ATE114472T1 - System des typs ''einmal täglich'' zur gepulsten minocyclinabgabe. - Google Patents

System des typs ''einmal täglich'' zur gepulsten minocyclinabgabe.

Info

Publication number: ATE114472T1
Authority: AT; Austria
Prior art keywords: pulsed; delivery system; once daily; minocycline; minocycline delivery
Prior art date: 1989-09-21

Application number

AT90115881T

Other languages

English (en)

Inventor

Nitin Vadilal Sheth

Joseph James Valorose Jr

Keith Anthony Ellway

Madurai Gurusamy Ganesan

Kieran George Mooney

Jerry Bain Johnson

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-21

Filing date

1990-08-20

Publication date

1994-12-15

1990-08-20 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1994-12-15 Application granted granted Critical

1994-12-15 Publication of ATE114472T1 publication Critical patent/ATE114472T1/de

Links

DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 title 1
229960004023 minocycline Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT90115881T 1989-09-21 1990-08-20 System des typs ''einmal täglich'' zur gepulsten minocyclinabgabe. ATE114472T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US41070889A	1989-09-21	1989-09-21

Publications (1)

Publication Number	Publication Date
ATE114472T1 true ATE114472T1 (de)	1994-12-15

Family

ID=23625892

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90115881T ATE114472T1 (de)	1989-09-21	1990-08-20	System des typs ''einmal täglich'' zur gepulsten minocyclinabgabe.

Country Status (25)

