ATE111107T1 - Heparinderivate und verfahren zu ihrer herstellung. - Google Patents

Heparinderivate und verfahren zu ihrer herstellung.

Info

Publication number: ATE111107T1
Authority: AT; Austria
Prior art keywords: comprised; heparins; derivatives; heparinic derivatives; heparinic
Prior art date: 1989-01-30

Application number

AT90100593T

Other languages

English (en)

Inventor

Silvano Piani

Gianfranco Tamagnone

Raul Roberto Alpino

Maria Rita Milani

Original Assignee

Alfa Wassermann Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-01-30

Filing date

1990-01-12

Publication date

1994-09-15

1990-01-12 Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa

1994-09-15 Application granted granted Critical

1994-09-15 Publication of ATE111107T1 publication Critical patent/ATE111107T1/de

Links

HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title 1
239000002628 heparin derivative Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
230000001371 heparinic effect Effects 0.000 abstract 3
229960002897 heparin Drugs 0.000 abstract 2
229920000669 heparin Polymers 0.000 abstract 2
238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
-1 alkali metal salts Chemical class 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
239000003146 anticoagulant agent Substances 0.000 abstract 1
229940127219 anticoagulant drug Drugs 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000014508 negative regulation of coagulation Effects 0.000 abstract 1
238000001228 spectrum Methods 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Materials Engineering (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Catalysts (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Saccharide Compounds (AREA)
Pyridine Compounds (AREA)
Materials For Medical Uses (AREA)

AT90100593T 1989-01-30 1990-01-12 Heparinderivate und verfahren zu ihrer herstellung. ATE111107T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8903328A IT1234826B (it)	1989-01-30	1989-01-30	Derivati eparinici e procedimento per la loro preparazione

Publications (1)

Publication Number	Publication Date
ATE111107T1 true ATE111107T1 (de)	1994-09-15

Family

ID=11105069

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90100593T ATE111107T1 (de)	1989-01-30	1990-01-12	Heparinderivate und verfahren zu ihrer herstellung.

Country Status (18)

Country	Link
US (1)	US5104860A (de)
EP (1)	EP0380943B1 (de)
JP (1)	JPH0678369B2 (de)
KR (1)	KR0161667B1 (de)
AT (1)	ATE111107T1 (de)
AU (1)	AU610034B2 (de)
CA (1)	CA2007616C (de)
DE (1)	DE69012154T2 (de)
DK (1)	DK0380943T3 (de)
ES (1)	ES2058609T3 (de)
FI (1)	FI96425C (de)
IE (1)	IE66563B1 (de)
IL (1)	IL92912A (de)
IT (1)	IT1234826B (de)
NO (1)	NO301719B1 (de)
NZ (1)	NZ232115A (de)
PT (1)	PT92991B (de)
ZA (1)	ZA90263B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1234826B (it) *	1989-01-30	1992-05-29	Alfa Wassermann Spa	Derivati eparinici e procedimento per la loro preparazione
US5250519A (en) *	1991-03-29	1993-10-05	Glycomed Incorporated	Non-anticoagulant heparin derivatives
IT1254216B (it) *	1992-02-25	1995-09-14	Opocrin Spa	Derivati polisaccaridici di eparina, eparan solfato, loro frazioni e frammenti, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1260137B (it) *	1992-04-17	1996-03-28	Alfa Wassermann Spa	Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
IT1260136B (it) *	1992-04-17	1996-03-28	Alfa Wassermann Spa	Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
US5668118A (en) *	1992-07-24	1997-09-16	Cavalier Pharmaceuticals	Method of synthesis of 2-O-desulfated Heparin and use thereof for inhibition of elastase and Cathepspin G
US5296471A (en) *	1992-12-22	1994-03-22	Glycomed Incorporated	Method for controlling o-desulfation of heparin and compositions produced thereby
US5696100A (en) *	1992-12-22	1997-12-09	Glycomed Incorporated	Method for controlling O-desulfation of heparin and compositions produced thereby
US5336620A (en) *	1993-01-27	1994-08-09	American Home Products Corporation	Process for the production of an anticoagulant composition
USD349205S (en)	1993-02-01	1994-08-02	Khuhawar Mamoon M	Shower caddy
IT1264101B1 (it) *	1993-03-29	1996-09-10	Alfa Wassermann Spa	Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
IT1264102B1 (it) *	1993-03-29	1996-09-10	Alfa Wassermann Spa	Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali
US20020055710A1 (en) *	1998-04-30	2002-05-09	Ronald J. Tuch	Medical device for delivering a therapeutic agent and method of preparation
USD368614S (en)	1995-03-31	1996-04-09	Selfix, Inc.	Under vanity organizer
AU754936B2 (en) *	1996-11-27	2002-11-28	Aventis Pharmaceuticals Inc.	Pharmaceutical composition comprising a compound having anti-Xa activity and a platelet aggregation antagonist compound
US6203536B1 (en)	1997-06-17	2001-03-20	Medtronic, Inc.	Medical device for delivering a therapeutic substance and method therefor
US6106454A (en) *	1997-06-17	2000-08-22	Medtronic, Inc.	Medical device for delivering localized radiation
US6013099A (en)	1998-04-29	2000-01-11	Medtronic, Inc.	Medical device for delivering a water-insoluble therapeutic salt or substance
US7259152B2 (en)	2000-06-07	2007-08-21	Alfa Wasserman, Inc.	Methods and compositions using sulodexide for the treatment of diabetic nephropathy
ATE426805T1 (de) *	2000-09-12	2009-04-15	Massachusetts Inst Technology	Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind
AU2007200688B2 (en) *	2000-09-12	2010-02-04	Massachusetts Institute Of Technology	Methods and products related to low molecular weight heparin
RU2225175C2 (ru) *	2001-09-03	2004-03-10	Городская больница № 1 г. Тольятти	Способ лечения нефролитиаза
JP4828795B2 (ja) *	2002-03-11	2011-11-30	モメンタファーマシューティカルズインコーポレイテッド	硫酸化多糖類の分析
EP1582531A1 (de)	2004-03-24	2005-10-05	Aventis Pharma S.A.	Verfahren zur Oxydierung nicht-fraktionierten Heparins und die Detektion der Anwesenheit oder Abwesenheit von Glykoserin in Heparin und in von Heparin abgeleiteten Produkten
EP1792621B1 (de)	2005-11-30	2012-04-04	Istituto di Ricerche Chimiche e Biochimiche "G. Ronzoni"	Oral verabreichbare Heparinderivate
US9139876B1 (en)	2007-05-03	2015-09-22	Momenta Pharmacueticals, Inc.	Method of analyzing a preparation of a low molecular weight heparin
WO2011090948A1 (en) *	2010-01-19	2011-07-28	Momenta Pharmaceuticals, Inc.	Evaluating heparin preparations
KR102082276B1 (ko) *	2010-09-14	2020-02-27	고쿠리츠 다이가쿠 호징 미야자키 다이가쿠	고순도 헤파린 및 그 제조방법
WO2012115952A1 (en)	2011-02-21	2012-08-30	Momenta Pharmaceuticals, Inc.	Evaluating heparin preparations
CN104411316B (zh)	2012-05-09	2018-05-01	坎泰克斯制药股份有限公司	骨髓抑制的治疗
US10052346B2 (en)	2015-02-17	2018-08-21	Cantex Pharmaceuticals, Inc.	Treatment of myelodysplastic syndromes with 2-O and,or 3-O desulfated heparinoids
WO2022015794A1 (en)	2020-07-14	2022-01-20	Optimvia, Llc	Methods for synthesizing non-anticoagulant heparan sulfate
JP2022540849A (ja)	2019-07-09	2022-09-20	オプティムヴィア、エルエルシー	抗凝固性多糖類の合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5318520B2 (de) *	1972-07-05	1978-06-15
FR2482611B1 (fr) *	1980-05-14	1986-03-07	Pharmindustrie	Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
EP0066908B1 (de) *	1981-05-21	1985-08-28	Akzo N.V.	Antithrombotikum auf Basis von Polysacchariden, Verfahren zur dessen Herstellung und medizinale Zusammensetzungen
IT1195497B (it) *	1983-03-08	1988-10-19	Opocrin Spa	Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
DE3422518A1 (de) *	1984-06-16	1985-12-19	B. Braun Melsungen Ag, 3508 Melsungen	Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
FR2614026B1 (fr) *	1987-04-16	1992-04-17	Sanofi Sa	Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
IT1234508B (it) *	1988-06-10	1992-05-19	Alfa Wassermann Spa	Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) *	1989-01-30	1992-05-29	Alfa Wassermann Spa	Derivati eparinici e procedimento per la loro preparazione

