ATE113275T1 - Arzneimittel. - Google Patents
Arzneimittel.Info
- Publication number
- ATE113275T1 ATE113275T1 AT90307633T AT90307633T ATE113275T1 AT E113275 T1 ATE113275 T1 AT E113275T1 AT 90307633 T AT90307633 T AT 90307633T AT 90307633 T AT90307633 T AT 90307633T AT E113275 T1 ATE113275 T1 AT E113275T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- hydrogen
- group
- together form
- linear polymethylene
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- -1 polymethylene Polymers 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 206010021036 Hyponatraemia Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898916395A GB8916395D0 (en) | 1989-07-18 | 1989-07-18 | Pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE113275T1 true ATE113275T1 (de) | 1994-11-15 |
Family
ID=10660199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90307633T ATE113275T1 (de) | 1989-07-18 | 1990-07-12 | Arzneimittel. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5254564A (de) |
| EP (1) | EP0409489B1 (de) |
| JP (1) | JPH0352864A (de) |
| KR (1) | KR910002801A (de) |
| AT (1) | ATE113275T1 (de) |
| AU (1) | AU632832B2 (de) |
| CA (1) | CA2021213A1 (de) |
| DE (1) | DE69013602T2 (de) |
| DK (1) | DK0409489T3 (de) |
| ES (1) | ES2064641T3 (de) |
| GB (1) | GB8916395D0 (de) |
| IE (1) | IE64923B1 (de) |
| NZ (1) | NZ234533A (de) |
| PT (1) | PT94711B (de) |
| ZA (1) | ZA905556B (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8916395D0 (en) * | 1989-07-18 | 1989-09-06 | Zambeletti Spa L | Pharmaceuticals |
| GB8926560D0 (en) * | 1989-11-24 | 1990-01-17 | Zambeletti Spa L | Pharmaceuticals |
| CA2081351A1 (en) * | 1990-04-28 | 1991-10-29 | Vittorio Vecchietti | 1-(2h-1-oxo-3, 4-dihydronaphtyl-6) -acetyl-piperidines, process for their preparation and therapeutic use |
| DE4217846C1 (de) * | 1992-05-29 | 1993-12-23 | Basf Ag | Verfahren zur Herstellung von 5-Dichloracetyl-3,3,6-trimethyl-9-oxo-1,5-diazabicyclo[4,3,0]nonan |
| US5389638A (en) * | 1993-09-10 | 1995-02-14 | Abbott Laboratories | Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors |
| US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| JP2003526594A (ja) * | 1997-07-14 | 2003-09-09 | アドラー コーポレーション | カッパ・アゴニスト抗掻痒薬学的製剤およびそれにより掻痒を治療する方法 |
| CN100503571C (zh) * | 2006-07-12 | 2009-06-24 | 中国药科大学 | 四氢异喹啉类衍生物、其制备方法及其医药用途 |
| US8367700B2 (en) * | 2008-12-17 | 2013-02-05 | Gruenenthal Gmbh | Substituted 4-(1.2,3,4-tetrahydroisoquinolin-2-yl)-4-oxobutyric acid amide as KCNQ2/3 modulators |
| CN103435545B (zh) * | 2013-08-14 | 2015-10-07 | 中国药科大学 | 四氢异喹啉季铵盐类衍生物、其制备方法及其镇痛用途 |
| RU2648445C1 (ru) * | 2016-11-03 | 2018-03-26 | Светлана Асылхановна Астафьева | 6-(3,3- диметил-3,4-дигидроизохинолин-1-ил) аминогексановая кислота и фармацевтическая композиция на ёе основе, обладающие анальгетической активностью |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2361390A1 (de) * | 1973-12-10 | 1975-06-19 | Merck Patent Gmbh | Isochinolinderivate und verfahren zu ihrer herstellung |
| GB8601796D0 (en) * | 1986-01-24 | 1986-02-26 | Zambeletti Spa L | Compounds |
| AU590912B2 (en) * | 1986-03-12 | 1989-11-23 | Consolidated Environmental Technologies Ltd. | The construction and use of subsea boreholes |
| ATE97893T1 (de) * | 1988-02-19 | 1993-12-15 | Smithkline Beecham Farma | 1,2,3,4-tetrahydroisoquinoline, verfharen zu ihrer herstellung und ihre verwendung als kappa- rezeptor agonisten. |
| PT89780A (pt) * | 1988-02-23 | 1989-10-04 | Glaxo Group Ltd | Processo para a preparacao de derivados da tetrahidroisoquinolina |
| GB8916395D0 (en) * | 1989-07-18 | 1989-09-06 | Zambeletti Spa L | Pharmaceuticals |
-
1989
- 1989-07-18 GB GB898916395A patent/GB8916395D0/en active Pending
-
1990
- 1990-07-12 AT AT90307633T patent/ATE113275T1/de not_active IP Right Cessation
- 1990-07-12 EP EP90307633A patent/EP0409489B1/de not_active Expired - Lifetime
- 1990-07-12 DK DK90307633.9T patent/DK0409489T3/da active
- 1990-07-12 DE DE69013602T patent/DE69013602T2/de not_active Expired - Fee Related
- 1990-07-12 ES ES90307633T patent/ES2064641T3/es not_active Expired - Lifetime
- 1990-07-16 ZA ZA905556A patent/ZA905556B/xx unknown
- 1990-07-16 CA CA002021213A patent/CA2021213A1/en not_active Abandoned
- 1990-07-16 NZ NZ234533A patent/NZ234533A/xx unknown
- 1990-07-16 AU AU59057/90A patent/AU632832B2/en not_active Ceased
- 1990-07-16 US US07/553,723 patent/US5254564A/en not_active Expired - Fee Related
- 1990-07-16 JP JP2185463A patent/JPH0352864A/ja active Pending
- 1990-07-16 IE IE258690A patent/IE64923B1/en not_active IP Right Cessation
- 1990-07-16 PT PT94711A patent/PT94711B/pt not_active IP Right Cessation
- 1990-07-18 KR KR1019900010897A patent/KR910002801A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| NZ234533A (en) | 1992-12-23 |
| EP0409489A3 (en) | 1991-05-15 |
| US5254564A (en) | 1993-10-19 |
| DE69013602T2 (de) | 1995-03-23 |
| EP0409489A2 (de) | 1991-01-23 |
| AU632832B2 (en) | 1993-01-14 |
| ES2064641T3 (es) | 1995-02-01 |
| JPH0352864A (ja) | 1991-03-07 |
| PT94711A (pt) | 1991-03-20 |
| ZA905556B (en) | 1991-06-26 |
| IE902586A1 (en) | 1991-02-27 |
| EP0409489B1 (de) | 1994-10-26 |
| AU5905790A (en) | 1991-01-24 |
| IE64923B1 (en) | 1995-09-20 |
| DK0409489T3 (da) | 1994-12-12 |
| GB8916395D0 (en) | 1989-09-06 |
| KR910002801A (ko) | 1991-02-26 |
| PT94711B (pt) | 1997-04-30 |
| CA2021213A1 (en) | 1991-01-19 |
| DE69013602D1 (de) | 1994-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |