fr) 2022-06-03 2023-12-07 Biomea Fusion, Inc. Composés de pyrimidine fusionnés en tant qu'inhibiteurs de la ménine
US12612401B2 (en) 2022-07-06 2026-04-28 Oppilan Pharma Limited Crystalline forms of an S1P receptor modulator
WO2024155710A1 (fr) 2023-01-18 2024-07-25 Biomea Fusion, Inc. Formes cristallines de n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phényl]-4-[[3(r)-[(l-oxo-2-propen-l-yl)amino]-l-pipéridinyl]méthyl]-2- pyridinecarboxamide en tant qu'inhibiteur covalent de l'interaction ménine-mll
US20250002458A1 (en) 2023-05-24 2025-01-02 Unicycive Therapeutics Inc. Salt forms of nicorandil derivative
WO2024249950A1 (fr) 2023-06-02 2024-12-05 Biomea Fusion, Inc. Composés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de la ménine
US20250145571A1 (en) 2023-09-26 2025-05-08 Unicycive Therapeutics, Inc. Amino acid prodrugs of nicorandil
WO2025194102A1 (fr) 2024-03-15 2025-09-18 Unicycive Therapeutics, Inc. Dérivés de nicorandil modifiés par de la pyridine
TW202602880A (zh) 2024-03-29 2026-01-16 美商拜歐美亞富成股份有限公司 雜環glp-1r促效劑
WO2026076074A1 (fr) 2024-10-02 2026-04-09 Stamford Pharmaceuticals Inc. Virus fonctionnalisés, compositions et procédés associés

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3538214A (en) * 1969-04-22 1970-11-03 Merck & Co Inc Controlled release medicinal tablets
US3995631A (en) * 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4077407A (en) * 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
US4111202A (en) * 1976-11-22 1978-09-05 Alza Corporation Osmotic system for the controlled and delivery of agent over time
US4180073A (en) * 1977-08-29 1979-12-25 Alza Corporation Device for delivering drug to biological environment
US4217898A (en) * 1978-10-23 1980-08-19 Alza Corporation System with microporous reservoir having surface for diffusional delivery of agent
US4235236A (en) * 1979-02-12 1980-11-25 Alza Corporation Device for dispensing drug by combined diffusional and osmotic operations
US4320759A (en) * 1980-04-28 1982-03-23 Alza Corporation Dispenser with diffuser
US4350271A (en) * 1980-08-22 1982-09-21 Alza Corporation Water absorbing fluid dispenser
US4327725A (en) * 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4439196A (en) * 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4449983A (en) * 1982-03-22 1984-05-22 Alza Corporation Simultaneous delivery of two drugs from unit delivery device
US4578075A (en) * 1982-12-20 1986-03-25 Alza Corporation Delivery system housing a plurality of delivery devices
US4673405A (en) * 1983-03-04 1987-06-16 Alza Corporation Osmotic system with instant drug availability
US4783337A (en) * 1983-05-11 1988-11-08 Alza Corporation Osmotic system comprising plurality of members for dispensing drug
NZ206600A (en) * 1983-05-11 1987-01-23 Alza Corp Osmotic drug delivery device
US4765989A (en) * 1983-05-11 1988-08-23 Alza Corporation Osmotic device for administering certain drugs
GB8319766D0 (en) * 1983-07-22 1983-08-24 Graham N B Controlled release device
GB2150830B (en) * 1983-12-05 1987-08-19 Alza Corp Drug dispenser
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
US4772474A (en) * 1985-08-09 1988-09-20 Alza Corporation Dispenser with internal arrangement of lamina means for dispensing beneficial agent
US4595583A (en) * 1984-03-19 1986-06-17 Alza Corporation Delivery system controlled administration of beneficial agent to ruminants
US4684524A (en) * 1984-03-19 1987-08-04 Alza Corporation Rate controlled dispenser for administering beneficial agent
US4678467A (en) * 1984-03-21 1987-07-07 Alza Corporation Dispenser comprising capsule with volume displacing member
US4615698A (en) * 1984-03-23 1986-10-07 Alza Corporation Total agent osmotic delivery system
CA1266827A (fr) * 1984-06-20 1990-03-20 Merck & Co., Inc. Pompe osmotique a porosite controlee
US4608048A (en) * 1984-12-06 1986-08-26 Alza Corporation Dispensing device with drug delivery patterns
US4685918A (en) * 1985-02-01 1987-08-11 Merck & Co., Inc. Lipid osmotic pump
CA1242394A (fr) * 1985-03-07 1988-09-27 National Research Development Corporation Dispositif a liberation controlee
US4627971A (en) * 1985-04-22 1986-12-09 Alza Corporation Osmotic device with self-sealing passageway
US4666704A (en) * 1985-05-24 1987-05-19 International Minerals & Chemical Corp. Controlled release delivery system for macromolecules
GB8521494D0 (en) * 1985-08-29 1985-10-02 Zyma Sa Controlled release tablet
US4723957A (en) * 1986-02-07 1988-02-09 Alza Corp. System for delivering drug with enhanced bioacceptability
US4842867A (en) * 1986-05-09 1989-06-27 Alza Corporation Pulsed drug delivery of doxylamine
US4716496A (en) * 1986-05-09 1987-12-29 Eaton Corporation Panel-mounted control station housing
US4816264A (en) * 1986-06-06 1989-03-28 Warner-Lambert Company Sustained release formulations
ES2022454B3 (es) * 1986-06-17 1991-12-01 Recordati Ind Chimica E Farm S P A Sistema terapeutico para la liberacion controlada de drogas.
GB8616669D0 (en) * 1986-07-09 1986-08-13 Merk Sharpe & Dohme Ltd Pharmaceutical compositions
CH668187A5 (de) * 1986-08-07 1988-12-15 Ciba Geigy Ag Therapeutisches system mit systemischer wirkung.
DE3629994A1 (de) * 1986-09-03 1988-03-17 Weissenbacher Ernst Rainer Pro Vorrichtung zur medikamentenapplikation in koerperhoehlen bzw. auf koerperoberflaechen
US4859470A (en) * 1988-06-02 1989-08-22 Alza Corporation Dosage form for delivering diltiazem
US4902514A (en) * 1988-07-21 1990-02-20 Alza Corporation Dosage form for administering nilvadipine for treating cardiovascular symptoms
IL92966A (en) * 1989-01-12 1995-07-31 Pfizer Dispensing devices powered by hydrogel

