ES2061972T3 - 1,2,3,4-tetrahidroisoquinoleinas, procedimiento para su preparacion y su uso como agonistas kapa-receptores. - Google Patents

1,2,3,4-tetrahidroisoquinoleinas, procedimiento para su preparacion y su uso como agonistas kapa-receptores.

Info

Publication number
ES2061972T3
ES2061972T3 ES89301374T ES89301374T ES2061972T3 ES 2061972 T3 ES2061972 T3 ES 2061972T3 ES 89301374 T ES89301374 T ES 89301374T ES 89301374 T ES89301374 T ES 89301374T ES 2061972 T3 ES2061972 T3 ES 2061972T3
Authority
ES
Spain
Prior art keywords
group
alkyl
aryl
halogen
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89301374T
Other languages
English (en)
Inventor
Vittorio Vecchietti
Giuseppe Giardina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SMITHKLINE BEECHAM FARMA
GlaxoSmithKline SpA
Original Assignee
SMITHKLINE BEECHAM FARMA
Smithkline Beecham Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888803919A external-priority patent/GB8803919D0/en
Priority claimed from GB888815089A external-priority patent/GB8815089D0/en
Application filed by SMITHKLINE BEECHAM FARMA, Smithkline Beecham Farmaceutici SpA filed Critical SMITHKLINE BEECHAM FARMA
Application granted granted Critical
Publication of ES2061972T3 publication Critical patent/ES2061972T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)

Abstract

UN COMPUESTO, O UN SOLVATO O UNA SAL DE EL, DA LA FORMULA(I), EN LA CUAL, RCO ES UN GRUPO ACILO EN EL QUE EL GRUPO R CONTIENE UN ANILLO HETEROCICLICO AROMATICO O CARBOCICLICO AROMATICO SUSTITUIDO O NO Y R1 Y R2 SON INDEPENDIENTEMENTE H, ALQUILO C1 - 6, ALQUENILO C2 - 6, CICLOALQUILO C3 - 6, O CICLOALQUILAQUILO C4 - 12 O JUNTOS DE UN POLIETILENO C2 - C8 LINEAL O RAMIFICADO O UN GRUPO ALQUENILO C2 0 6 OPCIONALMENTE SUSTITUIDO CON UN HETEROATOMO; R3 ES H, ALQUILO C1 - 6, O FENILO O R3 JUNTO CON R1 FORMA UN GRUPO - (CH2)3 - O - (CH2)4 -; R4 Y R5, QUE PUEDEN SER UNIDOS A LOS MISMOS ATOMOS DE C O DISTINTOS DE UN NUCLEO DE ISOQUINOLINA, SON H, HALOGENO, HIDROXI, ALQUILO C1 - 6, ARILO, O R4 JUNTO CON R5 FORMA UN GRUPO - (CH2)P -, DONDE P ES UNB ENTERI DE 1 A 5 Y UNO O MAS DE LAS MITADES - (CH2) - ESTA SUSTITUIDA OPCIONALMENTE POR UN GRUPO ALQUILO C1 - 6; R6 Y R6A QUE PUEDEN IGUALES O DISTINTOS SON H, ALQUILO C1 - 6, HALOGENO, - CH2OR2B, HIDROXI, ALCOXI C1 - 6, ALCOXICARBONILO0 C1 - 6, TIOL, ALQUILTIO C1 6, - O - O - CR6C, - NCOR6D, - NHSO2R6A, - CH2SO2NR6 Y R6G, EN LOS QUE DE R6B A R6G SON INDEPENDIENTMENTE H, ALQUILO C1 - 6, ARILO O ARALQUILO; CON LA EXCEPCION DE QUE R4, R5 Y R6A NO SON A UN MISMO TIEMPO H. ES UTIL PARA EL TRATAMIENTO DEL DOLOR.
ES89301374T 1988-02-19 1989-02-14 1,2,3,4-tetrahidroisoquinoleinas, procedimiento para su preparacion y su uso como agonistas kapa-receptores. Expired - Lifetime ES2061972T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888803919A GB8803919D0 (en) 1988-02-19 1988-02-19 Novel compounds
GB888815089A GB8815089D0 (en) 1988-06-24 1988-06-24 Novel compounds

Publications (1)

Publication Number Publication Date
ES2061972T3 true ES2061972T3 (es) 1994-12-16

Family

ID=26293513

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89301374T Expired - Lifetime ES2061972T3 (es) 1988-02-19 1989-02-14 1,2,3,4-tetrahidroisoquinoleinas, procedimiento para su preparacion y su uso como agonistas kapa-receptores.