1989
- 1989-01-30 IT IT8903328A patent/IT1234826B/it active
- 1989-12-28 IL IL9291289A patent/IL92912A/en unknown
1990
- 1990-01-09 US US07/462,462 patent/US5104860A/en not_active Expired - Fee Related
- 1990-01-11 CA CA002007616A patent/CA2007616C/en not_active Expired - Fee Related
- 1990-01-11 KR KR1019900000266A patent/KR0161667B1/ko not_active Expired - Fee Related
- 1990-01-12 AT AT90100593T patent/ATE111107T1/de not_active IP Right Cessation
- 1990-01-12 ES ES90100593T patent/ES2058609T3/es not_active Expired - Lifetime
- 1990-01-12 DK DK90100593.4T patent/DK0380943T3/da active
- 1990-01-12 EP EP90100593A patent/EP0380943B1/de not_active Expired - Lifetime
- 1990-01-12 DE DE69012154T patent/DE69012154T2/de not_active Expired - Fee Related
- 1990-01-15 ZA ZA90263A patent/ZA90263B/xx unknown
- 1990-01-15 NZ NZ232115A patent/NZ232115A/en unknown
- 1990-01-29 FI FI900446A patent/FI96425C/fi not_active IP Right Cessation
- 1990-01-29 IE IE31690A patent/IE66563B1/en not_active IP Right Cessation
- 1990-01-29 JP JP2020343A patent/JPH0678369B2/ja not_active Expired - Fee Related
- 1990-01-29 PT PT92991A patent/PT92991B/pt not_active IP Right Cessation
- 1990-01-29 NO NO900392A patent/NO301719B1/no not_active IP Right Cessation
- 1990-01-29 AU AU48858/90A patent/AU610034B2/en not_active Ceased

Also Published As

Publication number	Publication date
IT8903328A0 (it)	1989-01-30
IE66563B1 (en)	1996-01-24
IL92912A (en)	1994-06-24
PT92991B (pt)	1995-12-29
NZ232115A (en)	1991-05-28
KR0161667B1 (ko)	1998-11-16
NO900392L (no)	1990-07-31
FI96425B (fi)	1996-03-15
JPH0678369B2 (ja)	1994-10-05
EP0380943B1 (de)	1994-09-07
FI96425C (fi)	1996-06-25
CA2007616C (en)	1996-05-14
FI900446A0 (fi)	1990-01-29
ES2058609T3 (es)	1994-11-01
EP0380943A1 (de)	1990-08-08
IE900316L (en)	1990-07-30
KR900011789A (ko)	1990-08-02
DE69012154T2 (de)	1995-02-23
JPH02240102A (ja)	1990-09-25
PT92991A (pt)	1990-07-31
NO301719B1 (no)	1997-12-01
US5104860A (en)	1992-04-14
DK0380943T3 (da)	1994-12-19
AU4885890A (en)	1990-10-25
NO900392D0 (no)	1990-01-29
IT1234826B (it)	1992-05-29
DE69012154D1 (de)	1994-10-13
AU610034B2 (en)	1991-05-09
CA2007616A1 (en)	1990-07-30
ZA90263B (en)	1990-10-31
IL92912A0 (en)	1990-09-17

Legal Events

Date	Code	Title	Description
1995-04-15	UEP	Publication of translation of european patent specification
2004-10-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE111107T1 (de)	1994-09-15	Heparinderivate und verfahren zu ihrer herstellung.
ATE109164T1 (de)	1994-08-15	Heparinderivate und verfahren zu deren herstellung.
IE811074L (en)	1981-11-14	Sulphated polysaccharides
NO305992B1 (no)	1999-08-30	Halvsyntetiske glykosaminglykosaner med heparin- eller heparanstruktur og fremgangsmåte til fremstilling derav
ATE113612T1 (de)	1994-11-15	Polysulfat eines cyclodextrinderivates und verfahren zu dessen herstellung.
WO1990004607A3 (en)	1990-05-31	Novel dermatan sulfate and heparin oligosaccharides having antiatherosclerotic activity
DK0560730T3 (da)	1996-10-28	Aminosyrederivater med antithrombotisk virkning
ATE150468T1 (de)	1997-04-15	Dermatansulfatoligosaccharide, verfahren zu ihrer herstellung und diese enthaltende phamazeutische zusammensetzungen
DK0410326T3 (da)	1999-06-28	Genetisk styring af acetylering og pyruvylering af xanthangummi
KR910007532A (ko)	1991-05-30	항트롬보 활성을 지닌 설페이트화 글리코 사미노글리큐로난
ES2141781T3 (es)	2000-04-01	Utilizacion de hidroxietilalmidon para la mejora de la microcirculacion.
TW266215B (de)	1995-12-21