ATE113044T1 - Verfahren zur umwandlung des niedrigschmelzenden polymorphs von buspirone hydrochlorid in das höherschmelzende. - Google Patents

Verfahren zur umwandlung des niedrigschmelzenden polymorphs von buspirone hydrochlorid in das höherschmelzende.

Info

Publication number
ATE113044T1
ATE113044T1 AT88113969T AT88113969T ATE113044T1 AT E113044 T1 ATE113044 T1 AT E113044T1 AT 88113969 T AT88113969 T AT 88113969T AT 88113969 T AT88113969 T AT 88113969T AT E113044 T1 ATE113044 T1 AT E113044T1
Authority
AT
Austria
Prior art keywords
phone
converting
polymorphs
melting
buspirone hydrochloride
Prior art date
Application number
AT88113969T
Other languages
English (en)
Inventor
Robert J Behme
Terry T Kensler
Douglas G Mikolasek
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE113044T1 publication Critical patent/ATE113044T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Arrangement Or Mounting Of Propulsion Units For Vehicles (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Glass Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Gears, Cams (AREA)
  • Body Structure For Vehicles (AREA)
AT88113969T 1987-08-28 1988-08-26 Verfahren zur umwandlung des niedrigschmelzenden polymorphs von buspirone hydrochlorid in das höherschmelzende. ATE113044T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/090,302 US4810789A (en) 1987-08-28 1987-08-28 Process for buspirone hydrochloride polymorphic crystalline form conversion

Publications (1)

Publication Number Publication Date
ATE113044T1 true ATE113044T1 (de) 1994-11-15

Family

ID=22222189

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88113969T ATE113044T1 (de) 1987-08-28 1988-08-26 Verfahren zur umwandlung des niedrigschmelzenden polymorphs von buspirone hydrochlorid in das höherschmelzende.

Country Status (23)

Country Link
US (1) US4810789A (de)
EP (1) EP0304940B1 (de)
JP (1) JP2702519B2 (de)
KR (1) KR970011294B1 (de)
AT (1) ATE113044T1 (de)
AU (1) AU618746B2 (de)
CY (1) CY1839A (de)
DE (1) DE3851865T2 (de)
DK (1) DK478688A (de)
ES (1) ES2060632T3 (de)
FI (1) FI91066C (de)
HK (1) HK71495A (de)
HU (1) HU199831B (de)
IE (1) IE65988B1 (de)
IL (1) IL87292A (de)
MY (1) MY100863A (de)
NO (1) NO169284C (de)
NZ (1) NZ225895A (de)
OA (1) OA08907A (de)
PT (1) PT88355B (de)
SU (1) SU1731056A3 (de)
YU (1) YU46961B (de)
ZA (1) ZA885867B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
HU217129B (hu) * 1993-07-16 1999-11-29 EGIS Gyógyszergyár Rt. Eljárás nagy tisztaságú buspiron gyógyászati hatóanyag előállítására
ES2171443T3 (es) * 1993-11-09 2002-09-16 Syngenta Participations Ag Modificacion cristalina de (4-ciclopropil-6-metil-pirimidin-2-il)-fenilamina, procedimiento para su obtencion.
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
KR100322018B1 (ko) * 1999-01-23 2002-02-04 윤종용 음성대역 잡음 보상장치
US6465255B1 (en) * 1999-01-29 2002-10-15 The Regents Of The University Of California Method for identifying and probing phase transitions in materials
SI1505066T1 (sl) * 2002-04-19 2007-04-30 Faes Farma Sa Polimorf 4-(2-(4-(1-(2-etoksietil)-1h-benzimidazol-2-il) -1-piperidinil)-alfa, alfa-dimetil-benzenocetne kisline
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN118702676B (zh) * 2024-07-09 2026-01-27 济南大学 一种盐酸丁螺环酮晶型ii的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US3976776A (en) * 1972-12-06 1976-08-24 Mead Johnson & Company Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
US4351939A (en) * 1980-10-16 1982-09-28 Mead Johnson & Company Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process
US4476248A (en) * 1983-02-28 1984-10-09 The Upjohn Company Crystallization of ibuprofen
DD263531A5 (de) * 1986-10-21 1989-01-04 ������@���Kk�� Verfahren zur herstellung von verbrueckten bicyclischen imidverbindungen
US5015646A (en) * 1987-08-28 1991-05-14 Bristol-Myers Squibb Co. Pharmaceutically useful polymorphic modification of buspirone

Also Published As

Publication number Publication date
NO883806D0 (no) 1988-08-25
OA08907A (en) 1989-10-31
MY100863A (en) 1991-03-15
FI883960L (fi) 1989-03-01
YU46961B (sh) 1994-09-09
DE3851865D1 (de) 1994-11-24
NO883806L (no) 1989-03-01
KR890003739A (ko) 1989-04-17
NZ225895A (en) 1991-04-26
SU1731056A3 (ru) 1992-04-30
HU199831B (en) 1990-03-28
JP2702519B2 (ja) 1998-01-21
ZA885867B (en) 1989-05-30
AU2048088A (en) 1989-03-02
PT88355B (pt) 1995-12-29
PT88355A (pt) 1989-06-30
EP0304940B1 (de) 1994-10-19
IL87292A0 (en) 1989-01-31
FI883960A0 (fi) 1988-08-26
DE3851865T2 (de) 1995-02-23
DK478688A (da) 1989-03-01
IE65988B1 (en) 1995-11-29
ES2060632T3 (es) 1994-12-01
DK478688D0 (da) 1988-08-26
YU160488A (en) 1990-04-30
KR970011294B1 (ko) 1997-07-09
HK71495A (en) 1995-05-19
CY1839A (en) 1995-12-01
NO169284B (no) 1992-02-24
IE882362L (en) 1989-02-28
FI91066B (fi) 1994-01-31
IL87292A (en) 1992-07-15
NO169284C (no) 1992-06-03
AU618746B2 (en) 1992-01-09
FI91066C (fi) 1994-05-10
HUT47563A (en) 1989-03-28
US4810789A (en) 1989-03-07
EP0304940A1 (de) 1989-03-01
JPS6471872A (en) 1989-03-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee