ATE111107T1 - Heparinderivate und verfahren zu ihrer herstellung. - Google Patents

Heparinderivate und verfahren zu ihrer herstellung.

Info

Publication number: ATE111107T1
Authority: AT; Austria
Prior art keywords: comprised; heparins; derivatives; heparinic derivatives; heparinic
Prior art date: 1989-01-30

Application number

AT90100593T

Other languages

English (en)

Inventor

Silvano Piani

Gianfranco Tamagnone

Raul Roberto Alpino

Maria Rita Milani

Original Assignee

Alfa Wassermann Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-01-30

Filing date

1990-01-12

Publication date

1994-09-15

1990-01-12 Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa

1994-09-15 Application granted granted Critical

1994-09-15 Publication of ATE111107T1 publication Critical patent/ATE111107T1/de

Links

HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title 1
239000002628 heparin derivative Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
230000001371 heparinic effect Effects 0.000 abstract 3
229960002897 heparin Drugs 0.000 abstract 2
229920000669 heparin Polymers 0.000 abstract 2
238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
-1 alkali metal salts Chemical class 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
239000003146 anticoagulant agent Substances 0.000 abstract 1
229940127219 anticoagulant drug Drugs 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000014508 negative regulation of coagulation Effects 0.000 abstract 1
238000001228 spectrum Methods 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Materials Engineering (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Catalysts (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Saccharide Compounds (AREA)
Pyridine Compounds (AREA)
Materials For Medical Uses (AREA)

AT90100593T 1989-01-30 1990-01-12 Heparinderivate und verfahren zu ihrer herstellung. ATE111107T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8903328A IT1234826B (it)	1989-01-30	1989-01-30	Derivati eparinici e procedimento per la loro preparazione

Publications (1)

Publication Number	Publication Date
ATE111107T1 true ATE111107T1 (de)	1994-09-15

Family

ID=11105069

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90100593T ATE111107T1 (de)	1989-01-30	1990-01-12	Heparinderivate und verfahren zu ihrer herstellung.

Country Status (18)

Country	Link
US (1)	US5104860A (de)
EP (1)	EP0380943B1 (de)
JP (1)	JPH0678369B2 (de)
KR (1)	KR0161667B1 (de)
AT (1)	ATE111107T1 (de)
AU (1)	AU610034B2 (de)
CA (1)	CA2007616C (de)
DE (1)	DE69012154T2 (de)
DK (1)	DK0380943T3 (de)
ES (1)	ES2058609T3 (de)
FI (1)	FI96425C (de)
IE (1)	IE66563B1 (de)
IL (1)	IL92912A (de)
IT (1)	IT1234826B (de)
NO (1)	NO301719B1 (de)
NZ (1)	NZ232115A (de)
PT (1)	PT92991B (de)
ZA (1)	ZA90263B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1234826B (it) *	1989-01-30	1992-05-29	Alfa Wassermann Spa	Derivati eparinici e procedimento per la loro preparazione
US5250519A (en) *	1991-03-29	1993-10-05	Glycomed Incorporated	Non-anticoagulant heparin derivatives
IT1254216B (it) *	1992-02-25	1995-09-14	Opocrin Spa	Derivati polisaccaridici di eparina, eparan solfato, loro frazioni e frammenti, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1260137B (it) *	1992-04-17	1996-03-28	Alfa Wassermann Spa	Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
IT1260136B (it) *	1992-04-17	1996-03-28	Alfa Wassermann Spa	Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
US5668118A (en) *	1992-07-24	1997-09-16	Cavalier Pharmaceuticals	Method of synthesis of 2-O-desulfated Heparin and use thereof for inhibition of elastase and Cathepspin G
US5696100A (en) *	1992-12-22	1997-12-09	Glycomed Incorporated	Method for controlling O-desulfation of heparin and compositions produced thereby
US5296471A (en) *	1992-12-22	1994-03-22	Glycomed Incorporated	Method for controlling o-desulfation of heparin and compositions produced thereby
US5336620A (en) *	1993-01-27	1994-08-09	American Home Products Corporation	Process for the production of an anticoagulant composition
USD349205S (en)	1993-02-01	1994-08-02	Khuhawar Mamoon M	Shower caddy
IT1264102B1 (it) *	1993-03-29	1996-09-10	Alfa Wassermann Spa	Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali
IT1264101B1 (it) *	1993-03-29	1996-09-10	Alfa Wassermann Spa	Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
US20020055710A1 (en)	1998-04-30	2002-05-09	Ronald J. Tuch	Medical device for delivering a therapeutic agent and method of preparation
USD368614S (en)	1995-03-31	1996-04-09	Selfix, Inc.	Under vanity organizer
IL129877A (en) *	1996-11-27	2004-08-31	Aventis Pharm Prod Inc	A pharmaceutical preparation containing a component having an Xa antagonist activity and an antifouling agent
US6203536B1 (en)	1997-06-17	2001-03-20	Medtronic, Inc.	Medical device for delivering a therapeutic substance and method therefor
US6106454A (en) *	1997-06-17	2000-08-22	Medtronic, Inc.	Medical device for delivering localized radiation
US6013099A (en) *	1998-04-29	2000-01-11	Medtronic, Inc.	Medical device for delivering a water-insoluble therapeutic salt or substance
US7259152B2 (en)	2000-06-07	2007-08-21	Alfa Wasserman, Inc.	Methods and compositions using sulodexide for the treatment of diabetic nephropathy
AU2007200688B2 (en) *	2000-09-12	2010-02-04	Massachusetts Institute Of Technology	Methods and products related to low molecular weight heparin
DK1319183T3 (da)	2000-09-12	2009-05-18	Massachusetts Inst Technology	Fremgangsmåder og produkter relateret til heparin med lav molekylvægt
RU2225175C2 (ru) *	2001-09-03	2004-03-10	Городская больница № 1 г. Тольятти	Способ лечения нефролитиаза
JP4828795B2 (ja) *	2002-03-11	2011-11-30	モメンタファーマシューティカルズインコーポレイテッド	硫酸化多糖類の分析
EP1582531A1 (de)	2004-03-24	2005-10-05	Aventis Pharma S.A.	Verfahren zur Oxydierung nicht-fraktionierten Heparins und die Detektion der Anwesenheit oder Abwesenheit von Glykoserin in Heparin und in von Heparin abgeleiteten Produkten
ATE552004T1 (de)	2005-11-30	2012-04-15	Istituto G Ronzoni	Oral verabreichbare heparinderivate
US9139876B1 (en)	2007-05-03	2015-09-22	Momenta Pharmacueticals, Inc.	Method of analyzing a preparation of a low molecular weight heparin
US8435795B2 (en) *	2010-01-19	2013-05-07	Momenta Pharmaceuticals, Inc.	Evaluating heparin preparations
CA3020369C (en) *	2010-09-14	2019-11-26	Fuso Pharmaceutical Industries, Ltd.	High purity heparin and production method therefor
WO2012115952A1 (en)	2011-02-21	2012-08-30	Momenta Pharmaceuticals, Inc.	Evaluating heparin preparations
KR102165348B1 (ko)	2012-05-09	2020-10-14	캔텍스 파마슈티칼즈, 인크.	골수억제의 치료
WO2016133910A1 (en)	2015-02-17	2016-08-25	Cantex Pharmaceuticals, Inc.	Treatment of cancers and hematopoietic stem cell disorders privileged by cxcl12-cxcr4 interaction
WO2022015794A1 (en)	2020-07-14	2022-01-20	Optimvia, Llc	Methods for synthesizing non-anticoagulant heparan sulfate
EP3997238A1 (de)	2019-07-09	2022-05-18	Optimvia, LLC	Verfahren zur synthese von antikoagulierenden polysacchariden

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5318520B2 (de) *	1972-07-05	1978-06-15
FR2482611B1 (fr) *	1980-05-14	1986-03-07	Pharmindustrie	Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
DE3265781D1 (en) *	1981-05-21	1985-10-03	Akzo Nv	New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions
IT1195497B (it) *	1983-03-08	1988-10-19	Opocrin Spa	Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
DE3422518A1 (de) *	1984-06-16	1985-12-19	B. Braun Melsungen Ag, 3508 Melsungen	Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
FR2614026B1 (fr) *	1987-04-16	1992-04-17	Sanofi Sa	Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
IT1234508B (it) *	1988-06-10	1992-05-19	Alfa Wassermann Spa	Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) *	1989-01-30	1992-05-29	Alfa Wassermann Spa	Derivati eparinici e procedimento per la loro preparazione

