ATE112558T1 - Glycosidasehemmer. - Google Patents

Glycosidasehemmer.

Info

Publication number: ATE112558T1
Authority: AT; Austria
Prior art keywords: glycosidase inhibitors; glycosidase; allitol; dideoxy; imino
Prior art date: 1988-12-22

Application number

AT89870215T

Other languages

English (en)

Inventor

George William John Fleet

Of Oxford University

Original Assignee

Monsanto Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-22

Filing date

1989-12-21

Publication date

1994-10-15

1989-12-21 Application filed by Monsanto Co filed Critical Monsanto Co

1994-10-15 Application granted granted Critical

1994-10-15 Publication of ATE112558T1 publication Critical patent/ATE112558T1/de

Links

239000003316 glycosidase inhibitor Substances 0.000 title 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
RVNSAAIWCWTCTJ-DPYQTVNSSA-N (2s,3s,4r)-2-[(1r)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol Chemical compound OC[C@H](O)[C@@H]1NC[C@@H](O)[C@H]1O RVNSAAIWCWTCTJ-DPYQTVNSSA-N 0.000 abstract 1
102000005744 Glycoside Hydrolases Human genes 0.000 abstract 1
108010031186 Glycoside Hydrolases Proteins 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Virology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT89870215T 1988-12-22 1989-12-21 Glycosidasehemmer. ATE112558T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/288,735 US4894388A (en)	1988-12-22	1988-12-22	Glycosidase inhibitors and use thereof

Publications (1)

Publication Number	Publication Date
ATE112558T1 true ATE112558T1 (de)	1994-10-15

Family

ID=23108416

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89870215T ATE112558T1 (de)	1988-12-22	1989-12-21	Glycosidasehemmer.

Country Status (7)

Country	Link
US (1)	US4894388A (de)
EP (1)	EP0375651B1 (de)
JP (1)	JP2948847B2 (de)
AT (1)	ATE112558T1 (de)
CA (1)	CA2006269C (de)
DE (1)	DE68918681T2 (de)
ES (1)	ES2064487T3 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5043416A (en) *	1988-09-26	1991-08-27	Monsanto Company	Method of inhibiting virus
US5013842A (en) *	1990-01-22	1991-05-07	Monsanto Company	Synthesis of chiral pyrrolidine and piperidine glycosidase inhibitors
US5863903A (en) *	1994-03-09	1999-01-26	Novo Nordisk A/S	Use of hydroxy alkyl piperidine and pyrrolidine compounds to treat diabetes
ATE243196T1 (de) *	1994-03-09	2003-07-15	Novo Nordisk As	Piperidine und pyrrolidine
US5650413A (en) *	1995-06-07	1997-07-22	Glycodesign Inc.	Derivatives of swainsonine, processes for their preparation and their use as therapeutic agents
CZ120398A3 (cs)	1995-09-08	1998-12-16	Novo Nordisk A/S	Použití 2-alkylpyrrolidinových derivátů pro přípravu léčiva pro léčbu diabetu, 2-alkylpyrrolidiné deriváty
JP2001501213A (ja) *	1996-10-01	2001-01-30	グリコデザイン・インコーポレーテツド	スワインソニンの新規な３，５，および／または６置換された同族体、それらの製造方法および治療剤としてのそれらの使用
US6395745B1 (en)	1997-04-15	2002-05-28	Glycodesign, Inc.	Alkaloid halide salts of swainsonine and methods of use
AU9617298A (en) *	1997-10-24	1999-05-17	Glycodesign Inc.	Synthesis of swainsonine salts
US7256005B2 (en)	1999-08-10	2007-08-14	The Chancellor, Masters And Scholars Of The University Of Oxford	Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
ES2302697T3 (es)	1999-08-10	2008-08-01	The Chancellor, Masters And Scholars Of The University Of Oxford	Compuestos n-alquilicos de cadena larga y derivados oxa de los mismos y uso como composiciones antivirales.
US20100004156A1 (en)	2005-07-27	2010-01-07	Shalesh Kaushal	Small Compounds That Correct Protein Misfolding and Uses Thereof
JP2009545621A (ja) *	2006-08-02	2009-12-24	ユナイテッドセラピューティクスコーポレーション	ウィルス感染症のリポソーム処置
KR20090057035A (ko) *	2006-08-21	2009-06-03	유나이티드 세러퓨틱스 코오포레이션	바이러스 감염의 치료를 위한 병용 요법
KR20100127842A (ko) *	2008-03-26	2010-12-06	유니버시티 오브 옥스퍼드	소포체 표적화 리포좀
US8703744B2 (en) *	2009-03-27	2014-04-22	The Chancellor, Masters And Scholars Of The University Of Oxford	Cholesterol level lowering liposomes
IN2012DN00352A (de)	2009-06-16	2015-08-21	Bikam Pharmaceuticals Inc
US9133082B2 (en)	2011-06-14	2015-09-15	Bikam Pharmaceuticals, Inc.	Opsin-binding ligands, compositions and methods of use
CA2856703A1 (en)	2011-10-19	2013-04-25	Bikam Pharmaceuticals, Inc.	Opsin-binding ligands, compositions and methods of use
WO2013082000A1 (en)	2011-11-30	2013-06-06	Bikam Pharmaceuticals, Inc.	Opsin-binding ligands, compositions and methods of use
AU2012346537A1 (en)	2011-12-01	2014-07-17	Bikam Pharmaceuticals, Inc.	Opsin-binding ligands, compositions and methods of use
EP3274357B1 (de) *	2015-03-27	2019-12-11	Cornell University	Effiziente synthese von nikotinamidmononukleotid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3312716A (en) *	1964-08-11	1967-04-04	Aldrich Chem Co Inc	4-hydroxy-3-pyrrolidinemethanols
US4999360A (en) *	1987-12-21	1991-03-12	Monsanto Company	Method of inhibiting virus