Country	Link
US (2)	US5300304A (de)
EP (1)	EP0418565B1 (de)
JP (1)	JP3140764B2 (de)
KR (1)	KR100187950B1 (de)
CN (1)	CN1035039C (de)
AR (1)	AR244547A1 (de)
AT (1)	ATE114472T1 (de)
AU (1)	AU624998B2 (de)
CA (1)	CA2025703C (de)
CZ (1)	CZ283048B6 (de)
DD (1)	DD297558A5 (de)
DE (1)	DE69014513T2 (de)
DK (1)	DK0418565T3 (de)
ES (1)	ES2064564T3 (de)
FI (1)	FI96170C (de)
HU (1)	HU221804B1 (de)
IE (1)	IE66389B1 (de)
IL (1)	IL95423A (de)
NO (1)	NO177038C (de)
NZ (1)	NZ235319A (de)
PH (1)	PH30777A (de)
PL (1)	PL164770B1 (de)
PT (1)	PT95353B (de)
SK (1)	SK455990A3 (de)
ZA (1)	ZA907546B (de)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE114472T1 (de) *	1989-09-21	1994-12-15	American Cyanamid Co	System des typs ''einmal täglich'' zur gepulsten minocyclinabgabe.
TW212139B (de) *	1991-04-15	1993-09-01	Yamanouchi Pharma Co Ltd
US5262173A (en) *	1992-03-02	1993-11-16	American Cyanamid Company	Pulsatile once-a-day delivery systems for minocycline
AU742231B2 (en) *	1994-03-23	2001-12-20	Ortho-Mcneil Pharmaceutical, Inc.	Multilayered controlled release pharmaceutical dosage form
US5395626A (en) *	1994-03-23	1995-03-07	Ortho Pharmaceutical Corporation	Multilayered controlled release pharmaceutical dosage form
IL109539A0 (en) *	1994-05-03	1994-08-26	Yissum Res Dev Co	Substained-release pharmaceutical system for the delivery of antioxidants
DE19715594A1 (de)	1997-04-15	1998-10-22	Bayer Ag	Analgetika-Kombination
JP2001527023A (ja) *	1997-08-11	2001-12-25	アルザ・コーポレーション	胃で保持するのに適合した長期放出性活性剤剤形
US6312728B1 (en) *	1998-07-07	2001-11-06	Cascade Development, Inc.	Sustained release pharmaceutical preparation
US20030170181A1 (en) *	1999-04-06	2003-09-11	Midha Kamal K.	Method for preventing abuse of methylphenidate
WO2000059479A1 (en) *	1999-04-06	2000-10-12	Pharmaquest Ltd.	Pharmaceutical dosage form for pulsatile delivery of methylphenidate
US20020077276A1 (en) *	1999-04-27	2002-06-20	Fredeking Terry M.	Compositions and methods for treating hemorrhagic virus infections and other disorders
US6251432B1 (en) *	1999-07-01	2001-06-26	Abbott Laboratories	Sustained release dosage form unit having latex coating and method of making the same
US6237677B1 (en)	1999-08-27	2001-05-29	Delphi Technologies, Inc.	Efficiency condenser
KR100574213B1 (ko) *	2000-01-27	2006-04-27	다나베 세이야꾸 가부시키가이샤	서방성 제제 및 그의 제조 방법
US6991807B2 (en) *	2000-02-24	2006-01-31	Advancis Pharmaceutical, Corp.	Antibiotic composition
US6730320B2 (en) *	2000-02-24	2004-05-04	Advancis Pharmaceutical Corp.	Tetracycline antibiotic product, use and formulation thereof
US6544555B2 (en)	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
US6565882B2 (en)	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
IT1318625B1 (it)	2000-07-14	2003-08-27	Roberto Valducci	Formulazioni farmaceutiche solide orali a rilascio multifasicoph-dipendente.
US6541014B2 (en) *	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
US20020197314A1 (en)	2001-02-23	2002-12-26	Rudnic Edward M.	Anti-fungal composition
AU2002256092C1 (en) *	2001-04-05	2009-10-15	Collagenex Pharmaceuticals, Inc.	Controlled delivery of tetracycline compounds and tetracycline derivatives
US7211267B2 (en) *	2001-04-05	2007-05-01	Collagenex Pharmaceuticals, Inc.	Methods of treating acne
JP2003238393A (ja) *	2002-02-15	2003-08-27	Otsuka Pharmaceut Co Ltd	施錠性が改善された錠剤及びその製造方法
US6958161B2 (en)	2002-04-12	2005-10-25	F H Faulding & Co Limited	Modified release coated drug preparation
AUPS167602A0 (en) *	2002-04-12	2002-05-16	F.H. Faulding & Co. Limited	An improved modified release preparation
US20040114368A1 (en) *	2002-12-13	2004-06-17	Shyu Shing Jy	Light device having rotatable or movable view
ES2534827T3 (es)	2003-04-07	2015-04-29	Supernus Pharmaceuticals, Inc.	Formulaciones de tetraciclinas en dosis única diaria
AU2004258953B2 (en)	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
AU2004258949B2 (en)	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
JP2006528185A (ja)	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
WO2005009416A1 (en) *	2003-07-24	2005-02-03	Ranbaxy Laboratories Limited	Modified release compositions for minocycline
CA2535177A1 (en)	2003-08-11	2005-02-24	Advancis Pharmaceutical Corporation	Robust pellet
US8062672B2 (en)	2003-08-12	2011-11-22	Shionogi Inc.	Antibiotic product, use and formulation thereof
AU2004270170B2 (en)	2003-08-29	2011-01-27	Shionogi, Inc.	Antibiotic product, use and formulation thereof
CA2538064C (en) *	2003-09-15	2013-12-17	Advancis Pharmaceutical Corporation	Antibiotic product, use and formulation thereof
CN1332937C (zh) *	2003-12-31	2007-08-22	赤峰东陵药业有限责任公司	新四环霉素类衍生物
GB2414668B (en) *	2004-06-03	2009-07-29	Dexcel Ltd	Tetracycline modified release delivery system
CA2572292A1 (en)	2004-07-02	2006-02-09	Advancis Pharmaceutical Corporation	Tablet for pulsed delivery
US20060078621A1 (en) *	2004-10-13	2006-04-13	Wedinger Robert S	Method of providing customized drug delivery systems
US7541347B2 (en)	2007-04-02	2009-06-02	Medicis Pharmaceutical Coropration	Minocycline oral dosage forms for the treatment of acne
US20100215744A1 (en) *	2008-08-06	2010-08-26	Medicis Pharmaceutical Corporation	Hydroxypropyl Substitution Used to Regulate Dissolution of a Chemical
US7919483B2 (en) *	2005-06-24	2011-04-05	Medicis Pharmaceutical Corporation	Method for the treatment of acne
US8722650B1 (en)	2005-06-24	2014-05-13	Medicis Pharmaceutical Corporation	Extended-release minocycline dosage forms
US20080241235A1 (en) *	2007-04-02	2008-10-02	Medicis Pharmaceutical Corporation	Minocycline oral dosage forms for the treatment of acne
US7544373B2 (en)	2007-04-02	2009-06-09	Medicis Pharmaceutical Corporation	Minocycline oral dosage forms for the treatment of acne
US8252776B2 (en)	2007-04-02	2012-08-28	Medicis Pharmaceutical Corporation	Minocycline oral dosage forms for the treatment of acne
US9192615B2 (en)	2008-08-06	2015-11-24	Medicis Pharmaceutical Corporation	Method for the treatment of acne and certain dosage forms thereof
US20080242642A1 (en)	2007-04-02	2008-10-02	Medicis Pharmaceutical Corporation	Minocycline oral dosage forms for the treatment of acne
RU2414241C2 (ru) *	2005-08-26	2011-03-20	БиПиЭсАй ХОЛДИНГЗ, ИНК.	Лекарственные композиции, содержащие гипромеллозные матрицы контролируемого высвобождения
US8778924B2 (en)	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
EP2298324A1 (de) *	2006-01-24	2011-03-23	Paratek Pharmaceuticals, Inc.	Verfahren zur Verbesserung der oralen Bioverfügbarkeit von Tetracyclinen
US8299052B2 (en)	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
CN100512689C (zh) *	2006-09-28	2009-07-15	江南大学	一种用于降低卷烟烟气中焦油及自由基的添加剂及其添加方法
US20080241197A1 (en) *	2007-04-02	2008-10-02	Medicis Pharmaceutical Corporation	Minocycline dosage forms for the treatment of acne
WO2008121107A1 (en) *	2007-04-02	2008-10-09	Medicis Pharmaceutical Corporation	Minocycline oral dosage forms for the treatment of acne
US9561241B1 (en)	2011-06-28	2017-02-07	Medicis Pharmaceutical Corporation	Gastroretentive dosage forms for minocycline
TW201618783A (zh)	2014-08-07	2016-06-01	艾森塔製藥公司	以布魯頓(Bruton)氏酪胺酸激酶(BTK)佔據和BTK再合成速率為基礎之治療癌症、免疫和自體免疫疾病及發炎性疾病之方法
US20170182070A1 (en)	2014-10-08	2017-06-29	Mayne Pharma International Pty Ltd.	Controlled Release Doxycycline
CA2968316A1 (en)	2014-11-19	2016-05-26	Nestle Skin Health Sa	Modified release doxycycline composition
US11103517B2 (en) *	2015-04-07	2021-08-31	Dr. Reddy's Laboratories Ltd.	Pharmaceutical compositions for minocycline
EP3436513B1 (de) *	2016-03-29	2020-09-16	PTT Global Chemical Public Company Limited	Koaleszenzmittel aus succinatester
GB2551980A (en) *	2016-06-30	2018-01-10	Commw Scient Ind Res Org	Method and system for low level metal analysis of mineral samples

