ATE115550T1 - Glutamin- und asparginsäurederivate mit antigastrinwirkung und verfahren zu deren herstellung. - Google Patents

Glutamin- und asparginsäurederivate mit antigastrinwirkung und verfahren zu deren herstellung.

Info

Publication number: ATE115550T1
Authority: AT; Austria
Prior art keywords: antigastrin; aspartic acid; acid derivatives; group; glutaminic
Prior art date: 1989-11-02

Application number

AT90916273T

Other languages

English (en)

Inventor

Francesco Makovec

Claudio Lucio Rovati

Angelo Luigi Rovati

Original Assignee

Rotta Research Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-02

Filing date

1990-10-25

Publication date

1994-12-15

1990-10-25 Application filed by Rotta Research Lab filed Critical Rotta Research Lab

1994-12-15 Application granted granted Critical

1994-12-15 Publication of ATE115550T1 publication Critical patent/ATE115550T1/de

Links

FOQYDURHXZVLFT-UHFFFAOYSA-N 2-phenyl-2-pyridin-2-ylethanethioamide Chemical compound C=1C=CC=NC=1C(C(=S)N)C1=CC=CC=C1 FOQYDURHXZVLFT-UHFFFAOYSA-N 0.000 title abstract 2
150000001509 aspartic acid derivatives Chemical class 0.000 title abstract 2
230000000694 effects Effects 0.000 title abstract 2
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 title 1
229960002989 glutamic acid Drugs 0.000 title 1
GKDWRERMBNGKCZ-RNXBIMIWSA-N gastrin-17 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 GKDWRERMBNGKCZ-RNXBIMIWSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010060377 Hypergastrinaemia Diseases 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
-1 chloro, methyl Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
150000002306 glutamic acid derivatives Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT90916273T 1989-11-02 1990-10-25 Glutamin- und asparginsäurederivate mit antigastrinwirkung und verfahren zu deren herstellung. ATE115550T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT67937A IT1238664B (it)	1989-11-02	1989-11-02	Derivati degli acidi glutammico ed aspartico ad attivita' antigastrinica e procedimento per la loro preparazione

Publications (1)

Publication Number	Publication Date
ATE115550T1 true ATE115550T1 (de)	1994-12-15

Family

ID=11306521

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90916273T ATE115550T1 (de)	1989-11-02	1990-10-25	Glutamin- und asparginsäurederivate mit antigastrinwirkung und verfahren zu deren herstellung.

Country Status (10)

Country	Link
EP (1)	EP0498830B1 (de)
JP (1)	JPH05501411A (de)
AT (1)	ATE115550T1 (de)
AU (1)	AU6637690A (de)
CA (1)	CA2067569A1 (de)
DE (1)	DE69015208T2 (de)
ES (1)	ES2066232T3 (de)
IT (1)	IT1238664B (de)
PT (1)	PT95766A (de)
WO (1)	WO1991006529A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1241029B (it) *	1990-12-11	1993-12-27	Rotta Research Lab	Derivati amidici biciclici e policiclici degli acidi glutammico, aspartico e 2-ammino adipico ad attivita' antigastrinica e procedimento per la loro preparazione
IT1263116B (it) *	1992-04-09	1996-07-30	Rotta Research Lab	Derivati basici dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso farmaceutico
WO1997044341A1 (en) *	1996-05-17	1997-11-27	Rotta Research Laboratorium S.P.A.	Cyclic polyamides of glutamic acid and aspartic acid with anti-gastrin activity, a method for their preparation and their pharmaceutical use
WO1997045415A1 (en) *	1996-05-28	1997-12-04	Rotta Research Laboratorium S.P.A.	Polyamide derivatives or ornithine, lysine and analogous substances with cck-b and gastrin-antagonistic activity

1989
- 1989-11-02 IT IT67937A patent/IT1238664B/it active IP Right Grant
1990
- 1990-10-25 DE DE69015208T patent/DE69015208T2/de not_active Expired - Fee Related
- 1990-10-25 AU AU66376/90A patent/AU6637690A/en not_active Abandoned
- 1990-10-25 WO PCT/EP1990/001808 patent/WO1991006529A1/en not_active Ceased
- 1990-10-25 CA CA002067569A patent/CA2067569A1/en not_active Abandoned
- 1990-10-25 EP EP90916273A patent/EP0498830B1/de not_active Expired - Lifetime
- 1990-10-25 AT AT90916273T patent/ATE115550T1/de not_active IP Right Cessation
- 1990-10-25 ES ES90916273T patent/ES2066232T3/es not_active Expired - Lifetime
- 1990-10-25 JP JP2515145A patent/JPH05501411A/ja active Pending
- 1990-10-31 PT PT95766A patent/PT95766A/pt not_active Application Discontinuation

Also Published As

Publication number	Publication date
IT8967937A0 (it)	1989-11-02
ES2066232T3 (es)	1995-03-01
EP0498830B1 (de)	1994-12-14
EP0498830A1 (de)	1992-08-19
WO1991006529A1 (en)	1991-05-16
IT1238664B (it)	1993-09-01
JPH05501411A (ja)	1993-03-18
IT8967937A1 (it)	1991-05-02
PT95766A (pt)	1991-09-13
DE69015208T2 (de)	1995-05-04
AU6637690A (en)	1991-05-31
CA2067569A1 (en)	1991-05-03
DE69015208D1 (de)	1995-01-26

Similar Documents

Publication	Publication Date	Title
ZA911403B (en)	1991-11-27	Derivatives having a naphthalene structure,process for preparing these and pharmaceutical compositions containing them
DK116480A (da)	1980-09-21	Fremgangsmaade til fremstilling af substituerede chromoner
FI893467A0 (fi)	1989-07-18	Menetelmä lääkeaineena käyttökelpoisten 4-oksokinoliini-3-karboksyylihapon johdannaisten valmistamiseksi
PT98959A (pt)	1992-07-31	Processo de preparacao de compostos 6- ou 7-(2-imino-2-imidazolidina)-1,4-benzoxazinas e de composicoes farmaceuticas que os contem
IT1153216B (it)	1987-01-14	Procedimento per la preparazione di composti cianoeterociclici
ES535552A0 (es)	1986-05-16	Un procedimiento para la preparacion de nuevos derivados de tiazolidina.
ATE127794T1 (de)	1995-09-15	Benzimidazo- und azabenzimidazol-derivate, tromboxanrezeptorantagonisten, verfahren zu deren herstellung, herstellungszwischenprodukte, diese enthaltende zusammenstellungen.
ATE28565T1 (de)	1987-08-15	Spiro(4.(3+n))-2-aza-alkan-3-carbonsaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung.
PT71644B (de)	1982-01-21	Verfahren zur herstellung von 4-phenoxypiperidinen
DE3583872D1 (de)	1991-10-02	Dihydropyridin-derivate, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische zusammensetzungen, und verfahren zur herstellung dieser zusammensetzungen.
ATE115550T1 (de)	1994-12-15	Glutamin- und asparginsäurederivate mit antigastrinwirkung und verfahren zu deren herstellung.
ATE48276T1 (de)	1989-12-15	1,6-naphthyridin-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel.
DE69110124D1 (de)	1995-07-06	Indolderivate, herstellung und verwendung.
ATE6500T1 (de)	1984-03-15	2-alpha-methyl-dopaminimino-6,7-dihydroxy-1,2,3 4-tetrahydronaphthalin, seine salze, und verfahren zu dessen herstellung.
ES8602786A1 (es)	1985-12-01	Derivados de pirimidoisoquinolina
HUT53638A (en)	1990-11-28	Process for producing 15-amino-substituted 20,21-dinoreburnamenie derivatives and pharmaceutical compositions containing them
ATE165829T1 (de)	1998-05-15	Nootrope wirkstoffe
TH13340A (th)	1993-11-15	2 , 3 - ไดดีออกซี - 5 - ไตรฟลูออโรเมทธิลยุรีตีนที่ถูกแทนที่ ขบวนการเตรียมและการใช้ในเภสัชภัณฑ์
LV10711A (lv)	1995-06-20	Akrilskabes amida atvasinajumu iegusanas panemiens jaunie akrilskabes amida atvasinajumi farmaceitiskas kompozicijas kas satur sos savienojumus un to pielietojums medicina
TH919A (th)	1983-04-22	การเตรียมอนุพันธ์ 1-แอลคิล-2-อะมิโน-เททราลิน
TH1593A (th)	1984-06-01	แอลฟา-แอลคิล โพลิโอลีฟินิค คาร์บอกซิลิคแอซิด และอนุพันธ์ของสารนั้น ซึ่งใช้เป็นประโยชน์ในการรักษาโรคขี้เรื้อนกวาง
ES433899A1 (es)	1976-11-16	Procedimiento para la preparacion de nuevas bencilaminas.
MY101827A (en)	1992-01-31	2-[n-substitutedguanidino]-4-heteroarylthiazole antiulcer agents
TH1594A (th)	1984-06-01	สารประกอบไทรไซคลิค
ES433891A1 (es)	1976-11-16	Procedimiento para la preparacion de nuevas bencilaminas.

Legal Events

Date	Code	Title	Description
1995-05-15	UEP	Publication of translation of european patent specification
1997-01-15	REN	Ceased due to non-payment of the annual fee