Country Status (12)

Country Link
US (1) US4954509A (es)
EP (1) EP0330360B1 (es)
JP (1) JPH0219379A (es)
AT (1) ATE97893T1 (es)
AU (1) AU620845B2 (es)
CA (1) CA1333067C (es)
DE (1) DE68910999T2 (es)
DK (1) DK75589A (es)
ES (1) ES2061972T3 (es)
IE (1) IE62031B1 (es)
NZ (1) NZ228032A (es)
PT (1) PT89746B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR890012970A (ko) * 1988-02-23 1989-09-20 추후보충 테트라히드로 이소퀴놀린 유도체
GB8824400D0 (en) * 1988-10-18 1988-11-23 Glaxo Group Ltd Chemical compounds
GB8827479D0 (en) * 1988-11-24 1988-12-29 Zambeletti Spa L Novel compounds
GB8830219D0 (en) * 1988-12-23 1989-02-22 Zambeletti Spa L Novel compounds
DE3935371A1 (de) * 1988-12-23 1990-07-05 Merck Patent Gmbh Stickstoffhaltige ringverbindungen
GB8916395D0 (en) * 1989-07-18 1989-09-06 Zambeletti Spa L Pharmaceuticals
US5322848A (en) * 1989-11-24 1994-06-21 Dr. Lo Zembeletti S.P.A. N-acyl-substituted azacyclic compounds, processes for their preparation, and their use as pharmaceuticals
GB8926560D0 (en) * 1989-11-24 1990-01-17 Zambeletti Spa L Pharmaceuticals
US5532243A (en) * 1992-02-14 1996-07-02 The Dupont Merck Pharmaceutical Company Antipsychotic nitrogen-containing bicyclic compounds
US5389638A (en) * 1993-09-10 1995-02-14 Abbott Laboratories Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors
TW427978B (en) * 1996-02-03 2001-04-01 Hoffmann La Roche Tetrahydroisoquinoline derivatives
TW436484B (en) * 1996-04-24 2001-05-28 Dev Center Biotechnology 1,2,3,4-tetrahydroisoquinoline derivatives having a nitrogen-containing heterocyclic methyl substituent, the preparation process and pharmaceutical composition thereof
AU2003283646A1 (en) * 2002-12-02 2004-06-23 Pharmacia & Upjohn Company Llc The use of aryl- and heteroaryl-substituted tetrahydroisoquinolines in the treatment of chronic and neuropathic pain, migraine headaches, and urge, stress and mixed urinary incontinence
WO2004050629A2 (en) * 2002-12-02 2004-06-17 Pharmacia & Upjohn Company Llc The use of 4-phenyl substituted tetrahydroisoquinolines in the treatment of pain, migraine and urinary incontinence
MXPA05005829A (es) * 2002-12-02 2005-08-29 Pharmacia & Upjohn Co Llc El uso de tetrahidroisoquinolinas 4-fenil-sustituidas en el tratamiento del dolor, dolores de cabeza migranosos e incontinencia urinaria.
JO3316B1 (ar) 2013-05-30 2019-03-13 Lilly Co Eli مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل
TWI725408B (zh) 2018-04-20 2021-04-21 美商美國禮來大藥廠 多巴胺d1受體正向異位調節劑
MX2021004566A (es) * 2018-10-22 2021-06-08 C4X Discovery Ltd Compuestos terapeuticos.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2361390A1 (de) * 1973-12-10 1975-06-19 Merck Patent Gmbh Isochinolinderivate und verfahren zu ihrer herstellung
DE2504250A1 (de) * 1975-02-01 1976-08-05 Merck Patent Gmbh Tetrahydroisochinolin-derivate und verfahren zu ihrer herstellung
US4232160A (en) * 1978-10-18 1980-11-04 Miles Laboratories, Inc. Isoquinoline propionamides exhibiting analgesic properties
US4518779A (en) * 1982-09-27 1985-05-21 Pennwalt Corporation 1,2,3,4-Tetrahydro-1-aminomethyl-4-phenyl isoquinolines
GB8531615D0 (en) * 1985-12-23 1986-02-05 Zambeletti Spa L Compounds
GB8601796D0 (en) * 1986-01-24 1986-02-26 Zambeletti Spa L Compounds
KR890012970A (ko) * 1988-02-23 1989-09-20 추후보충 테트라히드로 이소퀴놀린 유도체
DE3935371A1 (de) * 1988-12-23 1990-07-05 Merck Patent Gmbh Stickstoffhaltige ringverbindungen

Also Published As

Publication number Publication date
AU620845B2 (en) 1992-02-27
EP0330360A1 (en) 1989-08-30
EP0330360B1 (en) 1993-12-01
JPH0219379A (ja) 1990-01-23
ATE97893T1 (de) 1993-12-15
AU3007089A (en) 1989-08-24
IE890519L (en) 1989-08-19
DK75589A (da) 1989-08-20
DE68910999T2 (de) 1994-03-24
PT89746B (pt) 1994-03-31
NZ228032A (en) 1991-12-23
DK75589D0 (da) 1989-02-17
CA1333067C (en) 1994-11-15
DE68910999D1 (de) 1994-01-13
US4954509A (en) 1990-09-04
IE62031B1 (en) 1994-12-14
PT89746A (pt) 1989-10-04

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