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB310814A (en) *	1927-08-05	1929-05-31	Bates Valve Bag Corp	Method of and apparatus for filling bags
GB327295A (en) *	1929-04-12	1930-04-03	Edward Lloyd Pease	Improvements in or relating to tanks having external cooling elements, applicable tooil tanks for electrical transformers
NL122039C (de) *	1960-10-20
US3148212A (en) *	1961-12-22	1964-09-08	American Cyanamid Co	Reductive alkylation process
AT290523B (de) *	1962-01-05	1971-06-11	Merck & Co Inc	Verfahren zur Herstellung neuer α-(3-Indolyl)-carbonsäuren
USRE26253E (en) *	1963-05-17	1967-08-15		And z-alkylamino-g-deoxytetracycline
US3356571A (en) *	1964-11-25	1967-12-05	American Cyanamid Co	Potentiation of tetracycline by polyacrylic acid or hydrolyzed polyacrylonitrile
CH434571A (de) *	1966-07-05	1967-04-30	Chemical And Pharmaceutical Pa	Verfahren zur Herstellung von Antibiotika mit verlängerter therapeutischer Wirkung
US3865935A (en) *	1972-08-10	1975-02-11	Abbott Lab	Tableting of erythromycin base
US4250166A (en) *	1977-05-27	1981-02-10	Shionogi & Co., Ltd.	Long acting preparation of cefalexin for effective treatments of bacterial infection sensitive to cefalexin
GB1561204A (en) *	1977-06-01	1980-02-13	Ici Ltd	Sustained release pharmaceutical composition
US4173626A (en) *	1978-12-11	1979-11-06	Merck & Co., Inc.	Sustained release indomethacin
FR2447192A1 (fr) *	1979-01-25	1980-08-22	Adria Lab Inc	Forme galenique a liberation prolongee d'indoprofene
US4353887A (en) *	1979-08-16	1982-10-12	Ciba-Geigy Corporation	Divisible tablet having controlled and delayed release of the active substance
DK150008C (da) *	1981-11-20	1987-05-25	Benzon As Alfred	Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat
JPS61210025A (ja) *	1985-03-14	1986-09-18	Teisan Seiyaku Kk	安定化された抗生物質複合顆粒製剤
GB8521494D0 (en) *	1985-08-29	1985-10-02	Zyma Sa	Controlled release tablet
US4837030A (en) *	1987-10-06	1989-06-06	American Cyanamid Company	Novel controlled release formulations of tetracycline compounds
EP0327295A3 (de) *	1988-02-01	1989-09-06	F.H. FAULDING & CO. LTD.	Tetracyclin-Dosisform
US5133974A (en) *	1989-05-05	1992-07-28	Kv Pharmaceutical Company	Extended release pharmaceutical formulations
ATE114472T1 (de) *	1989-09-21	1994-12-15	American Cyanamid Co	System des typs ''einmal täglich'' zur gepulsten minocyclinabgabe.

