ATE113282T1 - Heteroaryl piperazine als antipsychotische mittel. - Google Patents

Heteroaryl piperazine als antipsychotische mittel.

Info

Publication number
ATE113282T1
ATE113282T1 AT90307166T AT90307166T ATE113282T1 AT E113282 T1 ATE113282 T1 AT E113282T1 AT 90307166 T AT90307166 T AT 90307166T AT 90307166 T AT90307166 T AT 90307166T AT E113282 T1 ATE113282 T1 AT E113282T1
Authority
AT
Austria
Prior art keywords
sychotic
agents
heteroaryl piperazines
piperazines
heteroaryl
Prior art date
Application number
AT90307166T
Other languages
English (en)
Inventor
Harry R Howard
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE113282T1 publication Critical patent/ATE113282T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Gas Separation By Absorption (AREA)
  • Treating Waste Gases (AREA)
  • Hydrogenated Pyridines (AREA)
AT90307166T 1989-07-07 1990-06-29 Heteroaryl piperazine als antipsychotische mittel. ATE113282T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/002954 WO1991000863A1 (en) 1989-07-07 1989-07-07 Heteroaryl piperazine antipsychotic agents

Publications (1)

Publication Number Publication Date
ATE113282T1 true ATE113282T1 (de) 1994-11-15

Family

ID=22215102

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90307166T ATE113282T1 (de) 1989-07-07 1990-06-29 Heteroaryl piperazine als antipsychotische mittel.

Country Status (11)

Country Link
EP (1) EP0409435B1 (de)
JP (1) JPH0717633B2 (de)
AT (1) ATE113282T1 (de)
CA (1) CA2020611A1 (de)
DE (1) DE69013601T2 (de)
DK (1) DK0409435T3 (de)
ES (1) ES2062374T3 (de)
FI (1) FI920023A0 (de)
IE (1) IE63134B1 (de)
PT (1) PT94608A (de)
WO (1) WO1991000863A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599815A (en) * 1993-02-04 1997-02-04 Meiji Seika Kabushiki Kaisha Antipsychotic benzoisothiazolyl piperazine derivatives
FR2761067B1 (fr) * 1997-03-20 1999-04-23 Synthelabo Derives de quinolein-2-(1h)-one, leur preparation et leur application en therapeutique
OA12923A (en) * 2002-09-17 2006-10-13 Warner Lambert Co Heterocyclic substituted piperazines for the treatment of schizophrenia.
BR0314796A (pt) * 2002-09-26 2005-07-26 Warner Lambert Co Piperazinas substituìdas heterocìclicas para o tratamento de esquizofrenia
US7160888B2 (en) * 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
ES2600460T3 (es) 2005-05-10 2017-02-09 Intermune, Inc. Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés
AR055203A1 (es) 2005-08-31 2007-08-08 Otsuka Pharma Co Ltd Derivados de benzotiofeno con propiedades antipsicoticas
WO2008015516A1 (en) * 2006-07-28 2008-02-07 Pfizer Products Inc. Fused tricyclic heterocycles for the treatment of schizophrenia
JP2010504367A (ja) 2006-09-26 2010-02-12 グラクソ グループ リミテッド 性機能障害、認知障害、精神病性障害、不安、鬱病などを処置するための５ｈｔ１ａ受容体モジュレーターとしての５−｛２−［４−（２−メチル−５−キノリニル）−ｌ−ピペリジニル］エチル｝キノリノン誘導体
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
US8431576B2 (en) 2009-06-25 2013-04-30 Alkermes Pharma Ireland Limited Heterocyclic compounds for the treatment of neurological and psychological disorders
CA2937222C (en) 2009-06-25 2019-06-04 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds
HUE065359T2 (hu) 2011-03-18 2024-05-28 Alkermes Pharma Ireland Ltd Szorbitán-észtereket tartalmazó gyógyászati készítmények
JP5952912B2 (ja) 2011-12-15 2016-07-13 アルカーメス ファーマ アイルランド リミテッド 二級アミン化合物のプロドラッグ
JP6219918B2 (ja) 2012-03-19 2017-10-25 アルカームス ファーマ アイルランド リミテッド グリセロールエステルを含む医薬組成物
ES2765036T3 (es) 2012-03-19 2020-06-05 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que comprenden esteres de ácidos grasos
ES2950418T3 (es) 2012-03-19 2023-10-09 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que comprenden alcohol bencílico
EP2897592B1 (de) 2012-09-19 2020-02-19 Alkermes Pharma Ireland Limited Pharmazeutische zusammensetzungen mit verbesserter lagerstabilität
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
BR112016021535A8 (pt) 2014-03-20 2021-07-20 Alkermes Pharma Ireland Ltd kit compreendendo formulações de aripiprazol tendo velocidades de injeção aumentadas útil para o tratamento de uma desordem do sistema nervoso central e uso
JP5714152B2 (ja) * 2014-03-26 2015-05-07 江蘇恒誼薬業有限公司 アラルキルピペリジン（又はピペラジン）誘導体及びその統合失調症治療のための使用
MX382781B (es) 2014-04-02 2025-03-13 Intermune Inc Piridinonas anti-fibroticas.
EP3761983A1 (de) 2018-03-05 2021-01-13 Alkermes Pharma Ireland Limited Dosierstrategie für aripiprazol
EP4552566A1 (de) * 2019-01-28 2025-05-14 Abbott Diabetes Care, Inc. Analytsensoren und messverfahren zum nachweis von kreatinin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721721A (en) * 1984-12-18 1988-01-26 Rorer Pharmaceutical Corporation 6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
ATE81123T1 (de) * 1987-11-20 1992-10-15 Hoechst Roussel Pharma 3-(4(1-substituierte-4-piperazinyl)butyl>-4thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel.
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity

