ATE1150T1 - Anthracyclinglycosiden, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen. - Google Patents

Anthracyclinglycosiden, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen.

Info

Publication number: ATE1150T1
Authority: AT; Austria
Prior art keywords: compounds; compositions containing; anthracyclinglycosides; production; therapeutic compositions
Prior art date: 1979-02-02

Application number

AT80100447T

Other languages

English (en)

Inventor

Guiseppe Cassinelli

Federico Arcamone

Aurelio Dr. Di Marco

Original Assignee

Farmitalia Carlo Erba S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-02-02

Filing date

1980-01-29

Publication date

1982-06-15

1980-01-29 Application filed by Farmitalia Carlo Erba S.P.A. filed Critical Farmitalia Carlo Erba S.P.A.

1982-06-15 Application granted granted Critical

1982-06-15 Publication of ATE1150T1 publication Critical patent/ATE1150T1/de

Links

238000000034 method Methods 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 4
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
229960000975 daunorubicin Drugs 0.000 abstract 1
STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 1
229960004679 doxorubicin Drugs 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Furan Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT80100447T 1979-02-02 1980-01-29 Anthracyclinglycosiden, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen. ATE1150T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB7903700		1979-02-02
EP80100447A EP0014425B1 (de)	1979-02-02	1980-01-29	Anthracyclinglycosiden, Verfahren zu deren Herstellung und sie enthaltende therapeutische Zusammensetzungen

Publications (1)

Publication Number	Publication Date
ATE1150T1 true ATE1150T1 (de)	1982-06-15

Family

ID=10502917

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT80100447T ATE1150T1 (de)	1979-02-02	1980-01-29	Anthracyclinglycosiden, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen.

Country Status (6)

Country	Link
US (1)	US4254110A (de)
EP (1)	EP0014425B1 (de)
JP (1)	JPS55133370A (de)
AT (1)	ATE1150T1 (de)
DE (1)	DE3060481D1 (de)
DK (1)	DK45080A (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4314999A (en) *	1978-07-31	1982-02-09	Proter S.P.A.	N-Acyl derivatives of glucosamine having antitumor chemotherapeutic acitivity
US4393052A (en) *	1980-11-01	1983-07-12	Farmitalia Carlo Erba S.P.A.	Antitumor anthracycline glycosides, their preparation, intermediates therefor, and compositions and use thereof
GB2196626B (en) *	1986-10-15	1990-09-19	Erba Farmitalia	Antitumor anthracycline glycosides, their preparation, intermediates thereof, and compositions and use therefor
FR2660561B1 (fr) *	1990-04-06	1994-05-13	Technomed International	Sonde rectale.
US7388083B2 (en) *	2005-03-07	2008-06-17	Solux Corporation	Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
US8802830B2 (en)	2005-12-20	2014-08-12	Solux Corporation	Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en)	2008-01-08	2013-01-22	Solux Corporation	Method of aralkylation of 4′-hydroxyl group of anthracylins

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL130756C (de) *	1964-03-02
GB1550879A (en) *	1976-12-22	1979-08-22	Farmaceutici Italia	Antitumour glycosides
GB1542920A (en) *	1976-12-22	1979-03-28	Farmaceutici Italia	Antitumour glycosides
US4181795A (en) *	1978-05-22	1980-01-01	Purdue Research Foundation	Daunosamine synthesis

1980
- 1980-01-28 US US06/115,725 patent/US4254110A/en not_active Expired - Lifetime
- 1980-01-29 AT AT80100447T patent/ATE1150T1/de not_active IP Right Cessation
- 1980-01-29 DE DE8080100447T patent/DE3060481D1/de not_active Expired
- 1980-01-29 EP EP80100447A patent/EP0014425B1/de not_active Expired
- 1980-02-01 JP JP1015980A patent/JPS55133370A/ja active Granted
- 1980-02-01 DK DK45080A patent/DK45080A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
DK45080A (da)	1980-08-03
EP0014425A1 (de)	1980-08-20
DE3060481D1 (en)	1982-07-22
US4254110A (en)	1981-03-03
EP0014425B1 (de)	1982-06-02
JPS55133370A (en)	1980-10-17
JPS6321671B2 (de)	1988-05-09

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Legal Events

Date	Code	Title	Description
1982-08-15	UEP	Publication of translation of european patent specification
1989-10-15	REN	Ceased due to non-payment of the annual fee