1990
- 1990-08-20 AT AT90115881T patent/ATE114472T1/de not_active IP Right Cessation
- 1990-08-20 DE DE69014513T patent/DE69014513T2/de not_active Expired - Lifetime
- 1990-08-20 ES ES90115881T patent/ES2064564T3/es not_active Expired - Lifetime
- 1990-08-20 IL IL9542390A patent/IL95423A/en unknown
- 1990-08-20 DK DK90115881.6T patent/DK0418565T3/da active
- 1990-08-20 EP EP90115881A patent/EP0418565B1/de not_active Expired - Lifetime
- 1990-09-14 NZ NZ235319A patent/NZ235319A/xx unknown
- 1990-09-15 CN CN90107817A patent/CN1035039C/zh not_active Expired - Lifetime
- 1990-09-18 JP JP02246377A patent/JP3140764B2/ja not_active Expired - Lifetime
- 1990-09-19 CA CA002025703A patent/CA2025703C/en not_active Expired - Lifetime
- 1990-09-19 CZ CS904559A patent/CZ283048B6/cs not_active IP Right Cessation
- 1990-09-19 PH PH41222A patent/PH30777A/en unknown
- 1990-09-19 SK SK4559-90A patent/SK455990A3/sk not_active IP Right Cessation
- 1990-09-19 PT PT95353A patent/PT95353B/pt not_active IP Right Cessation
- 1990-09-20 NO NO904099A patent/NO177038C/no not_active IP Right Cessation
- 1990-09-20 ZA ZA907546A patent/ZA907546B/xx unknown
- 1990-09-20 IE IE339890A patent/IE66389B1/en not_active IP Right Cessation
- 1990-09-20 FI FI904634A patent/FI96170C/fi active IP Right Grant
- 1990-09-20 KR KR1019900014932A patent/KR100187950B1/ko not_active Expired - Lifetime
- 1990-09-20 PL PL90286971A patent/PL164770B1/pl unknown
- 1990-09-20 AR AR90317918A patent/AR244547A1/es active
- 1990-09-20 AU AU63031/90A patent/AU624998B2/en not_active Expired
- 1990-09-21 HU HU9006006A patent/HU221804B1/hu not_active IP Right Cessation
- 1990-09-21 DD DD90344125A patent/DD297558A5/de unknown
1992
- 1992-05-27 US US07/892,383 patent/US5300304A/en not_active Expired - Lifetime
1993
- 1993-07-14 US US08/091,322 patent/US5413777A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
NZ235319A (en)	1993-03-26
ZA907546B (en)	1991-07-31
IL95423A0 (en)	1991-06-30
DE69014513T2 (de)	1995-05-24
NO904099D0 (no)	1990-09-20
PT95353A (pt)	1991-08-14
PH30777A (en)	1997-10-17
PT95353B (pt)	1998-05-29
SK279358B6 (sk)	1998-10-07
DD297558A5 (de)	1992-01-16
SK455990A3 (en)	1998-10-07
FI96170C (fi)	1996-05-27
CN1050320A (zh)	1991-04-03
FI904634A0 (fi)	1990-09-20
NO904099L (no)	1991-03-22
PL164770B1 (pl)	1994-10-31
CA2025703A1 (en)	1991-03-22
HU906006D0 (en)	1991-03-28
FI96170B (fi)	1996-02-15
DK0418565T3 (da)	1995-01-23
CZ455990A3 (en)	1997-08-13
KR910005875A (ko)	1991-04-27
EP0418565A2 (de)	1991-03-27
AU6303190A (en)	1991-03-28
US5413777A (en)	1995-05-09
HK1000315A1 (en)	1998-02-27
IE66389B1 (en)	1995-12-27
HU221804B1 (hu)	2003-01-28
ES2064564T3 (es)	1995-02-01
NO177038C (no)	1995-07-12
CN1035039C (zh)	1997-06-04
JP3140764B2 (ja)	2001-03-05
IE903398A1 (en)	1991-04-10
CA2025703C (en)	2002-08-27
NO177038B (no)	1995-04-03
CZ283048B6 (cs)	1997-12-17
US5300304A (en)	1994-04-05
KR100187950B1 (ko)	1999-06-01
IL95423A (en)	1994-11-11
JPH03112930A (ja)	1991-05-14
AR244547A1 (es)	1993-11-30
AU624998B2 (en)	1992-06-25
DE69014513D1 (de)	1995-01-12
PL286971A1 (en)	1992-01-27
HUT59314A (en)	1992-05-28
EP0418565A3 (en)	1991-09-25
EP0418565B1 (de)	1994-11-30

Legal Events

Date	Code	Title	Description
2010-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE114472T1 (de)	1994-12-15	System des typs ''einmal täglich'' zur gepulsten minocyclinabgabe.
DE69202739D1 (de)	1995-07-06	Gemischtes Alkylmethylsiloxane zur Hautpflege.
LT2185B (lt)	1993-10-15	5'-dezoksi-5-fluorcitidino dariniu gavimo budas
FI915262A0 (fi)	1991-11-08	Hydrodesulforiseringsfoerfarande i flere steg.
DE69310443D1 (de)	1997-06-12	Präparat zur oralen Hygiene
DE69203249D1 (de)	1995-08-10	Vorrichtung zur Blutreinigung.
KR950700707A (ko)	1995-02-20	치과용 치료시스템
OA09194A (en)	1992-06-30	"Insecticidal treatment and compositions therefor".
AU5216690A (en)	1991-10-03	Periodontal disease treatment system
DE69202707D1 (de)	1995-07-06	Alkylmethylsiloxane zur Hautpflege.
DE58906881D1 (de)	1994-03-17	Gerät zur Zahnbehandlung.
IT1227849B (it)	1991-05-10	Composizione per l'igiene orale.
IT9047924A0 (it)	1990-05-08	Composizione per l'igiene orale.
DE69006899D1 (de)	1994-04-07	Mittel zur oralen Spülung.
DE69021536D1 (de)	1995-09-14	Zahnimplantatsystem.
EP0586848A3 (de)	1995-01-25	Implantat.
FR2720558B1 (fr)	1996-06-21	Système d'alimentation sécurisé.
IT1244668B (it)	1994-08-08	Impianto dentale endosseo.
DE59006623D1 (de)	1994-09-01	Vorrichtung zur Hubbegrenzung.
DK31992D0 (da)	1992-03-10	Hesteskosystem
IT9048026A0 (it)	1990-06-04	Preparato farmaceutico e/o cosmetico.
DE69002821D1 (de)	1993-09-23	Zusammensetzung zur haarbehandlung.
KR940007408U (ko)	1994-04-15	메세지 전달 카드
GB2235637B (en)	1993-06-02	Horseshoe sprinlker
ES1023915Y (es)	1994-04-01	Implante dental.