Also Published As

Publication number Publication date
NO900151L (no) 1990-07-13
US5516527A (en) 1996-05-14
HUT54038A (en) 1991-01-28
EP0378404A2 (fr) 1990-07-18
EP0378404A3 (en) 1990-10-03
JPH02229110A (ja) 1990-09-11
CA2007463A1 (fr) 1990-07-12
NZ232078A (en) 1991-02-26
AU615129B2 (en) 1991-09-19
KR900011486A (ko) 1990-08-01
EP0378404B1 (fr) 1994-08-31
KR920008702B1 (ko) 1992-10-08
IL92966A (en) 1995-07-31
PT92838A (pt) 1990-07-31
HU900108D0 (en) 1990-03-28
DE69011878T2 (de) 1994-12-15
AU4787790A (en) 1990-07-19
IE64201B1 (en) 1995-07-12
JPH07119171B2 (ja) 1995-12-20
CA2007463C (fr) 1995-01-17
ES2058775T3 (es) 1994-11-01
MY105761A (en) 1995-01-30
FI900153L (fi) 1990-07-13
FI900153A0 (fi) 1990-01-11
IE900104L (en) 1990-07-12
NO900151D0 (no) 1990-01-11
ZA90197B (en) 1991-07-31
US5792471A (en) 1998-08-11
DK0378404T3 (da) 1994-10-03
IL92966A0 (en) 1990-09-17
FI900153A7 (fi) 1990-07-13
PT92838B (pt) 1996-02-29
DE69011878D1 (de) 1994-10-06

Similar Documents

Publication Publication Date Title
ATE110578T1 (de) Von hydrogel angetriebene verabreichungsvorrichtung.
DE3866817D1 (de) Knochenzement zur kontrollierten abgabe von wirkstoffen.
DE69333607D1 (de) Vorrichtung zur Herstellung von vorgefüllten, sterilen Abgabevorrichtungen
DE59009462D1 (de) Implantierbare Vorrichtung zur dosierten Abgabe von Medikamenten in den menschlichen Körper.
DE69526893D1 (de) Stiftförmige Vorrichtung zur Verabreichung von Medikamenten mit unterschiedlich inkrementierter Dosierskala
DE69203990D1 (de) Einrichtung zur transdermalen Verabreichung von Medikamenten.
DK0457849T3 (da) Klæbemiddel til elektrotransport
KR900011485A (ko) 리오트로픽 액정에 의해 작동되는 분배 장치
DE69002034D1 (de) Vorrichtung mit gesteuerter wirkstoffabgabe.
ATE11224T1 (de) Wundheilende zusammensetzungen.
DE59000613D1 (de) Pflaster zur transdermalen anwendung.
ES2019634B3 (es) Terapia con clorfeniramina.
ATE194775T1 (de) Calcitonin enthaltende pharmazeutische zusammensetzungen
DK392288A (da) Human monoklonale antistoffer samt profylaktiske og terapeutiske midler mod infrektioese sygdomme, der indeholder samme som aktiv bestanddel
ES2055847T3 (es) Agente fijador de fosfato para administracion por via oral.
DE59712215D1 (de) Transdermales therapeutisches system mit einer östriol enthaltenden bisphosphatekombination
DK594889D0 (da) Reservoir til styret medikamentafgivelse, indretning indeholdende saadant reservoir samt fremgangsmaade til fremstilling og anvendelse af indretningen
NO920493D0 (no) Bifasisk, transdermal medikament-leveringsanordning

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee