ATE113044T1 - Verfahren zur umwandlung des niedrigschmelzenden polymorphs von buspirone hydrochlorid in das höherschmelzende. - Google Patents

Verfahren zur umwandlung des niedrigschmelzenden polymorphs von buspirone hydrochlorid in das höherschmelzende.

Info

Publication number: ATE113044T1
Authority: AT; Austria
Prior art keywords: phone; converting; polymorphs; melting; buspirone hydrochloride
Prior art date: 1987-08-28

Application number

AT88113969T

Other languages

English (en)

Inventor

Robert J Behme

Terry T Kensler

Douglas G Mikolasek

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-28

Filing date

1988-08-26

Publication date

1994-11-15

1988-08-26 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1994-11-15 Application granted granted Critical

1994-11-15 Publication of ATE113044T1 publication Critical patent/ATE113044T1/de

Links

QWCRAEMEVRGPNT-UHFFFAOYSA-N buspirone Chemical compound C1C(=O)N(CCCCN2CCN(CC2)C=2N=CC=CN=2)C(=O)CC21CCCC2 QWCRAEMEVRGPNT-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000002844 melting Methods 0.000 title 2
230000008018 melting Effects 0.000 title 2
229960001768 buspirone hydrochloride Drugs 0.000 title 1
229960002495 buspirone Drugs 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Body Structure For Vehicles (AREA)
Compositions Of Macromolecular Compounds (AREA)
Gears, Cams (AREA)
Glass Compositions (AREA)
Developing Agents For Electrophotography (AREA)
Arrangement Or Mounting Of Propulsion Units For Vehicles (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

AT88113969T 1987-08-28 1988-08-26 Verfahren zur umwandlung des niedrigschmelzenden polymorphs von buspirone hydrochlorid in das höherschmelzende. ATE113044T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/090,302 US4810789A (en)	1987-08-28	1987-08-28	Process for buspirone hydrochloride polymorphic crystalline form conversion

Publications (1)

Publication Number	Publication Date
ATE113044T1 true ATE113044T1 (de)	1994-11-15

Family

ID=22222189

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88113969T ATE113044T1 (de)	1987-08-28	1988-08-26	Verfahren zur umwandlung des niedrigschmelzenden polymorphs von buspirone hydrochlorid in das höherschmelzende.

Country Status (23)

Country	Link
US (1)	US4810789A (de)
EP (1)	EP0304940B1 (de)
JP (1)	JP2702519B2 (de)
KR (1)	KR970011294B1 (de)
AT (1)	ATE113044T1 (de)
AU (1)	AU618746B2 (de)
CY (1)	CY1839A (de)
DE (1)	DE3851865T2 (de)
DK (1)	DK478688A (de)
ES (1)	ES2060632T3 (de)
FI (1)	FI91066C (de)
HK (1)	HK71495A (de)
HU (1)	HU199831B (de)
IE (1)	IE65988B1 (de)
IL (1)	IL87292A (de)
MY (1)	MY100863A (de)
NO (1)	NO169284C (de)
NZ (1)	NZ225895A (de)
OA (1)	OA08907A (de)
PT (1)	PT88355B (de)
SU (1)	SU1731056A3 (de)
YU (1)	YU46961B (de)
ZA (1)	ZA885867B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5631017A (en) *	1993-03-26	1997-05-20	Beth Israel Deaconess Medical Center, Inc.	Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5484788A (en) *	1993-03-26	1996-01-16	Beth Israel Hospital Association	Buspirone as a systemic immunosuppressant
HU217129B (hu) *	1993-07-16	1999-11-29	EGIS Gyógyszergyár Rt.	Eljárás nagy tisztaságú buspiron gyógyászati hatóanyag előállítására
DE59410036D1 (de) *	1993-11-09	2002-03-14	Syngenta Participations Ag	Kristallmodifikation von (4-Cyclopropyl-6-methyl-pyrimidin-2-yl)- phenyl-amin, und Verfahren zu dessen Herstellung
US5637314A (en) *	1995-06-07	1997-06-10	Beth Israel Deaconess Medical Center, Inc.	Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
KR100322018B1 (ko) *	1999-01-23	2002-02-04	윤종용	음성대역 잡음 보상장치
US6465255B1 (en) *	1999-01-29	2002-10-15	The Regents Of The University Of California	Method for identifying and probing phase transitions in materials
EP1505066B1 (de) *	2002-04-19	2006-12-06	Faes Farma, S.A.	Polymorph von 4-[2-[4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl]ethyl]-alpha, alpha-dimethylbenzolessigsäure
JP2010013472A (ja) *	2009-09-09	2010-01-21	Faes Farma Sa	４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN118702676B (zh) *	2024-07-09	2026-01-27	济南大学	一种盐酸丁螺环酮晶型ii的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE759371A (fr) *	1969-11-24	1971-05-24	Bristol Myers Co	Azaspirodecanediones heterocycliques et procedes pour leur preparation
US3976776A (en) *	1972-12-06	1976-08-24	Mead Johnson & Company	Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
US4351939A (en) *	1980-10-16	1982-09-28	Mead Johnson & Company	Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process
US4476248A (en) *	1983-02-28	1984-10-09	The Upjohn Company	Crystallization of ibuprofen
DD263531A5 (de) *	1986-10-21	1989-01-04	��@��Kk��	Verfahren zur herstellung von verbrueckten bicyclischen imidverbindungen
US5015646A (en) *	1987-08-28	1991-05-14	Bristol-Myers Squibb Co.	Pharmaceutically useful polymorphic modification of buspirone