Also Published As

Publication number Publication date
EP0409435B1 (de) 1994-10-26
IE902450A1 (en) 1991-02-13
WO1991000863A1 (en) 1991-01-24
JPH0717633B2 (ja) 1995-03-01
FI920023A7 (fi) 1992-01-03
EP0409435A1 (de) 1991-01-23
JPH0344388A (ja) 1991-02-26
DK0409435T3 (da) 1994-11-21
PT94608A (pt) 1991-03-20
DE69013601D1 (de) 1994-12-01
CA2020611A1 (en) 1991-01-08
ES2062374T3 (es) 1994-12-16
DE69013601T2 (de) 1995-03-02
FI920023A0 (fi) 1992-01-03
IE63134B1 (en) 1995-03-22

Similar Documents

Publication Publication Date Title
ATE113282T1 (de) Heteroaryl piperazine als antipsychotische mittel.
ATE215530T1 (de) 7-substituierte-8-substituierte-9-substituierte amino-7-demethyl-6-deoxy-tetracycline als antibiotische mittel
KR900700486A (ko) 신규한 벤조피리도 피페리딘, 피페리딜리덴 및 피페라진 화합물, 조성물, 제조방법 및 이용방법
MX9102407A (es) 4 arilpiperazinas y 4-arilpiperidinas novedosas.
DE69319976D1 (de) 7-Substituierte-9-substituierte Glycylamido-6-Demethyl-6-Deoxytetracycline
ATE91684T1 (de) 1,2-cyclohexylaminoarylamide zu verwendung als analgetika.
DE69330733D1 (de) 9-[(Substituierte Glycyl)amido]-6-demethyl-6-deoxytetracycline als antibiotische Mittel
DE69724777D1 (de) Pentafluorobenzensulfonamiden und analoge
RU94038064A (ru) Производные пиперазина и пиперидина, их применение в качестве противопсихотических средств, способ их получения фармацевтическая композиция
DE69326650D1 (de) Piperidinderivate von Benzimidazole als antihistaminische und antiallergische Mittel
BG103399A (en) New heterocycle-substituted benzamides and their application for the treatment of diseases
DK1109817T3 (da) Phosphohalogenhydriner, deres fremstilling og anvendelse
NO934718D0 (no) Nye HIV protease inhibitorer
SE8404065D0 (sv) Novel biologically active compounds
FI932173A0 (fi) 4-(1,2-benzisoxazolyl)piperidinantipsykotiska medel
NO903640L (no) Fremgangsmaate for fremstilling av 2-(rs)-substituerte 2,3-dihydro-5-oksy-4,6,7-trimetylbenzofuraner.
DE69023557D1 (de) Stickstoff enthaltende Diheterocycloheteroethanoanthracenderivate als antipsychotische Mittel.
ES2104174T3 (es) Derivados de bencilamino, bencilamido y bencilimido ciclicos utilizados como agentes antipsicoticos.
DE69222143D1 (de) Indanderivate
ATE97130T1 (de) 13-brom und 13, 14-dibrom-ergoline, ihre herstellung und verwendung in arzneimitteln.
ATE120736T1 (de) Benzylselenobenzamide von aminopyridinen und picolylaminen.
ATE180474T1 (de) Imidazol-derivate und ihre verwendung als agrochemische mittel
ATE263139T1 (de) 3-alkoxylbenzylaminderivate und ihre verwendung als arzneimittel zur behandlung von schizophrenie
GR3015002T3 (en) 1,4-Dihydro-4-oxo-3-quinolone derivatives as selectively toxic mammalian antibacterial agents.
DE69523346D1 (de) Substituierte 6-h-1,3,4-thiadiazin-2-amine, deren verwendung als anaesthetisierende cardiovaskulare und hypometabole mittel, und eine sie enthaltende pharmazeutische zubereitung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee