IL95423A - Pulsatile once-a-day delivery systems for minocycline - Google Patents

Pulsatile once-a-day delivery systems for minocycline

Info

Publication number: IL95423A
Authority: IL; Israel
Prior art keywords: minocycline; medium; coated; deoxy; acid addition
Prior art date: 1989-09-21

Application number

IL9542390A

Other languages

English (en)

Other versions

IL95423A0 (en

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-21

Filing date

1990-08-20

Publication date

1994-11-11

1990-08-20 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1991-06-30 Publication of IL95423A0 publication Critical patent/IL95423A0/xx

1994-11-11 Publication of IL95423A publication Critical patent/IL95423A/en

Links

229960004023 minocycline Drugs 0.000 title claims abstract description 143
DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 title abstract 5
230000000541 pulsatile effect Effects 0.000 title description 3
239000008187 granular material Substances 0.000 claims abstract description 171
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239000002253 acid Substances 0.000 claims abstract description 54
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238000000034 method Methods 0.000 claims abstract description 34
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FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 claims description 146
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ZOKIJEBQDZFGMW-PSXMRANNSA-N [(2R)-2-[12-(4-azido-2-nitroanilino)dodecanoyloxy]-3-tetradecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCNc1ccc(cc1[N+]([O-])=O)N=[N+]=[N-] ZOKIJEBQDZFGMW-PSXMRANNSA-N 0.000 claims 1
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230000001419 dependent effect Effects 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
230000009429 distress Effects 0.000 description 1
238000009826 distribution Methods 0.000 description 1
229940075059 doryx Drugs 0.000 description 1
229960003722 doxycycline Drugs 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
238000006345 epimerization reaction Methods 0.000 description 1
230000003628 erosive effect Effects 0.000 description 1
238000001125 extrusion Methods 0.000 description 1
229940118764 francisella tularensis Drugs 0.000 description 1
235000011389 fruit/vegetable juice Nutrition 0.000 description 1
229910021485 fumed silica Inorganic materials 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
229940047650 haemophilus influenzae Drugs 0.000 description 1
210000003405 ileum Anatomy 0.000 description 1
239000012729 immediate-release (IR) formulation Substances 0.000 description 1
201000001371 inclusion conjunctivitis Diseases 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
229960004187 indoprofen Drugs 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
210000001630 jejunum Anatomy 0.000 description 1
229960001375 lactose Drugs 0.000 description 1
210000003750 lower gastrointestinal tract Anatomy 0.000 description 1
208000001581 lymphogranuloma venereum Diseases 0.000 description 1
238000005259 measurement Methods 0.000 description 1
229920003145 methacrylic acid copolymer Polymers 0.000 description 1
150000004702 methyl esters Chemical class 0.000 description 1
244000005700 microbiome Species 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
230000008693 nausea Effects 0.000 description 1
235000020925 non fasting Nutrition 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
238000010525 oxidative degradation reaction Methods 0.000 description 1
229940124531 pharmaceutical excipient Drugs 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
229940069328 povidone Drugs 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
229960003712 propranolol Drugs 0.000 description 1
239000002599 prostaglandin synthase inhibitor Substances 0.000 description 1
208000007865 relapsing fever Diseases 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
238000007789 sealing Methods 0.000 description 1
206010040872 skin infection Diseases 0.000 description 1
239000008279 sol Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000005563 spheronization Methods 0.000 description 1
238000012289 standard assay Methods 0.000 description 1
229940031000 streptococcus pneumoniae Drugs 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000002344 surface layer Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000006379 syphilis Diseases 0.000 description 1
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
238000002627 tracheal intubation Methods 0.000 description 1
206010061393 typhus Diseases 0.000 description 1
241000189072 typhus group Species 0.000 description 1
208000019206 urinary tract infection Diseases 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
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238000003466 welding Methods 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL9542390A 1989-09-21 1990-08-20 Pulsatile once-a-day delivery systems for minocycline IL95423A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US41070889A	1989-09-21	1989-09-21

Publications (2)

Publication Number	Publication Date
IL95423A0 IL95423A0 (en)	1991-06-30
IL95423A true IL95423A (en)	1994-11-11

Family

ID=23625892

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9542390A IL95423A (en)	1989-09-21	1990-08-20	Pulsatile once-a-day delivery systems for minocycline

Country Status (26)

Country	Link
US (2)	US5300304A (de)
EP (1)	EP0418565B1 (de)
JP (1)	JP3140764B2 (de)
KR (1)	KR100187950B1 (de)
CN (1)	CN1035039C (de)
AR (1)	AR244547A1 (de)
AT (1)	ATE114472T1 (de)
AU (1)	AU624998B2 (de)
CA (1)	CA2025703C (de)
CZ (1)	CZ283048B6 (de)
DD (1)	DD297558A5 (de)
DE (1)	DE69014513T2 (de)
DK (1)	DK0418565T3 (de)
ES (1)	ES2064564T3 (de)
FI (1)	FI96170C (de)
HK (1)	HK1000315A1 (de)
HU (1)	HU221804B1 (de)
IE (1)	IE66389B1 (de)
IL (1)	IL95423A (de)
NO (1)	NO177038C (de)
NZ (1)	NZ235319A (de)
PH (1)	PH30777A (de)
PL (1)	PL164770B1 (de)
PT (1)	PT95353B (de)
SK (1)	SK455990A3 (de)
ZA (1)	ZA907546B (de)

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1990
- 1990-08-20 EP EP90115881A patent/EP0418565B1/de not_active Expired - Lifetime
- 1990-08-20 AT AT90115881T patent/ATE114472T1/de not_active IP Right Cessation
- 1990-08-20 DK DK90115881.6T patent/DK0418565T3/da active
- 1990-08-20 DE DE69014513T patent/DE69014513T2/de not_active Expired - Lifetime
- 1990-08-20 IL IL9542390A patent/IL95423A/en unknown
- 1990-08-20 ES ES90115881T patent/ES2064564T3/es not_active Expired - Lifetime
- 1990-09-14 NZ NZ235319A patent/NZ235319A/xx unknown
- 1990-09-15 CN CN90107817A patent/CN1035039C/zh not_active Expired - Lifetime
- 1990-09-18 JP JP02246377A patent/JP3140764B2/ja not_active Expired - Lifetime
- 1990-09-19 SK SK4559-90A patent/SK455990A3/sk not_active IP Right Cessation
- 1990-09-19 PT PT95353A patent/PT95353B/pt not_active IP Right Cessation
- 1990-09-19 CA CA002025703A patent/CA2025703C/en not_active Expired - Lifetime
- 1990-09-19 CZ CS904559A patent/CZ283048B6/cs not_active IP Right Cessation
- 1990-09-19 PH PH41222A patent/PH30777A/en unknown
- 1990-09-20 FI FI904634A patent/FI96170C/fi active IP Right Grant
- 1990-09-20 AU AU63031/90A patent/AU624998B2/en not_active Expired
- 1990-09-20 NO NO904099A patent/NO177038C/no not_active IP Right Cessation
- 1990-09-20 IE IE339890A patent/IE66389B1/en not_active IP Right Cessation
- 1990-09-20 KR KR1019900014932A patent/KR100187950B1/ko not_active Expired - Lifetime
- 1990-09-20 ZA ZA907546A patent/ZA907546B/xx unknown
- 1990-09-20 PL PL90286971A patent/PL164770B1/pl unknown
- 1990-09-20 AR AR90317918A patent/AR244547A1/es active
- 1990-09-21 HU HU9006006A patent/HU221804B1/hu not_active IP Right Cessation
- 1990-09-21 DD DD90344125A patent/DD297558A5/de unknown
1992
- 1992-05-27 US US07/892,383 patent/US5300304A/en not_active Expired - Lifetime
1993
- 1993-07-14 US US08/091,322 patent/US5413777A/en not_active Expired - Lifetime
1997
- 1997-10-04 HK HK97101885A patent/HK1000315A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT95353A (pt)	1991-08-14
JPH03112930A (ja)	1991-05-14
DK0418565T3 (da)	1995-01-23
HU906006D0 (en)	1991-03-28
FI96170C (fi)	1996-05-27
FI96170B (fi)	1996-02-15
ZA907546B (en)	1991-07-31
PL164770B1 (pl)	1994-10-31
DE69014513T2 (de)	1995-05-24
CN1035039C (zh)	1997-06-04
HU221804B1 (hu)	2003-01-28
NO904099L (no)	1991-03-22
NO904099D0 (no)	1990-09-20
IL95423A0 (en)	1991-06-30
IE903398A1 (en)	1991-04-10
ATE114472T1 (de)	1994-12-15
EP0418565A3 (en)	1991-09-25
JP3140764B2 (ja)	2001-03-05
KR910005875A (ko)	1991-04-27
FI904634A0 (fi)	1990-09-20
DD297558A5 (de)	1992-01-16
CZ455990A3 (en)	1997-08-13
PL286971A1 (en)	1992-01-27
HK1000315A1 (en)	1998-02-27
EP0418565B1 (de)	1994-11-30
CA2025703A1 (en)	1991-03-22
CZ283048B6 (cs)	1997-12-17
PT95353B (pt)	1998-05-29
IE66389B1 (en)	1995-12-27
NO177038B (no)	1995-04-03
CN1050320A (zh)	1991-04-03
NZ235319A (en)	1993-03-26
NO177038C (no)	1995-07-12
EP0418565A2 (de)	1991-03-27
ES2064564T3 (es)	1995-02-01
SK279358B6 (sk)	1998-10-07
AU6303190A (en)	1991-03-28
PH30777A (en)	1997-10-17
US5413777A (en)	1995-05-09
CA2025703C (en)	2002-08-27
US5300304A (en)	1994-04-05
AR244547A1 (es)	1993-11-30
AU624998B2 (en)	1992-06-25
SK455990A3 (en)	1998-10-07
HUT59314A (en)	1992-05-28
DE69014513D1 (de)	1995-01-12
KR100187950B1 (ko)	1999-06-01

Legal Events

Date	Code	Title
1996-11-14	KB	Patent renewed
2000-11-21	KB	Patent renewed
2004-09-27	KB	Patent renewed
2008-12-29	KB	Patent renewed