1987
- 1987-08-28 US US07/090,302 patent/US4810789A/en not_active Expired - Lifetime
1988
- 1988-08-01 IL IL87292A patent/IL87292A/xx not_active IP Right Cessation
- 1988-08-02 MY MYPI88000876A patent/MY100863A/en unknown
- 1988-08-02 IE IE236288A patent/IE65988B1/en not_active IP Right Cessation
- 1988-08-05 AU AU20480/88A patent/AU618746B2/en not_active Ceased
- 1988-08-10 ZA ZA885867A patent/ZA885867B/xx unknown
- 1988-08-22 NZ NZ225895A patent/NZ225895A/en unknown
- 1988-08-22 YU YU160488A patent/YU46961B/sh unknown
- 1988-08-25 NO NO883806A patent/NO169284C/no unknown
- 1988-08-26 ES ES88113969T patent/ES2060632T3/es not_active Expired - Lifetime
- 1988-08-26 PT PT88355A patent/PT88355B/pt not_active IP Right Cessation
- 1988-08-26 JP JP63212318A patent/JP2702519B2/ja not_active Expired - Fee Related
- 1988-08-26 AT AT88113969T patent/ATE113044T1/de not_active IP Right Cessation
- 1988-08-26 DE DE3851865T patent/DE3851865T2/de not_active Expired - Fee Related
- 1988-08-26 OA OA59414A patent/OA08907A/xx unknown
- 1988-08-26 DK DK478688A patent/DK478688A/da not_active Application Discontinuation
- 1988-08-26 HU HU884472A patent/HU199831B/hu not_active IP Right Cessation
- 1988-08-26 SU SU884356323A patent/SU1731056A3/ru active
- 1988-08-26 EP EP88113969A patent/EP0304940B1/de not_active Expired - Lifetime
- 1988-08-26 FI FI883960A patent/FI91066C/fi not_active IP Right Cessation
- 1988-08-27 KR KR1019880010968A patent/KR970011294B1/ko not_active Expired - Fee Related
1995
- 1995-05-11 HK HK71495A patent/HK71495A/en not_active IP Right Cessation
- 1995-12-01 CY CY183995A patent/CY1839A/xx unknown