1988
- 1988-12-22 US US07/288,735 patent/US4894388A/en not_active Expired - Lifetime
1989
- 1989-12-21 EP EP89870215A patent/EP0375651B1/de not_active Expired - Lifetime
- 1989-12-21 DE DE68918681T patent/DE68918681T2/de not_active Expired - Fee Related
- 1989-12-21 CA CA002006269A patent/CA2006269C/en not_active Expired - Fee Related
- 1989-12-21 AT AT89870215T patent/ATE112558T1/de not_active IP Right Cessation
- 1989-12-21 ES ES89870215T patent/ES2064487T3/es not_active Expired - Lifetime
- 1989-12-21 JP JP1332491A patent/JP2948847B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US4894388A (en)	1990-01-16
JPH02212470A (ja)	1990-08-23
DE68918681D1 (de)	1994-11-10
DE68918681T2 (de)	1995-03-30
EP0375651A1 (de)	1990-06-27
EP0375651B1 (de)	1994-10-05
JP2948847B2 (ja)	1999-09-13
CA2006269C (en)	1998-09-15
ES2064487T3 (es)	1995-02-01
CA2006269A1 (en)	1990-06-22

Legal Events

Date	Code	Title	Description
1995-04-15	UEP	Publication of translation of european patent specification
2005-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE112558T1 (de)	1994-10-15	Glycosidasehemmer.
ATE116306T1 (de)	1995-01-15	Hypoglykämische oxazolidindion-derivate.
DK0559019T3 (da)	2000-03-27	14-beta-hydroxy-10-deacetyl-baccatin III og derivater deraf som antitumormidler
DK0486948T3 (da)	2001-02-05	Forbindelser, der hæmmer retrovirale proteaser
ATE21105T1 (de)	1986-08-15	7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
ES2101960T3 (es)	1997-07-16	Lactamas benzo-condensadas.
ES2054712T3 (es)	1994-08-16	Un procedimiento para la preparacion de los derivados de prolinal.
DK345989A (da)	1990-01-13	Quinolinderivater
DK249089A (da)	1989-11-27	Benzamid-forbindelser, der er nyttige som protease-inhibitorer
DK506587A (da)	1988-03-27	Imidderivater
PT86785A (pt)	1988-03-01	Novel naphthalene derivatives having use as antiallergy and antiinflammatory agents
ES2136887T3 (es)	1999-12-01	Derivados antifungicos de sordaridina.
ATE84787T1 (de)	1993-02-15	Prolin-derivate.
AR241157A2 (es)	1991-12-30	Derivados de la imida del acido n-fenil-3,4,5,6-tetrahidroftalico, procedimiento para su preparacion y composiciones que los contienen
DK0747392T3 (da)	2001-01-29	Dobbeltvirkende inhibitorer indeholdende 1,2-diazepiner
DK0436307T3 (da)	1995-05-08	Substituerede oxophthalazinyleddikesyrer og analoger deraf
ITMI931012A1 (it)	1994-11-18	Composti spiro-piranici dotati di caratteristiche fotocromatiche
FI861698A0 (fi)	1986-04-22	2-pyrrolidonderivat.
DE69007695D1 (de)	1994-05-05	Fucosidase-Inhibitoren.
ATE72435T1 (de)	1992-02-15	Derivate von phenyl-, pyrrolidin-2-ylsubstituierten 5-ring heterocyclen mit antipsychotischer wirkung.
ATE156486T1 (de)	1997-08-15	Fungizide 3,4-diaryl-(5h)-furan-2-onederivate
NO942668D0 (no)	1994-07-15	Alkylderivater av trazodon med CNS-aktivitet
ATE73768T1 (de)	1992-04-15	2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8inter-m-phenylene-pgi2-derivate.
ATE53996T1 (de)	1990-07-15	Antiarrhythmische mittel.
DK0625520T3 (da)	2000-01-31	Thiazolotriazol- og thiazolodiazolderivater med fungicid aktivitet