1989
- 1989-01-30 IT IT8903328A patent/IT1234826B/it active
- 1989-12-28 IL IL9291289A patent/IL92912A/en unknown
1990
- 1990-01-09 US US07/462,462 patent/US5104860A/en not_active Expired - Fee Related
- 1990-01-11 CA CA002007616A patent/CA2007616C/en not_active Expired - Fee Related
- 1990-01-11 KR KR1019900000266A patent/KR0161667B1/ko not_active Expired - Fee Related
- 1990-01-12 EP EP90100593A patent/EP0380943B1/de not_active Expired - Lifetime
- 1990-01-12 AT AT90100593T patent/ATE111107T1/de not_active IP Right Cessation
- 1990-01-12 DK DK90100593.4T patent/DK0380943T3/da active
- 1990-01-12 ES ES90100593T patent/ES2058609T3/es not_active Expired - Lifetime
- 1990-01-12 DE DE69012154T patent/DE69012154T2/de not_active Expired - Fee Related
- 1990-01-15 NZ NZ232115A patent/NZ232115A/en unknown
- 1990-01-15 ZA ZA90263A patent/ZA90263B/xx unknown
- 1990-01-29 PT PT92991A patent/PT92991B/pt not_active IP Right Cessation
- 1990-01-29 IE IE31690A patent/IE66563B1/en not_active IP Right Cessation
- 1990-01-29 FI FI900446A patent/FI96425C/fi not_active IP Right Cessation
- 1990-01-29 AU AU48858/90A patent/AU610034B2/en not_active Ceased
- 1990-01-29 JP JP2020343A patent/JPH0678369B2/ja not_active Expired - Fee Related
- 1990-01-29 NO NO900392A patent/NO301719B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69012154D1 (de)	1994-10-13
IT1234826B (it)	1992-05-29
IT8903328A0 (it)	1989-01-30
EP0380943A1 (de)	1990-08-08
EP0380943B1 (de)	1994-09-07
FI900446A0 (fi)	1990-01-29
DE69012154T2 (de)	1995-02-23
FI96425C (fi)	1996-06-25
NZ232115A (en)	1991-05-28
AU4885890A (en)	1990-10-25
PT92991B (pt)	1995-12-29
NO900392D0 (no)	1990-01-29
CA2007616A1 (en)	1990-07-30
NO900392L (no)	1990-07-31
PT92991A (pt)	1990-07-31
DK0380943T3 (da)	1994-12-19
KR0161667B1 (ko)	1998-11-16
US5104860A (en)	1992-04-14
CA2007616C (en)	1996-05-14
ZA90263B (en)	1990-10-31
NO301719B1 (no)	1997-12-01
IL92912A0 (en)	1990-09-17
AU610034B2 (en)	1991-05-09
KR900011789A (ko)	1990-08-02
IE66563B1 (en)	1996-01-24
JPH0678369B2 (ja)	1994-10-05
IE900316L (en)	1990-07-30
ES2058609T3 (es)	1994-11-01
FI96425B (fi)	1996-03-15
JPH02240102A (ja)	1990-09-25
IL92912A (en)	1994-06-24

Legal Events

Date	Code	Title	Description
1995-04-15	UEP	Publication of translation of european patent specification
2004-10-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE111107T1 (de)	1994-09-15	Heparinderivate und verfahren zu ihrer herstellung.
ATE109164T1 (de)	1994-08-15	Heparinderivate und verfahren zu deren herstellung.
IE811074L (en)	1981-11-14	Sulphated polysaccharides
NO305992B1 (no)	1999-08-30	Halvsyntetiske glykosaminglykosaner med heparin- eller heparanstruktur og fremgangsmåte til fremstilling derav
ATE113612T1 (de)	1994-11-15	Polysulfat eines cyclodextrinderivates und verfahren zu dessen herstellung.
ATE119547T1 (de)	1995-03-15	Oligosaccharide mit antiatherosclerotischer wirkung.
CA2265780A1 (en)	1998-03-19	Sulfated polysaccharides and uses thereof in medical treatment
DK0560730T3 (da)	1996-10-28	Aminosyrederivater med antithrombotisk virkning
ES2067493T3 (es)	1995-04-01	Agliconas de antibioticos a/16686.
DK0410326T3 (da)	1999-06-28	Genetisk styring af acetylering og pyruvylering af xanthangummi
GR3024416T3 (en)	1997-11-28	Process for the synthesis of semisynthetic glycosaminoglycans with heparin or heparan structure modified in position 2 of the alpha-L-iduronic-2-0-sulfate acid.
JPS55161803A (en)	1980-12-16	Polyion complex composed of chitin derivative