Also Published As

Publication number	Publication date
FI91066C (fi)	1994-05-10
ES2060632T3 (es)	1994-12-01
NO883806D0 (no)	1988-08-25
OA08907A (en)	1989-10-31
US4810789A (en)	1989-03-07
ZA885867B (en)	1989-05-30
SU1731056A3 (ru)	1992-04-30
IE65988B1 (en)	1995-11-29
DK478688D0 (da)	1988-08-26
IL87292A (en)	1992-07-15
HU199831B (en)	1990-03-28
KR970011294B1 (ko)	1997-07-09
NO169284B (no)	1992-02-24
NO169284C (no)	1992-06-03
DK478688A (da)	1989-03-01
IE882362L (en)	1989-02-28
JP2702519B2 (ja)	1998-01-21
DE3851865T2 (de)	1995-02-23
JPS6471872A (en)	1989-03-16
HK71495A (en)	1995-05-19
YU160488A (en)	1990-04-30
PT88355B (pt)	1995-12-29
MY100863A (en)	1991-03-15
NZ225895A (en)	1991-04-26
FI91066B (fi)	1994-01-31
EP0304940A1 (de)	1989-03-01
PT88355A (pt)	1989-06-30
KR890003739A (ko)	1989-04-17
AU618746B2 (en)	1992-01-09
FI883960A0 (fi)	1988-08-26
EP0304940B1 (de)	1994-10-19
AU2048088A (en)	1989-03-02
DE3851865D1 (de)	1994-11-24
IL87292A0 (en)	1989-01-31
HUT47563A (en)	1989-03-28
NO883806L (no)	1989-03-01
YU46961B (sh)	1994-09-09
CY1839A (en)	1995-12-01
FI883960L (fi)	1989-03-01

Legal Events

Date	Code	Title	Description
1995-04-15	UEP	Publication of translation of european patent specification
2006-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE40884T1 (de)	1989-03-15	Zwischenverbindungen fuer die herstellung von omeprazol.
FI875413A7 (fi)	1988-06-12	Menetelmä uusien terapeuttisesti käyttökelpoisten spiro-substituoitujen glutaarihappoamidien valmistamiseksi
DK543787D0 (da)	1987-10-16	Antibakterielle midler
ATE113044T1 (de)	1994-11-15	Verfahren zur umwandlung des niedrigschmelzenden polymorphs von buspirone hydrochlorid in das höherschmelzende.
FI881892A7 (fi)	1988-10-25	Menetelmä uusien, terapeuttisesti käyttökelpoisten 1,2,5,6-tetrahydropyridiinijohdannaisten valmistamiseksi
CS235488A2 (en)	1990-02-12	Method of new dihydropyridinamides production
GB2226817B (en)	1990-11-28	Intermediates for agriculturally useful acrylic acid derivatives
ATE106397T1 (de)	1994-06-15	Verfahren zur herstellung von 3,3- diarylacrylsäureamiden.
ATE43342T1 (de)	1989-06-15	Verfahren zur herstellung von hydrogeno- oder halogenosilanen.
ATE33824T1 (de)	1988-05-15	(-)-1-(2-fluorophenyl)-2-tertiobutylamino-1ethanol und seine therapeutische verwendung.
UA19274A (uk)	1997-12-25	Засіб для підвищеhhя продуктивhості шовковичhого шовкопряда
GR3005494T3 (de)	1993-05-24
RO89953A2 (ro)	1986-08-30	Procedeu de obtinere a peroxacizilor alifatici inferiori
IT8621415A1 (it)	1988-02-05	Procedimento per l'idratazione di oli vegetali
FI923164A7 (fi)	1992-07-09	Välituotteina käyttökelpoiset yhdisteet
RO89229A2 (ro)	1986-03-15	Procedeu de obtinere a unor esteri epoxi dispersabili in apa aplicabili prin electrodepunere anodica
RO81999A2 (ro)	1983-07-07	Procedeu de obtinere a unor adezivi pe baza de acrilati
ATE144257T1 (de)	1996-11-15	Tetrahydro-4-phenylimino-3-thiophenessigsäuren
DE58909563D1 (de)	1996-02-22	3-Anilino-2-hydroxycarbonyl-4-thiophenessigsäuren